Wheat growing process utilizing selective herebicide

ABSTRACT

A process for growing wheat and selectively preventing or controlling the growth of wild oats in the same site in which the wheat is being cultivated which comprises applying to said site an amount of an active compound sufficient to control the growth of wild oats without adversely affecting the growth of the wheat, said active compound being N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide or N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide.

This application is a division of application Ser. No. 814,568, filed Dec. 30, 1985, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to a novel pyrazolesulfonamide derivative, a process for preparing the compound and a herbicide cotaining the compounds as an active component. In order to protect important crops such as rice plants, wheat, cotton and sugar beets from damges by weeds to achieve an increased yield, it is indispensable to use a herbicide. In recent years in particular, a herbicide having selectivity (or discriminativity) is saught after as it can kill only weeds selectively (or discriminatively) without damages to crops by agricultural chemicals even when a foliage treatment is applied simultaneously on crops and weeds in a cultivated land wherein useful crops and weeds are grown together. Also, from viewpoints of the prevention of environmental pollution, the transportion, and the economical cost reduction in application of chemicals, studies and researches have been made over many years on such compounds that may achieve a higher herbicidal activity with use of chemcicals in a lower amount. Some of the compounds having such a property are presently used as the herbicide having selectivity. Still, however, there are further demands for new compounds having such a property.

Conventionally, a number of compounds having sulfonylurea structure has been known. Any of these, however, show very strong activities to sugar beets. For example, sugar beets have extremely high sensibility to chlorsulfuron which is known as a herbicide for wheat, and accordingly the sugar beets which are cultured as second crops of wheat are known to be seriously suffered from damages by agricultural chemicals even after two years, because of a trace amount of the acvtive component remaining in the soil. Also, other sulfonylurea compounds than the chlorsulfuron are also considered to have very particularly strong effect to sugar beets, and, of the sulfonylurea type compounds, the compound which may have the selectivity on sugar beets have been hitherto almost unknown.

As a prior technique, European Patent Publication No. 87,780 discloses a pyrazolesulfonylurea which may have the sturcture similar to the compound of this invention. However, there has been nothing disclosing the compound wherein a heterocyclic ring is substituted on a pyrazole ring as this invention discloses.

SUMMARY OF THE INVENTION

The present inventors have made researches over many years to develop herbicides having the selectivity on important crops, and have examined herbicidal properties of a number of compounds to create compounds having a higher herbicidal effect and the selectivity. As a result, it was found that a pyrazolesulfonamide derivative of Formula (I) shown below (hereinafter often referred to as "the compound of this invention") has a strong herbicidal effect to various weeds while retaining high safety to the important crops in either case of the soil treatment or the foliage treatment.

According to the invention, there is provided a pyrazolesulfonamide derivative represented by Formula (I): ##STR1## wherein Q represents a group of; ##STR2## wherein R¹, R² and R³ each independently represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a group of COOR¹⁰, a group of S(O)_(n) R¹¹, a group of NR¹² R¹³, a C₁ -C₈ alkoxy group, a group of SO₂ NR⁸ R⁹, a group of SO₂ OR¹¹ or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR¹⁰, a C₁ -C₈ alkoxy group or a C₁ -C₈ alkyl group;

R⁴ and R⁵ each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group, a halogenated C₁ -C₈ alkyl group, a nitro group, a group of COOR¹⁰, a group of S(O)_(n) R¹¹, a C₁ -C₈ alkoxy group or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a group of COOR¹⁰, a nitro group, a C₁ -C₈ alkoxy group or a C₁ -C₈ alkyl group;

R⁶ and R⁷ each independently represent a hydrogen atom, a halogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R⁸ and R⁹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group or a phenyl group;

R¹⁰ represents a hydrogen atom or a C₁ -C₈ alkyl group;

R¹¹ represents a C₁ -C₈ alkyl group and n is an integer of 0, 1 or 2;

R¹² and R¹³ each independently represent a hydrogen atom or a C₁ -C₈ alkyl group;

m represents an integer of 0, 1 or 2, and R represents a hydrogen atom or a C₁ -C₈ alkyl group;

B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C₁ -C₈ alkyl group, an arylalkyl group, a C₁ -C₈ alkoxy group, a halogenated C₁ -C₈ alkyl group, a group of COOR¹⁴, a group of CONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group of NR¹⁸ R¹⁹, a group of SO₂ NR²⁰ R²¹, a group of OH, an unsubstituted benzoyl group or a benzoyl group substituted with a halogen atom or a C₁ -C₈ alkyl group, or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR¹⁰ or a C₁ -C₈ alkyl group;

R¹⁴ represents a hydrogen atom, an unsubstituted C₁ -C₈ alkyl group (or a C₁ -C₈ alkyl group substituted with an unsubstituted C₁ -C₈ alkoxy group or a C₁ -C₈ alkoxy group substituted with a group of R¹⁰ O, a halogenated C₁ -C₈ alkoxy group, a cyano group, a phenoxy group, a c₁ -C₈ alkoxycarbonyl group, a group of R¹⁰ R¹¹ N, a C₃ -C₇ cycloalkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkylcarbonyl group), an unsubstituted C₁ -C₈ alkenyl group or a C₁ -C₈ alkenyl group substituted with a halogen atom, an unsubstituted C₁ -C₈ alkynyl group or a C₁ -C₈ alkynyl group substituted with a halogen atom, a halogenated C₁ -C₈ alkyl group, a C₃ -C₇ cycloalkyl group or a benzyl group;

R¹⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group or a phenyl group, and R¹⁶ represents a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R¹⁷ represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a phenyl group, a halogenated C₁ -C₈ alkyl group, a C₁ -C₈ alkenyloxy group or a C₁ -C₈ alkynyloxy group, and n represents an integer of 0, 1 or 2;

R¹⁸ and R¹⁹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkylcarbonyl group or a C₁ -C₈ alkylsulfonyl group;

R²⁰ and R²¹ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group or a C₁ -C₈ alkynyl group;

R¹⁰ is as defined above;

E represents a hydroge atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, or a C₁ -C₈ alkoxy group;

W represents an oxygen atom, a sulfur atom or a group of N--R¹⁶, wherein R¹⁶ is as defined above;

G represents a group of; ##STR3## wherein X and Y each independently represent a hydrogen atom, a halogen group, a C₁ -C₈ alkyl group, a C₁ -C₈ alkoxy group, a C₁ -C₈ alkoxyalkyl group, a halogenated C₁ -C₈ alkyl group, or a halogenated C₁ -C₈ alkoxy group, a group of NR²² R²³, a group of OCH(R¹⁰)COOR¹⁰, a group of COOR¹⁰, a cyclopropyl group, a group of CH(OR²⁴)₂, a C₁ -C₈ alkylthio group or a halogenated C₁ -C₈ alkylthio group;

R²² and R²³ each independently represent a hydrogen atom, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

R²⁴ represents a C₁ -C₈ alkyl group;

R¹⁰ is as defined above;

X¹ and Y¹ each independently represent a hydrogen atom, a halogen group, a C₁ -C₈ alkyl group or a C₁ -C₈ alkoxy group;

X² represents a C₁ -C₈ alkyl group, a C₁ -C₈ alkylthio group or a C₁ -C₈ alkoxy group, and Y² represents a C₁ -C₈ alkyl group;

Z represents a nitrogen atom or a group of C--R²⁵ ;

R²⁵ represents a hydrogen atom, a C₁ -C₈ alkyl group or a halogenated C₁ -C₈ alkyl group, a halogen atom, a C₁ -C₈ alkoxy group or a 5-membered ring containing an oxygen atom together with Y or Y¹ ;

with the proviso that the group: ##STR4## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR)_(m) --Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of CH₂ CN, a C₁ -C₈ alkoxyalkyl group, a C₁ -C₈ alkylthioalkyl group, a group of --CH₂ COOR¹⁰, a group of --COR¹⁰, a group of SO₂ R²⁴, a group of SO₂ NR¹⁰ R²⁴ or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR¹⁰ or a C₁ -C₈ alkyl group; R¹⁰ and R²⁴ is as defined above.

The above compound can be obtained by a process for preparing a pyrazolesulfonamide derivative represented by Formula (I)': ##STR5## wherein Q, m, R, B, D, E and G are as defined above, and

W' represents an oxygen atom or a sulfur atom;

which comprises allowing a pyrazolesulfonyl(thio)isocyanate derivative represented by Formula (II): ##STR6## wherein Q, m, R, B, D and W' are as defined above; with the proviso that the group --SO₂ N═C═W' in Formula (II) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR)_(m) --Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of CH₂ CN, a C₁ -C₈ alkoxyalkyl group, a C₁ -C₈ alkylthioalkyl group, a group of --CH₂ COOR¹⁰, a group of --COR¹⁰, a group of SO₂ R²⁴, a group of SO₂ NR¹⁰ R²⁴ or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR¹⁰ or a C₁ -C₈ alkyl group;

R¹⁰ and R²⁴ is as defined above;

to react with an aminopyrimidine, aminotriazine or aminotriazole derivative represented by Formula (III): ##STR7## wherein G and E are as defined above; in an inert solvent, or allowing a pyrazolesulfonyl(thio)carbamate derivative represented by Formula (IV): ##STR8## wherein Q, m, R, B, D and W' are as defined above; with the proviso that the group --SO₂ N═C═W' in Formula (II) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR)_(m) --Q is not substituted in the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of CH₂ CN, a C₁ -C₈ alkoxyalkyl group, a C₁ -C₈ alkylthioalkyl group, a group of --CH₂ COOR¹⁰, a group of --COR¹⁰, a group of SO₂ R²⁴, a group of SO₂ NR¹⁰ R²⁴ or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR¹⁰ or a C₁ -C₈ alkyl group;

R¹⁰ and R²⁴ is as defined above;

to react with an aminopyrimidine, aminotriazine or aminotriazole derivative represented by Formula (III): ##STR9## wherein G and E are as defined above; in an inert solvent.

Certain compounds of the above compounds show very high selectivity on beets. Also, certain compounds of the compound of this invention have the selectivity not only to beets but also to wheat, cotton. corn, etc. The certain compounds of the compound of this invention, having the selectivity on wheat, are suited for selectivity controlling wild oats. Wild oats are known to be improtant weeds growing with the culture of wheat. However, since wheat and wild oats belong to a plant species which is akin to each other, the known sulfonylurea type herbicides (the above-mentioned chlorosulfuron, for example) having the selectivity on wheat have also no effect to the wild oats, and thus it has been difficult to control them. The compound of this invention, on the other hand, shows a high herbicidal activity in a very low amount of the active component as compared with the conventional herbicides, and accordingly it is useful also as a herbicide for orchards and uncultivated lands.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The compound of this invention, represented by Formula (I) can be readily prepared by selecting either one of the procedures shown by the following reaction schemes. ##STR10## wherein B, D, Q, m, R, E, W' and G are as defined above.

Namely, a pyarazolesulfonyl(thio)isocyanate derivative (II) is dissolved in an inert solvent of sufficiently dried dioxane, acetonitrile, etc., to which a pyrimidine, triazine or triazole derivative shown by Formula (III) is added to carry out stirring, whereupon a compound of Formula (I)' which is a part of the compound of this invention is obtained by generally swift reaction. When the reaction proceeds with difficulty, a suitable base or bases such as triethylamine, triethylenediamine, pyridine, sodium alkoxide and sodium hydride may be added to allow the reaction to proceed readily. ##STR11## wherein B, D, Q, m, R, E, W', G and R²⁶ are as defined above.

Namely, a pyrazolesulfonamide derivative (V) is reacted with chloro(thio)formate or (thio)carbonate in a solvent such as acetone, methyl ethyl ketone and acetonitrile and in the presence of a base or bases such as potassium carbonate to form a compound (IV), followed by heating together with a compound (III) to obtain a compound (I)' which is a part of the compound of this invention. ##STR12## wherein B, D, Q, m, R, E, W', G and R¹⁶ are as defined above.

Namely, the above sulfonylguanidine type compound which is a part of the compound of this invention can be synthesized in accordance with the process disclosed in Japanese Unexamined Patent Publications No. 167570/1984, No. 6654/1985 and No. 36467/1985.

The starting pyrazolesulfonyl(thio)isocyanate (II) or pyrazolesulfonyl(thio)carbamate derivative (IV) used in the reactions in Reaction Scheme 1 and Raction Scheme 2 can be synthesized by first synthesizing a pyrazolesulfonamide (V) by selecting a suitable process as mentioned below, and further making reference to the process disclosed in European Patent Publication No. 87,780 and Japanese Unexamined Patent Publication No. 13266/1980.

This pyrazolesulfonamide which is an intermediate used in this invention is also a novel compound, and may be obtained by selecting a suitable process from the processes shown in Reaction Schemes 4 to 9 below. ##STR13##

In the above;

(a): NaNO₂.HCl or NaNO₂.HBr

(b): SO₂.Cu salt

(c): NH₄ OH or ammonium carbonate

(d): Cu salt

(e): POCl₃ or POBr₃

(f): P₂ S₅

(g): NaSH

(h): NaOH.NH₄ OH.NaOCl

(i): NaSCH₂ Ph

(j): Cl₂ /CH₃ COOH.H₂ O

(k): BuLi or LiN(i-Pr)₂, followed by Cl₂ or Br₂

(l): an oxidant

(m): (1) ClSO₃ H, (2) SOCl₂ or PCl₅

(n): (1) BuLi or LiN(i-Pr)₂, (2) SO₂, (3) N-chlorosuccinimide

(o): ClC(═S)NMe₂ /base

(p): heating

(q): R²⁷ Hal/base

In the above formulae, B, D, Q, m, R, E, W and G are as defined above; and R²⁷ is C₁ -C₈ alkyl group, a C₁ -C₈ alkenyl group, a C₁ -C₈ alkynyl group, a group of CH₂ CN, a C₁ -C₈ alkoxyalkyl group, a C₁ -C₈ alkylthioalkyl group, a group of CH₂ COOR¹⁰, a group of COR²⁴, a group of SO₂ R²⁴ or a group of SO₂ NR¹⁰ R²⁴ ; R¹⁰ and R²⁴ are as defined above.

Usually, pyrazolesulfonamide (V) is obtained by reacting a corresponding pyrazolesulfonylchloride with ammonia water or ammonium carbonate. In order to introduce a sulfonyl group into pyrazole, the following methods may be used:

(i) An amino group is subjected to diazonium decomposition in the presence of sulfur dioxide to obtain pyrazolesulfonylchloride.

(ii) Hydroxypyrazole is formed into o-pyrazolethiocarbamate, and thereafter a sulfur atom is introduced into pyrazole ring by a rearrangement reaction, followed further by oxidation to obtain pyrazolesulfonylchloride.

(iii) A sulfur atom is introduced into pyrazole by a nucleophilic substitution with a halogen atom, etc., followed further by oxidation, if necessary, to obtain pyrazolesulfonylchloride.

(iv) Carbanion of pyrazole is formed by use of a base, on which sulfur dioxide is acted, followed by halogenation to obtain pyrazolesulfonylchloride.

(v) Pyrazolesulfonylchloride is directly obtained by sulfuryl chloride.

(vi) A pyrazole derivative obtained by any of the above methods is modified with other functional group by utilizing an attribute of pyrazole.

More specifically;

(i) Taking the procedures of Reaction Scheme 4, aminopyrazole is formed into a diazonium salt with use of sodium nitrite, etc. in hydrochloric acid or hydrobromic acid, and then sulfur dioxide is acted on it in the presence of a catalyst such as copper salt usually used for the diazonium decomposition, to obtain the corresponding pyrazolesulfonylchloride. By allowing ammonia water to act on it, the desired pyrazolesulfonamide (V) can be obtained.

(ii) Taking the procedures of Reaction Scheme 8, hydroxypyrazole is used as a starting material to obtain o-pyrazolethiocarbamate, which is then heated for its transition to s-pyrazolethiolcarbamate, followed by oxidation with use of chlorine in a solvent such as acetic acid to obtain pyrazolesulfonylchloride. Similar to Reaction Scheme 3, the desired pyrazolesulfonamide can be obtained by allowing ammonia water to act on the pyrazolesulfonylchloride.

Both of these Reaction Schemes 4 and 8 are not affected by the position of substituent.

(iii) A nucleophilic substitution against pyrazole usually takes place most readily at the 5-position, and, in the next place, at 3-position it may sometimes takes place when an electron attractive group is substituted on the 4-position. Taking the procedures of Reaction Scheme 5 by utilizing this tendency, a sulfur atom is introduced into the 5-position by treating halogenated pyrazole with use of sodium hydrosulfide, sodium salt of benzylmercaptan, etc., followed by oxidation with use of chlorine in a solvent such as acetic acid to obtain pyrazolesulfonlchloride. Similar to Reaction Scheme 4, the desired pyrazolesulfonamide (V) can be obtained by allowing ammonia water to act on it. It is also possible to obtain the desired pyrazolesulfonamide (V) by forming an intermediate 5-mercaptopyrazole into sulfenamide, followed by oxidation thereof. The starting 5-position halogenated pyrazole can be obtained by diazo decomposition of aminopyrazole, a reaction of hydroxypyrazole with phosphorous oxychloride or phosphorous oxybromide, or by formation of a 5-position anion with use of a strong base such as butyl lithium and lithium diisopropylamide, followed by halogenation.

(iv) When a substituent is at the 1-position, the hydrogen at the 5-position of a pyrazole ring generally has relatively strong acidity. Taking the procedures of Reaction Scheme 7, an anion can be formed with use of a strong base such as butyl lithium and lithium diisopropylamide, thereafter treating it with sulfur dioxide and N-halogenosuccinimide to form pyrazolesulfonylchloride, and then treating it with ammonia water to obtain the desired pyrazolesulfonamide (V).

(v) As compared with the nucleophilic substitution, an electrophilic substitution against a pyrazole ring tends to take palce at the 4-position. Taking the procedures of Reaction Scheme 6, pyrazole-4-sulfonylchloride can be directly obtained with use of chlorosulfonic acid.

(vi) Taking the procedures of Reaction Scheme 9, alkylation, acylation or sulfonylation of pyrazolesulfonamide having no substituent at the 1-position results in alkylation, acylation or sulfonylation at the 1-position or the 2-position. According to this procedures, it is somethimes possible to obtain two kinds of compounds as a mixture wherein the substituents at the 3-position and the 5-position have been replaced with each other, but it is possible to separate these compounds by column chromatography, recrystallization, etc. for use as an intermediate for the compound of this invention.

It is also possible by utilizing an attribute of pyrazole to obtain various types of pyrazolesulfonamide (V) by newly intorducing a substituent into pyrazolesulfonamide, or by modifying a substituent having been introduced in it.

Pyrazoles used as starting materials in the above reactions can be synthesized in most cases by making reference to A. N. Kost and I. I. Groundberg, Advan. Heterocyclic Chem., Vol. 6, p. 347, 1966; T. L. Yacobs, Heterocyclic Compounds, R. C. Elderfield, Vol. 5, p. 45, Wiley, New York, 1957; or K. Shofield, M. R. Grimmett and B. R. T. Keene, Heterocyclic Nitrogen Compounds The Azoles, Cambridge University Press, London, Newyork, Melbourne, 1976; Kevin T. Potts, Comprehensive Heterocyclic Chemistry, Vol. 5, p. 167, Pergamon Press, 1984. When the group of (CHR)_(m) --Q is substituted on the 1-position of a pyrazole ring, it can be obtained by using (CHR)_(m) --QNHNH₂ in place of hydrazine, methylhydrazine, phenylhydrazine, etc. in the above publications.

Usually, it is possible for one skilled in the art to obtain an intermediate of the compound of this invention by studying experimental conditions on the basis of the descriptions hereinabove and the known arts in the above publications. In the following, synthesis examples for synthesizing the compound of this invention and the intermediate pyrazolesulfonamide will be described concretely as Exampels and Reference Examples, by which, however, by no means the invention is limited.

REFERENCE EXAMPLE 1 Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

(1) Synthesis of ethyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate:

14 g of ethyl 5-amino-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 50 ml of conc. hydrochloric acid, and the solution obtained was cooled to -5° C., to which 5.5 g of sodium nitrite dissolved in 10 ml of water was added cropwise, and thereafter, stirred for 10 minutes, followed by addition of 0.6 g of urea. The solution thus obtained was added dropwise at 5° C. to a solution obtained by adding 2 g of sulfur dioxide and 0.6 g of cuprous chloride to 50 ml of 1,2-dichloroethane. After stirring at room temperature for 1 hour, 200 ml of ice water was added thereto, followed by extraction with chloroform. Seperation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 13.1 g of the title compound. m.p.: 38° to 42° C.

(2) Synthesis of ethyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate:

12 g of ethyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 60 ml of dimethylformamide, to which 9.5 g of 70% sodium hydrosulfide was added and then heated at 90° to 100° C. for 5 hours. After the reaction was completed, ice water was added to make the reaction mixture acidic with use of conc. hydrochloric acid, followed by extraction with chloroform. Separation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 11.4 g of the title compound. m.p.: 73° to 76° C.

(3) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide:

5.8 g of ethyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 50 ml of 80% acetic acid, into which chlorine was brown at 5° to 15° C. until it is saturated. After the reaction was completed, 200 ml of ice water was added, followed by extraction with 1,2-dichloroethane. Separation of the layer of 1,2-dichloroethane, washing with water, drying and concentration were then carried out to obtain 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonylchloride. The sulfonylchloride obtained was dissolved in 50 ml of 1,2-dichloroethan, followed by addition of 4 g of ammonium carbonate (containing 30% of ammonia) and stirring at room temperature for 3 hours. After filtration of inorganic salt, solvent was evaporated to obtain 5.7 g of the title compound. The amount obtained after purification by use of a silica gel column chromatography was 3.9 g. m.p.: 134° to 135° C.

REFERENCE EXAMPLE 2 Synthesis of 4-ethoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 1. m.p.: 166° to 167° C.

Each of the intermediates had the following property.

Ethyl 5-amino-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, obtained by heating 2-hydrazinopyridine and ethyl β-ethyl-α-cyanochlotonate in n-butyl alcohol. m.p.: 80° to 81° C.

Ethyl 5-chloro-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 49° to 52° C.

Ethyl 5-mercapto-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 99° to 101° C.

REFERENCE EXAMPLE 3 Synthesis of 4-methoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 and 2. m.p.: 151° to 153° C.

Each of the intermediates had the following property.

Methyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 86° to 88° C.

Methyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 120° to 121° C.

REFERENCE EXAMPLE 4 Synthesis of 1-(3,5-dichloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 and 2. m.p.: 161° C.

Each of the intermediates had the following property.

Ethyl 5-chloro-1-(3,5-dichloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 81° to 82° C.

REFERENCE EXAMPLE 5 Synthesis of 4-ethoxycarbonyl-1-(3-methylpyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 and 2. m.p.: 165° to 170° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.

Ethyl 5-chloro-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.

Ethyl 5-mercapto-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.

REFERENCE EXAMPLE 6 Synthesis of 4-ethoxycarbonyl-1-(2-pyrimidyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 and 2. m.p.: 175° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 190° to 191° C.

Ethyl 5-chloro-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 80° to 84° C.

Ethyl 5-mercapto-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 131° to 133° C.

REFERENCE EXAMPLE 7 Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole-4-sulfonamide

(1) Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole:

10 g of acetylacetone was added to 20 ml of ethanol, to which 10.9 g of 2-hydrazinopyridine was further added little by little under ice cooling. After stirring overnight at room temperature, distillation was carried out under reduced pressure. b.p.: 85° to 90° C./0.8 mmHg. Amount obtained: 14.5 g.

(2) Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole-4-sulfonamide:

10.4 g of 3,5-dimethyl-1-(2-pyridyl)pyrazole dissolved in 12.5 ml of chloroform under ice-cooling was added dropwise to a mixed solution of 18 ml of chlorosulfonic acid and 18 ml of chloroform. The mixture was stirred at room temperature for 1 hour and then heated under reflux for 4.5 hours. Next, after chloroform was evaporated under reduced pressure, 25.1 g of phosphorous pentachloride was added little by little, followed by heating at 90° to 100° C. for 1 hour while elevating the temperature gradually. After cooling, ice water was added to the reaction mixture, which was then extracted with benzene. After benzene was evaporated under reduced pressure, 18 g of 28% ammonia water was added dropwise thereto. After stirring overnight at room temperature, solvent was evaporated under reduced pressure to obtain 12.6 g of the title compound as crystals. m.p.: 160° to 163° C.

REFERENCE EXAMPLE 8 Synthesis of 4-bromo-1-(2-pyridyl)pyrazole-3 -sulfonamide

(1) Synthesis of 2-(3-amino-2-pyrazolin-1-yl)pyridine:

The compound was synthesized from 2-hydrazinopyridine and acrylonitrile following the procedures disclosed in U.S. Pat. No. 4,347,251. m.p.: 169° to 171° C.

(2) Synthesis of 3-amino-1-(2-pyridyl)pyrazole:

10 g of 2-(3-amino-2-pyrazolin-1-yl)pyridine was added to a 500 ml acetone suspensison of 50 g of active manganese dioxide ground into powder. After stirring at room temperature for 2 hours, insolubles were filtered off and acetone was evaporated under reduced pressure to obtain 6.4 g of the deisred product as crystals. m.p.: 98° to 101° C.

(3) Synthesis of 3-amino-4-bromo-1-(2-pyridyl)pyrazole:

5.6 g of 3-amino-1-(2-pyridyl)pyrazole was added to 35 ml of acetic acid, to which 5.8 g of bromine was further added dropwise at room temperature. After stirring at room temperature for 20 minutes, crystals precipitated were collected by filtration and dissolved in 50 ml of diluted hydrochloric acid. To this hydrochloric acid solution, added was an aqueous solution of 30% potassium hydroxide for neutralization to obtain 5.3 g of the title compound as crystals. m.p.: 145° to 146° C.

(4) Synthesis of 4-bromo-1-(2-pyridyl)pyrazole-3-sulfonamide:

3 g of 3-amino-4-bromo-1-(2-pyridyl)pyrazole was suspended in 60 ml of hydrochloric acid, to which 2.5 ml of an aqueous solution containing 1.2 g of sodium nitrite was added dropwise at -10° to -5° C. to prepare a solution of diazonium salt. This solution of diazonium salt was added dropwise at 5° C. to 30 ml of acetic acid saturated with sulfur dioxide containing 0.5 g of cuprous chloride. After stirring at room temperature for 20 minutes, 100 ml of water and 300 ml of 1,2-dichloroethane were added and stirred to separate an organic layer. To the organic layer, added was 10 ml of 28% ammonia water, followed by vigorous stirring at room temperature for 1 hour. Thereafter, solvent was evaporated under reduced pressure and 200 ml of ethyl acetate was added. After further stirring, insolubles were filtered off and ethyl acetate was evaporated to obtain 2.2 g of the title compound as a crude product. This crude product was purified by a silica gel column chromatography (developed with ethyl acetate) to obtain 0.5 g of the title compound as a pure product. m.p.: 201° to 203° C.

REFERENCE EXAMPLE 9 Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide

(1) Synthesis of α-ethoxymethylene-2-pyridineacetonitrile:

A mixture of 25 g of 2-pyridineacetonitrile, 63 g of ethyl orthoformate and 11 g of acetate anhydride was stirred at 120° to 130° C. for 3 hours, and thereafter 30 g of ethyl orthoformate and 11 g of acetic anhydride were further added, followed by stirring at 120° to 130° C. for 2 hours while evaporating the low boiling compound. After cooling, distillation was carried out under reduced pressure to obtain 22.7 g of distillates having b.p. of 100° to 130° C./0.1 mmHg (principal distillates: 110° C./0.1 mmHg). To the distillates obtained, added was diisopropyl ether, and then insoluble solids were filtered off and the filtrate was concentrated to obtain 20.7 g of the title compound.

(2) Synthesis of 5-amino-1-methyl-4-(2-pyridyl)pyrazole:

10 g of α-ethoxymethylene-2-pyridineacetonitrile was dissolved in 100 ml of ethanol, to which 3.1 g of methylhydrazine was added at room temperature. After heating under reflux for 4 hours, concentration under reduced pressure was carried out to obtain 10 g of the title compound. m.p.: 113° to 114° C.

(3) Synthesis of 1-methyl-4-(2-pyridyl)pyrazole:

10 g of 5-aminio-1-methyl-4-(2-pyridyl)pyrazole was dissolved in a solution of 10 ml of conc. sulfuric acid, 30 ml of phosphorous acid and 50 ml of water, to which 15 ml of an aqueous solution containing 5.1 g of sodium nitrite was added dropwise at -10° to -5° C. to prepare a soution of diazonium salt. This solution of diazonium salt was added to 100 ml of 50% hypophosphorous acid containing 0.5 g of cupric oxide, followed by stirring at room temperature, and further stirring at 40° C. for 1 hour. After the reacton was completed, the reaction mixture was made alkaline under ice-cooling with use of 28% ammonia water, followed by extraction with chloroform by adding an excess amount of water. After the liquid extracted with chloroform was dried with use of anhydrous sodium sulfate, solvent was evaporated under reduced pressure to obtain an oily product. The oily product was purified by a silica gel column chromatograpghy to obtain 5.9 g of the title compound as an oily product.

(4) Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide:

A 200 ml solution of anhydrous diethyl ether containing 5.9 g of 1-methyl-4-(2-pyridyl)pyrazole was cooled to -70° C., to which was added dropwise a lithium diisopropylamide solution separately prepared (prepared by use of 3.9 g of diisopropylamine and a hexane solution of 15% n-butyllithium). After stirring of the mixture at the same temperature for 1 hour, sulfur dioxide gas was blown into it, followed by further stirring for 1 hour. Filtration was carried out at the stage a cooler was removed and the temperature of the reaction mixture was returned to room temperature, to obtain 10 g of solid lithium sulfinate. 10 g of the lithium sulfinate obtained was added at 5° to 10° C. to 6 g of a suspension comprising 100 ml of water, 100 ml of methylene chloride and 6 g of N-chlorosuccinimide. After vigorous stirring at 5° C. for 20 minutes, 100 ml of 28% ammonia water was added dropwise thereto, followed by further stirring at room temperature for 1 hour. After separation of organic layer, aqueous layer was extracted with dichloromethane and the extract was combined with the organic layer, followed by drying with use of anhydrous sodium sulfate, and then solvent was evaporated under reduced pressure. Crystals precipitated from 3.4 g of an oily crude product were collected by filtration and washed with methanol to obtain 0.9 g of the title compound. m.p.: 195° to 197° C.

Reference Example 9-2 Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide: (another procedures)

The above can be also obtained by the process of Reference Example 1. Each of the intermediates had the following property.

5-Chloro-1-methyl-4-(2-pyridyl)pyrazole, m.p.: 81° to 82° C.

5-Mercapto-1-methyl-4-(2-pyridyl)pyrazole, m.p.: 223° to 228° C.

REFERENCE EXAMPLE 10 Synthesis of 4-ethoxycarbonyl-1-(3-pyridazinyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 189° to 191° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 136° to 137° C.

Ethyl 5-chloro-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 100° to 107° C.

Ethyl 5-mercapto-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 155° to 159° C.

REFERENCE EXAMPLE 11 Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Examples 1 to 6. m.p.: 196° to 198° C.

REFERENCE EXAMPLE 12 Synthesis of 1-(3-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 178° to 179° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(3-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 65° to 66° C.

Ethyl 5-chloro-1-(3-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 114° to 115° C.

Ethyl 1-(3-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 62° to 65° C.

REFERENCE EXAMPLE 13 Synthesis of 1-(5-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following the above Reference Example. m.p.: 114° to 115° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(5-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 132° to 133° C.

Ethyl 5-chloro-1-(5-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 109° to 114° C.

Ethyl 1-(5-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 138° to 139° C.

REFERENCE EXAMPLE 14 Synthesis of 1-(6-chloropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following the above Reference Example. m.p.: 143° to 145° C.

Each of the intermediates had the following property. Methyl 5-amino-1-(6-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 140° C.

Methyl 1-(6-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 118° to 120° C.

REFERENCE EXAMPLE 15 Synthesis of 1-(6-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

1 g of sulfonamide obtained in Reference Example 14 and 0.3 g of sodium hydroxide were refluxed with stirring for 1 hour in a mixed solvent of ethanol and water. After solvent was evaporated, water was added, followed by neutralization with use of hydrochloric acid. Crystals precipitated were collected by filtration and washed with water to obtain 0.8 g of 1-(6-chloropyridin-2-yl)-4-carboxypyrazole-5-sulfonamide. m.p.: 179° to 182° C.

Next, the above sulfonamide was introduced in ethanol saturated with hydrogen chloride, and, while stirring, heated under reflux for 7 hours. After solvent was evaporated, water was added, followed by extraction with chloroform. Extract liquid was evaporated to dryness to obtain 0.62 g of the title compound. m.p.: 125° to 128° C.

REFERENCE EXAMPLE 16 Synthesis of 4-ethoxycarbonyl-1-(4-methylpyridyn-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 135° to 137° C.

The intermediate had the following property.

Ethyl 5-amino-1-(4-methylpyridyn-2-yl)pyrazole-4-carboxylate, m.p.: 99° to 100° C.

REFERENCE EXAMPLE 17 Synthesis of 4-ethoxycarbonyl-1-(6-methylpyridyn-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 131° to 133° C.

REFERENCE EXAMPLE 18 Synthesis of 4-methoxycarbonyl-1-(pyrimidin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 263° to 265° C.

Each of the intermediates had the following property.

Methyl 5-amino-1-(pyrimidin-2yl)pyrazole-4-carboxylate, m.p.: 176° to 179° C.

Methyl 5-chloro-1-(pyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 153° to 156° C.

Methyl 5-mercapto-1-(pyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 185° to 186° C.

REFERENCE EXAMPLE 19 Synthesis of 4-n-propyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Sulfonamide obtained in Reference Example 1 was hydrolyzed following the procedures in Reference Example 15 to obtain 4-carboxy-1-(2-pyridyl)pyrazole-5-sulfonamide (m.p.: 270° to 271° C.), followed by esterification with use of n-propyl alcohol to obtain the title compound. m.p.: 153° to 154° C.

REFERENCE EXAMPLE 20 Synthesis of 4-i-propyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 19 except that the reaction was carried out for 72 hours for the esterification using i-propyl alcohol. m.p.: 123° to 124° C.

REFERENCE EXAMPLE 21 Synthesis of 1-(6-chloropyridin-2-yl)-4-methoxycarbonyl-3-methylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6, 14 and 15. m.p.: 119° to 120° C.

Each of the intermediates had the following property.

Methyl 5-amino-1-(6-chloropyridin-2-yl)-3-methylpyrazole-4-carboxylate, m.p.: 185° to 187° C.

Methyl 1-(6-chloropyridin-2-yl)-5-mercapto-3-methylpyrazole-4-carboxylate, m.p.: 142° to 144° C.

REFERENCE EXAMPLE 22 Synthesis of 4-ethoxycarbonyl-1-(3-fluoropyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Examples 1 to 6. m.p.: 177° to 178° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 136° to 138° C.

Ethyl 5-chloro-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 73° to 76° C.

Ethyl 5-mercapto-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 71° to 74° C.

REFERENCE EXAMPLE 23 Synthesis of 4-ethoxycarbonyl-1-(pyrazin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 189° to 191° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(pyrazin-2-yl)pyrazole-4-carboxylate, m.p.: 138° to 140° C.

Ethyl 5-chloro-1-(pyrazin-2-yl)pyrazole-4-carboxylate, m.p.: 107° to 114° C.

Ethyl 5-mercapto-1-(pyrazin-2-yl)pyrazole-4-carboxylate,m.p.: 130° to 137° C.

4-Ethoxycarbonyl-1-(pyrazin-2-yl)pyrazole-5-sulfonylchloride, m.p.: 105° to 106° C.

REFERENCE EXAMPLE 24 Synthesis of 4-methoxycarbonyl-1-(4-methylpyrimidin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 165° to 168° C.

Each of the intermediate had the following property.

Methyl 5-amino-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 163° to 165° C.

Methyl 5-chloro-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 85° to 87° C.

Methyl 5-mercapto-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 127° to 130° C.

REFERENCE EXAMPLE 25 Synthesis of 5-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide

(1) Synthesis of 3-methyl-1-(2-pyridyl)pyrazole:

54.7 g of acetylacetoaldehyde dimethylacetal (purity: 90%) was dissolved in 350 ml of ethanol, to which was added dropwise at room temperature 40.7 g of 2-hydrazinopyridine dissolved in 200 ml of ethanol. After stirring at room temperature for 2 hours, the reaction mixture was heated under reflux, and 40 ml of conc. hydrochloric acid was added thereto after cooling. After stirring at 60° C. for 30 minutes, the reaction mixture was concentrated, followed by addition of ice water, was made alkaline with use of ammonia water, and thereafter extracted with chloroform. After drying of organiclayer, solvent was evaporated under reduced pressure to obtain 59.2 g of an oily product. The oily product obtained was distilled under reduced pressure to obtain 52.9 g of the title compound as an oily product. b.p.: 115° to 120° C./10 mmHg.

(2) Synthesis of N-t-butyl-[3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide:

To 30 ml of chlorosulfonic acid contained in 60 ml of chloroform, 30 g of 3-methyl-1-(2-pyridyl)pyrazole was added dropwise under ice-cooling, followed by stirring at 60° C. for 3 hours. To a residue obtained by evaporating chloroform under reduced pressure, 30 ml of thionyl chloride was added dropwise at about 60° C. over a period of 1 hour. After the addition, the reaction mixture was stirred at 95° C. for 30 minutes while heating under reflux. After cooling, it was poured into ice water and extracted with chloroform, organic layer was washed with water and dried, and thereafter solvent was evaporated under reduced pressure to obtain 49 g of crude 3-methyl-1-(2-pyridyl)pyrazole-4-sulfonylchloride as an oily product. The sulfonylchloride obtained was dissolved in 50 ml of tetrahydrofuran, and then was added dropwise at 0° to 10° C. to 41.4 g of t-butylamine contained in 100 ml of tetrahydrofuran. After stirring at room temperature for 1.5 hour, filtration was carried out, and filtrate obtained was concentrated to give a residue, to which ethyl acetate was added, followed by washing with diluted hydrochloric acid and drying, and then solvent was evaporated to give crystals. Crystals obtained was washed with ether to obtain 48.6 g of the title compound. m.p.: 174° to 175° C.

(3) Synthesis of N-t-butyl-[5-carboxy-3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide:

15 g of N-t-butyl-[3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide was dissolved in 300 ml of tetrahydrofuran, to which a lithium diisopropylamine solution (obtained by adding dropwise 75 ml of a 15% n-butyllithium-hexane solution to 11.3 g of diisopropylamine contained in 50 ml of tetrahydrofuran, at -60° to -50° C.) was added dropwise at -70° to -65° C. over a period of 20 minutes. After stirring at the same temperature for 1 hour, carbonic acid gas was blown into the reaction mixture for 30 minutes and further for 30 minutes while the temperature thereof was returned to room temperature. The reaction mixture thus treated was poured into ice water to make it acidic with use of conc. hydrochloric acid, and then extracted with ethyl acetate. Organic layer was dried, and solvent was evaporated under reduced pressure to give crystals, which were then washed with ether to obtain 11.8 g of the title compound. m.p.: 170° to 172° C.

(4) Synthesis of 5-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide:

11 g of N-t-butyl-[5-carboxy-3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide was added to 50 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 6 hours, followed by concentration under reduced pressure to obtain crude 5-carboxy-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide. Subsequently, 250 ml of methanol were added to the residue, which was then saturated with hydrogen chloride and heated under reflux for 20 hours with stirring. The reaction mixture was concentrated under reduced pressure, followed by addition of ice water, and extracted with ethyl acetate. Organic layer was washed with water and, after drying, solvent was evaporated under reduced pressure to give crystals, which were then washed with ether to obtain the title compound as crystals. m.p.: 175° to 177° C.

REFERENCE EXAMPLE 26 Synthesis of 1-(3-chloro-6-methoxypyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide

Following the above Reference Examples 1 to 6, methyl 5-mercapto-1-(6-methoxypyridin-2yl)pyrazole-4-carboxylate was synthesized from methyl 5-amino-1-(6-methoxypyridin-2-yl)pyrazole-4-carboxylate (m.p.: 131° to 132° C.), and then derived to sulfonamide. The sulfonamide formed was a 1:1 mixture (white solids) of 1-(3-chloro-6-methoxypyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide and 4-methoxycarbonyl-1-(6-methoxypyridin-2-yl)pyrazole-5-sulfonamide.

Subsequently, following the procedures in Example 1, the sulfonamide was reacted with methyl chloroformate, and the product was formed by toluene recrystallization to give N-[4-methoxycarbonyl-1-(3-chloro-6-methoxypyridin-2-yl)pyrazole-5-sulfonyl]methylcarbamate. m.p.: 131° to 132° C.

REFERENCE EXAMPLE 27 Synthesis of 4-methoxycarbonyl-1-(3-trifluoromethylpyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 194° to 195° C.

Each of the intermediates had the following property.

Methyl 5-amino-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 107° to 110° C.

Methyl 5-chloro-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 72° to 73° C.

Methyl 5-mercapto-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 88° to 91° C.

REFERENCE EXAMPLE 28 Synthesis of 4-methoxycarbonyl-1-(6-methylpyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 15. m.p.: 125° to 129° C.

The intermediate had the following property.

1-(6-methylpyridin-2-yl)-4-carboxypyrazole-5-sulfonamide, m.p.: 201° to 202° C.

REFERENCE EXAMPLE 29 Synthesis of 4-ethoxycarbonyl-1-(6-methylpyridin-2-yl)-3-methylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 162° to 163° C.

Each of the intermediates had the following property.

Ethyl 5-amino-3-methyl-1-(6-methylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 108° to 109° C.

Ethyl 5-chloro-3-methyl-1-(6-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily product.

Ethyl 3-methyl-1-(6-methylpyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 100° to 101° C.

REFERENCE EXAMPLE 30 Synthesis of 4-methoxycarbonyl-1-(6-methylpyridin-2-yl)-3-methylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 15 and 19. m.p.: 155° to 159° C.

The intermediate had the following property.

3-Methyl-1-(6-methylpyridin-2-yl)-4-carboxypyrazole-5-sulfonamide, m.p.: 196° to 198° C.

REFERENCE EXAMPLE 31 Synthesis of 4-ethoxycarbonyl-1-(6-ethylpyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 87° to 88° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(6-ethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 116° to 117° C.

Ethyl 5-chloro-1-(6-ethylpyridin-2-yl)pyrazole-4-carboxylate, an oily product.

Ethyl 1-(6-ethylpyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 79° to 80° C.

REFERENCE EXAMPLE 32 Synthesis of 4-ethoxycarbonyl-1-(6-fluoropyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 22. m.p.: 114° to 116° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 86° to 88° C.

Ethyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 57° to 60° C.

Ethyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 105° to 107° C.

REFERENCE EXAMPLE 33 Synthesis of 1-(6-bromopyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 142° to 144° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(6-bromopyridin-2-yl)pyrazole-4-carboxylate, m.p.: 135° to 137° C.

Ethyl 1-(6-bromopyridin-2-yl)-5-chloropyrazole-4-carboxylate, m.p.: 91° to 94° C.

Synthesis of ethyl 5-benzylthio-1-(6-bromopyridin-2-yl)pyrazole-4-carboxylate

In 30 ml of dimethylformamide was dissolved 8 g of the above ethyl 1-(6-bromopyridin-2-yl)-5-chloropyrazole-4-carboxylate, to which added were 3 g of benzylmercaptan and 3.5 g of anhydrous potassium carbonate, followed by stirring overnight at room temperature. After the reaction, water was added to the reaction mixture, which was extracted with benzene, followed by washing with water and drying, and then solvent was evaporated to obtain the above carboxylate. This compound was further reacted following the procedures in Reference Example 1 to obtain 4 g of the title sulfonamide.

REFERENCE EXAMPLE 34 Synthesis of 4-ethoxycarbonyl-1-(4-pyrimidyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 238° to 239° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 135° to 136° C.

Ethyl 5-chloro-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 139° to 142° C.

Ethyl 5-mercapto-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 143° to 147° C.

REFERENCE EXAMPLE 35 Synthesis of 4-cyano-1-(4-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 211° to 213° C.

Each of the intermediates had the following property.

5-Amino-4-cyano-1-(2-pyridyl)pyrazole, obtained by heating 2-hydrazinopyridine and ethoxymethylenemalononitrile in n-butyl alcohol, m.p.: 197° to 200° C.

5-Chloro-4-cyano-1-(2-pyridyl)pyrazole, m.p.: 130° to 133° C.

4-Cyano-5-mercapto-1-(2-pyridyl)pyrazole, m.p.: 206° to 210° C.

5-Benzylthio-4-cyano-1-(2-pyridyl)pyrazole, obtained by reacting 5-chloro-4-cyano-1-(2-pyridyl)pyrazole with benzylmercaptan and sodium ethylate at room temperature in dimethylformamide. m.p.: 110° to 115° C.

REFERENCE EXAMPLE 36 Synthesis of 4-ethoxycarbonyl-1-(4-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 288° to 289° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(4-pyridyl)pyrazole-4-carboxylate, m.p.: 140° to 141° C.

Ethyl 5-chloro-1-(4-pyridyl)pyrazole-4-carboxylate, taken out by extraction with chloroform, after the reaction and after nutralized with use of potassium carbonate.

Ethyl 5-mercapto-1-(4-pyridyl)pyrazole-4-carboxylate, m.p.: 195° to 198° C.

Subsequently, 5.3 g of ethyl 5-mercapto-1-(4-pyridyl)pyrazole-4-carboxylate was suspended in 150 ml of water, and chlorine was passed to the suspension for 15 minutes under ice-cooling. Thereafter, 50 ml of tetrahydrofuran and 30 ml of ammonia water was added thereto, followed by stirring at room temperature for 30 minutes. The reaction mixture was concentrated to collect by filtration white solids formed, which were then washed with water and dried to obtain 3.0 g of the title compound.

REFERENCE EXAMPLE 37 Synthesis of 1-(6-dimethylaminopyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

The sulfonamide obtained in Reference Example 32 was dissolved in dimethylformamide, to which were added dimethylamine and anhydrous potassium carbonate, followed by stirring overnight at room temperature to obtain the title compound. m.p.: 157° to 160° C.

REFERENCE EXAMPLE 38 Synthesis of 4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 145° to 147° C.

Each of the intermediates had the following property.

5-Amino-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 136° to 138° C.

5-Chloro-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 101° to 102° C.

5-Mercapto-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 144° to 147° C.

REFERENCE EXAMPLE 39 Synthesis of 1-(6-fluoropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6 and Reference Example 22. m.p.: 174° to 175° C.

Each of the intermediates had the following property.

Methyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 143° to 145° C.

Methyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 112° to 115° C.

Methyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 120° to 122° C.

REFERENCE EXAMPLE 40 Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole-4-sulfonamide

m.p.: 188° to 190° C.

(1) Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole:

5.9 g of picolinoylacetone was added to 20 ml of ethanol, to which 1.7 g of methylhydrazine was added dropwise little by little under ice-cooling. After stirring overnight at room temperature, the reaction mixture was heated under reflux for 5 hours, followed by concentration to obtain 6.1 g of an oily product.

(2) Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole-4-sulfonamide:

To a mixed solution of 4.2 g of chlorosulfonic acid and 10 ml of chloroform, 5.7 g of 1,3-dimethyl-5-(2-pyridyl)pyrazole dissolved in 5 ml of chloroform was added dropwise under ice-cooling. After stirring at room temperature for 1 hour, the reaction mixture was heated under reflux for 3 hours. Subsequently, chloroform was evaporated under reduced pressure, followed by addition of 30 ml of thionyl chloride and heating under reflux for 6 hours. After the thionyl chloride was evaporated under reduced pressure, 50 ml of tetrahydrofuran was added to the reaction mixture, to which 20 ml of 28% ammonia water was further added dropwise under ice-cooling. After stirring at room temperature for 3 hours, solvent was evaporated, followed by washing with water to obtain 3.5 g of crude product, which was washed with hot benzene to obtain 2.9 g of the title compound. m.p.: 188° to 190° C.

REFERENCE EXAMPLE 41 Synthesis of 4-ethoxycarbonyl- 1-(5-nitropyridin-2-yl)pyrazole-3-sulfonamide

m.p.: 245° to 247° C.

Synthesis of the intermediate was carried out in the following manner.

3-benzylthio-4-ethoxycarbonyl-1-(5-nitropyridin-2-yl)pyrazole:

To 50 ml of dimethylformamide, 2.0 g of 5(3)-benzylthio-4-ethoxycarbonylpyrazole, 1.33 g of 2-chloro-5-nitropyridine and 1.5 g of anhydrous potassium carbonate were added, followed by heating at room temperature for 1 hour and further at a temperature of 60° to 70° C. for 1 hour. After cooling, water was added to the reaction mixture, which was then extracted with chloroform. The layer of chloroform was separated, and after washing with water and drying, solvent was evaporated to obtain 2.5 g of the title compound. m.p.: 164.5° to 165.5° C.

Subsequently, the derivation of the desired product may be carried out following the procedures in Reference Examples 1 to 6.

REFERENCE EXAMPLE 42 Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide: (procedures other than Reference Example 11)

Properties of intermediates:

Methyl 5-amino-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 115° to 116° C.

Methyl 5-chloro-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 111° to 112° C.

Methyl 3-methyl-5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 102° to 105° C.

Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide

In 200 ml of methylene chloride, 20.4 g of methyl 3-methyl-5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved, and thereafter 200 ml of water was added. While maintaining the mixture at not higher than 5° C., 64 ml of conc. hydrochloric acid was added thereto, to which 250 ml of an aqueous solution of sodium hypochlorite (effective chlorine concentration: 6%) was added dropwise at -5° C., followed by stirring at -5° C. for 10 minutes. After separation of organic layer, extraction was carried out by adding 100 ml of methylene chloride to the aqueous layer. Organic layer was combined with the previous organic layer, followed by washing with an aqueous solution of sodium bisulfite, and then 40 ml of 28% ammonia water was added at 10° C. or lower. After stirring at room temperature for 10 minutes, solvent was evaporated. Crystals precipitated were filtered, washed with water, further washed with ether and dried to obtain 18.3 g of the title compound. m.p.: 196° to 198° C.

REFERENCE EXAMPLE 43 Synthesis of 1-(6-fluoropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide

Synthesis was carried out following Reference Examples 1 to 6. m.p.: 174° to 175° C.

Each of the intermediates had the following property.

Methyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 143° to 145° C.

Methyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 112° to 115° C.

Methyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 120° to 122° C.

REFERENCE EXAMPLE 44 Synthesis of 1-(6-dimethylsulfamoylpyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide

(1) Synthesis of 2-chloro-6-dimethylsulfamoylpyridine:

To 50 ml of dimethylformamide were added 10 g of 2,6-dichloropyridine, 8.4 g of benzylmercaptan and 10 g of potassium carbonate, which was then stirred at room temperature for 1 hour, followed by heating to 60° to 70° C. After cooling, water was added to the reaction mixture to carry out extraction with chloroform. Extract was subjected to evaporation under reduced pressure, and thereafter, crystals obtained were dissolved in 200 ml of an aqueous solution of 90% acetic acid. Chlorine gas was blown into the reaction mixture over a period of 10 minutes under ice-cooling. Thereafter, water was added to the reaction mixture, which was then extracted with about 150 ml of chloroform. After the extraction was completed, washing with water was carried out several times, and then 12 g of an aqueous solution of 50% dimethylamine was added dropwise with stirring at about 10° C. After stirring for 1 hour, the layer of chloroform was evaporated under reduced pressure to obtain 12.4 g of 2-chloro-6-dimethylsulfamoylpyridine. m.p.: 53° to 55° C.

(2) Synthesis of 6-dimethylsulfamoyl-2-hydrazinopyridine:

To 12 g of 2-chloro-6-dimethylsulfamoylpyridine were added 30 ml of n-butanol and 4 g of hydrazine hydrate. The mixture was stirred at room temperature for 30 minutes, followed by heating under reflux for 18 hours. After cooling, crystals obtained were filtered and washed with water to obtain 6.1 g of 6-dimethylsulfamoyl-2-hydrazinopyridine. m.p.: 117° to 120° C.

(3) Ethyl 5-amino-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate was synthesized following Reference Example 2. m.p.: 197° to 198° C.

(4) Ethyl 5-chloro-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate was synthesized following Reference Example 1. m.p.: 117° to 120° C.

(5) Ethyl 5-benzylthio-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate:

To 50 ml of dried dimethylformamide, added were 4.2 g of ethyl 5-chloro-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate and 1.46 g of benzylmercaptan and 3.2 g of potassium carbonate, followed by stirring at room temperature for 24 hours in the atmosphere of N₂. After the reaction, inorganic salt was filtered off and dimethylformamide was evaporated from the filtrate to obtain 4.4 g of the title compound as an oily product.

(6) 1-(6-dimethylsulfamoylpyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide was synthesized following Reference Example 1. m.p.: 102° to 104° C.

REFERENCE EXAMPLE 45 Synthesis of 4-allylcarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

To a mixture of 2.2 of 4-carboxy-1-(2-pyridyl)pyrazole-5-sulfonamide and 20 ml of allyl alcohol, 1 ml of methanesulfonic acid was added, followed by stirring at 110° C. for 18 hours. The reaction mixture was concentrated under reduced pressure, and purified by silica gel chromatography to obtain 0.7 g of the title compound. m.p.: 140° to 142° C.

REFERENCE EXAMPLE 46 4-Propargyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 45. m.p.: 106° to 108° C.

REFERENCE EXAMPLE 47 4-(2-chloroethyl)oxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide

Synthesis was carried out following Reference Example 45. m.p.: 119° to 121° C.

REFERENCE EXAMPLE 48 Synthesis of 1-(4,6-dimethylpyrimidin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonmamide

Synthesis was carried out following Reference Examples 1 to 6 and Reference Example 35. m.p.: 164° to 165° C.

Each of the intermediates had the following property.

Ethyl 5-amino-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 184° to 186° C.

Ethyl 5-chloro-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 88° to 89° C.

Ethyl 5-benzylmercapto-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 84° to 85° C.

EXAMPLE 1 Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide (Compound No. 49)

2.0 g of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide, 0.82 g of methyl chloroformate and 1.4 g of anhydrous potassium carbonate were heated under reflux in 50 ml of anhydrous acetonitrile for 4 hours. After the reaction was completed, solvent was evaporated under reduced pressure. After dilution with ice water, insolubles were filtered off, and the filtrate was precipitated with use of diluted hydrochloric acid. Crystals precipitated were filtered, washed with water and dried to obtain 2.2 g of N-[4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonyl]methylcarbamate. m.p.: 127° to 129° C.

0.95 g of N-[4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonyl]methylcarbamate and 0.41 g of 2-amino-4,6-dimethoxypyrimidine were heated under reflux in 30 ml of toluene for 6 hours while allowing the toluene to evaporate little by little. Toluene having been decreased was occasionally supplemented. After the reaction was completed, toluene was evaporated under reduced pressure. Isopropyl ether was added to the residue, which was then stirred to obtain 1.1 g of the title compound as crystals. m.p.: 140° to 142° C.

EXAMPLE 2 Synthesis of N-[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide (Compound No. 51)

To a 70 ml acetone mixture of 8.5 g of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide and 6.0 g of anhydrous potassium carbonate, added was 3.3 g of n-butylisocyanate at room temperature, followed by heating under reflux for 3 hours. After the reaction was completed, acetone was evaporated under reduced pressure, and then the residue was emptied into ice water to filter insolbles off, and then the filtrate was precipitated with hydrochloric acid. Crystals precipitated was filtered, washed with water and dried to obtain 10.8 g of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide. m.p.: 180° to 181° C.

Subsequently, the above compound was added to 100 ml of dried toluene, into which 7.5 g of phosgene was blown while heating under reflux, and thereafter the reaction mixture was further heated under reflux for 1.5 hours. After the reaction was completed, solvent was evaporated under reduced pressure to obtain 8.4 g of crude 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonylisocyanate. 1.3 g of this crude suflonylisocyanate was added to a 30 ml solution of dried acetonitrile, containing 0.42 g of 2-amino-4-methoxy-6-methyltriazine, followed by stirring at room temperature. After the reaction mixture was concentrated, ether was added thereto, followed by stirring at room temperature, and crystals formed were filtered, washed with ether and dried to obtain 1.2 g of the title compound. m.p.: 133° to 136° C.

EXAMPLE 3 Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-[(2-pyridyl)methyl]pyrazole-3-sulfonamide (Compound No. 6218)

0.7 g of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonylpyrazole-5(3)-sulfonamide was dissolved in 10 ml of tetrahydrofuran, to which 0.6 g of potassium t-butylate and 0.29 g of 2-chloromethylpyridine hydrochloride were added, and the mixture was refluxed for 5 hours. Tetrahydrofuran was evaporated under reduced pressure, and then 20 ml of ice water was added and insolbles were filtered off. To the aqueous layer obtained, added was 35% hydrochloric acid to make it acidic, followed by addition of chloroform to carry out extraction. Organic layer was washed with water and dried, and then solvent was evaporated to obtain 0.3 g of an oily product. This oily product was dissolved in a small amount of acetonitrile, to which a small amount of diisopropylether was added, whereupon the title compound in a pure form was crystalized, and was collected by filtration. Amount obtained was 0.18 g. m.p.: 95° to 96° C.

In the following, examples of specific compounds included in the compound of this invention are shown in Table 1 to Table 14 in addition to the compounds synthesized in the above Examples 1 to 3, by which, however, this invention is not limited.

The compounds shown in Table 1 to Table 14 can be synthesized following the procedures in Examples 1 and 2. Properties of some of these compounds are shown in Table 15. In Table 15, the compound number correspond to the compound number in Table 1 to Table 14.

                                      TABLE 1                                      __________________________________________________________________________      ##STR14##                                                                     No.  A       B    D         X  Y        Z                                      __________________________________________________________________________     1    Q.sub.1 H    COOMe     Me Me       CH                                     2    Q.sub.1 H    COOMe     Me OMe      CH                                     3    Q.sub.1 H    COOMe     OMe                                                                               OMe      CH                                     4    Q.sub.1 H    COOMe     Me Me       N                                      5    Q.sub.1 H    COOMe     Me OMe      N                                      6    Q.sub.1 H    COOMe     OMe                                                                               OMe      N                                      7    Q.sub.1 H    COOMe     Me Cl       CH                                     8    Q.sub.1 H    COOMe     Me OEt      CH                                     9    Q.sub.1 H    COOMe     Me H        CH                                     10   Q.sub.1 H    COOMe     Me CH.sub.2 OMe                                                                            CH                                     11   Q.sub.1 H    COOMe     Me CF.sub.3 CH                                     12   Q.sub.1 H    COOMe     Me OCH.sub.2 CF.sub.3                                                                      CH                                     13   Q.sub.1 H    COOMe     Me OCH.sub.2 COOMe                                                                         CH                                     14   Q.sub.1 H    COOMe     Cl Cl       CH                                     15   Q.sub.1 H    COOMe     Br Br       CH                                     16   Q.sub.1 H    COOMe     Me Cl       N                                      17   Q.sub.1 H    COOMe     Cl NMe.sub.2                                                                               N                                      18   Q.sub.1 H    COOMe     OMe                                                                               NMe.sub.2                                                                               N                                      19   Q.sub.1 H    COOMe     Me OEt      N                                      20   Q.sub.1 H    COOMe     Me NHEt     N                                      21   Q.sub.1 H    COOMe     Me CH.sub.2 OMe                                                                            N                                      22   Q.sub.1 H    COOMe     Me OCH(Me)COOH                                                                             N                                      23   Q.sub.1 H    COOMe     Me COOMe    CH                                     24   Q.sub.1 H    COOMe     Me COOEt    CH                                     25   Q.sub.1 H    COOMe     OMe                                                                               COOMe    CH                                     26   Q.sub.1 H    COOMe     Cl COOMe    CH                                     27   Q.sub.1 H    COOMe     Me                                                                                 ##STR15##                                                                              CH                                     28   Q.sub.1 H    COOMe     Me OCHF.sub.2                                                                              CH                                     29   Q.sub.1 H    COOMe     OCHF.sub.2                                                                        OCHF.sub.2                                                                              CH                                     30   Q.sub.1 H    COOMe     Cl OCHF.sub.2                                                                              CH                                     31   Q.sub.1 H    COOMe     Cl OMe      CH                                     32   Q.sub.1 H    COOMe     Cl NH.sub.2 CH                                     33   Q.sub.1 H    COOMe     Me Me       CMe                                    34   Q.sub.1 H    COOMe     Me Me       CCl                                    35   Q.sub.1 H    COOMe     Me OMe      CCl                                    36   Q.sub.1 H    COOMe     OMe                                                                               OMe      CF                                     37   Q.sub.1 H    COOMe     Me Me       COMe                                   38   Q.sub.1 H    COOMe     OMe                                                                               OMe      CCF.sub.3                              39   Q.sub.1 H    COOMe     Me N(Me)OMe CH                                     40   Q.sub.1 H    COOMe     Me SMe      CH                                     41   Q.sub.1 H    COOMe     Me CH(OMe).sub.2                                                                           CH                                     42   Q.sub.1 H    COOMe     OMe                                                                               CH(OEt).sub.2                                                                           N                                      43   Q.sub.1 H    COOMe     OMe                                                                                ##STR16##                                                                              N                                      44   Q.sub.1 H    COOMe     Me SCHF.sub.2                                                                              CH                                     45   Q.sub.1 H    COOMe     Me SCHF.sub.2                                                                              N                                      46   Q.sub.1 H    COOMe     Me OCF.sub.2 CF.sub.2 H                                                                    CH                                     47   Q.sub.1 H    COOEt     Me Me       CH                                     48   Q.sub.1 H    COOEt     Me OMe      CH                                     49   Q.sub.1 H    COOEt     OMe                                                                               OMe      CH                                     50   Q.sub.1 H    COOEt     Me Me       N                                      51   Q.sub.1 H    COOEt     Me OMe      N                                      52   Q.sub.1 H    COOEt     OMe                                                                               OMe      N                                      53   Q.sub.1 H    COOEt     Me Cl       CH                                     54   Q.sub.1 H    COOEt     Me OEt      CH                                     55   Q.sub.1 H    COOEt     Me H        CH                                     56   Q.sub.1 H    COOEt     Me CH.sub.2 OMe                                                                            CH                                     57   Q.sub.1 H    COOEt     Me CF.sub.3 CH                                     58   Q.sub.1 H    COOEt     Me OCH.sub.2 CF.sub.3                                                                      CH                                     59   Q.sub.1 H    COOEt     Me OCH.sub.2 COOMe                                                                         CH                                     60   Q.sub.1 H    COOEt     Cl Cl       CH                                     61   Q.sub.1 H    COOEt     Br Br       CH                                     62   Q.sub.1 H    COOEt     Me Cl       N                                      63   Q.sub.1 H    COOEt     Cl NMe.sub.2                                                                               N                                      64   Q.sub.1 H    COOEt     OMe                                                                               NMe.sub.2                                                                               N                                      65   Q.sub.1 H    COOEt     Me OEt      N                                      66   Q.sub.1 H    COOEt     Me NHEt     N                                      67   Q.sub.1 H    COOEt     Me CH.sub.2 OMe                                                                            N                                      68   Q.sub.1 H    COOEt     Me OCH(Me)COOH                                                                             N                                      69   Q.sub.1 H    COOEt     Me COOMe    CH                                     70   Q.sub.1 H    COOEt     Me COOEt    CH                                     71   Q.sub.1 H    COOEt     OMe                                                                               COOMe    CH                                     72   Q.sub.1 H    COOEt     Cl COOMe    CH                                     73   Q.sub.1 H    COOEt     Me                                                                                 ##STR17##                                                                              CH                                     74   Q.sub.1 H    COOEt     Me OCHF.sub.2                                                                              CH                                     75   Q.sub.1 H    COOEt     OCHF.sub.2                                                                        OCHF.sub.2                                                                              CH                                     76   Q.sub.1 H    COOEt     Cl OCHF.sub.2                                                                              CH                                     77   Q.sub.1 H    COOEt     Cl OMe      CH                                     78   Q.sub.1 H    COOEt     Cl NH.sub.2 CH                                     79   Q.sub.1 H    COOEt     Me Me       CMe                                    80   Q.sub.1 H    COOEt     Me Me       CCl                                    81   Q.sub.1 H    COOEt     Me OMe      CCl                                    82   Q.sub.1 H    COOEt     OMe                                                                               OMe      CF                                     83   Q.sub.1 H    COOEt     Me Me       COMe                                   84   Q.sub.1 H    COOEt     OMe                                                                               OMe      CCF.sub.3                              85   Q.sub.1 H    COOEt     Me N(Me)OMe CH                                     86   Q.sub.1 H    COOEt     Me SMe      CH                                     87   Q.sub.1 H    COOEt     Me CH(OMe).sub.2                                                                           CH                                     88   Q.sub.1 H    COOEt     OMe                                                                               CH(OEt).sub.2                                                                           N                                      89   Q.sub.1 H    COOEt     OMe                                                                                ##STR18##                                                                              N                                      90   Q.sub.1 H    COOEt     Me SCHF.sub.2                                                                              CH                                     91   Q.sub.1 H    COOEt     Me SCHF.sub.2                                                                              N                                      92   Q.sub.1 H    COOEt     Me OCF.sub.2 CF.sub.2 H                                                                    CH                                     93   Q.sub.1 H    COOH      Me Me       CH                                     94   Q.sub.1 H    COOH      Me OMe      CH                                     95   Q.sub.1 H    COOH      OMe                                                                               OMe      CH                                     96   Q.sub.1 H    COOH      Me OMe      N                                      97   Q.sub.1 H    COOH      OMe                                                                               OMe      N                                      98   Q.sub.1 H    COOPrn    Me Me       CH                                     99   Q.sub.1 H    COOPrn    Me OMe      CH                                     100  Q.sub.1 H    COOPrn    OMe                                                                               OMe      CH                                     101  Q.sub.1 H    COOPrn    Me OMe      N                                      102  Q.sub.1 H    COOPrn    OMe                                                                               OMe      N                                      103  Q.sub.1 H    COOPri    Me Me       CH                                     104  Q.sub.1 H    COOPri    Me OMe      CH                                     105  Q.sub.1 H    COOPri    OMe                                                                               OMe      CH                                     106  Q.sub.1 H    COOPri    Me OMe      N                                      107  Q.sub.1 H    COOPri    OMe                                                                               OMe      N                                      108  Q.sub.1 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me Me       CH                                     109  Q.sub.1 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     110  Q.sub.1 H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     111  Q.sub.1 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      112  Q.sub.1 H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      N                                      113  Q.sub.1 H    COOCH.sub.2 CF.sub.3                                                                     Me OMe      CH                                     114  Q.sub.1 H    COOCH.sub.2 CF.sub.3                                                                     OMe                                                                               OMe      CH                                     115  Q.sub.1 H    COOCH.sub.2 CF.sub.3                                                                     Me OMe      N                                      116  Q.sub.1 H    COOBun    Me OMe      CH                                     117  Q.sub.1 H    COOBun    OMe                                                                               OMe      CH                                     118  Q.sub.1 H    COOBun    Me OMe      N                                      119  Q.sub.1 H    COOCH.sub.2 CHCH.sub.2                                                                   Me Me       CH                                     120  Q.sub.1 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     121  Q.sub.1 H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     122  Q.sub.1 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      123  Q.sub.1 H    COOCH.sub.2 CHCH.sub. 2                                                                  OMe                                                                               OMe      N                                      124  Q.sub.1 H    COOCH.sub.2 CCH                                                                          Me Me       CH                                     125  Q.sub.1 H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     126  Q.sub.1 H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     127  Q.sub.1 H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      128  Q.sub.1 H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      N                                      129  Q.sub.1 H    COOCH.sub.2 CH.sub.2 OMe                                                                 Me OMe      CH                                     130  Q.sub.1 H    COOCH.sub.2 CH.sub.2 OMe                                                                 OMe                                                                               OMe      CH                                     131  Q.sub.1 H    COOCH.sub.2 CH.sub.2 OMe                                                                 Me OMe      N                                      132  Q.sub.1 Me   COOMe     Me Me       CH                                     133  Q.sub.1 Me   COOMe     Me OMe      CH                                     134  Q.sub.1 Me   COOMe     OMe                                                                               OMe      CH                                     135  Q.sub.1 Me   COOMe     Me OMe      N                                      136  Q.sub.1 Me   COOMe     OMe                                                                               OMe      N                                      137  Q.sub.1 Me   COOEt     Me Me       CH                                     138  Q.sub.1 Me   COOEt     Me OMe      CH                                     139  Q.sub.1 Me   COOEt     OMe                                                                               OMe      CH                                     140  Q.sub.1 Me   COOEt     Me OMe      N                                      141  Q.sub.1 Me   COOEt     OMe                                                                               OMe      N                                      142  Q.sub.1 Et   COOMe     Me OMe      CH                                     143  Q.sub.1 Et   COOMe     OMe                                                                               OMe      CH                                     144  Q.sub.1 Et   COOMe     Me OMe      N                                      145  Q.sub.1 Et   COOEt     Me OMe      CH                                     146  Q.sub.1 Et   COOEt     OMe                                                                               OMe      CH                                     147  Q.sub.1 Et   COOEt     Me OMe      N                                      148  Q.sub.1 Cl   COOMe     Me Me       CH                                     149  Q.sub.1 Cl   COOMe     Me OMe      CH                                     150  Q.sub.1 Cl   COOMe     OMe                                                                               OMe      CH                                     151  Q.sub.1 Cl   COOMe     Me OMe      N                                      152  Q.sub.1 Cl   COOMe     OMe                                                                               OMe      N                                      153  Q.sub.1 Cl   COOEt     Me Me       CH                                     154  Q.sub.1 Cl   COOEt     Me OMe      CH                                     155  Q.sub.1 Cl   COOEt     OMe                                                                               OMe      CH                                     156  Q.sub.1 Cl   COOEt     Me OMe      N                                      157  Q.sub.1 Cl   COOEt     OMe                                                                               OMe      N                                      158  Q.sub.1 F    COOMe     Me Me       CH                                     159  Q.sub.1 F    COOMe     Me OMe      CH                                     160  Q.sub.1 F    COOMe     OMe                                                                               OMe      CH                                     161  Q.sub.1 F    COOMe     Me OMe      N                                      162  Q.sub.1 F    COOMe     OMe                                                                               OMe      N                                      163  Q.sub.1 Br   COOMe     Me Me       CH                                     164  Q.sub.1 Br   COOMe     Me OMe      CH                                     165  Q.sub.1 Br   COOMe     OMe                                                                               OMe      CH                                     166  Q.sub.1 Br   COOMe     Me OMe      N                                      167  Q.sub.1 Br   COOMe     OMe                                                                               OMe      N                                      168  Q.sub.1 OMe  COOMe     Me Me       CH                                     169  Q.sub.1 OMe  COOMe     Me OMe      CH                                     170  Q.sub.1 OMe  COOMe     OMe                                                                               OMe      CH                                     171  Q.sub.1 OMe  COOMe     Me OMe      N                                      172  Q.sub.1 OMe  COOMe     OMe                                                                               OMe      N                                      173  Q.sub.1 OMe  COOEt     Me Me       CH                                     174  Q.sub.1 OMe  COOEt     Me OMe      CH                                     175  Q.sub.1 OMe  COOEt     OMe                                                                               OMe      CH                                     176  Q.sub.1 OMe  COOEt     Me OMe      N                                      177  Q.sub.1 OMe  COOEt     OMe                                                                               OMe      N                                      178  Q.sub.1 OEt  COOMe     Me Me       CH                                     179  Q.sub.1 OEt  COOMe     Me OMe      CH                                     180  Q.sub.1 OEt  COOMe     OMe                                                                               OMe      CH                                     181  Q.sub.1 OEt  COOMe     OMe                                                                               OMe      N                                      182  Q.sub.1 CF.sub.3                                                                            COOMe     Me OMe      CH                                     183  Q.sub.1 CF.sub.3                                                                            COOMe     OMe                                                                               OMe      CH                                     184  Q.sub.1 CF.sub.3                                                                            COOMe     Me OMe      N                                      185  Q.sub.1 SMe  COOMe     Me OMe      CH                                     186  Q.sub.1 SMe  COOMe     OMe                                                                               OMe      CH                                     187  Q.sub.1 SMe  COOMe     Me OMe      N                                      188  Q.sub.1 SO.sub.2 Me                                                                         COOMe     Me OMe      CH                                     189  Q.sub.1 SO.sub.2 Me                                                                         COOMe     OMe                                                                               OMe      CH                                     190  Q.sub.1 SO.sub.2 Me                                                                         COOMe     Me OMe      N                                      191  Q.sub.1 CO.sub.2 Me                                                                         COOMe     Me OMe      CH                                     192  Q.sub.1 CO.sub.2 Me                                                                         COOMe     OMe                                                                               OMe      CH                                     193  Q.sub.1 CO.sub.2 Me                                                                         COOMe     Me OMe      N                                      194  Q.sub.1 CH.sub.2 OMe                                                                        COOMe     Me Me       CH                                     195  Q.sub.1 CH.sub.2 OMe                                                                        COOMe     Me OMe      CH                                     196  Q.sub.1 CH.sub.2 OMe                                                                        COOMe     OMe                                                                               OMe      CH                                     197  Q.sub.1 CH.sub.2 OMe                                                                        COOMe     Me OMe      N                                      198  Q.sub.1 CH.sub.2 OMe                                                                        COOMe     OMe                                                                               OMe      N                                      199  Q.sub.1 NO.sub.2                                                                            COOMe     Me Me       CH                                     200  Q.sub.1 NO.sub.2                                                                            COOMe     Me OMe      CH                                     201  Q.sub.1 NO.sub.2                                                                            COOMe     OMe                                                                               OMe      CH                                     202  Q.sub.1 NO.sub.2                                                                            COOMe     Me OMe      N                                      203  Q.sub.1 NO.sub.2                                                                            COOMe     OMe                                                                               OMe      N                                      204  Q.sub.1 OH   COOMe     Me OMe      CH                                     205  Q.sub.1 OH   COOMe     OMe                                                                               OMe      CH                                     206  Q.sub.1 OH   COOMe     Me OMe      N                                      207  Q.sub.1 H    Cl        Me Me       CH                                     208  Q.sub.1 H    Cl        Me OMe      CH                                     209  Q.sub.1 H    Cl        OMe                                                                               OMe      CH                                     210  Q.sub.1 H    Cl        Me OMe      N                                      211  Q.sub.1 H    Cl        OMe                                                                               OMe      N                                      212  Q.sub.1 H    Br        Me OMe      CH                                     213  Q.sub.1 H    Br        OMe                                                                               OMe      CH                                     214  Q.sub.1 H    Br        OMe                                                                               OMe      N                                      215  Q.sub.1 H    Br        Me OMe      N                                      216  Q.sub.1 Me   Cl        Me Me       CH                                     217  Q.sub.1 Me   Cl        Me OMe      CH                                     218  Q.sub.1 Me   Cl        OMe                                                                               OMe      CH                                     219  Q.sub.1 Me   Cl        Me OMe      N                                      220  Q.sub.1 Me   Cl        OMe                                                                               OMe      N                                      221  Q.sub.1 H    NO.sub.2  Me Me       N                                      222  Q.sub.1 H    NO.sub.2  Me Me       CH                                     223  Q.sub.1 H    NO.sub.2  Me OMe      CH                                     224  Q.sub.1 H    NO.sub.2  OMe                                                                               OMe      CH                                     225  Q.sub.1 H    NO.sub.2  Me OMe      N                                      226  Q.sub.1 H    NO.sub.2  OMe                                                                               OMe      N                                      227  Q.sub.1 Me   NO.sub.2  Me OMe      CH                                     228  Q.sub.1 Me   NO.sub.2  OMe                                                                               OMe      CH                                     229  Q.sub.1 Me   NO.sub.2  Me OMe      N                                      230  Q.sub.1 H    OMe       Me OMe      CH                                     231  Q.sub.1 H    OMe       OMe                                                                               OMe      CH                                     232  Q.sub.1 H    OMe       Me OMe      N                                      233  Q.sub.1 H    OEt       Me OMe      CH                                     234  Q.sub.1 H    OEt       OMe                                                                               OMe      CH                                     235  Q.sub.1 H    OEt       Me OMe      N                                      236  Q.sub.1 Me   OMe       Me OMe      CH                                     237  Q.sub.1 Me   OMe       OMe                                                                               OMe      CH                                     238  Q.sub.1 Me   OMe       Me OMe      N                                      239  Q.sub.1 H    CONMe.sub.2                                                                              Me OMe      CH                                     240  Q.sub.1 H    CONMe.sub.2                                                                              OMe                                                                               OMe      CH                                     241  Q.sub.1 H    CONMe.sub.2                                                                              Me OMe      N                                      242  Q.sub.1 H    CONEt.sub.2                                                                              Me OMe      CH                                     243  Q.sub.1 H    CONEt.sub.2                                                                              OMe                                                                               OMe      CH                                     244  Q.sub.1 H    CONEt.sub.2                                                                              Me OMe      N                                      245  Q.sub.1 H    CONHMe    Me OMe      CH                                     246  Q.sub.1 H    CONHMe    OMe                                                                               OMe      CH                                     247  Q.sub.1 H    CONHMe    Me OMe      N                                      248  Q.sub.1 H    CONHPh    Me OMe      CH                                     249  Q.sub.1 H    CONHPh    OMe                                                                               OMe      CH                                     250  Q.sub.1 H    CONHPh    Me OMe      N                                      251  Q.sub.1 H    CON(Me)OMe                                                                               Me OMe      CH                                     252  Q.sub.1 H    CON(Me)OMe                                                                               OMe                                                                               OMe      CH                                     253  Q.sub.1 H    CON(Me)OMe                                                                               Me OMe      N                                      254  Q.sub.1 H    SMe       Me OMe      CH                                     255  Q.sub.1 H    SMe       OMe                                                                               OMe      CH                                     256  Q.sub.1 H    SMe       Me OMe      N                                      257  Q.sub.1 H    SO.sub.2 Me                                                                              Me OMe      CH                                     258  Q.sub.1 H    SO.sub. 2 Me                                                                             OMe                                                                               OMe      CH                                     259  Q.sub.1 H    SO.sub.2 Me                                                                              Me OMe      N                                      260  Q.sub.1 H    SO.sub.2 Et                                                                              Me OMe      CH                                     261  Q.sub.1 H    SO.sub.2 Et                                                                              OMe                                                                               OMe      CH                                     262  Q.sub.1 H    SO.sub.2 Et                                                                              Me OMe      N                                      263  Q.sub.1 H    SO.sub.3 Me                                                                              Me OMe      CH                                     264  Q.sub.1 H    SO.sub.3 Me                                                                              OMe                                                                               OMe      CH                                     265  Q.sub.1 H    SO.sub.3 Me                                                                              Me OMe      N                                      266  Q.sub.1 H    SO.sub.2 Ph                                                                              Me OMe      CH                                     267  Q.sub.1 H    SO.sub.2 Ph                                                                              OMe                                                                               OMe      CH                                     268  Q.sub.1 H    SO.sub.2 Ph                                                                              Me OMe      N                                      269  Q.sub.1 H    SO.sub.2 NMe.sub.2                                                                       Me Me       CH                                     270  Q.sub.1 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     271  Q.sub.1 H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     272  Q.sub.1 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      273  Q.sub.1 H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      N                                      274  Q.sub.1 H    SO.sub.2 NEt.sub.2                                                                       Me OMe      CH                                     275  Q.sub.1 H    SO.sub.2 NEt.sub.2                                                                       OMe                                                                               OMe      CH                                     276  Q.sub.1 H    SO.sub.2 NEt.sub.2                                                                       Me OMe      N                                      277  Q.sub.1 H    SO.sub.2 NHMe                                                                            Me OMe      CH                                     278  Q.sub.1 H    SO.sub.2 NHMe                                                                            OMe                                                                               OMe      CH                                     279  Q.sub.1 H    SO.sub.2 NHMe                                                                            Me OMe      N                                      280  Q.sub.1 H    SO.sub.2 NHPh                                                                            Me OMe      CH                                     281  Q.sub.1 H    SO.sub.2 NHPh                                                                            OMe                                                                               OMe      CH                                     282  Q.sub.1 H    SO.sub.2 NHPh                                                                            Me OMe      N                                      283  Q.sub.1 Me   SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     284  Q.sub.1 Me   SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     285  Q.sub.1 Me   SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      286  Q.sub.1 H    CN        Me Me       CH                                     287  Q.sub.1 H    CN        Me OMe      CH                                     288  Q.sub.1 H    CN        OMe                                                                               OMe      CH                                     289  Q.sub.1 H    CN        Me OMe      N                                      290  Q.sub.1 H    CN        OMe                                                                               OMe      N                                      291  Q.sub.1 Me   CN        Me Me       CH                                     292  Q.sub.1 Me   CN        Me OMe      CH                                     293  Q.sub.1 Me   CN        OMe                                                                               OMe      CH                                     294  Q.sub.1 Me   CN        Me OMe      N                                      295  Q.sub.1 Me   CN        OMe                                                                               OMe      N                                      296  Q.sub.1 H    NMe.sub.2 Me Me       CH                                     297  Q.sub.1 H    NMe.sub.2 Me OMe      CH                                     298  Q.sub.1 H    NMe.sub.2 OMe                                                                               OMe      CH                                     299  Q.sub.1 H    NMe.sub.2 Me OMe      N                                      300  Q.sub.1 H    NMe.sub.2 OMe                                                                               OMe      N                                      301  Q.sub.1 H    NHCOMe    Me OMe      CH                                     302  Q.sub.1 H    NHCOMe    OMe                                                                               OMe      CH                                     303  Q.sub.1 H    NHCOMe    Me OMe      N                                      304  Q.sub.1 H    Me        Me Me       CH                                     305  Q.sub.1 H    Me        Me OMe      CH                                     306  Q.sub.1 H    Me        OMe                                                                               OMe      CH                                     307  Q.sub.1 H    Me        Me OMe      N                                      308  Q.sub.1 H    Me        OMe                                                                               OMe      N                                      309  Q.sub.1 H    Et        Me Me       CH                                     310  Q.sub.1 H    Et        Me OMe      CH                                     311  Q.sub.1 H    Et        OMe                                                                               OMe      CH                                     312  Q.sub.1 H    Et        Me OMe      N                                      313  Q.sub.1 H    Et        OMe                                                                               OMe      N                                      314  Q.sub.1 H    Prn       Me OMe      CH                                     315  Q.sub.1 H    Prn       OMe                                                                               OMe      CH                                     316  Q.sub.1 H    Prn       Me OMe      N                                      317  Q.sub.1 Me   H         Me Me       CH                                     318  Q.sub.1 Me   H         Me OMe      CH                                     319  Q.sub.1 Me   H         OMe                                                                               OMe      CH                                     320  Q.sub.1 Me   H         Me OMe      N                                      321  Q.sub.1 Me   H         OMe                                                                               OMe      N                                      322  Q.sub.1 H    H         Me Me       CH                                     323  Q.sub.1 H    H         Me OMe      CH                                     324  Q.sub. 1                                                                               H    H         OMe                                                                               OMe      CH                                     325  Q.sub.1 H    H         Me OMe      N                                      326  Q.sub.1 H    H         OMe                                                                               OMe      N                                      327  Q.sub.1 H    COPh      Me Me       CH                                     328  Q.sub.1 H    COPh      Me OMe      CH                                     329  Q.sub.1 H    COPh      OMe                                                                               OMe      CH                                     330  Q.sub.1 H    COPh      Me OMe      N                                      331  Q.sub.1 H    COPh      OMe                                                                               OMe      N                                      332  Q.sub.1 Me   COPh      Me Me       CH                                     333  Q.sub.1 Me   COPh      Me OMe      CH                                     334  Q.sub.1 Me   COPh      OMe                                                                               OMe      CH                                     335  Q.sub.1 Me   COPh      Me OMe      N                                      336  Q.sub.1 Me   COPh      OMe                                                                               OMe      N                                      337  Q.sub.1 H    COPh2,4Cl.sub.2                                                                          Me OMe      CH                                     338  Q.sub.1 H    COPh2,4Cl.sub.2                                                                          OMe                                                                               OMe      CH                                     339  Q.sub.1 H    COPh2,4Cl.sub.2                                                                          Me OMe      N                                      340  Q.sub.1 H    COPh2Me   Me OMe      CH                                     341  Q.sub.1 H    COPh2Me   OMe                                                                               OMe      CH                                     342  Q.sub.1 H    COPh2Me   Me OMe      N                                      343  H       Q.sub.1                                                                             H         Me Me       CH                                     344  H       Q.sub.1                                                                             H         Me OMe      CH                                     345  H       Q.sub.1                                                                             H         OMe                                                                               OMe      CH                                     346  H       Q.sub.1                                                                             H         Me OMe      N                                      347  H       Q.sub.1                                                                             H         OMe                                                                               OMe      N                                      348  Me      Q.sub.1                                                                             H         Me Me       CH                                     349  Me      Q.sub.1                                                                             H         Me OMe      CH                                     350  Me      Q.sub.1                                                                             H         OMe                                                                               OMe      CH                                     351  Me      Q.sub.1                                                                             H         Me OMe      N                                      352  Me      Q.sub.1                                                                             H         OMe                                                                               OMe      N                                      353  H       Q.sub.1                                                                             Me        Me Me       CH                                     354  H       Q.sub.1                                                                             Me        Me OMe      CH                                     355  H       Q.sub.1                                                                             Me        OMe                                                                               OMe      CH                                     356  H       Q.sub.1                                                                             Me        Me OMe      N                                      357  H       Q.sub.1                                                                             Me        OMe                                                                               OMe      N                                      358  Me      Q.sub.1                                                                             Me        Me Me       CH                                     359  Me      Q.sub.1                                                                             Me        Me OMe      CH                                     360  Me      Q.sub.1                                                                             Me        OMe                                                                               OMe      CH                                     361  Me      Q.sub.1                                                                             Me        Me OMe      N                                      362  Me      Q.sub.1                                                                             Me        OMe                                                                               OMe      N                                      363  H       Q.sub.1                                                                             COOMe     Me Me       CH                                     364  H       Q.sub.1                                                                             COOMe     Me OMe      CH                                     365  H       Q.sub.1                                                                             COOMe     OMe                                                                               OMe      CH                                     366  H       Q.sub.1                                                                             COOMe     Me OMe      N                                      367  H       Q.sub.1                                                                             COOMe     OMe                                                                               OMe      N                                      368  H       Q.sub.1                                                                             COOEt     Me Me       CH                                     369  H       Q.sub.1                                                                             COOEt     Me OMe      CH                                     370  H       Q.sub.1                                                                             COOEt     OMe                                                                               OMe      CH                                     371  H       Q.sub.1                                                                             COOEt     Me OMe      N                                      372  H       Q.sub.1                                                                             COOEt     OMe                                                                               OMe      N                                      373  Me      Q.sub.1                                                                             COOMe     Me Me       CH                                     374  Me      Q.sub.1                                                                             COOMe     Me OMe      CH                                     375  Me      Q.sub.1                                                                             COOMe     OMe                                                                               OMe      CH                                     376  Me      Q.sub.1                                                                             COOMe     Me OMe      N                                      377  Me      Q.sub.1                                                                             COOMe     OMe                                                                               OMe      N                                      378  Me      Q.sub.1                                                                             COOEt     Me Me       CH                                     379  Me      Q.sub.1                                                                             COOEt     Me OMe      CH                                     380  Me      Q.sub.1                                                                             COOEt     OMe                                                                               OMe      CH                                     381  Me      Q.sub.1                                                                             COOEt     Me OMe      N                                      382  Me      Q.sub.1                                                                             COOEt     OMe                                                                               OMe      N                                      383  CH.sub.2 OCH.sub.3                                                                     Q.sub.1                                                                             COOMe     Me OMe      CH                                     384  CH.sub.2 OCH.sub.3                                                                     Q.sub.1                                                                             COOMe     OMe                                                                               OMe      CH                                     385  CH.sub.2 OCH.sub.3                                                                     Q.sub.1                                                                             COOMe     Me OMe      N                                      386  CH.sub.2 SCH.sub.3                                                                     Q.sub.1                                                                             COOMe     Me OMe      CH                                     387  CH.sub.2 SCH.sub.3                                                                     Q.sub.1                                                                             COOMe     OMe                                                                               OMe      CH                                     388  CH.sub.2 SCH.sub.3                                                                     Q.sub.1                                                                             COOMe     Me OMe      N                                      389  Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     390  Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     391  Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      392  Me      Q.sub.1                                                                             NO.sub.2  Me OMe      CH                                     393  Me      Q.sub.1                                                                             NO.sub.2  OMe                                                                               OMe      CH                                     394  Me      Q.sub.1                                                                             NO.sub.2  Me OMe      N                                      395  Me      Q.sub.1                                                                             OMe       Me OMe      CH                                     396  Me      Q.sub.1                                                                             OMe       OMe                                                                               OMe      CH                                     397  Me      Q.sub.1                                                                             OMe       Me OMe      N                                      398  Me      Q.sub.1                                                                             CN        Me OMe      CH                                     399  Me      Q.sub.1                                                                             CN        OMe                                                                               OMe      CH                                     400  Me      Q.sub.1                                                                             CN        Me OMe      N                                      401  H       H    Q.sub.1   Me Me       CH                                     402  H       H    Q.sub.1   Me OMe      CH                                     403  H       H    Q.sub.1   OMe                                                                               OMe      CH                                     404  H       H    Q.sub.1   Me OMe      N                                      405  H       H    Q.sub.1   OMe                                                                               OMe      N                                      406  Me      H    Q.sub.1   Me Me       CH                                     407  Me      H    Q.sub.1   Me OMe      CH                                     408  Me      H    Q.sub.1   OMe                                                                               OMe      CH                                     409  Me      H    Q.sub.1   Me OMe      N                                      410  Me      H    Q.sub.1   OMe                                                                               OMe      N                                      411  Et      H    Q.sub.1   Me OMe      CH                                     412  Et      H    Q.sub.1   OMe                                                                               OMe      CH                                     413  Et      H    Q.sub.1   Me OMe      N                                      414  CH.sub.2 CHCH.sub.2                                                                    H    Q.sub.1   Me OMe      CH                                     415  CH.sub.2 CHCH.sub.2                                                                    H    Q.sub.1   OMe                                                                               OMe      CH                                     416  CH.sub.2 CHCH.sub.2                                                                    H    Q.sub.1   Me OMe      N                                      417  CH.sub.2 C CH                                                                          H    Q.sub.1   Me OMe      CH                                     418  CH.sub.2 CCH                                                                           H    Q.sub.1   OMe                                                                               OMe      CH                                     419  CH.sub.2 CCH                                                                           H    Q.sub.1   Me OMe      N                                      420  CH.sub.2 CN                                                                            H    Q.sub.1   Me OMe      CH                                     421  CH.sub.2 CN                                                                            H    Q.sub.1   OMe                                                                               OMe      CH                                     422  CH.sub.2 CN                                                                            H    Q.sub.1   Me OMe      N                                      423  CH.sub.2 COOMe                                                                         H    Q.sub.1   Me OMe      CH                                     424  CH.sub.2 COOMe                                                                         H    Q.sub.1   OMe                                                                               OMe      CH                                     425  CH.sub.2 COOMe                                                                         H    Q.sub.1   Me OMe      N                                      426  CH.sub.2 COOEt                                                                         H    Q.sub.1   Me Me       CH                                     427  CH.sub.2 COOEt                                                                         H    Q.sub.1   Me OMe      CH                                     428  CH.sub.2 COOEt                                                                         H    Q.sub.1   OMe                                                                               OMe      CH                                     429  CH.sub.2 COOEt                                                                         H    Q.sub.1   Me OMe      N                                      430  CH.sub.2 COOEt                                                                         H    Q.sub.1   OMe                                                                               OMe      N                                      431  CH.sub.2 OMe                                                                           H    Q.sub.1   Me Me       CH                                     432  CH.sub.2 OMe                                                                           H    Q.sub.1   Me OMe      CH                                     433  CH.sub.2 OMe                                                                           H    Q.sub.1   OMe                                                                               OMe      CH                                     434  CH.sub.2 OMe                                                                           H    Q.sub.1   Me OMe      N                                      435  CH.sub.2 OMe                                                                           H    Q.sub.1   OMe                                                                               OMe      N                                      436  CH.sub.2 SMe                                                                           H    Q.sub.1   Me Me       CH                                     437  CH.sub.2 SMe                                                                           H    Q.sub.1   Me OMe      CH                                     438  CH.sub.2 SMe                                                                           H    Q.sub.1   OMe                                                                               OMe      CH                                     439  CH.sub.2 SMe                                                                           H    Q.sub.1   Me OMe      N                                      440  CH.sub.2 SMe                                                                           H    Q.sub.1   OMe                                                                               OMe      N                                      441  SO.sub.2 NMe.sub.2                                                                     H    Q.sub.1   Me Me       CH                                     442  SO.sub.2 NMe.sub.2                                                                     H    Q.sub.1   Me OMe      CH                                     443  SO.sub.2 NMe.sub.2                                                                     H    Q.sub.1   OMe                                                                               OMe      CH                                     444  SO.sub.2 NMe.sub.2                                                                     H    Q.sub.1   Me OMe      N                                      445  SO.sub.2 NMe.sub.2                                                                     H    Q.sub.1   OMe                                                                               OMe      N                                      446  SO.sub.2 Me                                                                            H    Q.sub.1   Me Me       CH                                     447  SO.sub.2 Me                                                                            H    Q.sub.1   Me OMe      CH                                     448  SO.sub.2 Me                                                                            H    Q.sub.1   OMe                                                                               OMe      CH                                     449  SO.sub.2 Me                                                                            H    Q.sub.1   Me OMe      N                                      450  SO.sub.2 Me                                                                            H    Q.sub.1   OMe                                                                               OMe      N                                      451  Ph      H    Q.sub.1   Me Me       CH                                     452  Ph      H    Q.sub.1   Me OMe      CH                                     453  Ph      H    Q.sub.1   OMe                                                                               OMe      CH                                     454  Ph      H    Q.sub.1   Me OMe      N                                      455  Ph      H    Q.sub.1   OMe                                                                               OMe      N                                      456  Ph2-Cl  H    Q.sub.1   Me OMe      CH                                     457  Ph2-Cl  H    Q.sub.1   OMe                                                                               OMe      CH                                     458  Ph2-Cl  H    Q.sub.1   Me OMe      N                                      459  Ph2-Me  H    Q.sub.1   Me OMe      CH                                     460  Ph2-Me  H    Q.sub.1   OMe                                                                               OMe      CH                                     461  Ph2-Me  H    Q.sub.1   Me OMe      N                                      462  Ph2-COOMe                                                                              H    Q.sub.1   Me OMe      CH                                     463  Ph2-COOMe                                                                              H    Q.sub.1   OMe                                                                               OMe      CH                                     464  Ph2-COOMe                                                                              H    Q.sub.1   Me OMe      N                                      465  H       Me   Q.sub.1   Me Me       CH                                     466  H       Me   Q.sub.1   Me OMe      CH                                     467  H       Me   Q.sub.1   OMe                                                                               OMe      CH                                     468  H       Me   Q.sub.1   Me OMe      N                                      469  H       Me   Q.sub.1   OMe                                                                               OMe      N                                      470  Me      Me   Q.sub.1   Me Me       CH                                     471  Me      Me   Q.sub.1   Me OMe      CH                                     472  Me      Me   Q.sub.1   OMe                                                                               OMe      CH                                     473  Me      Me   Q.sub.1   Me OMe      N                                      474  Me      Me   Q.sub.1   OMe                                                                               OMe      N                                      475  Ph      Me   Q.sub.1   Me Me       CH                                     476  Ph      Me   Q.sub.1   Me OMe      CH                                     477  Ph      Me   Q.sub.1   OMe                                                                               OMe      CH                                     478  Ph      Me   Q.sub.1   Me OMe      N                                      479  Ph      Me   Q.sub.1   OMe                                                                               OMe      N                                      480  Q.sub.1 H    COOMe Me   OCH.sub.2 CH.sub.2 C                              481  Q.sub.1 H    COOEt Me   OCH.sub.2 CH.sub.2 C                              482  Q.sub.2                                                                            H   COOMe      Me   Me    CH                                          483  Q.sub.2                                                                            H   COOMe      Me   OMe   CH                                          484  Q.sub.2 H    COOMe     OMe                                                                               OMe      CH                                     485  Q.sub.2 H    COOMe     Me Me       N                                      486  Q.sub.2 H    COOMe     Me OMe      N                                      487  Q.sub.2 H    COOMe     OMe                                                                               OMe      N                                      488  Q.sub.2 H    COOMe     Me OCHF.sub.2                                                                              CH                                     489  Q.sub.2 H    COOMe     Cl OMe      CH                                     490  Q.sub.2 H    COOEt     Me Me       CH                                     491  Q.sub.2 H    COOEt     Me OMe      CH                                     492  Q.sub.2 H    COOEt     OMe                                                                               OMe      CH                                     493  Q.sub.2 H    COOEt     Me Me       N                                      494  Q.sub.2 H    COOEt     Me OMe      N                                      495  Q.sub.2 H    COOEt     OMe                                                                               OMe      N                                      496  Q.sub.2 H    COOEt     Me OCHF.sub.2                                                                              CH                                     497  Q.sub.2 H    COOEt     Cl OMe      CH                                     498  Q.sub.2 H    COOPrn    Me OMe      CH                                     499  Q.sub. 2                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     500  Q.sub.2 H    COOPrn    Me OMe      N                                      501  Q.sub.2 H    COOPri    Me OMe      CH                                     502  Q.sub.2 H    COOPri    OMe                                                                               OMe      CH                                     503  Q.sub.2 H    COOPri    Me OMe      N                                      504  Q.sub.2 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     505  Q.sub.2 H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     506  Q.sub.2 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      507  Q.sub.2 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     508  Q.sub.2 H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     509  Q.sub.2 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      510  Q.sub.2 H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     511  Q.sub.2 H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     512  Q.sub.2 H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      513  Q.sub.2 Me   COOMe     Me Me       CH                                     514  Q.sub.2 Me   COOMe     Me OMe      CH                                     515  Q.sub.2 Me   COOMe     OMe                                                                               OMe      CH                                     516  Q.sub.2 Me   COOMe     Me OMe      N                                      517  Q.sub.2 Me   COOMe     OMe                                                                               OMe      N                                      518  Q.sub.2 Me   COOEt     Me Me       CH                                     519  Q.sub.2 Me   COOEt     Me OMe      CH                                     520  Q.sub.2 Me   COOEt     OMe                                                                               OMe      CH                                     521  Q.sub.2 Me   COOEt     Me OMe      N                                      522  Q.sub.2 Me   COOEt     OMe                                                                               OMe      N                                      523  Q.sub.2 Cl   COOMe     Me OMe      CH                                     524  Q.sub.2 Cl   COOMe     OMe                                                                               OMe      CH                                     525  Q.sub.2 Cl   COOMe     Me OMe      N                                      526  Q.sub.2 Cl   COOEt     Me OMe      CH                                     527  Q.sub.2 Cl   COOEt     OMe                                                                               OMe      CH                                     528  Q.sub.2 Cl   COOEt     Me OMe      N                                      529  Q.sub.2 OMe  COOMe     Me OMe      CH                                     530  Q.sub.2 OMe  COOMe     OMe                                                                               OMe      CH                                     531  Q.sub.2 OMe  COOMe     Me OMe      N                                      532  Q.sub.2 OMe  COOEt     Me OMe      CH                                     533  Q.sub.2 OMe  COOEt     OMe                                                                               OMe      CH                                     534  Q.sub.2 OMe  COOEt     Me OMe      N                                      535  Q.sub.2 H    Cl        Me OMe      CH                                     536  Q.sub.2 H    Cl        OMe                                                                               OMe      CH                                     537  Q.sub.2 H    Cl        Me OMe      N                                      538  Q.sub.2 H    NO.sub.2  Me OMe      CH                                     539  Q.sub.2 H    NO.sub.2  OMe                                                                               OMe      CH                                     540  Q.sub.2 H    NO.sub.2  Me OMe      N                                      541  Q.sub.2 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     542  Q.sub.2 H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     543  Q.sub.2 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      544  Q.sub.2 H    CN        Me OMe      CH                                     545  Q.sub.2 H    CN        OMe                                                                               OMe      CH                                     546  Q.sub.2 H    CN        Me OMe      N                                      547  Q.sub.2 Me   CN        Me OMe      CH                                     548  Q.sub.2 Me   CN        OMe                                                                               OMe      CH                                     549  Q.sub.2 Me   CN        Me OMe      N                                      550  Q.sub.2 H    Me        Me OMe      CH                                     551  Q.sub.2 H    Me        OMe                                                                               OMe      CH                                     552  Q.sub.2 H    Me        Me OMe      N                                      553  Q.sub.2 H    Et        Me OMe      CH                                     554  Q.sub.2 H    Et        OMe                                                                               OMe      CH                                     555  Q.sub.2 H    Et        Me OMe      N                                      556  Q.sub.2 H    H         Me OMe      CH                                     557  Q.sub.2 H    H         OMe                                                                               OMe      CH                                     558  Q.sub.2 H    H         Me OMe      N                                      559  Q.sub.2 H    COPh      Me OMe      CH                                     560  Q.sub.2 H    COPh      OMe                                                                               OMe      CH                                     561  Q.sub.2 H    COPh      Me OMe      N                                      562  Me      Q.sub.2                                                                             COOMe     Me OMe      CH                                     563  Me      Q.sub.2                                                                             COOMe     OMe                                                                               OMe      CH                                     564  Me      Q.sub.2                                                                             COOMe     Me OMe      N                                      565  H       H    Q.sub.2   Me OMe      CH                                     566  H       H    Q.sub.2   OMe                                                                               OMe      CH                                     567  H       H    Q.sub.2   Me OMe      N                                      568  Me      H    Q.sub.2   Me Me       CH                                     569  Me      H    Q.sub.2   Me OMe      CH                                     570  Me      H    Q.sub.2   OMe                                                                               OMe      CH                                     571  Me      H    Q.sub.2   Me OMe      N                                      572  Me      H    Q.sub.2   OMe                                                                               OMe      N                                      573  Me      Me   Q.sub.2   Me OMe      CH                                     574  Me      Me   Q.sub.2   OMe                                                                               OMe      CH                                     575  Me      Me   Q.sub.2   Me OMe      N                                      576  Q.sub.3 H    COOMe     Me Me       CH                                     577  Q.sub.3 H    COOMe     Me OMe      CH                                     578  Q.sub.3 H    COOMe     OMe                                                                               OMe      CH                                     579  Q.sub.3 H    COOMe     Me OMe      N                                      580  Q.sub.3 H    COOMe     OMe                                                                               OMe      N                                      581  Q.sub.3 H    COOEt     Me Me       CH                                     582  Q.sub.3 H    COOEt     Me OMe      CH                                     583  Q.sub.3 H    COOEt     OMe                                                                               OMe      CH                                     584  Q.sub.3 H    COOEt     Me OMe      N                                      585  Q.sub.3 H    COOEt     OMe                                                                               OMe      N                                      586  Q.sub.3 Me   COOMe     Me OMe      CH                                     587  Q.sub.3 Me   COOMe     OMe                                                                               OMe      CH                                     588  Q.sub.3 Me   COOMe     Me OMe      N                                      589  Q.sub.3 Me   COOEt     Me OMe      CH                                     590  Q.sub.3 Me   COOEt     OMe                                                                               OMe      CH                                     591  Q.sub.3 Me   COOEt     Me OMe      N                                      592  Q.sub.3 H    CN        Me OMe      CH                                     593  Q.sub.3 H    CN        OMe                                                                               OMe      CH                                     594  Q.sub.3 H    CN        Me OMe      N                                      595  Q.sub.3 H    H         Me OMe      CH                                     596  Q.sub.3 H    H         OMe                                                                               OMe      CH                                     597  Q.sub.3 H    H         Me OMe      N                                      598  Me      H    Q.sub.3   Me Me       CH                                     599  Me      H    Q.sub.3   Me OMe      CH                                     600  Me      H    Q.sub.3   OMe                                                                               OMe      CH                                     601  Me      H    Q.sub.3   Me OMe      N                                      602  Me      H    Q.sub.3   OMe                                                                               OMe      N                                      603  Q.sub.4 H    COOMe     Me Me       CH                                     604  Q.sub.4 H    COOMe     Me OMe      CH                                     605  Q.sub.4 H    COOMe     OMe                                                                               OMe      CH                                     606  Q.sub.4 H    COOMe     Me OMe      N                                      607  Q.sub.4 H    COOMe     OMe                                                                               OMe      N                                      608  Q.sub.4 H    COOEt     Me Me       CH                                     609  Q.sub.4 H    COOEt     Me OMe      CH                                     610  Q.sub.4 H    COOEt     OMe                                                                               OMe      CH                                     611  Q.sub.4 H    COOEt     Me OMe      N                                      612  Q.sub.4 H    COOEt     OMe                                                                               OMe      N                                      613  Q.sub.4 Me   COOMe     Me OMe      CH                                     614  Q.sub.4 Me   COOMe     OMe                                                                               OMe      CH                                     615  Q.sub.4 Me   COOMe     Me OMe      N                                      616  Q.sub.4 Me   COOEt     Me OMe      CH                                     617  Q.sub.4 Me   COOEt     OMe                                                                               OMe      CH                                     618  Q.sub.4 Me   COOEt     Me OMe      N                                      619  Q.sub.4 H    CN        Me OMe      CH                                     620  Q.sub.4 H    CN        OMe                                                                               OMe      CH                                     621  Q.sub.4 H    CN        Me OMe      N                                      622  Q.sub.4 H    H         Me OMe      CH                                     623  Q.sub.4 H    H         OMe                                                                               OMe      CH                                     624  Q.sub.4 H    H         Me OMe      N                                      625  Me      H    Q.sub.4   Me Me       CH                                     626  Me      H    Q.sub.4   Me OMe      CH                                     627  Me      H    Q.sub.4   OMe                                                                               OMe      CH                                     628  Me      H    Q.sub.4   Me OMe      N                                      629  Me      H    Q.sub.4   OMe                                                                               OMe      N                                      630  Q.sub.5 H    COOMe     Me Me       CH                                     631  Q.sub.5 H    COOMe     Me OMe      CH                                     632  Q.sub.5 H    COOMe     OMe                                                                               OMe      CH                                     633  Q.sub.5 H    COOMe     Me Me       N                                      634  Q.sub.5 H    COOMe     Me OMe      N                                      635  Q.sub.5 H    COOMe     OMe                                                                               OMe      N                                      636  Q.sub.5 H    COOMe     Me OCHF.sub.2                                                                              CH                                     637  Q.sub.5 H    COOMe     Cl OMe      CH                                     638  Q.sub.5 H    COOEt     Me Me       CH                                     639  Q.sub.5 H    COOEt     Me OMe      CH                                     640  Q.sub.5 H    COOEt     OMe                                                                               OMe      CH                                     641  Q.sub.5 H    COOEt     Me Me       N                                      642  Q.sub.5 H    COOEt     Me OMe      N                                      643  Q.sub.5 H    COOEt     OMe                                                                               OMe      N                                      644  Q.sub.5 H    COOEt     Me OCHF.sub.2                                                                              CH                                     645  Q.sub.5 H    COOEt     Cl OMe      CH                                     646  Q.sub.5 H    COOPrn    Me OMe      CH                                     647  Q.sub.5 H    COOPrn    OMe                                                                               OMe      CH                                     648  Q.sub.5 H    COOPrn    Me OMe      N                                      649  Q.sub.5 H    COOPri    Me OMe      CH                                     650  Q.sub.5 H    COOPri    OMe                                                                               OMe      CH                                     651  Q.sub.5 H    COOPri    Me OMe      N                                      652  Q.sub.5 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     653  Q.sub.5 H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     654  Q.sub.5 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      655  Q.sub.5 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     656  Q.sub.5 H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     657  Q.sub.5 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      658  Q.sub.5 H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     659  Q.sub.5 H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     660  Q.sub.5 H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      661  Q.sub.5 Me   COOMe     Me Me       CH                                     662  Q.sub.5 Me   COOMe     Me OMe      CH                                     663  Q.sub.5 Me   COOMe     OMe                                                                               OMe      CH                                     664  Q.sub.5 Me   COOMe     Me OMe      N                                      665  Q.sub.5 Me   COOMe     OMe                                                                               OMe      N                                      666  Q.sub.5 Me   COOEt     Me Me       CH                                     667  Q.sub.5 Me   COOEt     Me OMe      CH                                     668  Q.sub.5 Me   COOEt     OMe                                                                               OMe      CH                                     669  Q.sub.5 Me   COOEt     Me OMe      N                                      670  Q.sub.5 Me   COOEt     OMe                                                                               OMe      N                                      671  Q.sub.5 Cl   COOMe     Me OMe      CH                                     672  Q.sub.5 Cl   COOMe     OMe                                                                               OMe      CH                                     673  Q.sub.5 Cl   COOMe     Me OMe      N                                      674  Q.sub.5 Cl   COOEt     Me OMe      CH                                     675  Q.sub.5 Cl   COOEt     OMe                                                                               OMe      CH                                     676  Q.sub.5 Cl   COOEt     Me OMe      N                                      677  Q.sub.5 OMe  COOMe     Me OMe      CH                                     678  Q.sub.5 OMe  COOMe     OMe                                                                               OMe      CH                                     679  Q.sub.5 OMe  COOMe     Me OMe      N                                      680  Q.sub.5 OMe  COOEt     Me OMe      CH                                     681  Q.sub.5 OMe  COOEt     OMe                                                                               OMe      CH                                     682  Q.sub.5 OMe  COOEt     Me OMe      N                                      683  Q.sub.5 H    Cl        Me OMe      CH                                     684  Q.sub.5 H    Cl        OMe                                                                               OMe      CH                                     685  Q.sub.5 H    Cl        Me OMe      N                                      686  Q.sub.5 H    NO.sub.2  Me OMe      CH                                     687  Q.sub.5 H    NO.sub.2  OMe                                                                               OMe      CH                                     688  Q.sub.5 H    NO.sub.2  Me OMe      N                                      689  Q.sub.5 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     690  Q.sub.5 H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     691  Q.sub.5 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      692  Q.sub.5 H    CN        Me OMe      CH                                     693  Q.sub.5 H    CN        OMe                                                                               OMe      CH                                     694  Q.sub.5 H    CN        Me OMe      N                                      695  Q.sub.5 Me   CN        Me OMe      CH                                     696  Q.sub.5 Me   CN        OMe                                                                               OMe      CH                                     697  Q.sub.5 Me   CN        Me OMe      N                                      698  Q.sub.5 H    Me        Me OMe      CH                                     699  Q.sub.5 H    Me        OMe                                                                               OMe      CH                                     700  Q.sub.5 H    Me        Me OMe      N                                      701  Q.sub.5 H    Et        Me OMe      CH                                     702  Q.sub.5 H    Et        OMe                                                                               OMe      CH                                     703  Q.sub.5 H    Et        Me OMe      N                                      704  Q.sub.5 H    H         Me OMe      CH                                     705  Q.sub.5 H    H         OMe                                                                               OMe      CH                                     706  Q.sub.5 H    H         Me OMe      N                                      707  Q.sub.5 H    COPh      Me OMe      CH                                     708  Q.sub.5 H    COPh      OMe                                                                               OMe      CH                                     709  Q.sub.5 H    COPh      Me OMe      N                                      710  Me      Q.sub.5                                                                             COOMe     Me OMe      CH                                     711  Me      Q.sub.5                                                                             COOMe     OMe                                                                               OMe      CH                                     712  Me      Q.sub.5                                                                             COOMe     Me OMe      N                                      713  H       H    Q.sub.5   Me OMe      CH                                     714  H       H    Q.sub.5   OMe                                                                               OMe      CH                                     715  H       H    Q.sub.5   Me OMe      N                                      716  Me      H    Q.sub.5   Me Me       CH                                     717  Me      H    Q.sub.5   Me OMe      CH                                     718  Me      H    Q.sub.5   OMe                                                                               OMe      CH                                     719  Me      H    Q.sub.5   Me OMe      N                                      720  Me      H    Q.sub.5   OMe                                                                               OMe      N                                      721  Me      Me   Q.sub.5   Me OMe      CH                                     722  Me      Me   Q.sub.5   OMe                                                                               OMe      CH                                     723  Me      Me   Q.sub.5   Me OMe      N                                      724  Q.sub.6 H    COOMe     Me Me       CH                                     725  Q.sub.6 H    COOMe     Me OMe      CH                                     726  Q.sub.6 H    COOMe     OMe                                                                               OMe      CH                                     727  Q.sub.6 H    COOMe     Me OMe      N                                      728  Q.sub.6 H    COOMe     OMe                                                                               OMe      N                                      729  Q.sub.6 H    COOEt     Me Me       CH                                     730  Q.sub.6 H    COOEt     Me OMe      CH                                     731  Q.sub.6 H    COOEt     OMe                                                                               OMe      CH                                     732  Q.sub.6 H    COOEt     Me OMe      N                                      733  Q.sub.6 H    COOEt     OMe                                                                               OMe      N                                      734  Q.sub.6 Me   COOMe     Me OMe      CH                                     735  Q.sub.6 Me   COOMe     OMe                                                                               OMe      CH                                     736  Q.sub.6 Me   COOMe     Me OMe      N                                      737  Q.sub.6 Me   COOEt     Me OMe      CH                                     738  Q.sub.6 Me   COOEt     OMe                                                                               OMe      CH                                     739  Q.sub.6 Me   COOEt     Me OMe      N                                      740  Q.sub.6 H    CN        Me OMe      CH                                     741  Q.sub.6 H    CN        OMe                                                                               OMe      CH                                     742  Q.sub.6 H    CN        Me OMe      N                                      743  Q.sub.6 H    H         Me OMe      CH                                     744  Q.sub.6 H    H         OMe                                                                               OMe      CH                                     745  Q.sub.6 H    H         Me OMe      N                                      746  Me      H    Q.sub.6   Me Me       CH                                     747  Me      H    Q.sub.6   Me OMe      CH                                     748  Me      H    Q.sub.6   OMe                                                                               OMe      CH                                     749  Me      H    Q.sub.6   Me OMe      N                                      750  Me      H    Q.sub.6   OMe                                                                               OMe      N                                      751  Q.sub.7 H    COOMe     Me OMe      CH                                     752  Q.sub.7 H    COOMe     OMe                                                                               OMe      CH                                     753  Q.sub.7 H    COOEt     Me OMe      CH                                     754  Q.sub.7 H    COOEt     OMe                                                                               OMe      CH                                     755  Q.sub.7 Me   COOMe     Me OMe      CH                                     756  Q.sub.7 Me   COOMe     OMe                                                                               OMe      CH                                     757  Q.sub.7 Me   COOEt     Me OMe      CH                                     758  Q.sub.7 Me   COOEt     OMe                                                                               OMe      CH                                     759  Q.sub.7 H    H         Me OMe      CH                                     760  Q.sub.7 H    H         OMe                                                                               OMe      CH                                     761  Me      H    Q.sub.7   Me OMe      CH                                     762  Me      H    Q.sub.7   OMe                                                                               OMe      CH                                     763  Q.sub.8 H    COOMe     Me Me       CH                                     764  Q.sub.8 H    COOMe     Me OMe      CH                                     765  Q.sub.8 H    COOMe     OMe                                                                               OMe      CH                                     766  Q.sub.8 H    COOMe     Me Me       N                                      767  Q.sub.8 H    COOMe     Me OMe      N                                      768  Q.sub.8 H    COOMe     OMe                                                                               OMe      N                                      769  Q.sub.8 H    COOMe     Me OCHF.sub.2                                                                              CH                                     770  Q.sub.8 H    COOMe     Cl OMe      CH                                     771  Q.sub.8 H    COOEt     Me Me       CH                                     772  Q.sub.8 H    COOEt     Me OMe      CH                                     773  Q.sub.8 H    COOEt     OMe                                                                               OMe      CH                                     774  Q.sub.8 H    COOEt     Me Me       N                                      775  Q.sub.8 H    COOEt     Me OMe      N                                      776  Q.sub.8 H    COOEt     OMe                                                                               OMe      N                                      777  Q.sub.8 H    COOEt     Me OCHF.sub.2                                                                              CH                                     778  Q.sub.8 H    COOEt     Cl OMe      CH                                     779  Q.sub.8 H    COOPrn    Me OMe      CH                                     780  Q.sub.8 H    COOPrn    OMe                                                                               OMe      CH                                     781  Q.sub.8 H    COOPrn    Me OMe      N                                      782  Q.sub.8 H    COOPri    Me OMe      CH                                     783  Q.sub.8 H    COOPri    OMe                                                                               OMe      CH                                     784  Q.sub.8 H    COOPri    Me OMe      N                                      785  Q.sub.8 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     786  Q.sub.8 H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     787  Q.sub.8 H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      788  Q.sub.8 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     789  Q.sub.8 H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     790  Q.sub.8 H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      791  Q.sub.8 H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     792  Q.sub.8 H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     793  Q.sub.8 H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      794  Q.sub.8 Me   COOMe     Me Me       CH                                     795  Q.sub.8 Me   COOMe     Me OMe      CH                                     796  Q.sub.8 Me   COOMe     OMe                                                                               OMe      CH                                     797  Q.sub.8 Me   COOMe     Me OMe      N                                      798  Q.sub.8 Me   COOMe     OMe                                                                               OMe      N                                      799  Q.sub.8 Me   COOEt     Me Me       CH                                     800  Q.sub.8 Me   COOEt     Me OMe      CH                                     801  Q.sub.8 Me   COOEt     OMe                                                                               OMe      CH                                     802  Q.sub.8 Me   COOEt     Me OMe      N                                      803  Q.sub.8 Me   COOEt     OMe                                                                               OMe      N                                      804  Q.sub.8 Cl   COOMe     Me OMe      CH                                     805  Q.sub.8 Cl   COOMe     OMe                                                                               OMe      CH                                     806  Q.sub.8 Cl   COOMe     Me OMe      N                                      807  Q.sub.8 Cl   COOEt     Me OMe      CH                                     808  Q.sub.8 Cl   COOEt     OMe                                                                               OMe      CH                                     809  Q.sub.8 Cl   COOEt     Me OMe      N                                      810  Q.sub.8 OMe  COOMe     Me OMe      CH                                     811  Q.sub.8 OMe  COOMe     OMe                                                                               OMe      CH                                     812  Q.sub.8 OMe  COOMe     Me OMe      N                                      813  Q.sub.8 OMe  COOEt     Me OMe      CH                                     814  Q.sub.8 OMe  COOEt     OMe                                                                               OMe      CH                                     815  Q.sub.8 OMe  COOEt     Me OMe      N                                      816  Q.sub.8 H    Cl        Me OMe      CH                                     817  Q.sub.8 H    Cl        OMe                                                                               OMe      CH                                     818  Q.sub.8 H    Cl        Me OMe      N                                      819  Q.sub.8 H    NO.sub.2  Me OMe      CH                                     820  Q.sub.8 H    NO.sub.2  OMe                                                                               OMe      CH                                     821  Q.sub.8 H    NO.sub.2  Me OMe      N                                      822  Q.sub.8 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     823  Q.sub.8 H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     824  Q.sub.8 H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      825  Q.sub.8 H    CN        Me OMe      CH                                     826  Q.sub.8 H    CN        OMe                                                                               OMe      CH                                     827  Q.sub.8 H    CN        Me OMe      N                                      828  Q.sub.8 Me   CN        Me OMe      CH                                     829  Q.sub.8 Me   CN        OMe                                                                               OMe      CH                                     830  Q.sub.8 Me   CN        Me OMe      N                                      831  Q.sub.8 H    Me        Me OMe      CH                                     832  Q.sub.8 H    Me        OMe                                                                               OMe      CH                                     833  Q.sub.8 H    Me        Me OMe      N                                      834  Q.sub.8 H    Et        Me OMe      CH                                     835  Q.sub.8 H    Et        OMe                                                                               OMe      CH                                     836  Q.sub.8 H    Et        Me OMe      N                                      837  Q.sub.8 H    H         Me OMe      CH                                     838  Q.sub.8 H    H         OMe                                                                               OMe      CH                                     839  Q.sub.8 H    H         Me OMe      N                                      840  Q.sub.8 H    COPh      Me OMe      CH                                     841  Q.sub.8 H    COPh      OMe                                                                               OMe      CH                                     842  Q.sub.8 H    COPh      Me OMe      N                                      843  Me      Q.sub.8                                                                             COOMe     Me OMe      CH                                     844  Me      Q.sub.8                                                                             COOMe     OMe                                                                               OMe      CH                                     845  Me      Q.sub.8                                                                             COOMe     Me OMe      N                                      846  H       H    Q.sub.8   Me OMe      CH                                     847  H       H    Q.sub.8   OMe                                                                               OMe      CH                                     848  H       H    Q.sub.8   Me OMe      N                                      849  Me      H    Q.sub.8   Me Me       CH                                     850  Me      H    Q.sub.8   Me OMe      CH                                     851  Me      H    Q.sub.8   OMe                                                                               OMe      CH                                     852  Me      H    Q.sub.8   Me OMe      N                                      853  Me      H    Q.sub.8   OMe                                                                               OMe      N                                      854  Me      Me   Q.sub.8   Me OMe      CH                                     855  Me      Me   Q.sub.8   OMe                                                                               OMe      CH                                     856  Me      Me   Q.sub.8   Me OMe      N                                      857  Q.sub.9 H    COOMe     Me Me       CH                                     858  Q.sub.9 H    COOMe     Me OMe      CH                                     859  Q.sub.9 H    COOMe     OMe                                                                               OMe      CH                                     860  Q.sub.9 H    COOMe     Me OMe      N                                      861  Q.sub.9 H    COOMe     OMe                                                                               OMe      N                                      862  Q.sub.9 H    COOEt     Me Me       CH                                     863  Q.sub.9 H    COOEt     Me OMe      CH                                     __________________________________________________________________________

    __________________________________________________________________________     864  Q.sub.9 H    COOEt     OMe                                                                               OMe      CH                                     865  Q.sub.9 H    COOEt     Me OMe      N                                      866  Q.sub.9 H    COOEt     OMe                                                                               OMe      N                                      867  Q.sub.9 Me   COOMe     Me OMe      CH                                     868  Q.sub.9 Me   COOMe     OMe                                                                               OMe      CH                                     869  Q.sub.9 Me   COOMe     Me OMe      N                                      870  Q.sub.9 Me   COOEt     Me OMe      CH                                     871  Q.sub.9 Me   COOEt     OMe                                                                               OMe      CH                                     872  Q.sub.9 Me   COOEt     Me OMe      N                                      873  Q.sub.9 H    CN        Me OMe      CH                                     874  Q.sub.9 H    CN        OMe                                                                               OMe      CH                                     875  Q.sub.9 H    CN        Me OMe      N                                      876  Q.sub.9 H    H         Me OMe      CH                                     877  Q.sub.9 H    H         OMe                                                                               OMe      CH                                     878  Q.sub.9 H    H         Me OMe      N                                      879  Me      H    Q.sub.9   Me Me       CH                                     880  Me      H    Q.sub.9   Me OMe      CH                                     881  Me      H    Q.sub.9   OMe                                                                               OMe      CH                                     882  Me      H    Q.sub.9   Me OMe      N                                      883  Me      H    Q.sub.9   OMe                                                                               OMe      N                                      884  Me      Me   Q.sub.9   Me OMe      N                                      885  Q.sub.10                                                                               H    COOMe     Me Me       CH                                     886  Q.sub.10                                                                               H    COOMe     Me OMe      CH                                     887  Q.sub.10                                                                               H    COOMe     OMe                                                                               OMe      CH                                     888  Q.sub.10                                                                               H    COOMe     Me OMe      N                                      889  Q.sub.10                                                                               H    COOMe     OMe                                                                               OMe      N                                      890  Q.sub.10                                                                               H    COOEt     Me Me       CH                                     891  Q.sub.10                                                                               H    COOEt     Me OMe      CH                                     892  Q.sub.10                                                                               H    COOEt     OMe                                                                               OMe      CH                                     893  Q.sub.10                                                                               H    COOEt     Me OMe      N                                      894  Q.sub.10                                                                               H    COOEt     OMe                                                                               OMe      N                                      895  Q.sub.10                                                                               Me   COOMe     Me OMe      CH                                     895  Q.sub.10                                                                               Me   COOMe     Me OMe      CH                                     896  Q.sub.10                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     897  Q.sub.10                                                                               Me   COOMe     Me OMe      N                                      898  Q.sub.10                                                                               Me   COOEt     Me OMe      CH                                     899  Q.sub.10                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     900  Q.sub.10                                                                               Me   COOEt     Me OMe      N                                      901  Q.sub.10                                                                               H    CN        Me OMe      CH                                     902  Q.sub.10                                                                               H    CN        OMe                                                                               OMe      CH                                     903  Q.sub.10                                                                               H    CN        Me OMe      N                                      904  Q.sub.10                                                                               H    H         Me OMe      CH                                     905  Q.sub.10                                                                               H    H         OMe                                                                               OMe      CH                                     906  Q.sub.10                                                                               H    H         Me OMe      N                                      907  Me      H    Q.sub.10  Me Me       CH                                     908  Me      H    Q.sub.10  Me OMe      CH                                     909  Me      H    Q.sub.10  OMe                                                                               OMe      CH                                     910  Me      H    Q.sub.10  Me OMe      N                                      911  Me      H    Q.sub.10  OMe                                                                               OMe      N                                      912  Q.sub.11                                                                               H    COOMe     Me Me       CH                                     913  Q.sub.11                                                                               H    COOMe     Me OMe      CH                                     914  Q.sub.11                                                                               H    COOMe     OMe                                                                               OMe      CH                                     915  Q.sub.11                                                                               H    COOMe     Me OMe      N                                      916  Q.sub.11                                                                               H    COOMe     OMe                                                                               OMe      N                                      917  Q.sub.11                                                                               H    COOEt     Me Me       CH                                     918  Q.sub.11                                                                               H    COOEt     Me OMe      CH                                     919  Q.sub.11                                                                               H    COOEt     OMe                                                                               OMe      CH                                     920  Q.sub.11                                                                               H    COOEt     Me OMe      N                                      921  Q.sub.11                                                                               H    COOEt     OMe                                                                               OMe      N                                      922  Q.sub.11                                                                               Me   COOMe     Me OMe      CH                                     923  Q.sub.11                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     924  Q.sub.11                                                                               Me   COOMe     Me OMe      N                                      925  Q.sub.11                                                                               Me   COOEt     Me OMe      CH                                     926  Q.sub.11                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     927  Q.sub.11                                                                               Me   COOEt     Me OMe      N                                      928  Q.sub.11                                                                               H    CN        Me OMe      CH                                     929  Q.sub.11                                                                               H    CN        OMe                                                                               OMe      CH                                     930  Q.sub.11                                                                               H    CN        Me OMe      N                                      931  Q.sub.11                                                                               H    H         Me OMe      CH                                     932  Q.sub.11                                                                               H    H         OMe                                                                               OMe      CH                                     933  Q.sub.11                                                                               H    H         Me OMe      N                                      934  Me      H    Q.sub.11  Me Me       CH                                     935  Me      H    Q.sub.11  Me OMe      CH                                     936  Me      H    Q.sub.11  OMe                                                                               OMe      CH                                     937  Me      H    Q.sub.11  Me OMe      N                                      938  Me      H    Q.sub.11  OMe                                                                               OMe      N                                      939  Q.sub.12                                                                               H    COOMe     Me Me       CH                                     940  Q.sub.12                                                                               H    COOMe     Me OMe      CH                                     941  Q.sub.12                                                                               H    COOMe     OMe                                                                               OMe      CH                                     942  Q.sub.12                                                                               H    COOMe     Me OMe      N                                      943  Q.sub.12                                                                               H    COOMe     OMe                                                                               OMe      N                                      944  Q.sub.12                                                                               H    COOEt     Me Me       CH                                     945  Q.sub.12                                                                               H    COOEt     Me OMe      CH                                     946  Q.sub.12                                                                               H    COOEt     OMe                                                                               OMe      CH                                     947  Q.sub.12                                                                               H    COOEt     Me OMe      N                                      948  Q.sub.12                                                                               H    COOEt     OMe                                                                               OMe      N                                      949  Q.sub.12                                                                               Me   COOMe     Me OMe      CH                                     950  Q.sub.12                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     951  Q.sub.12                                                                               Me   COOMe     Me OMe      N                                      952  Q.sub.12                                                                               Me   COOEt     Me OMe      CH                                     953  Q.sub.12                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     954  Q.sub.12                                                                               Me   COOEt     Me OMe      N                                      955  Q.sub.12                                                                               H    CN        Me OMe      CH                                     956  Q.sub.12                                                                               H    CN        OMe                                                                               OMe      CH                                     957  Q.sub.12                                                                               H    CN        Me OMe      N                                      958  Q.sub.12                                                                               H    H         Me OMe      CH                                     959  Q.sub.12                                                                               H    H         OMe                                                                               OMe      CH                                     960  Q.sub.12                                                                               H    H         Me OMe      N                                      961  Me      H    Q.sub.12  Me Me       CH                                     962  Me      H    Q.sub.12  Me OMe      CH                                     963  Me      H    Q.sub.12  OMe                                                                               OMe      CH                                     964  Me      H    Q.sub.12  Me OMe      N                                      965  Me      H    Q.sub.12  OMe                                                                               OMe      N                                      966  Q.sub.13                                                                               H    COOMe     Me OMe      CH                                     967  Q.sub.13                                                                               H    COOMe     OMe                                                                               OMe      CH                                     968  Q.sub.13                                                                               H    COOEt     Me OMe      CH                                     969  Q.sub.13                                                                               H    COOEt     OMe                                                                               OMe      CH                                     970  Q.sub.13                                                                               Me   COOMe     Me OMe      CH                                     971  Q.sub.13                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     972  Q.sub.13                                                                               Me   COOEt     Me OMe      CH                                     973  Q.sub.13                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     974  Q.sub.13                                                                               H    H         Me OMe      CH                                     975  Q.sub.13                                                                               H    H         OMe                                                                               OMe      CH                                     976  Me      H    Q.sub.13  Me OMe      CH                                     977  Me      H    Q.sub.13  OMe                                                                               OMe      CH                                     978  Q.sub.14                                                                               H    COOMe     Me Me       CH                                     979  Q.sub.14                                                                               H    COOMe     Me OMe      CH                                     980  Q.sub.14                                                                               H    COOMe     OMe                                                                               OMe      CH                                     981  Q.sub.14                                                                               H    COOMe     Me OMe      N                                      982  Q.sub.14                                                                               H    COOMe     OMe                                                                               OMe      N                                      983  Q.sub.14                                                                               H    COOEt     Me Me       CH                                     984  Q.sub.14                                                                               H    COOEt     Me OMe      CH                                     985  Q.sub.14                                                                               H    COOEt     OMe                                                                               OMe      CH                                     986  Q.sub.14                                                                               H    COOEt     Me OMe      N                                      987  Q.sub.14                                                                               H    COOEt     OMe                                                                               OMe      N                                      988  Q.sub.14                                                                               Me   COOMe     Me OMe      CH                                     989  Q.sub.14                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     990  Q.sub.14                                                                               Me   COOMe     Me OMe      N                                      991  Q.sub.14                                                                               Me   COOEt     Me OMe      CH                                     992  Q.sub.14                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     993  Q.sub.14                                                                               Me   COOEt     Me OMe      N                                      994  Q.sub.14                                                                               H    CN        Me OMe      CH                                     995  Q.sub.14                                                                               H    CN        OMe                                                                               OMe      CH                                     996  Q.sub.14                                                                               H    CN        Me OMe      N                                      997  Q.sub.14                                                                               H    H         Me OMe      CH                                     998  Q.sub.14                                                                               H    H         OMe                                                                               OMe      CH                                     999  Q.sub.14                                                                               H    H         Me OMe      N                                      1000 Me      H    Q.sub.14  Me Me       CH                                     1001 Me      H    Q.sub.14  Me OMe      CH                                     1002 Me      H    Q.sub.14  OMe                                                                               OMe      CH                                     1003 Me      H    Q.sub.14  Me OMe      N                                      1004 Me      H    Q.sub.14  OMe                                                                               OMe      N                                      1005 Q.sub.15                                                                               H    COOMe     Me Me       CH                                     1006 Q.sub.15                                                                               H    COOMe     Me OMe      CH                                     1007 Q.sub.15                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1008 Q.sub.15                                                                               H    COOMe     Me OMe      N                                      1009 Q.sub.15                                                                               H    COOMe     OMe                                                                               OMe      N                                      1010 Q.sub.15                                                                               H    COOEt     Me Me       CH                                     1011 Q.sub.15                                                                               H    COOEt     Me OMe      CH                                     1012 Q.sub.15                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1013 Q.sub.15                                                                               H    COOEt     Me OMe      N                                      1014 Q.sub.15                                                                               H    COOEt     OMe                                                                               OMe      N                                      1015 Q.sub.15                                                                               Me   COOMe     Me OMe      CH                                     1016 Q.sub.15                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1017 Q.sub.15                                                                               Me   COOMe     Me OMe      N                                      1018 Q.sub.15                                                                               Me   COOEt     Me OMe      CH                                     1019 Q.sub.15                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1020 Q.sub.15                                                                               Me   COOEt     Me OMe      N                                      1021 Q.sub.15                                                                               H    CN        Me OMe      CH                                     1022 Q.sub.15                                                                               H    CN        OMe                                                                               OMe      CH                                     1023 Q.sub.15                                                                               H    CN        Me OMe      N                                      1024 Q.sub.15                                                                               H    H         Me OMe      CH                                     1025 Q.sub.15                                                                               H    H         OMe                                                                               OMe      CH                                     1026 Q.sub.15                                                                               H    H         Me OMe      N                                      1027 Me      H    Q.sub.15  Me Me       CH                                     1028 Me      H    Q.sub.15  Me OMe      CH                                     1029 Me      H    Q.sub.15  OMe                                                                               OMe      CH                                     1030 Me      H    Q.sub.15  Me OMe      N                                      1031 Me      H    Q.sub.15  OMe                                                                               OMe      N                                      1032 Q.sub.16                                                                               H    COOMe     Me Me       CH                                     1033 Q.sub.16                                                                               H    COOMe     Me OMe      CH                                     1034 Q.sub.16                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1035 Q.sub.16                                                                               H    COOMe     Me OMe      N                                      1036 Q.sub.16                                                                               H    COOMe     OMe                                                                               OMe      N                                      1037 Q.sub.16                                                                               H    COOEt     Me Me       CH                                     1038 Q.sub.16                                                                               H    COOEt     Me OMe      CH                                     1039 Q.sub.16                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1040 Q.sub.16                                                                               H    COOEt     Me OMe      N                                      1041 Q.sub.16                                                                               H    COOEt     OMe                                                                               OMe      N                                      1042 Q.sub.16                                                                               Me   COOMe     Me OMe      CH                                     1043 Q.sub.16                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1044 Q.sub.16                                                                               Me   COOMe     Me OMe      N                                      1045 Q.sub.16                                                                               Me   COOEt     Me OMe      CH                                     1046 Q.sub.16                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1047 Q.sub.16                                                                               Me   COOEt     Me OMe      N                                      1048 Q.sub.16                                                                               H    CN        Me OMe      CH                                     1049 Q.sub.16                                                                               H    CN        OMe                                                                               OMe      CH                                     1050 Q.sub.16                                                                               H    CN        Me OMe      N                                      1051 Q.sub.16                                                                               H    H         Me OMe      CH                                     1052 Q.sub.16                                                                               H    H         OMe                                                                               OMe      CH                                     1053 Q.sub.16                                                                               H    H         Me OMe      N                                      1054 Me      H    Q.sub.16  Me Me       CH                                     1055 Me      H    Q.sub.16  Me OMe      CH                                     1056 Me      H    Q.sub.16  OMe                                                                               OMe      CH                                     1057 Me      H    Q.sub.16  Me OMe      N                                      1058 Me      H    Q.sub.16  OMe                                                                               OMe      N                                      1059 Q.sub.17                                                                               H    COOMe     Me OMe      CH                                     1060 Q.sub.17                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1061 Q.sub.17                                                                               H    COOEt     Me OMe      CH                                     1062 Q.sub.17                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1063 Q.sub.17                                                                               Me   COOMe     Me OMe      CH                                     1064 Q.sub.17                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1065 Q.sub.17                                                                               Me   COOEt     Me OMe      CH                                     1066 Q.sub.17                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1067 Q.sub.17                                                                               H    H         Me OMe      CH                                     1068 Q.sub.17                                                                               H    H         OMe                                                                               OMe      CH                                     1069 Me      H    Q.sub.17  Me OMe      CH                                     1070 Me      H    Q.sub.17  OMe                                                                               OMe      CH                                     1071 Q.sub.18                                                                               H    COOMe     Me Me       CH                                     1072 Q.sub.18                                                                               H    COOMe     Me OMe      CH                                     1073 Q.sub.18                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1074 Q.sub.18                                                                               H    COOMe     Me OMe      N                                      1075 Q.sub.18                                                                               H    COOMe     OMe                                                                               OMe      N                                      1076 Q.sub.18                                                                               H    COOEt     Me Me       CH                                     1077 Q.sub.18                                                                               H    COOEt     Me OMe      CH                                     1078 Q.sub.18                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1079 Q.sub.18                                                                               H    COOEt     Me OMe      N                                      1080 Q.sub.18                                                                               H    COOEt     OMe                                                                               OMe      N                                      1081 Q.sub.18                                                                               Me   COOMe     Me OMe      CH                                     1082 Q.sub.18                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1083 Q.sub.18                                                                               Me   COOMe     Me OMe      N                                      1084 Q.sub.18                                                                               Me   COOEt     Me OMe      CH                                     1085 Q.sub.18                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1086 Q.sub.18                                                                               Me   COOEt     Me OMe      N                                      1087 Q.sub.18                                                                               H    CN        Me OMe      CH                                     1088 Q.sub.18                                                                               H    CN        OMe                                                                               OMe      CH                                     1089 Q.sub.18                                                                               H    CN        Me OMe      N                                      1090 Q.sub.18                                                                               H    H         Me OMe      CH                                     1091 Q.sub.18                                                                               H    H         OMe                                                                               OMe      CH                                     1092 Q.sub.18                                                                               H    H         Me OMe      N                                      1093 Me      H    Q.sub.18  Me Me       CH                                     1094 Me      H    Q.sub.18  Me OMe      CH                                     1095 Me      H    Q.sub.18  OMe                                                                               OMe      CH                                     1096 Me      H    Q.sub.18  Me OMe      N                                      1097 Me      H    Q.sub.18  OMe                                                                               OMe      N                                      1098 Q.sub.19                                                                               H    COOMe     Me Me       CH                                     1099 Q.sub.19                                                                               H    COOMe     Me OMe      CH                                     1100 Q.sub.19                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1101 Q.sub.19                                                                               H    COOMe     Me OMe      N                                      1102 Q.sub.19                                                                               H    COOMe     OMe                                                                               OMe      N                                      1103 Q.sub.19                                                                               H    COOEt     Me Me       CH                                     1104 Q.sub.19                                                                               H    COOEt     Me OMe      CH                                     1105 Q.sub.19                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1106 Q.sub.19                                                                               H    COOEt     Me OMe      N                                      1107 Q.sub.19                                                                               H    COOEt     OMe                                                                               OMe      N                                      1108 Q.sub.19                                                                               Me   COOMe     Me OMe      CH                                     1109 Q.sub.19                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1110 Q.sub.19                                                                               Me   COOMe     Me OMe      N                                      1111 Q.sub.19                                                                               Me   COOEt     Me OMe      CH                                     1112 Q.sub.19                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1113 Q.sub.19                                                                               Me   COOEt     Me OMe      N                                      1114 Q.sub.19                                                                               H    CN        Me OMe      CH                                     1115 Q.sub.19                                                                               H    CN        OMe                                                                               OMe      CH                                     1116 Q.sub.19                                                                               H    CN        Me OMe      N                                      1117 Q.sub.19                                                                               H    H         Me OMe      CH                                     1118 Q.sub.19                                                                               H    H         OMe                                                                               OMe      CH                                     1119 Q.sub.19                                                                               H    H         Me OMe      N                                      1120 Me      H    Q.sub.19  Me Me       CH                                     1121 Me      H    Q.sub.19  Me OMe      CH                                     1122 Me      H    Q.sub.19  OMe                                                                               OMe      CH                                     1123 Me      H    Q.sub.19  Me OMe      N                                      1124 Me      H    Q.sub.19  OMe                                                                               OMe      N                                      1125 Q.sub.20                                                                               H    COOMe     Me Me       CH                                     1126 Q.sub.20                                                                               H    COOMe     Me OMe      CH                                     1127 Q.sub.20                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1128 Q.sub.20                                                                               H    COOMe     Me OMe      N                                      1129 Q.sub.20                                                                               H    COOMe     OMe                                                                               OMe      N                                      1130 Q.sub.20                                                                               H    COOEt     Me Me       CH                                     1131 Q.sub.20                                                                               H    COOEt     Me OMe      CH                                     1132 Q.sub.20                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1133 Q.sub.20                                                                               H    COOEt     Me OMe      N                                      1134 Q.sub.20                                                                               H    COOEt     OMe                                                                               OMe      N                                      1135 Q.sub.20                                                                               Me   COOMe     Me OMe      CH                                     1136 Q.sub.20                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1137 Q.sub.20                                                                               Me   COOMe     Me OMe      N                                      1138 Q.sub.20                                                                               Me   COOEt     Me OMe      CH                                     1139 Q.sub.20                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1140 Q.sub.20                                                                               Me   COOEt     Me OMe      N                                      1141 Q.sub.20                                                                               H    CN        Me OMe      CH                                     1142 Q.sub.20                                                                               H    CN        OMe                                                                               OMe      CH                                     1143 Q.sub.20                                                                               H    CN        Me OMe      N                                      1144 Q.sub.20                                                                               H    H         Me OMe      CH                                     1145 Q.sub.20                                                                               H    H         OMe                                                                               OMe      CH                                     1146 Q.sub.20                                                                               H    H         Me OMe      N                                      1147 Me      H    Q.sub.20  Me Me       CH                                     1148 Me      H    Q.sub.20  Me OMe      CH                                     1149 Me      H    Q.sub.20  OMe                                                                               OMe      CH                                     1150 Me      H    Q.sub.20  Me OMe      N                                      1151 Me      H    Q.sub.20  OMe                                                                               OMe      N                                      1152 Q.sub.21                                                                               H    COOMe     Me Me       CH                                     1153 Q.sub.21                                                                               H    COOMe     Me OMe      CH                                     1154 Q.sub.21                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1155 Q.sub.21                                                                               H    COOMe     Me OMe      N                                      1156 Q.sub.21                                                                               H    COOMe     OMe                                                                               OMe      N                                      1157 Q.sub.21                                                                               H    COOEt     Me Me       CH                                     1158 Q.sub.21                                                                               H    COOEt     Me OMe      CH                                     1159 Q.sub.21                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1160 Q.sub.21                                                                               H    COOEt     Me OMe      N                                      1161 Q.sub.21                                                                               H    COOEt     OMe                                                                               OMe      N                                      1162 Q.sub.21                                                                               Me   COOMe     Me OMe      CH                                     1163 Q.sub.21                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1164 Q.sub.21                                                                               Me   COOMe     Me OMe      N                                      1165 Q.sub.21                                                                               Me   COOEt     Me OMe      CH                                     1166 Q.sub.21                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1167 Q.sub.21                                                                               Me   COOEt     Me OMe      N                                      1168 Q.sub.21                                                                               H    CN        Me OMe      CH                                     1169 Q.sub.21                                                                               H    CN        OMe                                                                               OMe      CH                                     1170 Q.sub.21                                                                               H    CN        Me OMe      N                                      1171 Q.sub.21                                                                               H    H         Me OMe      CH                                     1172 Q.sub.21                                                                               H    H         OMe                                                                               OMe      CH                                     1173 Q.sub.21                                                                               H    H         Me OMe      N                                      1174 Me      H    Q.sub.21  Me Me       CH                                     1175 Me      H    Q.sub.21  Me OMe      CH                                     1176 Me      H    Q.sub.21  OMe                                                                               OMe      CH                                     1177 Me      H    Q.sub.21  Me OMe      N                                      1178 Me      H    Q.sub.21  OMe                                                                               OMe      N                                      1179 Q.sub.22                                                                               H    COOMe     Me Me       CH                                     1180 Q.sub.22                                                                               H    COOMe     Me OMe      CH                                     1181 Q.sub.22                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1182 Q.sub.22                                                                               H    COOMe     Me OMe      N                                      1183 Q.sub.22                                                                               H    COOMe     OMe                                                                               OMe      N                                      1184 Q.sub.22                                                                               H    COOEt     Me Me       CH                                     1185 Q.sub.22                                                                               H    COOEt     Me OMe      CH                                     1186 Q.sub.22                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1187 Q.sub.22                                                                               H    COOEt     Me OMe      N                                      1188 Q.sub.22                                                                               H    COOEt     OMe                                                                               OMe      N                                      1189 Q.sub.22                                                                               Me   COOMe     Me OMe      CH                                     1190 Q.sub.22                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1191 Q.sub.22                                                                               Me   COOMe     Me OMe      N                                      1192 Q.sub.22                                                                               Me   COOEt     Me OMe      CH                                     1193 Q.sub.22                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1194 Q.sub.22                                                                               Me   COOEt     Me OMe      N                                      1195 Q.sub.22                                                                               H    CN        Me OMe      CH                                     1196 Q.sub.22                                                                               H    CN        OMe                                                                               OMe      CH                                     1197 Q.sub.22                                                                               H    CN        Me OMe      N                                      1198 Q.sub.22                                                                               H    H         Me OMe      CH                                     1199 Q.sub.22                                                                               H    H         OMe                                                                               OMe      CH                                     1200 Q.sub.22                                                                               H    H         Me OMe      N                                      1201 Me      H    Q.sub.22  Me Me       CH                                     1202 Me      H    Q.sub.22  Me OMe      CH                                     1203 Me      H    Q.sub.22  OMe                                                                               OMe      CH                                     1204 Me      H    Q.sub.22  Me OMe      N                                      1205 Me      H    Q.sub.22  OMe                                                                               OMe      N                                      1206 Q.sub.23                                                                               H    COOMe     Me OMe      CH                                     1207 Q.sub.23                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1208 Q.sub.23                                                                               H    COOEt     Me OMe      CH                                     1209 Q.sub.23                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1210 Q.sub.23                                                                               Me   COOMe     Me OMe      CH                                     1211 Q.sub.23                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1212 Q.sub.23                                                                               Me   COOEt     Me OMe      CH                                     1213 Q.sub.23                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1214 Q.sub.23                                                                               H    H         Me OMe      CH                                     1215 Q.sub.23                                                                               H    H         OMe                                                                               OMe      CH                                     1216 Me      H    Q.sub.23  Me OMe      CH                                     1217 Me      H    Q.sub.23  OMe                                                                               OMe      CH                                     1218 Q.sub.24                                                                               H    COOMe     Me Me       CH                                     1219 Q.sub.24                                                                               H    COOMe     Me OMe      CH                                     1220 Q.sub.24                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1221 Q.sub.24                                                                               H    COOMe     Me OMe      N                                      1222 Q.sub.24                                                                               H    COOMe     OMe                                                                               OMe      N                                      1223 Q.sub.24                                                                               H    COOEt     Me Me       CH                                     1224 Q.sub.24                                                                               H    COOEt     Me OMe      CH                                     1225 Q.sub.24                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1226 Q.sub.24                                                                               H    COOEt     Me OMe      N                                      1227 Q.sub.24                                                                               H    COOEt     OMe                                                                               OMe      N                                      1228 Q.sub.24                                                                               Me   COOMe     Me OMe      CH                                     1229 Q.sub.24                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1230 Q.sub.24                                                                               Me   COOMe     Me OMe      N                                      1231 Q.sub.24                                                                               Me   COOEt     Me OMe      CH                                     1232 Q.sub.24                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1233 Q.sub.24                                                                               Me   COOEt     Me OMe      N                                      1234 Q.sub.24                                                                               H    CN        Me OMe      CH                                     1235 Q.sub.24                                                                               H    CN        OMe                                                                               OMe      CH                                     1236 Q.sub.24                                                                               H    CN        Me OMe      N                                      1237 Q.sub.24                                                                               H    H         Me OMe      CH                                     1238 Q.sub.24                                                                               H    H         OMe                                                                               OMe      CH                                     1239 Q.sub.24                                                                               H    H         Me OMe      N                                      1240 Me      H    Q.sub.24  Me Me       CH                                     1241 Me      H    Q.sub.24  Me OMe      CH                                     1242 Me      H    Q.sub.24  OMe                                                                               OMe      CH                                     1243 Me      H    Q.sub.24  Me OMe      N                                      1244 Me      H    Q.sub.24  OMe                                                                               OMe      N                                      1245 Q.sub.25                                                                               H    COOMe     Me Me       CH                                     1246 Q.sub.25                                                                               H    COOMe     Me OMe      CH                                     1247 Q.sub.25                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1248 Q.sub.25                                                                               H    COOMe     Me OMe      N                                      1249 Q.sub.25                                                                               H    COOMe     OMe                                                                               OMe      N                                      1250 Q.sub.25                                                                               H    COOEt     Me Me       CH                                     1251 Q.sub.25                                                                               H    COOEt     Me OMe      CH                                     1252 Q.sub.25                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1253 Q.sub.25                                                                               H    COOEt     Me OMe      N                                      1254 Q.sub.25                                                                               H    COOEt     OMe                                                                               OMe      N                                      1255 Q.sub.25                                                                               Me   COOMe     Me OMe      CH                                     1256 Q.sub.25                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1257 Q.sub.25                                                                               Me   COOMe     Me OMe      N                                      1258 Q.sub.25                                                                               Me   COOEt     Me OMe      CH                                     1259 Q.sub.25                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1260 Q.sub.25                                                                               Me   COOEt     Me OMe      N                                      1261 Q.sub.25                                                                               H    CN        Me OMe      CH                                     1262 Q.sub.25                                                                               H    CN        OMe                                                                               OMe      CH                                     1263 Q.sub.25                                                                               H    CN        Me OMe      N                                      1264 Q.sub.25                                                                               H    H         Me OMe      CH                                     1265 Q.sub.25                                                                               H    H         OMe                                                                               OMe      CH                                     1266 Q.sub.25                                                                               H    H         Me OMe      N                                      1267 Me      H    Q.sub.25  Me Me       CH                                     1268 Me      H    Q.sub.25  Me OMe      CH                                     1269 Me      H    Q.sub.25  OMe                                                                               OMe      CH                                     1270 Me      H    Q.sub.25  Me OMe      N                                      1271 Me      H    Q.sub.25  OMe                                                                               OMe      N                                      1272 Q.sub.26                                                                               H    COOMe     Me OMe      CH                                     1273 Q.sub.26                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1274 Q.sub.26                                                                               H    COOEt     Me OMe      CH                                     1275 Q.sub.26                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1276 Q.sub.26                                                                               Me   COOMe     Me OMe      CH                                     1277 Q.sub.26                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1278 Q.sub.26                                                                               Me   COOEt     Me OMe      CH                                     1279 Q.sub.26                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1280 Q.sub.26                                                                               H    H         Me OMe      CH                                     1281 Q.sub.26                                                                               H    H         OMe                                                                               OMe      CH                                     1282 Me      H    Q.sub.26  Me OMe      CH                                     1283 Me      H    Q.sub.26  OMe                                                                               OMe      CH                                     1284 Q.sub.27                                                                               H    COOMe     Me OMe      CH                                     1285 Q.sub.27                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1286 Q.sub.27                                                                               H    COOEt     Me OMe      CH                                     1287 Q.sub.27                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1288 Q.sub.27                                                                               Me   COOMe     Me OMe      CH                                     1289 Q.sub.27                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1290 Q.sub.27                                                                               Me   COOEt     Me OMe      CH                                     1291 Q.sub.27                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1292 Q.sub.27                                                                               H    H         Me OMe      CH                                     1293 Q.sub.27                                                                               H    H         OMe                                                                               OMe      CH                                     1294 Me      H    Q.sub.27  Me OMe      CH                                     1295 Me      H    Q.sub.27  OMe                                                                               OMe      CH                                     1296 Q.sub.28                                                                               H    COOMe     Me Me       CH                                     1297 Q.sub.28                                                                               H    COOMe     Me OMe      CH                                     1298 Q.sub.28                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1299 Q.sub.28                                                                               H    COOMe     Me OMe      N                                      1300 Q.sub.28                                                                               H    COOMe     OMe                                                                               OMe      N                                      1301 Q.sub.28                                                                               H    COOEt     Me Me       CH                                     1302 Q.sub.28                                                                               H    COOEt     Me OMe      CH                                     1303 Q.sub.28                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1304 Q.sub.28                                                                               H    COOEt     Me OMe      N                                      1305 Q.sub.28                                                                               H    COOEt     OMe                                                                               OMe      N                                      1306 Q.sub.28                                                                               Me   COOMe     Me OMe      CH                                     1307 Q.sub.28                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1308 Q.sub.28                                                                               Me   COOMe     Me OMe      N                                      1309 Q.sub.28                                                                               Me   COOEt     Me OMe      CH                                     1310 Q.sub.28                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1311 Q.sub.28                                                                               Me   COOEt     Me OMe      N                                      1312 Q.sub.28                                                                               H    CN        Me OMe      CH                                     1313 Q.sub.28                                                                               H    CN        OMe                                                                               OMe      CH                                     1314 Q.sub.28                                                                               H    CN        Me OMe      N                                      1315 Q.sub.28                                                                               H    H         Me OMe      CH                                     1316 Q.sub.28                                                                               H    H         OMe                                                                               OMe      CH                                     1317 Q.sub.28                                                                               H    H         Me OMe      N                                      1318 Me      H    Q.sub.28  Me Me       CH                                     1319 Me      H    Q.sub.28  Me OMe      CH                                     1320 Me      H    Q.sub.28  OMe                                                                               OMe      CH                                     1321 Me      H    Q.sub.28  Me OMe      N                                      1322 Me      H    Q.sub.28  OMe                                                                               OMe      N                                      1323 Q.sub.29                                                                               H    COOMe     Me OMe      CH                                     1324 Q.sub.29                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1325 Q.sub.29                                                                               H    COOEt     Me OMe      CH                                     1326 Q.sub.29                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1327 Q.sub.29                                                                               Me   COOMe     Me OMe      CH                                     1328 Q.sub.29                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1329 Q.sub.29                                                                               Me   COOEt     Me OMe      CH                                     1330 Q.sub.29                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1331 Q.sub.29                                                                               H    H         Me OMe      CH                                     1332 Q.sub.29                                                                               H    H         OMe                                                                               OMe      CH                                     1333 Me      H    Q.sub.29  Me OMe      CH                                     1334 Me      H    Q.sub.29  OMe                                                                               OMe      CH                                     1335 Q.sub.30                                                                               H    COOMe     Me OMe      CH                                     1336 Q.sub.30                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1337 Q.sub.30                                                                               H    COOEt     Me OMe      CH                                     1338 Q.sub.30                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1339 Q.sub.30                                                                               Me   COOMe     Me OMe      CH                                     1340 Q.sub.30                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1341 Q.sub.30                                                                               Me   COOEt     Me OMe      CH                                     1342 Q.sub.30                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1343 Q.sub.30                                                                               H    H         Me OMe      CH                                     1344 Q.sub.30                                                                               H    H         OMe                                                                               OMe      CH                                     1345 Me      H    Q.sub.30  Me OMe      CH                                     1346 Me      H    Q.sub.30  OMe                                                                               OMe      CH                                     1347 Q.sub.31                                                                               H    COOMe     Me OMe      CH                                     1348 Q.sub.31                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1349 Q.sub.31                                                                               H    COOEt     Me OMe      CH                                     1350 Q.sub.31                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1351 Q.sub.31                                                                               Me   COOMe     Me OMe      CH                                     1352 Q.sub.31                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1353 Q.sub.31                                                                               Me   COOEt     Me OMe      CH                                     1354 Q.sub.31                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1355 Q.sub.31                                                                               H    H         Me OMe      CH                                     1356 Q.sub.31                                                                               H    H         OMe                                                                               OMe      CH                                     1357 Me      H    Q.sub.31  Me OMe      CH                                     1358 Me      H    Q.sub.31  OMe                                                                               OMe      CH                                     1359 Q.sub.32                                                                               H    COOMe     Me Me       CH                                     1360 Q.sub.32                                                                               H    COOMe     Me OMe      CH                                     1361 Q.sub.32                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1362 Q.sub.32                                                                               H    COOMe     Me Me       N                                      1363 Q.sub.32                                                                               H    COOMe     Me OMe      N                                      1364 Q.sub.32                                                                               H    COOMe     OMe                                                                               OMe      N                                      1365 Q.sub.32                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     1366 Q.sub.32                                                                               H    COOMe     Cl OMe      CH                                     1367 Q.sub.32                                                                               H    COOEt     Me Me       CH                                     1368 Q.sub.32                                                                               H    COOEt     Me OMe      CH                                     1369 Q.sub.32                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1370 Q.sub.32                                                                               H    COOEt     Me Me       N                                      1371 Q.sub.32                                                                               H    COOEt     Me OMe      N                                      1372 Q.sub.32                                                                               H    COOEt     OMe                                                                               OMe      N                                      1373 Q.sub.32                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     1374 Q.sub.32                                                                               H    COOEt     Cl OMe      CH                                     1375 Q.sub.32                                                                               H    COOPrn    Me OMe      CH                                     1376 Q.sub.32                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     1377 Q.sub.32                                                                               H    COOPrn    Me OMe      N                                      1378 Q.sub.32                                                                               H    COOPri    Me OMe      CH                                     1379 Q.sub.32                                                                               H    COOPri    OMe                                                                               OMe      CH                                     1380 Q.sub.32                                                                               H    COOPri    Me OMe      N                                      1381 Q.sub.32                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     1382 Q.sub.32                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     1383 Q.sub.32                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      1384 Q.sub. 32                                                                              H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     1385 Q.sub.32                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     1386 Q.sub.32                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      1387 Q.sub.32                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     1388 Q.sub.32                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     1389 Q.sub.32                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      1390 Q.sub.32                                                                               Me   COOMe     Me Me       CH                                     1391 Q.sub.32                                                                               Me   COOMe     Me OMe      CH                                     1392 Q.sub.32                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1393 Q.sub.32                                                                               Me   COOMe     Me OMe      N                                      1394 Q.sub.32                                                                               Me   COOMe     OMe                                                                               OMe      N                                      1395 Q.sub.32                                                                               Me   COOEt     Me Me       CH                                     1396 Q.sub.32                                                                               Me   COOEt     Me OMe      CH                                     1397 Q.sub.32                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1398 Q.sub.32                                                                               Me   COOEt     Me OMe      N                                      1399 Q.sub.32                                                                               Me   COOEt     OMe                                                                               OMe      N                                      1400 Q.sub.32                                                                               Cl   COOMe     Me OMe      CH                                     1401 Q.sub.32                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     1402 Q.sub.32                                                                               Cl   COOMe     Me OMe      N                                      1403 Q.sub. 32                                                                              Cl   COOEt     Me OMe      CH                                     1404 Q.sub.32                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     1405 Q.sub.32                                                                               Cl   COOEt     Me OMe      N                                      1406 Q.sub.32                                                                               OMe  COOMe     Me OMe      CH                                     1407 Q.sub.32                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     1408 Q.sub.32                                                                               OMe  COOMe     Me OMe      N                                      1409 Q.sub.32                                                                               OMe  COOEt     Me OMe      CH                                     1410 Q.sub.32                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     1411 Q.sub.32                                                                               OMe  COOEt     Me OMe      N                                      1412 Q.sub.32                                                                               H    Cl        Me OMe      CH                                     1413 Q.sub.32                                                                               H    Cl        OMe                                                                               OMe      CH                                     1414 Q.sub.32                                                                               H    Cl        Me OMe      N                                      1415 Q.sub.32                                                                               H    NO.sub.2  Me OMe      CH                                     1416 Q.sub.32                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     1417 Q.sub.32                                                                               H    NO.sub.2  Me OMe      N                                      1418 Q.sub.32                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     1419 Q.sub.32                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     1420 Q.sub.32                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      1421 Q.sub.32                                                                               H    CN        Me OMe      CH                                     1422 Q.sub.32                                                                               H    CN        OMe                                                                               OMe      CH                                     1423 Q.sub.32                                                                               H    CN        Me OMe      N                                      1424 Q.sub.32                                                                               Me   CN        Me OMe      CH                                     1425 Q.sub.32                                                                               Me   CN        OMe                                                                               OMe      CH                                     1426 Q.sub.32                                                                               Me   CN        Me OMe      N                                      1427 Q.sub.32                                                                               H    Me        Me OMe      CH                                     1428 Q.sub.32                                                                               H    Me        OMe                                                                               OMe      CH                                     1429 Q.sub.32                                                                               H    Me        Me OMe      N                                      1430 Q.sub.32                                                                               H    Et        Me OMe      CH                                     1431 Q.sub.32                                                                               H    Et        OMe                                                                               OMe      CH                                     1432 Q.sub.32                                                                               H    Et        Me OMe      N                                      1433 Q.sub.32                                                                               H    H         Me OMe      CH                                     1434 Q.sub.32                                                                               H    H         OMe                                                                               OMe      CH                                     1435 Q.sub.32                                                                               H    H         Me OMe      N                                      1436 Q.sub.32                                                                               H    COPh      Me OMe      CH                                     1437 Q.sub.32                                                                               H    COPh      OMe                                                                               OMe      CH                                     1438 Q.sub.32                                                                               H    COPh      Me OMe      N                                      1439 Me      Q.sub.32                                                                            COOMe     Me OMe      CH                                     1440 Me      Q.sub.32                                                                            COOMe     OMe                                                                               OMe      CH                                     1441 Me      Q.sub.32                                                                            COOMe     Me OMe      N                                      1442 H       H    Q.sub.32  Me OMe      CH                                     1443 H       H    Q.sub.32  OMe                                                                               OMe      CH                                     1444 H       H    Q.sub.32  Me OMe      N                                      1445 Me      H    Q.sub.32  Me Me       CH                                     1446 Me      H    Q.sub.32  Me OMe      CH                                     1447 Me      H    Q.sub.32  OMe                                                                               OMe      CH                                     1448 Me      H    Q.sub.32  Me OMe      N                                      1449 Me      H    Q.sub.32  OMe                                                                               OMe      N                                      1450 Me      Me   Q.sub.32  Me OMe      CH                                     1451 Me      Me   Q.sub.32  OMe                                                                               OMe      CH                                     1452 Me      Me   Q.sub.32  Me OMe      N                                      1453 Q.sub.33                                                                               H    COOMe     Me Me       CH                                     1454 Q.sub.33                                                                               H    COOMe     Me OMe      CH                                     1455 Q.sub.33                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1456 Q.sub.33                                                                               H    COOMe     Me OMe      N                                      1457 Q.sub.33                                                                               H    COOMe     OMe                                                                               OMe      N                                      1458 Q.sub.33                                                                               H    COOEt     Me Me       CH                                     1459 Q.sub.33                                                                               H    COOEt     Me OMe      CH                                     1460 Q.sub.33                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1461 Q.sub.33                                                                               H    COOEt     Me OMe      N                                      1462 Q.sub.33                                                                               H    COOEt     OMe                                                                               OMe      N                                      1463 Q.sub.33                                                                               Me   COOMe     Me OMe      CH                                     1464 Q.sub.33                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1465 Q.sub.33                                                                               Me   COOMe     Me OMe      N                                      1466 Q.sub.33                                                                               Me   COOEt     Me OMe      CH                                     1467 Q.sub.33                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1468 Q.sub.33                                                                               Me   COOEt     Me OMe      N                                      1469 Q.sub.33                                                                               H    CN        Me OMe      CH                                     1470 Q.sub.33                                                                               H    CN        OMe                                                                               OMe      CH                                     1471 Q.sub.33                                                                               H    CN        Me OMe      N                                      1472 Q.sub.33                                                                               H    H         Me OMe      CH                                     1473 Q.sub.33                                                                               H    H         OMe                                                                               OMe      CH                                     1474 Q.sub.33                                                                               H    H         Me OMe      N                                      1475 Me      H    Q.sub.33  Me Me       CH                                     1476 Me      H    Q.sub.33  Me OMe      CH                                     1477 Me      H    Q.sub.33  OMe                                                                               OMe      CH                                     1478 Me      H    Q.sub.33  Me OMe      N                                      1479 Me      H    Q.sub.33  OMe                                                                               OMe      N                                      1480 Q.sub.34                                                                               H    COOMe     Me Me       CH                                     1481 Q.sub.34                                                                               H    COOMe     Me OMe      CH                                     1482 Q.sub.34                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1483 Q.sub.34                                                                               H    COOMe     Me OMe      N                                      1484 Q.sub.34                                                                               H    COOMe     OMe                                                                               OMe      N                                      1485 Q.sub.34                                                                               H    COOEt     Me Me       CH                                     1486 Q.sub.34                                                                               H    COOEt     Me OMe      CH                                     1487 Q.sub.34                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1488 Q.sub.34                                                                               H    COOEt     Me OMe      N                                      1489 Q.sub.34                                                                               H    COOEt     OMe                                                                               OMe      N                                      1490 Q.sub.34                                                                               Me   COOMe     Me OMe      CH                                     1491 Q.sub.34                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1492 Q.sub.34                                                                               Me   COOMe     Me OMe      N                                      1493 Q.sub.34                                                                               Me   COOEt     Me OMe      CH                                     1494 Q.sub.34                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1495 Q.sub.34                                                                               Me   COOEt     Me OMe      N                                      1496 Q.sub.34                                                                               H    CN        Me OMe      CH                                     1497 Q.sub.34                                                                               H    CN        OMe                                                                               OMe      CH                                     1498 Q.sub.34                                                                               H    CN        Me OMe      N                                      1499 Q.sub.34                                                                               H    H         Me OMe      CH                                     1500 Q.sub.34                                                                               H    H         OMe                                                                               OMe      CH                                     1501 Q.sub.34                                                                               H    H         Me OMe      N                                      1502 Me      H    Q.sub.34  Me Me       CH                                     1503 Me      H    Q.sub.34  Me OMe      CH                                     1504 Me      H    Q.sub.34  OMe                                                                               OMe      CH                                     1505 Me      H    Q.sub.34  Me OMe      N                                      1506 Me      H    Q.sub.34  OMe                                                                               OMe      N                                      1507 Q.sub.35                                                                               H    COOMe     Me Me       CH                                     1508 Q.sub.35                                                                               H    COOMe     Me OMe      CH                                     1509 Q.sub.35                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1510 Q.sub.35                                                                               H    COOMe     Me OMe      N                                      1511 Q.sub.35                                                                               H    COOMe     OMe                                                                               OMe      N                                      1512 Q.sub.35                                                                               H    COOEt     Me Me       CH                                     1513 Q.sub.35                                                                               H    COOEt     Me OMe      CH                                     1514 Q.sub.35                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1515 Q.sub.35                                                                               H    COOEt     Me OMe      N                                      1516 Q.sub.35                                                                               H    COOEt     OMe                                                                               OMe      N                                      1517 Q.sub.35                                                                               Me   COOMe     Me OMe      CH                                     1518 Q.sub.35                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1519 Q.sub.35                                                                               Me   COOMe     Me OMe      N                                      1520 Q.sub.35                                                                               Me   COOEt     Me OMe      CH                                     1521 Q.sub.35                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1522 Q.sub.35                                                                               Me   COOEt     Me OMe      N                                      1523 Q.sub.35                                                                               H    CN        Me OMe      CH                                     1524 Q.sub.35                                                                               H    CN        OMe                                                                               OMe      CH                                     1525 Q.sub.35                                                                               H    CN        Me OMe      N                                      1526 Q.sub.35                                                                               H    H         Me OMe      CH                                     1527 Q.sub.35                                                                               H    H         OMe                                                                               OMe      CH                                     1528 Q.sub.35                                                                               H    H         Me OMe      N                                      1529 Me      H    Q.sub.35  Me Me       CH                                     1530 Me      H    Q.sub.35  Me OMe      CH                                     1531 Me      H    Q.sub.35  OMe                                                                               OMe      CH                                     1532 Me      H    Q.sub.35  Me OMe      N                                      1533 Me      H    Q.sub.35  OMe                                                                               OMe      N                                      1534 Q.sub.36                                                                               H    COOMe     Me OMe      CH                                     1535 Q.sub.36                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1536 Q.sub.36                                                                               H    COOEt     Me OMe      CH                                     1537 Q.sub.36                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1538 Q.sub.36                                                                               Me   COOMe     Me OMe      CH                                     1539 Q.sub.36                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1540 Q.sub.36                                                                               Me   COOEt     Me OMe      CH                                     1541 Q.sub.36                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1542 Q.sub.36                                                                               H    H         Me OMe      CH                                     1543 Q.sub.36                                                                               H    H         OMe                                                                               OMe      CH                                     1544 Me      H    Q.sub.36  Me OMe      CH                                     1545 Me      H    Q.sub.36  OMe                                                                               OMe      CH                                     1546 Q.sub.37                                                                               H    COOMe     Me Me       CH                                     1547 Q.sub.37                                                                               H    COOMe     Me OMe      CH                                     1548 Q.sub.37                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1549 Q.sub.37                                                                               H    COOMe     Me OMe      N                                      1550 Q.sub.37                                                                               H    COOMe     OMe                                                                               OMe      N                                      1551 Q.sub.37                                                                               H    COOEt     Me Me       CH                                     1552 Q.sub.37                                                                               H    COOEt     Me OMe      CH                                     1553 Q.sub.37                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1554 Q.sub.37                                                                               H    COOEt     Me OMe      N                                      1555 Q.sub.37                                                                               H    COOEt     OMe                                                                               OMe      N                                      1556 Q.sub.37                                                                               Me   COOMe     Me OMe      CH                                     1557 Q.sub.37                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1558 Q.sub.37                                                                               Me   COOMe     Me OMe      N                                      1559 Q.sub.37                                                                               Me   COOEt     Me OMe      CH                                     1560 Q.sub.37                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1561 Q.sub.37                                                                               Me   COOEt     Me OMe      N                                      1562 Q.sub.37                                                                               H    CN        Me OMe      CH                                     1563 Q.sub.37                                                                               H    CN        OMe                                                                               OMe      CH                                     1564 Q.sub.37                                                                               H    CN        Me OMe      N                                      1565 Q.sub.37                                                                               H    H         Me OMe      CH                                     1566 Q.sub.37                                                                               H    H         OMe                                                                               OMe      CH                                     1567 Q.sub.37                                                                               H    H         Me OMe      N                                      1568 Me      H    Q.sub.37  Me Me       CH                                     1569 Me      H    Q.sub.37  Me OMe      CH                                     1570 Me      H    Q.sub.37  OMe                                                                               OMe      CH                                     1571 Me      H    Q.sub.37  Me OMe      N                                      1572 Me      H    Q.sub.37  OMe                                                                               OMe      N                                      1573 Q.sub.38                                                                               H    COOMe     Me Me       CH                                     1574 Q.sub.38                                                                               H    COOMe     Me OMe      CH                                     1575 Q.sub.38                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1576 Q.sub.38                                                                               H    COOMe     Me OMe      N                                      1577 Q.sub.38                                                                               H    COOMe     OMe                                                                               OMe      N                                      1578 Q.sub.38                                                                               H    COOEt     Me Me       CH                                     1579 Q.sub.38                                                                               H    COOEt     Me OMe      CH                                     1580 Q.sub.38                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1581 Q.sub.38                                                                               H    COOEt     Me OMe      N                                      1582 Q.sub.38                                                                               H    COOEt     OMe                                                                               OMe      N                                      1583 Q.sub.38                                                                               Me   COOMe     Me OMe      CH                                     1584 Q.sub.38                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1585 Q.sub.38                                                                               Me   COOMe     Me OMe      N                                      1586 Q.sub.38                                                                               Me   COOEt     Me OMe      CH                                     1587 Q.sub.38                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1588 Q.sub.38                                                                               Me   COOEt     Me OMe      N                                      1589 Q.sub.38                                                                               H    CN        Me OMe      CH                                     1590 Q.sub.38                                                                               H    CN        OMe                                                                               OMe      CH                                     1591 Q.sub.38                                                                               H    CN        Me OMe      N                                      1592 Q.sub.38                                                                               H    H         Me OMe      CH                                     1593 Q.sub.38                                                                               H    H         OMe                                                                               OMe      CH                                     1594 Q.sub.38                                                                               H    H         Me OMe      N                                      1595 Me      H    Q.sub.38  Me Me       CH                                     1596 Me      H    Q.sub.38  Me OMe      CH                                     1597 Me      H    Q.sub.38  OMe                                                                               OMe      CH                                     1598 Me      H    Q.sub.38  Me OMe      N                                      1599 Me      H    Q.sub.38  OMe                                                                               OMe      N                                      1600 Q.sub.39                                                                               H    COOMe     Me Me       CH                                     1601 Q.sub.39                                                                               H    COOMe     Me OMe      CH                                     1602 Q.sub.39                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1603 Q.sub.39                                                                               H    COOMe     Me OMe      N                                      1604 Q.sub.39                                                                               H    COOMe     OMe                                                                               OMe      N                                      1605 Q.sub.39                                                                               H    COOEt     Me Me       CH                                     1606 Q.sub.39                                                                               H    COOEt     Me OMe      CH                                     1607 Q.sub.39                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1608 Q.sub.39                                                                               H    COOEt     Me OMe      N                                      1609 Q.sub.39                                                                               H    COOEt     OMe                                                                               OMe      N                                      1610 Q.sub.39                                                                               Me   COOMe     Me OMe      CH                                     1611 Q.sub.39                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1612 Q.sub.39                                                                               Me   COOMe     Me OMe      N                                      1613 Q.sub.39                                                                               Me   COOEt     Me OMe      CH                                     1614 Q.sub.39                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1615 Q.sub.39                                                                               Me   COOEt     Me OMe      N                                      1616 Q.sub.39                                                                               H    CN        Me OMe      CH                                     1617 Q.sub.39                                                                               H    CN        OMe                                                                               OMe      CH                                     1618 Q.sub.39                                                                               H    CN        Me OMe      N                                      1619 Q.sub.39                                                                               H    H         Me OMe      CH                                     1620 Q.sub.39                                                                               H    H         OMe                                                                               OMe      CH                                     1621 Q.sub.39                                                                               H    H         Me OMe      N                                      1622 Me      H    Q.sub.39  Me Me       CH                                     1623 Me      H    Q.sub.39  Me OMe      CH                                     1624 Me      H    Q.sub.39  OMe                                                                               OMe      CH                                     1625 Me      H    Q.sub.39  Me OMe      N                                      1626 Me      H    Q.sub.39  OMe                                                                               OMe      N                                      1627 Q.sub.40                                                                               H    COOMe     Me OMe      CH                                     1628 Q.sub.40                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1629 Q.sub.40                                                                               H    COOEt     Me OMe      CH                                     1630 Q.sub.40                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1631 Q.sub.40                                                                               Me   COOMe     Me OMe      CH                                     1632 Q.sub.40                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1633 Q.sub.40                                                                               Me   COOEt     Me OMe      CH                                     1634 Q.sub.40                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1635 Q.sub.40                                                                               H    H         Me OMe      CH                                     1636 Q.sub.40                                                                               H    H         OMe                                                                               OMe      CH                                     1637 Me      H    Q.sub.40  Me OMe      CH                                     1638 Me      H    Q.sub.40  OMe                                                                               OMe      CH                                     1639 Q.sub.41                                                                               H    COOMe     Me Me       CH                                     1640 Q.sub.41                                                                               H    COOMe     Me OMe      CH                                     1641 Q.sub.41                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1642 Q.sub.41                                                                               H    COOMe     Me OMe      N                                      1643 Q.sub.41                                                                               H    COOMe     OMe                                                                               OMe      N                                      1644 Q.sub.41                                                                               H    COOEt     Me Me       CH                                     1645 Q.sub.41                                                                               H    COOEt     Me OMe      CH                                     1646 Q.sub.41                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1647 Q.sub.41                                                                               H    COOEt     Me OMe      N                                      1648 Q.sub.41                                                                               H    COOEt     OMe                                                                               OMe      N                                      1649 Q.sub.41                                                                               Me   COOMe     Me OMe      CH                                     1650 Q.sub.41                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1651 Q.sub.41                                                                               Me   COOMe     Me OMe      N                                      1652 Q.sub.41                                                                               Me   COOEt     Me OMe      CH                                     1653 Q.sub.41                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1654 Q.sub.41                                                                               Me   COOEt     Me OMe      N                                      1655 Q.sub.41                                                                               H    CN        Me OMe      CH                                     1656 Q.sub.41                                                                               H    CN        OMe                                                                               OMe      CH                                     1657 Q.sub.41                                                                               H    CN        Me OMe      N                                      1658 Q.sub.41                                                                               H    H         Me OMe      CH                                     1659 Q.sub.41                                                                               H    H         OMe                                                                               OMe      CH                                     1660 Q.sub.41                                                                               H    H         Me OMe      N                                      1661 Me      H    Q.sub.41  Me Me       CH                                     1662 Me      H    Q.sub.41  Me OMe      CH                                     1663 Me      H    Q.sub.41  OMe                                                                               OMe      CH                                     1664 Me      H    Q.sub.41  Me OMe      N                                      1665 Me      H    Q.sub.41  OMe                                                                               OMe      N                                      1666 Q.sub.42                                                                               H    COOMe     Me Me       CH                                     1667 Q.sub.42                                                                               H    COOMe     Me OMe      CH                                     1668 Q.sub.42                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1669 Q.sub.42                                                                               H    COOMe     Me OMe      N                                      1670 Q.sub.42                                                                               H    COOMe     OMe                                                                               OMe      N                                      1671 Q.sub.42                                                                               H    COOEt     Me Me       CH                                     1672 Q.sub.42                                                                               H    COOEt     Me OMe      CH                                     1673 Q.sub.42                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1674 Q.sub.42                                                                               H    COOEt     Me OMe      N                                      1675 Q.sub.42                                                                               H    COOEt     OMe                                                                               OMe      N                                      1676 Q.sub.42                                                                               Me   COOMe     Me OMe      CH                                     1677 Q.sub.42                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1678 Q.sub.42                                                                               Me   COOMe     Me OMe      N                                      1679 Q.sub.42                                                                               Me   COOEt     Me OMe      CH                                     1680 Q.sub.42                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1681 Q.sub.42                                                                               Me   COOEt     Me OMe      N                                      1682 Q.sub.42                                                                               H    CN        Me OMe      CH                                     1683 Q.sub.42                                                                               H    CN        OMe                                                                               OMe      CH                                     1684 Q.sub.42                                                                               H    CN        Me OMe      N                                      1685 Q.sub.42                                                                               H    H         Me OMe      CH                                     1686 Q.sub.42                                                                               H    H         OMe                                                                               OMe      CH                                     1687 Q.sub.42                                                                               H    H         Me OMe      N                                      1688 Me      H    Q.sub.42  Me Me       CH                                     1689 Me      H    Q.sub.42  Me OMe      CH                                     1690 Me      H    Q.sub.42  OMe                                                                               OMe      CH                                     1691 Me      H    Q.sub.42  Me OMe      N                                      1692 Me      H    Q.sub.42  OMe                                                                               OMe      N                                      1693 Q.sub.43                                                                               H    COOMe     Me Me       CH                                     1694 Q.sub.43                                                                               H    COOMe     Me OMe      CH                                     1695 Q.sub.43                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1696 Q.sub.43                                                                               H    COOMe     Me OMe      N                                      1697 Q.sub.43                                                                               H    COOMe     OMe                                                                               OMe      N                                      1698 Q.sub.43                                                                               H    COOEt     Me Me       CH                                     1699 Q.sub.43                                                                               H    COOEt     Me OMe      CH                                     1700 Q.sub.43                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1701 Q.sub.43                                                                               H    COOEt     Me OMe      N                                      1702 Q.sub.43                                                                               H    COOEt     OMe                                                                               OMe      N                                      1703 Q.sub.43                                                                               Me   COOMe     Me OMe      CH                                     1704 Q.sub.43                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1705 Q.sub.43                                                                               Me   COOMe     Me OMe      N                                      1706 Q.sub.43                                                                               Me   COOEt     Me OMe      CH                                     1707 Q.sub.43                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1708 Q.sub.43                                                                               Me   COOEt     Me OMe      N                                      1709 Q.sub.43                                                                               H    CN        Me OMe      CH                                     1710 Q.sub.43                                                                               H    CN        OMe                                                                               OMe      CH                                     1711 Q.sub.43                                                                               H    CN        Me OMe      N                                      1712 Q.sub.42                                                                               H    H         Me OMe      CH                                     1713 Q.sub.43                                                                               H    H         OMe                                                                               OMe      CH                                     1714 Q.sub.43                                                                               H    H         Me OMe      N                                      1715 Me      H    Q.sub.43  Me Me       CH                                     1716 Me      H    Q.sub.43  Me OMe      CH                                     1717 Me      H    Q.sub.43  OMe                                                                               OMe      CH                                     1718 Me      H    Q.sub.43  Me OMe      N                                      1719 Me      H    Q.sub.43  OMe                                                                               OMe      N                                      1720 Q.sub.44                                                                               H    COOMe     Me OMe      CH                                     1721 Q.sub.44                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1722 Q.sub.44                                                                               H    COOEt     Me OMe      CH                                     1723 Q.sub.44                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1724 Q.sub.44                                                                               Me   COOMe     Me OMe      CH                                     1725 Q.sub.44                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1726 Q.sub.44                                                                               Me   COOEt     Me OMe      CH                                     1727 Q.sub.44                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1728 Q.sub.44                                                                               H    H         Me OMe      CH                                     1729 Q.sub.44                                                                               H    H         OMe                                                                               OMe      CH                                     1730 Me      H    Q.sub.44  Me OMe      CH                                     1731 Me      H    Q.sub.44  OMe                                                                               OMe      CH                                     1732 Q.sub.45                                                                               H    COOMe     Me Me       CH                                     1733 Q.sub.45                                                                               H    COOMe     Me OMe      CH                                     1734 Q.sub.45                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1735 Q.sub.45                                                                               H    COOMe     Me Me       N                                      1736 Q.sub.45                                                                               H    COOMe     Me OMe      N                                      1737 Q.sub.45                                                                               H    COOMe     OMe                                                                               OMe      N                                      1738 Q.sub.45                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     1739 Q.sub.45                                                                               H    COOMe     Cl OMe      CH                                     1740 Q.sub.45                                                                               H    COOEt     Me Me       CH                                     1741 Q.sub.45                                                                               H    COOEt     Me OMe      CH                                     1742 Q.sub.45                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1743 Q.sub.45                                                                               H    COOEt     Me Me       N                                      1744 Q.sub.45                                                                               H    COOEt     Me OMe      N                                      1745 Q.sub.45                                                                               H    COOEt     OMe                                                                               OMe      N                                      1746 Q.sub.45                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     1747 Q.sub.45                                                                               H    COOEt     Cl OMe      CH                                     1748 Q.sub.45                                                                               H    COOPrn    Me OMe      CH                                     1749 Q.sub.45                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     1750 Q.sub.45                                                                               H    COOPrn    Me OMe      N                                      1751 Q.sub.45                                                                               H    COOPri    Me OMe      CH                                     1752 Q.sub.45                                                                               H    COOPri    OMe                                                                               OMe      CH                                     1753 Q.sub.45                                                                               H    COOPri    Me OMe      N                                      1754 Q.sub.45                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     1755 Q.sub.45                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     1756 Q.sub.45                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      1757 Q.sub.45                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     1758 Q.sub.45                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     1759 Q.sub.45                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      1760 Q.sub.45                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     1761 Q.sub.45                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     1762 Q.sub.45                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      1763 Q.sub.45                                                                               Me   COOMe     Me Me       CH                                     1764 Q.sub.45                                                                               Me   COOMe     Me OMe      CH                                     1765 Q.sub.45                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1766 Q.sub.45                                                                               Me   COOMe     Me OMe      N                                      1767 Q.sub.45                                                                               Me   COOMe     OMe                                                                               OMe      N                                      1768 Q.sub. 45                                                                              Me   COOEt     Me Me       CH                                     1769 Q.sub.45                                                                               Me   COOEt     Me OMe      CH                                     1770 Q.sub.45                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1771 Q.sub.45                                                                               Me   COOEt     Me OMe      N                                      1772 Q.sub.45                                                                               Me   COOEt     OMe                                                                               OMe      N                                      1773 Q.sub.45                                                                               Cl   COOMe     Me OMe      CH                                     1774 Q.sub.45                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     1775 Q.sub.45                                                                               Cl   COOMe     Me OMe      N                                      __________________________________________________________________________

    __________________________________________________________________________     1776 Q.sub.45                                                                               Cl   COOEt     Me OMe      CH                                     1777 Q.sub.45                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     1778 Q.sub.45                                                                               Cl   COOEt     Me OMe      N                                      1779 Q.sub.45                                                                               OMe  COOMe     Me OMe      CH                                     1780 Q.sub.45                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     1781 Q.sub.45                                                                               OMe  COOMe     Me OMe      N                                      1782 Q.sub.45                                                                               OMe  COOEt     Me OMe      CH                                     1783 Q.sub.45                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     1784 Q.sub.45                                                                               OMe  COOEt     Me OMe      N                                      1785 Q.sub.45                                                                               H    Cl        Me OMe      CH                                     1786 Q.sub.45                                                                               H    Cl        OMe                                                                               OMe      CH                                     1787 Q.sub.45                                                                               H    Cl        Me OMe      N                                      1788 Q.sub.45                                                                               H    NO.sub.2  Me OMe      CH                                     1789 Q.sub.45                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     1790 Q.sub.45                                                                               H    NO.sub.2  Me OMe      N                                      1791 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     1792 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     1793 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      1794 Q.sub.45                                                                               H    CN        Me OMe      CH                                     1795 Q.sub.45                                                                               H    CN        OMe                                                                               OMe      CH                                     1796 Q.sub.45                                                                               H    CN        Me OMe      N                                      1797 Q.sub.45                                                                               Me   CN        Me OMe      CH                                     1798 Q.sub.45                                                                               Me   CN        OMe                                                                               OMe      CH                                     1799 Q.sub.45                                                                               Me   CN        Me OMe      N                                      1800 Q.sub.45                                                                               H    Me        Me OMe      CH                                     1801 Q.sub.45                                                                               H    Me        OMe                                                                               OMe      CH                                     1802 Q.sub.45                                                                               H    Me        Me OMe      N                                      1803 Q.sub.45                                                                               H    Et        Me OMe      CH                                     1804 Q.sub.45                                                                               H    Et        OMe                                                                               OMe      CH                                     1805 Q.sub.45                                                                               H    Et        Me OMe      N                                      1806 Q.sub.45                                                                               H    H         Me OMe      CH                                     1807 Q.sub.45                                                                               H    H         OMe                                                                               OMe      CH                                     1808 Q.sub.45                                                                               H    H         Me OMe      N                                      1809 Q.sub.45                                                                               H    COPh      Me OMe      CH                                     1810 Q.sub.45                                                                               H    COPh      OMe                                                                               OMe      CH                                     1811 Q.sub.45                                                                               H    COPh      Me OMe      N                                      1812 Me      Q.sub.45                                                                            COOMe     Me OMe      CH                                     1813 Me      Q.sub.45                                                                            COOMe     OMe                                                                               OMe      CH                                     1814 Me      Q.sub.45                                                                            COOMe     Me OMe      N                                      1815 H       H    Q.sub.45  Me OMe      CH                                     1816 H       H    Q.sub.45  OMe                                                                               OMe      CH                                     1817 H       H    Q.sub.45  Me OMe      N                                      1818 Me      H    Q.sub.45  Me Me       CH                                     1819 Me      H    Q.sub.45  Me OMe      CH                                     1820 Me      H    Q.sub.45  OMe                                                                               OMe      CH                                     1821 Me      H    Q.sub.45  Me OMe      N                                      1822 Me      H    Q.sub.45  OMe                                                                               OMe      N                                      1823 Me      Me   Q.sub.45  Me OMe      CH                                     1824 Me      Me   Q.sub.45  OMe                                                                               OMe      CH                                     1825 Me      Me   Q.sub.45  Me OMe      N                                      1826 Q.sub.46                                                                               H    COOMe     Me Me       CH                                     1827 Q.sub.46                                                                               H    COOMe     Me OMe      CH                                     1828 Q.sub.46                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1829 Q.sub.46                                                                               H    COOMe     Me OMe      N                                      1830 Q.sub.46                                                                               H    COOMe     OMe                                                                               OMe      N                                      1831 Q.sub.46                                                                               H    COOEt     Me Me       CH                                     1832 Q.sub.46                                                                               H    COOEt     Me OMe      CH                                     1833 Q.sub.46                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1834 Q.sub.46                                                                               H    COOEt     Me OMe      N                                      1835 Q.sub.46                                                                               H    COOEt     OMe                                                                               OMe      N                                      1836 Q.sub.46                                                                               Me   COOMe     Me OMe      CH                                     1837 Q.sub.46                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1838 Q.sub.46                                                                               Me   COOMe     Me OMe      N                                      1839 Q.sub.46                                                                               Me   COOEt     Me OMe      CH                                     1840 Q.sub.46                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1841 Q.sub.46                                                                               Me   COOEt     Me OMe      N                                      1842 Q.sub.46                                                                               H    CN        Me OMe      CH                                     1843 Q.sub.46                                                                               H    CN        OMe                                                                               OMe      CH                                     1844 Q.sub.46                                                                               H    CN        Me OMe      N                                      1845 Q.sub.46                                                                               H    H         Me OMe      CH                                     1846 Q.sub.46                                                                               H    H         OMe                                                                               OMe      CH                                     1847 Q.sub.46                                                                               H    H         Me OMe      N                                      1848 Me      H    Q.sub.46  Me Me       CH                                     1849 Me      H    Q.sub.46  Me OMe      CH                                     1850 Me      H    Q.sub.46  OMe                                                                               OMe      CH                                     1851 Me      H    Q.sub.46  Me OMe      N                                      1852 Me      H    Q.sub.46  OMe                                                                               OMe      N                                      1853 Q.sub.47                                                                               H    COOMe     Me Me       CH                                     1854 Q.sub.47                                                                               H    COOMe     Me OMe      CH                                     1855 Q.sub.47                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1856 Q.sub.47                                                                               H    COOMe     Me OMe      N                                      1857 Q.sub.47                                                                               H    COOMe     OMe                                                                               OMe      N                                      1858 Q.sub.47                                                                               H    COOEt     Me Me       CH                                     1859 Q.sub.47                                                                               H    COOEt     Me OMe      CH                                     1860 Q.sub.47                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1861 Q.sub.47                                                                               H    COOEt     Me OMe      N                                      1862 Q.sub.47                                                                               H    COOEt     OMe                                                                               OMe      N                                      1863 Q.sub.47                                                                               Me   COOMe     Me OMe      CH                                     1864 Q.sub.47                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1865 Q.sub.47                                                                               Me   COOMe     Me OMe      N                                      1866 Q.sub.47                                                                               Me   COOEt     Me OMe      CH                                     1867 Q.sub.47                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1868 Q.sub.47                                                                               Me   COOEt     Me OMe      N                                      1869 Q.sub.47                                                                               H    CN        Me OMe      CH                                     1870 Q.sub.47                                                                               H    CN        OMe                                                                               OMe      CH                                     1871 Q.sub.47                                                                               H    CN        Me OMe      N                                      1872 Q.sub.47                                                                               H    H         Me OMe      CH                                     1873 Q.sub.47                                                                               H    H         OMe                                                                               OMe      CH                                     1874 Q.sub.47                                                                               H    H         Me OMe      N                                      1875 Me      H    Q.sub.47  Me Me       CH                                     1876 Me      H    Q.sub.47  Me OMe      CH                                     1877 Me      H    Q.sub.47  OMe                                                                               OMe      CH                                     1878 Me      H    Q.sub.47  Me OMe      N                                      1879 Me      H    Q.sub.47  OMe                                                                               OMe      N                                      1880 Q.sub.48                                                                               H    COOMe     Me Me       CH                                     1881 Q.sub.48                                                                               H    COOMe     Me OMe      CH                                     1882 Q.sub.48                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1883 Q.sub.48                                                                               H    COOMe     Me OMe      N                                      1884 Q.sub.48                                                                               H    COOMe     OMe                                                                               OMe      N                                      1885 Q.sub.48                                                                               H    COOEt     Me Me       CH                                     1886 Q.sub.48                                                                               H    COOEt     Me OMe      CH                                     1887 Q.sub.48                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1888 Q.sub.48                                                                               H    COOEt     Me OMe      N                                      1889 Q.sub.48                                                                               H    COOEt     OMe                                                                               OMe      N                                      1890 Q.sub.48                                                                               Me   COOMe     Me OMe      CH                                     1891 Q.sub.48                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1892 Q.sub.48                                                                               Me   COOMe     Me OMe      N                                      1893 Q.sub.48                                                                               Me   COOEt     Me OMe      CH                                     1894 Q.sub.48                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1895 Q.sub.48                                                                               Me   COOEt     Me OMe      N                                      1896 Q.sub.48                                                                               H    CN        Me OMe      CH                                     1897 Q.sub.48                                                                               H    CN        OMe                                                                               OMe      CH                                     1898 Q.sub.48                                                                               H    CN        Me OMe      N                                      1899 Q.sub.48                                                                               H    H         Me OMe      CH                                     1900 Q.sub.48                                                                               H    H         OMe                                                                               OMe      CH                                     1901 Q.sub.48                                                                               H    H         Me OMe      N                                      1902 Me      H    Q.sub.48  Me Me       CH                                     1903 Me      H    Q.sub.48  Me OMe      CH                                     1904 Me      H    Q.sub.48  OMe                                                                               OMe      CH                                     1905 Me      H    Q.sub.48  Me OMe      N                                      1906 Me      H    Q.sub.48  OMe                                                                               OMe      N                                      1907 Q.sub.49                                                                               H    COOMe     Me Me       CH                                     1908 Q.sub.49                                                                               H    COOMe     Me OMe      CH                                     1909 Q.sub.49                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1910 Q.sub.49                                                                               H    COOMe     Me OMe      N                                      1911 Q.sub.49                                                                               H    COOMe     OMe                                                                               OMe      N                                      1912 Q.sub.49                                                                               H    COOEt     Me Me       CH                                     1913 Q.sub.49                                                                               H    COOEt     Me OMe      CH                                     1914 Q49     H    COOEt     OMe                                                                               OMe      CH                                     1915 Q.sub.49                                                                               H    COOEt     Me OMe      N                                      1916 Q.sub.49                                                                               H    COOEt     OMe                                                                               OMe      N                                      1917 Q.sub.49                                                                               Me   COOMe     Me OMe      CH                                     1918 Q.sub.49                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1919 Q.sub.49                                                                               Me   COOMe     Me OMe      N                                      1920 Q.sub.49                                                                               Me   COOEt     Me OMe      CH                                     1921 Q.sub.49                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1922 Q.sub.49                                                                               Me   COOEt     Me OMe      N                                      1923 Q.sub.49                                                                               H    CN        Me OMe      CH                                     1924 Q.sub.49                                                                               H    CN        OMe                                                                               OMe      CH                                     1925 Q.sub.49                                                                               H    CN        Me OMe      N                                      1926 Q.sub.49                                                                               H    H         Me OMe      CH                                     1927 Q.sub.49                                                                               H    H         OMe                                                                               OMe      CH                                     1928 Q.sub.49                                                                               H    H         Me OMe      N                                      1929 Me      H    Q.sub.49  Me Me       CH                                     1930 Me      H    Q.sub.49  Me OMe      CH                                     1931 Me      H    Q.sub.49  OMe                                                                               OMe      CH                                     1932 Me      H    Q.sub.49  Me OMe      N                                      1933 Me      H    Q.sub.49  OMe                                                                               OMe      N                                      1934 Q.sub.50                                                                               H    COOMe     Me Me       CH                                     1935 Q.sub.50                                                                               H    COOMe     Me OMe      CH                                     1936 Q.sub.50                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1937 Q.sub.50                                                                               H    COOMe     Me OMe      N                                      1938 Q.sub.50                                                                               H    COOMe     OMe                                                                               OMe      N                                      1939 Q.sub.50                                                                               H    COOEt     Me Me       CH                                     1940 Q.sub.50                                                                               H    COOEt     Me OMe      CH                                     1941 Q.sub.50                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1942 Q.sub.50                                                                               H    COOEt     Me OMe      N                                      1943 Q.sub.50                                                                               H    COOEt     OMe                                                                               OMe      N                                      1944 Q.sub.50                                                                               Me   COOMe     Me OMe      CH                                     1945 Q.sub.50                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1946 Q.sub.50                                                                               Me   COOMe     Me OMe      N                                      1947 Q.sub.50                                                                               Me   COOEt     Me OMe      CH                                     1948 Q.sub.50                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1949 Q.sub.50                                                                               Me   COOEt     Me OMe      N                                      1950 Q.sub.50                                                                               H    CN        Me OMe      CH                                     1951 Q.sub.50                                                                               H    CN        OMe                                                                               OMe      CH                                     1952 Q.sub.50                                                                               H    CN        Me OMe      N                                      1953 Q.sub.50                                                                               H    H         Me OMe      CH                                     1954 Q.sub.50                                                                               H    H         OMe                                                                               OMe      CH                                     1955 Q.sub.50                                                                               H    H         Me OMe      N                                      1956 Me      H    Q.sub.50  Me Me       CH                                     1957 Me      H    Q.sub.50  Me OMe      CH                                     1958 Me      H    Q.sub.50  OMe                                                                               OMe      CH                                     1959 Me      H    Q.sub.50  Me OMe      N                                      1960 Me      H    Q.sub.50  OMe                                                                               OMe      N                                      1961 Q.sub.51                                                                               H    COOMe     Me Me       CH                                     1962 Q.sub.51                                                                               H    COOMe     Me OMe      CH                                     1963 Q.sub.51                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1964 Q.sub.51                                                                               H    COOMe     Me OMe      N                                      1965 Q.sub.51                                                                               H    COOMe     OMe                                                                               OMe      N                                      1966 Q.sub.51                                                                               H    COOEt     Me Me       CH                                     1967 Q.sub.51                                                                               H    COOEt     Me OMe      CH                                     1968 Q.sub.51                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1969 Q.sub.51                                                                               H    COOEt     Me OMe      N                                      1970 Q.sub.51                                                                               H    COOEt     OMe                                                                               OMe      N                                      1971 Q.sub.51                                                                               Me   COOMe     Me OMe      CH                                     1972 Q.sub.51                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1973 Q.sub.51                                                                               Me   COOMe     Me OMe      N                                      1974 Q.sub.51                                                                               Me   COOEt     Me OMe      CH                                     1975 Q.sub.51                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1976 Q.sub.51                                                                               Me   COOEt     Me OMe      N                                      1977 Q.sub.51                                                                               H    CN        Me OMe      CH                                     1978 Q.sub.51                                                                               H    CN        OMe                                                                               OMe      CH                                     1979 Q.sub.51                                                                               H    CN        Me OMe      N                                      1980 Q.sub.51                                                                               H    H         Me OMe      CH                                     1981 Q.sub.51                                                                               H    H         OMe                                                                               OMe      CH                                     1982 Q.sub.51                                                                               H    H         Me OMe      N                                      1983 Me      H    Q.sub.51  Me Me       CH                                     1984 Me      H    Q.sub.51  Me OMe      CH                                     1985 Me      H    Q.sub.51  OMe                                                                               OMe      CH                                     1986 Me      H    Q.sub.51  Me OMe      N                                      1987 Me      H    Q.sub.51  OMe                                                                               OMe      N                                      1988 Q.sub.52                                                                               H    COOMe     Me OMe      CH                                     1989 Q.sub.52                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1990 Q.sub.52                                                                               H    COOEt     Me OMe      CH                                     1991 Q.sub.52                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1992 Q.sub.52                                                                               Me   COOMe     Me OMe      CH                                     1993 Q.sub.52                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1994 Q.sub.52                                                                               Me   COOEt     Me OMe      CH                                     1995 Q.sub.52                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1996 Q.sub.52                                                                               H    H         Me OMe      CH                                     1997 Q.sub.52                                                                               H    H         OMe                                                                               OMe      CH                                     1998 Me      H    Q.sub. 52 Me OMe      CH                                     1999 Me      H    Q.sub.52  OMe                                                                               OMe      CH                                     2000 Q.sub.53                                                                               H    COOMe     Me OMe      CH                                     2001 Q.sub.53                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2002 Q.sub.53                                                                               H    COOEt     Me OMe      CH                                     2003 Q.sub.53                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2004 Q.sub.53                                                                               Me   COOMe     Me OMe      CH                                     2005 Q.sub.53                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2006 Q.sub.53                                                                               Me   COOEt     Me OMe      CH                                     2007 Q.sub.53                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2008 Q.sub.53                                                                               H    H         Me OMe      CH                                     2009 Q.sub.53                                                                               H    H         OMe                                                                               OMe      CH                                     2010 Me      H    Q.sub.53  Me OMe      CH                                     2011 Me      H    Q.sub.53  OMe                                                                               OMe      CH                                     2012 Q.sub.54                                                                               H    COOMe     Me Me       CH                                     2013 Q.sub.54                                                                               H    COOMe     Me OMe      CH                                     2014 Q.sub.54                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2015 Q.sub.54                                                                               H    COOMe     Me OMe      N                                      2016 Q.sub.54                                                                               H    COOMe     OMe                                                                               OMe      N                                      2017 Q.sub.54                                                                               H    COOEt     Me Me       CH                                     2018 Q.sub.54                                                                               H    COOEt     Me OMe      CH                                     2019 Q.sub.54                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2020 Q.sub.54                                                                               H    COOEt     Me OMe      N                                      2021 Q.sub.54                                                                               H    COOEt     OMe                                                                               OMe      N                                      2022 Q.sub.54                                                                               Me   COOMe     Me OMe      CH                                     2023 Q.sub.54                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2024 Q.sub.54                                                                               Me   COOMe     Me OMe      N                                      2025 Q.sub.54                                                                               Me   COOEt     Me OMe      CH                                     2026 Q.sub.54                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2027 Q.sub.54                                                                               Me   COOEt     Me OMe      N                                      2028 Q.sub.54                                                                               H    CN        Me OMe      CH                                     2029 Q.sub.54                                                                               H    CN        OMe                                                                               OMe      CH                                     2030 Q.sub.54                                                                               H    CN        Me OMe      N                                      2031 Q.sub.54                                                                               H    H         Me OMe      CH                                     2032 Q.sub.54                                                                               H    H         OMe                                                                               OMe      CH                                     2033 Q.sub.54                                                                               H    H         Me OMe      N                                      2034 Me      H    Q.sub.54  Me Me       CH                                     2035 Me      H    Q.sub.54  Me OMe      CH                                     2036 Me      H    Q.sub.54  OMe                                                                               OMe      CH                                     2037 Me      H    Q.sub.54  Me OMe      N                                      2038 Me      H    Q.sub.54  OMe                                                                               OMe      N                                      2039 Q.sub.55                                                                               H    COOMe     Me Me       CH                                     2040 Q.sub.55                                                                               H    COOMe     Me OMe      CH                                     2041 Q.sub.55                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2042 Q.sub.55                                                                               H    COOMe     Me OMe      N                                      2043 Q.sub.55                                                                               H    COOMe     OMe                                                                               OMe      N                                      2044 Q.sub.55                                                                               H    COOEt     Me Me       CH                                     2045 Q.sub.55                                                                               H    COOEt     Me OMe      CH                                     2046 Q.sub.55                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2047 Q.sub.55                                                                               H    COOEt     Me OMe      N                                      2048 Q.sub.55                                                                               H    COOEt     OMe                                                                               OMe      N                                      2049 Q.sub.55                                                                               Me   COOMe     Me OMe      CH                                     2050 Q.sub.55                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2051 Q.sub.55                                                                               Me   COOMe     Me OMe      N                                      2052 Q.sub.55                                                                               Me   COOEt     Me OMe      CH                                     2053 Q.sub.55                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2054 Q.sub.55                                                                               Me   COOEt     Me OMe      N                                      2055 Q.sub.55                                                                               H    CN        Me OMe      CH                                     2056 Q.sub.55                                                                               H    CN        OMe                                                                               OMe      CH                                     2057 Q.sub.55                                                                               H    CN        Me OMe      N                                      2058 Q.sub.55                                                                               H    H         Me OMe      CH                                     2059 Q.sub.55                                                                               H    H         OMe                                                                               OMe      CH                                     2060 Q.sub.55                                                                               H    H         Me OMe      N                                      2061 Me      H    Q.sub.55  Me Me       CH                                     2062 Me      H    Q.sub.55  Me OMe      CH                                     2063 Me      H    Q.sub.55  OMe                                                                               OMe      CH                                     2064 Me      H    Q.sub.55  Me OMe      N                                      2065 Me      H    Q.sub.55  OMe                                                                               OMe      N                                      2066 Q.sub.56                                                                               H    COOMe     Me Me       CH                                     2067 Q.sub.56                                                                               H    COOMe     Me OMe      CH                                     2068 Q.sub.56                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2069 Q.sub.56                                                                               H    COOMe     Me OMe      N                                      2070 Q.sub.56                                                                               H    COOMe     OMe                                                                               OMe      N                                      2071 Q.sub.56                                                                               H    COOEt     Me Me       CH                                     2072 Q.sub.56                                                                               H    COOEt     Me OMe      CH                                     2073 Q.sub.56                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2074 Q.sub.56                                                                               H    COOEt     Me OMe      N                                      2075 Q.sub.56                                                                               H    COOEt     OMe                                                                               OMe      N                                      2076 Q.sub.56                                                                               Me   COOMe     Me OMe      CH                                     2077 Q.sub.56                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2078 Q.sub.56                                                                               Me   COOMe     Me OMe      N                                      2079 Q.sub.56                                                                               Me   COOEt     Me OMe      CH                                     2080 Q.sub.56                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2081 Q.sub.56                                                                               Me   COOEt     Me OMe      N                                      2082 Q.sub.56                                                                               H    CN        Me OMe      CH                                     2083 Q.sub.56                                                                               H    CN        OMe                                                                               OMe      CH                                     2084 Q.sub.56                                                                               H    CN        Me OMe      N                                      2085 Q.sub.56                                                                               H    H         Me OMe      CH                                     2086 Q.sub.56                                                                               H    H         OMe                                                                               OMe      CH                                     2087 Q.sub.56                                                                               H    H         Me OMe      N                                      2088 Me      H    Q.sub.56  Me Me       CH                                     2089 Me      H    Q.sub.56  Me OMe      CH                                     2090 Me      H    Q.sub.56  OMe                                                                               OMe      CH                                     2091 Me      H    Q.sub.56  Me OMe      N                                      2092 Me      H    Q.sub.56  OMe                                                                               OMe      N                                      2093 Q.sub.57                                                                               H    COOMe     Me OMe      CH                                     2094 Q.sub.57                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2095 Q.sub.57                                                                               H    COOEt     Me OMe      CH                                     2096 Q.sub.57                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2097 Q.sub.57                                                                               Me   COOMe     Me OMe      CH                                     2098 Q.sub.57                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2099 Q.sub.57                                                                               Me   COOEt     Me OMe      CH                                     2100 Q.sub.57                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2101 Q.sub.57                                                                               H    H         Me OMe      CH                                     2102 Q.sub.57                                                                               H    H         OMe                                                                               OMe      CH                                     2103 Me      H    Q.sub.57  Me OMe      CH                                     2104 Me      H    Q.sub.57  OMe                                                                               OMe      CH                                     2105 Q.sub.58                                                                               H    COOMe     Me OMe      CH                                     2106 Q.sub.58                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2107 Q.sub.58                                                                               H    COOEt     Me OMe      CH                                     2108 Q.sub.58                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2109 Q.sub.58                                                                               Me   COOMe     Me OMe      CH                                     2110 Q.sub.58                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2111 Q.sub.58                                                                               Me   COOEt     Me OMe      CH                                     2112 Q.sub.58                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2113 Q.sub.58                                                                               H    H         Me OMe      CH                                     2114 Q.sub.58                                                                               H    H         OMe                                                                               OMe      CH                                     2115 Me      H    Q.sub.58  Me OMe      CH                                     2116 Me      H    Q.sub.58  OMe                                                                               OMe      CH                                     2117 Q.sub.59                                                                               H    COOMe     Me Me       CH                                     2118 Q.sub.59                                                                               H    COOMe     Me OMe      CH                                     2119 Q.sub.59                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2120 Q.sub.59                                                                               H    COOMe     Me Me       N                                      2121 Q.sub.59                                                                               H    COOMe     Me OMe      N                                      2122 Q.sub.59                                                                               H    COOMe     OMe                                                                               OMe      N                                      2123 Q.sub.59                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     2124 Q.sub.59                                                                               H    COOMe     Cl OMe      CH                                     2125 Q.sub.59                                                                               H    COOEt     Me Me       CH                                     2126 Q.sub.59                                                                               H    COOEt     Me OMe      CH                                     2127 Q.sub.59                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2128 Q.sub.59                                                                               H    COOEt     Me Me       N                                      2129 Q.sub.59                                                                               H    COOEt     Me OMe      N                                      2130 Q.sub.59                                                                               H    COOEt     OMe                                                                               OMe      N                                      2131 Q.sub.59                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     2132 Q.sub.59                                                                               H    COOEt     Cl OMe      CH                                     2133 Q.sub.59                                                                               H    COOPrn    Me OMe      CH                                     2134 Q.sub.59                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     2135 Q.sub.59                                                                               H    COOPrn    Me OMe      N                                      2136 Q.sub.59                                                                               H    COOPri    Me OMe      CH                                     2137 Q.sub.59                                                                               H    COOPri    OMe                                                                               OMe      CH                                     2138 Q.sub.59                                                                               H    COOPri    Me OMe      N                                      2139 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     2140 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     2141 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      2142 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     2143 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     2144 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub. 2                                                                  Me OMe      N                                      2145 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     2146 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     2147 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      2148 Q.sub.59                                                                               Me   COOMe     Me Me       CH                                     2149 Q.sub.59                                                                               Me   COOMe     Me OMe      CH                                     2150 Q.sub.59                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2151 Q.sub.59                                                                               Me   COOMe     Me OMe      N                                      2152 Q.sub.59                                                                               Me   COOMe     OMe                                                                               OMe      N                                      2153 Q.sub.59                                                                               Me   COOEt     Me Me       CH                                     2154 Q.sub.59                                                                               Me   COOEt     Me OMe      CH                                     2155 Q.sub.59                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2156 Q.sub.59                                                                               Me   COOEt     Me OMe      N                                      2157 Q.sub.59                                                                               Me   COOEt     OMe                                                                               OMe      N                                      2158 Q.sub.59                                                                               Cl   COOMe     Me OMe      CH                                     2159 Q.sub.59                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     2160 Q.sub.59                                                                               Cl   COOMe     Me OMe      N                                      2161 Q.sub.59                                                                               Cl   COOEt     Me OMe      CH                                     2162 Q.sub.59                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     2163 Q.sub.59                                                                               Cl   COOEt     Me OMe      N                                      2164 Q.sub.59                                                                               OMe  COOMe     Me OMe      CH                                     2165 Q.sub.59                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     2166 Q.sub.59                                                                               OMe  COOMe     Me OMe      N                                      2167 Q.sub.59                                                                               OMe  COOEt     Me OMe      CH                                     2168 Q.sub.59                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     2169 Q.sub.59                                                                               OMe  COOEt     Me OMe      N                                      2170 Q.sub.59                                                                               H    Cl        Me OMe      CH                                     2171 Q.sub.59                                                                               H    Cl        OMe                                                                               OMe      CH                                     2172 Q.sub.59                                                                               H    Cl        Me OMe      N                                      2173 Q.sub.59                                                                               H    NO.sub.2  Me OMe      CH                                     2174 Q.sub.59                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     2175 Q.sub.59                                                                               H    NO.sub.2  Me OMe      N                                      2176 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     2177 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     2178 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      2179 Q.sub.59                                                                               H    CN        Me OMe      CH                                     2180 Q.sub.59                                                                               H    CN        OMe                                                                               OMe      CH                                     2181 Q.sub.59                                                                               H    CN        Me OMe      N                                      2182 Q.sub.59                                                                               Me   CN        Me OMe      CH                                     2183 Q.sub.59                                                                               Me   CN        OMe                                                                               OMe      CH                                     2184 Q.sub.59                                                                               Me   CN        Me OMe      N                                      2185 Q.sub.59                                                                               H    Me        Me OMe      CH                                     2186 Q.sub.59                                                                               H    Me        OMe                                                                               OMe      CH                                     2187 Q.sub.59                                                                               H    Me        Me OMe      N                                      2188 Q.sub.59                                                                               H    Et        Me OMe      CH                                     2189 Q.sub.59                                                                               H    Et        OMe                                                                               OMe      CH                                     2190 Q.sub.59                                                                               H    Et        Me OMe      N                                      2191 Q.sub.59                                                                               H    H         Me OMe      CH                                     2192 Q.sub.59                                                                               H    H         OMe                                                                               OMe      CH                                     2193 Q.sub.59                                                                               H    H         Me OMe      N                                      2194 Q.sub.59                                                                               H    COPh      Me OMe      CH                                     2195 Q.sub.59                                                                               H    COPh      OMe                                                                               OMe      CH                                     2196 Q.sub.59                                                                               H    COPh      Me OMe      N                                      2197 Me      Q.sub.59                                                                            COOMe     Me OMe      CH                                     2198 Me      Q.sub.59                                                                            COOMe     OMe                                                                               OMe      CH                                     2199 Me      Q.sub.59                                                                            COOMe     Me OMe      N                                      2200 H       H    Q.sub.59  Me OMe      CH                                     2201 H       H    Q.sub.59  OMe                                                                               OMe      CH                                     2202 H       H    Q.sub.59  Me OMe      N                                      2203 Me      H    Q.sub.59  Me Me       CH                                     2204 Me      H    Q.sub.59  Me OMe      CH                                     2205 Me      H    Q.sub.59  OMe                                                                               OMe      CH                                     2206 Me      H    Q.sub.59  Me OMe      N                                      2207 Me      H    Q.sub.59  OMe                                                                               OMe      N                                      2208 Me      Me   Q.sub.59  Me OMe      CH                                     2209 Me      Me   Q.sub.59  OMe                                                                               OMe      CH                                     2210 Me      Me   Q.sub.59  Me OMe      N                                      2211 Q.sub.60                                                                               H    COOMe     Me Me       CH                                     2212 Q.sub.60                                                                               H    COOMe     Me OMe      CH                                     2213 Q.sub.60                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2214 Q.sub.60                                                                               H    COOMe     Me OMe      N                                      2215 Q.sub.60                                                                               H    COOMe     OMe                                                                               OMe      N                                      2216 Q.sub.60                                                                               H    COOEt     Me Me       CH                                     2217 Q.sub.60                                                                               H    COOEt     Me OMe      CH                                     2218 Q.sub.60                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2219 Q.sub.60                                                                               H    COOEt     Me OMe      N                                      2220 Q.sub.60                                                                               H    COOEt     OMe                                                                               OMe      N                                      2221 Q.sub.60                                                                               Me   COOMe     Me OMe      CH                                     2222 Q.sub.60                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2223 Q.sub.60                                                                               Me   COOMe     Me OMe      N                                      2224 Q.sub.60                                                                               Me   COOEt     Me OMe      CH                                     2225 Q.sub.60                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2226 Q.sub.60                                                                               Me   COOEt     Me OMe      N                                      2227 Q.sub.60                                                                               H    CN        Me OMe      CH                                     2228 Q.sub.60                                                                               H    CN        OMe                                                                               OMe      CH                                     2229 Q.sub.60                                                                               H    CN        Me OMe      N                                      2230 Q.sub.60                                                                               H    H         Me OMe      CH                                     2231 Q.sub.60                                                                               H    H         OMe                                                                               OMe      CH                                     2232 Q.sub.60                                                                               H    H         Me OMe      N                                      2233 Me      H    Q.sub.60  Me Me       CH                                     2234 Me      H    Q.sub.60  Me OMe      CH                                     2235 Me      H    Q.sub.60  OMe                                                                               OMe      CH                                     2236 Me      H    Q.sub.60  Me OMe      N                                      2237 Me      H    Q.sub.60  OMe                                                                               OMe      N                                      2238 Q.sub.61                                                                               H    COOMe     Me Me       CH                                     2239 Q.sub.61                                                                               H    COOMe     Me OMe      CH                                     2240 Q.sub.61                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2241 Q.sub.61                                                                               H    COOMe     Me OMe      N                                      2242 Q.sub.61                                                                               H    COOMe     OMe                                                                               OMe      N                                      2243 Q.sub.61                                                                               H    COOEt     Me Me       CH                                     2244 Q.sub.61                                                                               H    COOEt     Me OMe      CH                                     2245 Q.sub.61                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2246 Q.sub.61                                                                               H    COOEt     Me OMe      N                                      2247 Q.sub.61                                                                               H    COOEt     OMe                                                                               OMe      N                                      2248 Q.sub.61                                                                               Me   COOMe     Me OMe      CH                                     2249 Q.sub.61                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2250 Q.sub.61                                                                               Me   COOMe     Me OMe      N                                      2251 Q.sub.61                                                                               Me   COOEt     Me OMe      CH                                     2252 Q.sub.61                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2253 Q.sub.61                                                                               Me   COOEt     Me OMe      N                                      2254 Q.sub.61                                                                               H    CN        Me OMe      CH                                     2255 Q.sub.61                                                                               H    CN        OMe                                                                               OMe      CH                                     2256 Q.sub.61                                                                               H    CN        Me OMe      N                                      2257 Q.sub.61                                                                               H    H         Me OMe      CH                                     2258 Q.sub.61                                                                               H    H         OMe                                                                               OMe      CH                                     2259 Q.sub.61                                                                               H    H         Me OMe      N                                      2260 Me      H    Q.sub.61  Me Me       CH                                     2261 Me      H    Q.sub.61  Me OMe      CH                                     2262 Me      H    Q.sub.61  OMe                                                                               OMe      CH                                     2263 Me      H    Q.sub. 61 Me OMe      N                                      2264 Me      H    Q.sub.61  OMe                                                                               OMe      N                                      2265 Q.sub.62                                                                               H    COOMe     Me Me       CH                                     2266 Q.sub.62                                                                               H    COOMe     Me OMe      CH                                     2267 Q.sub.62                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2268 Q.sub.62                                                                               H    COOMe     Me OMe      N                                      2269 Q.sub.62                                                                               H    COOMe     OMe                                                                               OMe      N                                      2270 Q.sub.62                                                                               H    COOEt     Me Me       CH                                     2271 Q.sub.62                                                                               H    COOEt     Me OMe      CH                                     2272 Q.sub.62                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2273 Q.sub.62                                                                               H    COOEt     Me OMe      N                                      2274 Q.sub.62                                                                               H    COOEt     OMe                                                                               OMe      N                                      2275 Q.sub.62                                                                               Me   COOMe     Me OMe      CH                                     2276 Q.sub.62                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2277 Q.sub.62                                                                               Me   COOMe     Me OMe      N                                      2278 Q.sub.62                                                                               Me   COOEt     Me OMe      CH                                     2279 Q.sub.62                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2280 Q.sub.62                                                                               Me   COOEt     Me OMe      N                                      2281 Q.sub.62                                                                               H    CN        Me OMe      CH                                     2282 Q.sub.62                                                                               H    CN        OMe                                                                               OMe      CH                                     2283 Q.sub.62                                                                               H    CN        Me OMe      N                                      2284 Q.sub.62                                                                               H    H         Me OMe      CH                                     2285 Q.sub.62                                                                               H    H         OMe                                                                               OMe      CH                                     2286 Q.sub.62                                                                               H    H         Me OMe      N                                      2287 Me      H    Q.sub.62  Me Me       CH                                     2288 Me      H    Q.sub. 62 Me OMe      CH                                     2289 Me      H    Q.sub.62  OMe                                                                               OMe      CH                                     2290 Me      H    Q.sub.62  Me OMe      N                                      2291 Me      H    Q.sub.62  OMe                                                                               OMe      N                                      2292 Q.sub.63                                                                               H    COOMe     Me OMe      CH                                     2293 Q.sub.63                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2294 Q.sub.63                                                                               H    COOEt     Me OMe      CH                                     2295 Q.sub.63                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2296 Q.sub.63                                                                               Me   COOMe     Me OMe      CH                                     2297 Q.sub.63                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2298 Q.sub.63                                                                               Me   COOEt     Me OMe      CH                                     2299 Q.sub.63                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2300 Q.sub.63                                                                               H    H         Me OMe      CH                                     2301 Q.sub.63                                                                               H    H         OMe                                                                               OMe      CH                                     2302 Me      H    Q.sub.63  Me OMe      CH                                     2303 Me      H    Q.sub.63  OMe                                                                               OMe      CH                                     2304 Q.sub.64                                                                               H    COOMe     Me OMe      CH                                     2305 Q.sub.64                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2306 Q.sub.64                                                                               H    COOEt     Me OMe      CH                                     2307 Q.sub.64                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2308 Q.sub.64                                                                               Me   COOMe     Me OMe      CH                                     2309 Q.sub.64                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2310 Q.sub.64                                                                               Me   COOEt     Me OMe      CH                                     2311 Q.sub.64                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2312 Q.sub.64                                                                               H    H         Me OMe      CH                                     2313 Q.sub.64                                                                               H    H         OMe                                                                               OMe      CH                                     2314 Me      H    Q.sub.64  Me OMe      CH                                     2315 Me      H    Q.sub.64  OMe                                                                               OMe      CH                                     2316 Q.sub.65                                                                               H    COOMe     Me Me       CH                                     2317 Q.sub.65                                                                               H    COOMe     Me OMe      CH                                     2318 Q.sub.65                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2319 Q.sub.65                                                                               H    COOMe     Me OMe      N                                      2320 Q.sub.65                                                                               H    COOMe     OMe                                                                               OMe      N                                      2321 Q.sub.65                                                                               H    COOEt     Me Me       CH                                     2322 Q.sub.65                                                                               H    COOEt     Me OMe      CH                                     2323 Q.sub.65                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2324 Q.sub.65                                                                               H    COOEt     Me OMe      N                                      2325 Q.sub.65                                                                               H    COOEt     OMe                                                                               OMe      N                                      2326 Q.sub.65                                                                               Me   COOMe     Me OMe      CH                                     2327 Q.sub.65                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2328 Q.sub.65                                                                               Me   COOMe     Me OMe      N                                      2329 Q.sub.65                                                                               Me   COOEt     Me OMe      CH                                     2330 Q.sub.65                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2331 Q.sub.65                                                                               Me   COOEt     Me OMe      N                                      2332 Q.sub.65                                                                               H    CN        Me OMe      CH                                     2333 Q.sub.65                                                                               H    CN        OMe                                                                               OMe      CH                                     2334 Q.sub.65                                                                               H    CN        Me OMe      N                                      2335 Q.sub.65                                                                               H    H         Me OMe      CH                                     2336 Q.sub.65                                                                               H    H         OMe                                                                               OMe      CH                                     2337 Q.sub.65                                                                               H    H         Me OMe      N                                      2338 Me      H    Q.sub. 65 Me Me       CH                                     2339 Me      H    Q.sub.65  Me OMe      CH                                     2340 Me      H    Q.sub.65  OMe                                                                               OMe      CH                                     2341 Me      H    Q.sub.65  Me OMe      N                                      2342 Me      H    Q.sub.65  OMe                                                                               OMe      N                                      2343 Q.sub.66                                                                               H    COOMe     Me OMe      CH                                     2344 Q.sub.66                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2345 Q.sub.66                                                                               H    COOEt     Me OMe      CH                                     2346 Q.sub.66                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2347 Q.sub.66                                                                               Me   COOMe     Me OMe      CH                                     2348 Q.sub.66                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2349 Q.sub.66                                                                               Me   COOEt     Me OMe      CH                                     2350 Q.sub.66                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2351 Q.sub.66                                                                               H    H         Me OMe      CH                                     2352 Q.sub.66                                                                               H    H         OMe                                                                               OMe      CH                                     2353 Me      H    Q.sub.66  Me OMe      CH                                     2354 Me      H    Q.sub.66  OMe                                                                               OMe      CH                                     2355 Q.sub.67                                                                               H    COOMe     Me OMe      CH                                     2356 Q.sub.67                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2357 Q.sub.67                                                                               H    COOEt     Me OMe      CH                                     2358 Q.sub.67                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2359 Q.sub.67                                                                               Me   COOMe     Me OMe      CH                                     2360 Q.sub.67                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2361 Q.sub.67                                                                               Me   COOEt     Me OMe      CH                                     2362 Q.sub.67                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2363 Q.sub.67                                                                               H    H         Me OMe      CH                                     2364 Q.sub.67                                                                               H    H         OMe                                                                               OMe      CH                                     2365 Me      H    Q.sub.67  Me OMe      CH                                     2366 Me      H    Q.sub.67  OMe                                                                               OMe      CH                                     2367 Q.sub.68                                                                               H    COOMe     Me OMe      CH                                     2368 Q.sub.68                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2369 Q.sub.68                                                                               H    COOEt     Me OMe      CH                                     2370 Q.sub.68                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2371 Q.sub.68                                                                               Me   COOMe     Me OMe      CH                                     2372 Q.sub.68                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2373 Q.sub.68                                                                               Me   COOEt     Me OMe      CH                                     2374 Q.sub.68                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2375 Q.sub.68                                                                               H    H         Me OMe      CH                                     2376 Q.sub.68                                                                               H    H         OMe                                                                               OMe      CH                                     2377 Me      H    Q.sub.68  Me OMe      CH                                     2378 Me      H    Q.sub.68  Me OMe      CH                                     2379 Q.sub.69                                                                               H    COOMe     Me OMe      CH                                     2380 Q.sub.69                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2381 Q.sub.69                                                                               H    COOEt     Me OMe      CH                                     2382 Q.sub.69                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2383 Q.sub.69                                                                               Me   COOMe     Me OMe      CH                                     2384 Q.sub.69                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2385 Q.sub.69                                                                               Me   COOEt     Me OMe      CH                                     2386 Q.sub.69                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2387 Q.sub.69                                                                               H    H         Me OMe      CH                                     2388 Q.sub.69                                                                               H    H         OMe                                                                               OMe      CH                                     2389 Me      H    Q.sub.69  Me OMe      CH                                     2390 Me      H    Q.sub.69  OMe                                                                               OMe      CH                                     2391 Q.sub.70                                                                               H    COOMe     Me Me       CH                                     2392 Q.sub.70                                                                               H    COOMe     Me OMe      CH                                     2393 Q.sub.70                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2394 Q.sub.70                                                                               H    COOMe     Me OMe      N                                      2395 Q.sub.70                                                                               H    COOMe     OMe                                                                               OMe      N                                      2396 Q.sub.70                                                                               H    COOEt     Me Me       CH                                     2397 Q.sub.70                                                                               H    COOEt     Me OMe      CH                                     2398 Q.sub.70                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2399 Q.sub.70                                                                               H    COOEt     Me OMe      N                                      2400 Q.sub.70                                                                               H    COOEt     OMe                                                                               OMe      N                                      2401 Q.sub.70                                                                               Me   COOMe     Me OMe      CH                                     2402 Q.sub.70                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2403 Q.sub.70                                                                               Me   COOMe     Me OMe      N                                      2404 Q.sub.70                                                                               Me   COOEt     Me OMe      CH                                     2405 Q.sub.70                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2406 Q.sub.70                                                                               Me   COOEt     Me OMe      N                                      2407 Q.sub.70                                                                               H    CN        Me OMe      CH                                     2408 Q.sub.70                                                                               H    CN        OMe                                                                               OMe      CH                                     2409 Q.sub.70                                                                               H    CN        Me OMe      N                                      2410 Q.sub.70                                                                               H    H         Me OMe      CH                                     2411 Q.sub.70                                                                               H    H         OMe                                                                               OMe      CH                                     2412 Q.sub.70                                                                               H    H         Me OMe      N                                      2413 Me      H    Q.sub. 70 Me Me       CH                                     2414 Me      H    Q.sub.70  Me OMe      CH                                     2415 Me      H    Q.sub.70  OMe                                                                               OMe      CH                                     2416 Me      H    Q.sub.70  Me OMe      N                                      2417 Me      H    Q.sub.70  OMe                                                                               OMe      N                                      2418 Q.sub.71                                                                               H    COOMe     Me OMe      CH                                     2419 Q.sub.71                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2420 Q.sub.71                                                                               H    COOEt     Me OMe      CH                                     2421 Q.sub.71                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2422 Q.sub.71                                                                               Me   COOMe     Me OMe      CH                                     2423 Q.sub.71                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2424 Q.sub.71                                                                               Me   COOEt     Me OMe      CH                                     2425 Q.sub.71                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2426 Q.sub.71                                                                               H    H         Me OMe      CH                                     2427 Q.sub.71                                                                               H    H         OMe                                                                               OMe      CH                                     2428 Me      H    Q.sub.71  Me OMe      CH                                     2429 Me      H    Q.sub.71  OMe                                                                               OMe      CH                                     2430 Q.sub.72                                                                               H    COOMe     Me OMe      CH                                     2431 Q.sub.72                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2432 Q.sub.72                                                                               H    COOEt     Me OMe      CH                                     2433 Q.sub.72                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2434 Q.sub.72                                                                               Me   COOMe     Me OMe      CH                                     2435 Q.sub.72                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2436 Q.sub.72                                                                               Me   COOEt     Me OMe      CH                                     2437 Q.sub.72                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2438 Q.sub.72                                                                               H    H         Me OMe      CH                                     2439 Q.sub.72                                                                               H    H         OMe                                                                               OMe      CH                                     2440 Me      H    Q.sub.72  Me OMe      CH                                     2441 Me      H    Q.sub.72  OMe                                                                               OMe      CH                                     2442 Q.sub.73                                                                               H    COOMe     Me OMe      CH                                     2443 Q.sub.73                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2444 Q.sub.73                                                                               H    COOEt     Me OMe      CH                                     2445 Q.sub.73                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2446 Q.sub.73                                                                               Me   COOMe     Me OMe      CH                                     2447 Q.sub.73                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2448 Q.sub.73                                                                               Me   COOEt     Me OMe      CH                                     2449 Q.sub.73                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2450 Q.sub.73                                                                               H    H         Me OMe      CH                                     2451 Q.sub.73                                                                               H    H         OMe                                                                               OMe      CH                                     2452 Me      H    Q.sub.73  Me OMe      CH                                     2453 Me      H    Q.sub.73  OMe                                                                               OMe      CH                                     2454 Q.sub.74                                                                               H    COOMe     Me OMe      CH                                     2455 Q.sub.74                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2456 Q.sub.74                                                                               H    COOEt     Me OMe      CH                                     2457 Q.sub.74                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2458 Q.sub.74                                                                               Me   COOMe     Me OMe      CH                                     2459 Q.sub.74                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2460 Q.sub.74                                                                               Me   COOEt     Me OMe      CH                                     2461 Q.sub.74                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2462 Q.sub.74                                                                               H    H         Me OMe      CH                                     2463 Q.sub.74                                                                               H    H         OMe                                                                               OMe      CH                                     2464 Me      H    Q.sub.74  Me OMe      CH                                     2465 Me      H    Q.sub.74  OMe                                                                               OMe      CH                                     2466 Q.sub.75                                                                               H    COOMe     Me OMe      CH                                     2467 Q.sub.75                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2468 Q.sub.75                                                                               H    COOEt     Me OMe      CH                                     2469 Q.sub.75                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2470 Q.sub.75                                                                               Me   COOMe     Me OMe      CH                                     2471 Q.sub.75                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2472 Q.sub.75                                                                               Me   COOEt     Me OMe      CH                                     2473 Q.sub.75                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2474 Q.sub.75                                                                               H    H         Me OMe      CH                                     2475 Q.sub.75                                                                               H    H         OMe                                                                               OMe      CH                                     2476 Me      H    Q.sub.75  Me OMe      CH                                     2477 Me      H    Q.sub.75  OMe                                                                               OMe      CH                                     2478 Q.sub.76                                                                               H    COOMe     Me OMe      CH                                     2479 Q.sub.76                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2480 Q.sub.76                                                                               H    COOEt     Me OMe      CH                                     2481 Q.sub.76                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2482 Q.sub.76                                                                               Me   COOMe     Me OMe      CH                                     2483 Q.sub.76                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2484 Q.sub.76                                                                               Me   COOEt     Me OMe      CH                                     2485 Q.sub.76                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2486 Q.sub.76                                                                               H    H         Me OMe      CH                                     2487 Q.sub.76                                                                               H    H         OMe                                                                               OMe      CH                                     2488 Me      H    Q.sub. 76 Me OMe      CH                                     2489 Me      H    Q.sub.76  OMe                                                                               OMe      CH                                     5347 Q.sub.10                                                                               Me   COOMe     Me Me       CH                                     5348 Q.sub.77                                                                               H    COOMe     Me OMe      CH                                     5349 Q.sub.77                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5350 Q.sub.77                                                                               H    COOEt     Me OMe      CH                                     5351 Q.sub.77                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5352 Q.sub.77                                                                               Me   COOMe     Me OMe      CH                                     5353 Q.sub.77                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5354 Q.sub.77                                                                               Me   COOEt     Me OMe      CH                                     5355 Q.sub.77                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5356 Q.sub.77                                                                               H    H         Me OMe      CH                                     5357 Q.sub.77                                                                               H    H         OMe                                                                               OMe      CH                                     5358 Me      H    Q.sub.77  Me OMe      CH                                     5359 Me      H    Q.sub.77  OMe                                                                               OMe      CH                                     5360 Q.sub.78                                                                               H    COOMe     Me Me       CH                                     5361 Q.sub.78                                                                               H    COOMe     Me OMe      CH                                     5362 Q.sub.78                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5363 Q.sub.78                                                                               H    COOMe     Me Me       N                                      5364 Q.sub.78                                                                               H    COOMe     Me OMe      N                                      5365 Q.sub.78                                                                               H    COOMe     OMe                                                                               OMe      N                                      5366 Q.sub.78                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     5367 Q.sub.78                                                                               H    COOMe     Cl OMe      CH                                     5368 Q.sub.78                                                                               H    COOEt     Me Me       CH                                     5369 Q.sub.78                                                                               H    COOEt     Me OMe      CH                                     5370 Q.sub.78                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5371 Q.sub.78                                                                               H    COOEt     Me Me       N                                      5372 Q.sub.78                                                                               H    COOEt     Me OMe      N                                      5373 Q.sub.78                                                                               H    COOEt     OMe                                                                               OMe      N                                      5374 Q.sub.78                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     5375 Q.sub.78                                                                               H    COOEt     Cl OMe      CH                                     5376 Q.sub.78                                                                               H    COOPrn    Me OMe      CH                                     5377 Q.sub.78                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     5378 Q.sub.78                                                                               H    COOPrn    Me OMe      N                                      5379 Q.sub.78                                                                               H    COOPri    Me OMe      CH                                     5380 Q.sub.78                                                                               H    COOPri    OMe                                                                               OMe      CH                                     5381 Q.sub.78                                                                               H    COOPri    Me OMe      N                                      5382 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     5383 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     5384 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      5385 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     5386 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     5387 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      5388 Q.sub.78                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     5389 Q.sub.78                                                                               H    COOCH.sub.2 C CH                                                                         OMe                                                                               OMe      CH                                     5390 Q.sub.78                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      5391 Q.sub.78                                                                               Me   COOMe     Me Me       CH                                     5392 Q.sub.78                                                                               Me   COOMe     Me OMe      CH                                     5393 Q.sub.78                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5394 Q.sub.78                                                                               Me   COOMe     Me OMe      N                                      5395 Q.sub.78                                                                               Me   COOMe     OMe                                                                               OMe      N                                      5396 Q.sub.78                                                                               Me   COOEt     Me Me       CH                                     5397 Q.sub.78                                                                               Me   COOEt     Me OMe      CH                                     5398 Q.sub.78                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5399 Q.sub.78                                                                               Me   COOEt     Me OMe      N                                      5400 Q.sub.78                                                                               Me   COOEt     OMe                                                                               OMe      N                                      5401 Q.sub.78                                                                               Cl   COOMe     Me OMe      CH                                     5402 Q.sub.78                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     5403 Q.sub.78                                                                               Cl   COOMe     Me OMe      N                                      5404 Q.sub.78                                                                               Cl   COOEt     Me OMe      CH                                     5405 Q.sub.78                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     5406 Q.sub.78                                                                               Cl   COOEt     Me OMe      N                                      5407 Q.sub.78                                                                               OMe  COOMe     Me OMe      CH                                     5408 Q.sub.78                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     5409 Q.sub.78                                                                               OMe  COOMe     Me OMe      N                                      5410 Q.sub.78                                                                               OMe  COOEt     Me OMe      CH                                     5411 Q.sub.78                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     5412 Q.sub.78                                                                               OMe  COOEt     Me OMe      N                                      5413 Q.sub.78                                                                               H    Cl        Me OMe      CH                                     5414 Q.sub.78                                                                               H    Cl        OMe                                                                               OMe      CH                                     5415 Q.sub.78                                                                               H    Cl        Me OMe      N                                      5416 Q.sub.78                                                                               H    NO.sub.2  Me OMe      CH                                     5417 Q.sub.78                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     5418 Q.sub.78                                                                               H    NO.sub.2  Me OMe      N                                      5419 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     5420 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     5421 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      5422 Q.sub.78                                                                               H    CN        Me OMe      CH                                     5423 Q.sub.78                                                                               H    CN        OMe                                                                               OMe      CH                                     5424 Q.sub.78                                                                               H    CN        Me OMe      N                                      5425 Q.sub.78                                                                               Me   CN        Me OMe      CH                                     5426 Q.sub.78                                                                               Me   CN        OMe                                                                               OMe      CH                                     5427 Q.sub.78                                                                               Me   CN        Me OMe      N                                      5428 Q.sub.78                                                                               H    Me        Me OMe      CH                                     5429 Q.sub.78                                                                               H    Me        OMe                                                                               OMe      CH                                     5430 Q.sub.78                                                                               H    Me        Me OMe      N                                      5431 Q.sub.78                                                                               H    Et        Me OMe      CH                                     5432 Q.sub.78                                                                               H    Et        OMe                                                                               OMe      CH                                     5433 Q.sub.78                                                                               H    Et        Me OMe      N                                      5434 Q.sub.78                                                                               H    H         Me OMe      CH                                     5435 Q.sub.78                                                                               H    H         OMe                                                                               OMe      CH                                     5436 Q.sub.78                                                                               H    H         Me OMe      N                                      5437 Q.sub.78                                                                               H    COPh      Me OMe      CH                                     5438 Q.sub.78                                                                               H    COPh      OMe                                                                               OMe      CH                                     5439 Q.sub.78                                                                               H    COPh      Me OMe      N                                      5440 Me      Q.sub.78                                                                            COOMe     Me OMe      CH                                     5441 Me      Q.sub.78                                                                            COOMe     OMe                                                                               OMe      CH                                     5442 Me      Q.sub.78                                                                            COOMe     Me OMe      N                                      5443 H       H    Q.sub.78  Me OMe      CH                                     5444 H       H    Q.sub.78  OMe                                                                               OMe      CH                                     5445 H       H    Q.sub.78  Me OMe      N                                      5446 Me      H    Q.sub.78  Me Me       CH                                     5447 Me      H    Q.sub.78  Me OMe      CH                                     5448 Me      H    Q.sub.78  OMe                                                                               OMe      CH                                     5449 Me      H    Q.sub.78  Me OMe      N                                      5450 Me      H    Q.sub.78  OMe                                                                               OMe      N                                      5451 Me      Me   Q.sub.78  Me OMe      CH                                     5452 Me      Me   Q.sub.78  OMe                                                                               OMe      CH                                     5453 Me      Me   Q.sub.78  Me OMe      N                                      5454 Q.sub.79                                                                               H    COOMe     Me Me       CH                                     5455 Q.sub.79                                                                               H    COOMe     Me OMe      CH                                     5456 Q.sub.79                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5457 Q.sub.79                                                                               H    COOMe     Me Me       N                                      5458 Q.sub.79                                                                               H    COOMe     Me OMe      N                                      5459 Q.sub.79                                                                               H    COOMe     OMe                                                                               OMe      N                                      5460 Q.sub.79                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     5461 Q.sub.79                                                                               H    COOMe     Cl OMe      CH                                     5462 Q.sub.79                                                                               H    COOEt     Me Me       CH                                     5463 Q.sub.79                                                                               H    COOEt     Me OMe      CH                                     5464 Q.sub.79                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5465 Q.sub.79                                                                               H    COOEt     Me Me       N                                      5466 Q.sub.79                                                                               H    COOEt     Me OMe      N                                      5467 Q.sub.79                                                                               H    COOEt     OMe                                                                               OMe      N                                      5468 Q.sub.79                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     5469 Q.sub.79                                                                               H    COOEt     Cl OMe      CH                                     5470 Q.sub.79                                                                               H    COOPrn    Me OMe      CH                                     5471 Q.sub.79                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     5472 Q.sub.79                                                                               H    COOPrn    Me OMe      N                                      5473 Q.sub.79                                                                               H    COOPri    Me OMe      CH                                     5474 Q.sub.79                                                                               H    COOPri    OMe                                                                               OMe      CH                                     5475 Q.sub.79                                                                               H    COOPri    Me OMe      N                                      5476 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     5477 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     5478 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      5479 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     5480 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     5481 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub. 2                                                                  Me OMe      N                                      5482 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     5483 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     5484 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      5485 Q.sub.79                                                                               Me   COOMe     Me Me       CH                                     5486 Q.sub.79                                                                               Me   COOMe     Me OMe      CH                                     5487 Q.sub.79                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5488 Q.sub.79                                                                               Me   COOMe     Me OMe      N                                      5489 Q.sub.79                                                                               Me   COOMe     OMe                                                                               OMe      N                                      5490 Q.sub.79                                                                               Me   COOEt     Me Me       CH                                     5491 Q.sub.79                                                                               Me   COOEt     Me OMe      CH                                     5492 Q.sub.79                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5493 Q.sub.79                                                                               Me   COOEt     Me OMe      N                                      5494 Q.sub.79                                                                               Me   COOEt     OMe                                                                               OMe      N                                      5495 Q.sub.79                                                                               Cl   COOMe     Me OMe      CH                                     5496 Q.sub.79                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     5497 Q.sub.79                                                                               Cl   COOMe     Me OMe      N                                      5498 Q.sub.79                                                                               Cl   COOEt     Me OMe      CH                                     5499 Q.sub.79                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     5500 Q.sub.79                                                                               Cl   COOEt     Me OMe      N                                      5501 Q.sub.79                                                                               OMe  COOMe     Me OMe      CH                                     5502 Q.sub.79                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     5503 Q.sub.79                                                                               OMe  COOMe     Me OMe      N                                      5504 Q.sub.79                                                                               OMe  COOEt     Me OMe      CH                                     5505 Q.sub.79                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     5506 Q.sub.79                                                                               OMe  COOEt     Me OMe      N                                      5507 Q.sub.79                                                                               H    Cl        Me OMe      CH                                     5508 Q.sub.79                                                                               H    Cl        OMe                                                                               OMe      CH                                     5509 Q.sub.79                                                                               H    Cl        Me OMe      N                                      5510 Q.sub.79                                                                               H    NO.sub.2  Me OMe      CH                                     5511 Q.sub.79                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     5512 Q.sub.79                                                                               H    NO.sub.2  Me OMe      N                                      5513 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     5514 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     5515 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      5516 Q.sub.79                                                                               H    CN        Me OMe      CH                                     5517 Q.sub.79                                                                               H    CN        OMe                                                                               OMe      CH                                     5518 Q.sub.79                                                                               H    CN        Me OMe      N                                      5519 Q.sub.79                                                                               Me   CN        Me OMe      CH                                     5520 Q.sub.79                                                                               Me   CN        OMe                                                                               OMe      CH                                     5521 Q.sub.79                                                                               Me   CN        Me OMe      N                                      5522 Q.sub.79                                                                               H    Me        Me OMe      CH                                     5523 Q.sub.79                                                                               H    Me        OMe                                                                               OMe      CH                                     5524 Q.sub.79                                                                               H    Me        Me OMe      N                                      5525 Q.sub.79                                                                               H    Et        Me OMe      CH                                     5526 Q.sub.79                                                                               H    Et        OMe                                                                               OMe      CH                                     5527 Q.sub.79                                                                               H    Et        Me OMe      N                                      5528 Q.sub.79                                                                               H    H         Me OMe      CH                                     5529 Q.sub.79                                                                               H    H         OMe                                                                               OMe      CH                                     5530 Q.sub.79                                                                               H    H         Me OMe      N                                      5531 Q.sub.79                                                                               H    COPh      Me OMe      CH                                     5532 Q.sub.79                                                                               H    COPh      OMe                                                                               OMe      CH                                     5533 Q.sub.79                                                                               H    COPh      Me OMe      N                                      5534 Me      Q.sub.79                                                                            COOMe     Me OMe      CH                                     5535 Me      Q.sub.79                                                                            COOMe     OMe                                                                               OMe      CH                                     5536 Me      Q.sub.79                                                                            COOMe     Me OMe      N                                      5537 H       H    Q.sub.79  Me OMe      CH                                     5538 H       H    Q.sub.79  OMe                                                                               OMe      CH                                     5539 H       H    Q.sub.79  Me OMe      N                                      5540 Me      H    Q.sub.79  Me Me       CH                                     5541 Me      H    Q.sub.79  Me OMe      CH                                     5542 Me      H    Q.sub.79  OMe                                                                               OMe      CH                                     5543 Me      H    Q.sub.79  Me OMe      N                                      5544 Me      H    Q.sub.79  OMe                                                                               OMe      N                                      5545 Me      Me   Q.sub.79  Me OMe      CH                                     5546 Me      Me   Q.sub.79  OMe                                                                               OMe      CH                                     5547 Me      Me   Q.sub.79  Me OMe      N                                      5548 Q.sub.80                                                                               H    COOMe     Me Me       CH                                     5549 Q.sub.80                                                                               H    COOMe     Me OMe      CH                                     5550 Q.sub.80                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5551 Q.sub.80                                                                               H    COOMe     Me OMe      N                                      5552 Q.sub.80                                                                               H    COOMe     OMe                                                                               OMe      N                                      5553 Q.sub.80                                                                               H    COOEt     Me Me       CH                                     5554 Q.sub.80                                                                               H    COOEt     Me OMe      CH                                     5555 Q.sub.80                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5556 Q.sub.80                                                                               H    COOEt     Me OMe      N                                      5557 Q.sub.80                                                                               H    COOEt     OMe                                                                               OMe      N                                      5558 Q.sub.80                                                                               Me   COOMe     Me OMe      CH                                     5559 Q.sub.80                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5560 Q.sub.80                                                                               Me   COOMe     Me OMe      N                                      5561 Q.sub.80                                                                               Me   COOEt     Me OMe      CH                                     5562 Q.sub.80                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5563 Q.sub.80                                                                               Me   COOEt     Me OMe      N                                      5564 Q.sub.80                                                                               H    CN        Me OMe      CH                                     5565 Q.sub.80                                                                               H    CN        OMe                                                                               OMe      CH                                     5566 Q.sub.80                                                                               H    CN        Me OMe      N                                      5567 Q.sub.80                                                                               H    H         Me OMe      CH                                     5568 Q.sub.80                                                                               H    H         OMe                                                                               OMe      CH                                     5569 Q.sub.80                                                                               H    H         Me OMe      N                                      5570 Me      H    Q.sub.80  Me Me       CH                                     5571 Me      H    Q.sub.80  Me OMe      CH                                     5572 Me      H    Q.sub.80  OMe                                                                               OMe      CH                                     5573 Me      H    Q.sub.80  Me OMe      N                                      5574 Me      H    Q.sub.80  OMe                                                                               OMe      N                                      5575 Q.sub.81                                                                               H    COOMe     Me OMe      CH                                     5576 Q.sub.81                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5577 Q.sub.81                                                                               H    COOEt     Me OMe      CH                                     5578 Q.sub.81                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5579 Q.sub.81                                                                               Me   COOMe     Me OMe      CH                                     5580 Q.sub.81                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5581 Q.sub.81                                                                               Me   COOEt     Me OMe      CH                                     5582 Q.sub.81                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5583 Q.sub.81                                                                               H    H         Me OMe      CH                                     5584 Q.sub.81                                                                               H    H         OMe                                                                               OMe      CH                                     5585 Me      H    Q.sub.81  Me OMe      CH                                     5586 Me      H    Q.sub.81  OMe                                                                               OMe      CH                                     5587 Q.sub.82                                                                               H    COOMe     Me OMe      CH                                     5588 Q.sub.82                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5589 Q.sub.82                                                                               H    COOEt     Me OMe      CH                                     5590 Q.sub.82                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5591 Q.sub.82                                                                               Me   COOMe     Me OMe      CH                                     5592 Q.sub.82                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5593 Q.sub.82                                                                               Me   COOEt     Me OMe      CH                                     5594 Q.sub.82                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5595 Q.sub.82                                                                               H    H         Me OMe      CH                                     5596 Q.sub.82                                                                               H    H         OMe                                                                               OMe      CH                                     5597 Me      H    Q.sub.82  Me OMe      CH                                     5598 Me      H    Q.sub.82  OMe                                                                               OMe      CH                                     5599 Q.sub.83                                                                               H    COOMe     Me OMe      CH                                     5600 Q.sub.83                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5601 Q.sub.83                                                                               H    COOEt     Me OMe      CH                                     5602 Q.sub.83                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5603 Q.sub.83                                                                               Me   COOMe     Me OMe      CH                                     5604 Q.sub.83                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5605 Q.sub.83                                                                               Me   COOEt     Me OMe      CH                                     5606 Q.sub.83                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5607 Q.sub.83                                                                               H    H         Me OMe      CH                                     5608 Q.sub.83                                                                               H    H         OMe                                                                               OMe      CH                                     5609 Me      H    Q.sub.83  Me OMe      CH                                     5610 Me      H    Q.sub.83  OMe                                                                               OMe      CH                                     __________________________________________________________________________

    __________________________________________________________________________     1776 Q.sub.45                                                                               Cl   COOEt     Me OMe      CH                                     1777 Q.sub.45                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     1778 Q.sub.45                                                                               Cl   COOEt     Me OMe      N                                      1779 Q.sub.45                                                                               OMe  COOMe     Me OMe      CH                                     1780 Q.sub.45                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     1781 Q.sub.45                                                                               OMe  COOMe     Me OMe      N                                      1782 Q.sub.45                                                                               OMe  COOEt     Me OMe      CH                                     1783 Q.sub.45                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     1784 Q.sub.45                                                                               OMe  COOEt     Me OMe      N                                      1785 Q.sub.45                                                                               H    Cl        Me OMe      CH                                     1786 Q.sub.45                                                                               H    Cl        OMe                                                                               OMe      CH                                     1787 Q.sub.45                                                                               H    Cl        Me OMe      N                                      1788 Q.sub.45                                                                               H    NO.sub.2  Me OMe      CH                                     1789 Q.sub.45                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     1790 Q.sub.45                                                                               H    NO.sub.2  Me OMe      N                                      1791 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     1792 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     1793 Q.sub.45                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      1794 Q.sub.45                                                                               H    CN        Me OMe      CH                                     1795 Q.sub.45                                                                               H    CN        OMe                                                                               OMe      CH                                     1796 Q.sub.45                                                                               H    CN        Me OMe      N                                      1797 Q.sub.45                                                                               Me   CN        Me OMe      CH                                     1798 Q.sub.45                                                                               Me   CN        OMe                                                                               OMe      CH                                     1799 Q.sub.45                                                                               Me   CN        Me OMe      N                                      1800 Q.sub.45                                                                               H    Me        Me OMe      CH                                     1801 Q.sub.45                                                                               H    Me        OMe                                                                               OMe      CH                                     1802 Q.sub.45                                                                               H    Me        Me OMe      N                                      1803 Q.sub.45                                                                               H    Et        Me OMe      CH                                     1804 Q.sub.45                                                                               H    Et        OMe                                                                               OMe      CH                                     1805 Q.sub.45                                                                               H    Et        Me OMe      N                                      1806 Q.sub.45                                                                               H    H         Me OMe      CH                                     1807 Q.sub.45                                                                               H    H         OMe                                                                               OMe      CH                                     1808 Q.sub.45                                                                               H    H         Me OMe      N                                      1809 Q.sub.45                                                                               H    COPh      Me OMe      CH                                     1810 Q.sub.45                                                                               H    COPh      OMe                                                                               OMe      CH                                     1811 Q.sub.45                                                                               H    COPh      Me OMe      N                                      1812 Me      Q.sub.45                                                                            COOMe     Me OMe      CH                                     1813 Me      Q.sub.45                                                                            COOMe     OMe                                                                               OMe      CH                                     1814 Me      Q.sub.45                                                                            COOMe     Me OMe      N                                      1815 H       H    Q.sub.45  Me OMe      CH                                     1816 H       H    Q.sub.45  OMe                                                                               OMe      CH                                     1817 H       H    Q.sub.45  Me OMe      N                                      1818 Me      H    Q.sub.45  Me Me       CH                                     1819 Me      H    Q.sub.45  Me OMe      CH                                     1820 Me      H    Q.sub.45  OMe                                                                               OMe      CH                                     1821 Me      H    Q.sub.45  Me OMe      N                                      1822 Me      H    Q.sub.45  OMe                                                                               OMe      N                                      1823 Me      Me   Q.sub.45  Me OMe      CH                                     1824 Me      Me   Q.sub.45  OMe                                                                               OMe      CH                                     1825 Me      Me   Q.sub.45  Me OMe      N                                      1826 Q.sub.46                                                                               H    COOMe     Me Me       CH                                     1827 Q.sub.46                                                                               H    COOMe     Me OMe      CH                                     1828 Q.sub.46                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1829 Q.sub.46                                                                               H    COOMe     Me OMe      N                                      1830 Q.sub.46                                                                               H    COOMe     OMe                                                                               OMe      N                                      1831 Q.sub.46                                                                               H    COOEt     Me Me       CH                                     1832 Q.sub.46                                                                               H    COOEt     Me OMe      CH                                     1833 Q.sub.46                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1834 Q.sub.46                                                                               H    COOEt     Me OMe      N                                      1835 Q.sub.46                                                                               H    COOEt     OMe                                                                               OMe      N                                      1836 Q.sub.46                                                                               Me   COOMe     Me OMe      CH                                     1837 Q.sub.46                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1838 Q.sub.46                                                                               Me   COOMe     Me OMe      N                                      1839 Q.sub.46                                                                               Me   COOEt     Me OMe      CH                                     1840 Q.sub.46                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1841 Q.sub.46                                                                               Me   COOEt     Me OMe      N                                      1842 Q.sub.46                                                                               H    CN        Me OMe      CH                                     1843 Q.sub.46                                                                               H    CN        OMe                                                                               OMe      CH                                     1844 Q.sub.46                                                                               H    CN        Me OMe      N                                      1845 Q.sub.46                                                                               H    H         Me OMe      CH                                     1846 Q.sub.46                                                                               H    H         OMe                                                                               OMe      CH                                     1847 Q.sub.46                                                                               H    H         Me OMe      N                                      1848 Me      H    Q.sub.46  Me Me       CH                                     1849 Me      H    Q.sub.46  Me OMe      CH                                     1850 Me      H    Q.sub.46  OMe                                                                               OMe      CH                                     1851 Me      H    Q.sub.46  Me OMe      N                                      1852 Me      H    Q.sub.46  OMe                                                                               OMe      N                                      1853 Q.sub.47                                                                               H    COOMe     Me Me       CH                                     1854 Q.sub.47                                                                               H    COOMe     Me OMe      CH                                     1855 Q.sub.47                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1856 Q.sub.47                                                                               H    COOMe     Me OMe      N                                      1857 Q.sub.47                                                                               H    COOMe     OMe                                                                               OMe      N                                      1858 Q.sub.47                                                                               H    COOEt     Me Me       CH                                     1859 Q.sub.47                                                                               H    COOEt     Me OMe      CH                                     1860 Q.sub.47                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1861 Q.sub.47                                                                               H    COOEt     Me OMe      N                                      1862 Q.sub.47                                                                               H    COOEt     OMe                                                                               OMe      N                                      1863 Q.sub.47                                                                               Me   COOMe     Me OMe      CH                                     1864 Q.sub.47                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1865 Q.sub.47                                                                               Me   COOMe     Me OMe      N                                      1866 Q.sub.47                                                                               Me   COOEt     Me OMe      CH                                     1867 Q.sub.47                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1868 Q.sub.47                                                                               Me   COOEt     Me OMe      N                                      1869 Q.sub.47                                                                               H    CN        Me OMe      CH                                     1870 Q.sub.47                                                                               H    CN        OMe                                                                               OMe      CH                                     1871 Q.sub.47                                                                               H    CN        Me OMe      N                                      1872 Q.sub.47                                                                               H    H         Me OMe      CH                                     1873 Q.sub.47                                                                               H    H         OMe                                                                               OMe      CH                                     1874 Q.sub.47                                                                               H    H         Me OMe      N                                      1875 Me      H    Q.sub.47  Me Me       CH                                     1876 Me      H    Q.sub.47  Me OMe      CH                                     1877 Me      H    Q.sub.47  OMe                                                                               OMe      CH                                     1878 Me      H    Q.sub.47  Me OMe      N                                      1879 Me      H    Q.sub.47  OMe                                                                               OMe      N                                      1880 Q.sub.48                                                                               H    COOMe     Me Me       CH                                     1881 Q.sub.48                                                                               H    COOMe     Me OMe      CH                                     1882 Q.sub.48                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1883 Q.sub.48                                                                               H    COOMe     Me OMe      N                                      1884 Q.sub.48                                                                               H    COOMe     OMe                                                                               OMe      N                                      1885 Q.sub.48                                                                               H    COOEt     Me Me       CH                                     1886 Q.sub.48                                                                               H    COOEt     Me OMe      CH                                     1887 Q.sub.48                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1888 Q.sub.48                                                                               H    COOEt     Me OMe      N                                      1889 Q.sub.48                                                                               H    COOEt     OMe                                                                               OMe      N                                      1890 Q.sub.48                                                                               Me   COOMe     Me OMe      CH                                     1891 Q.sub.48                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1892 Q.sub.48                                                                               Me   COOMe     Me OMe      N                                      1893 Q.sub.48                                                                               Me   COOEt     Me OMe      CH                                     1894 Q.sub.48                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1895 Q.sub.48                                                                               Me   COOEt     Me OMe      N                                      1896 Q.sub.48                                                                               H    CN        Me OMe      CH                                     1897 Q.sub.48                                                                               H    CN        OMe                                                                               OMe      CH                                     1898 Q.sub.48                                                                               H    CN        Me OMe      N                                      1899 Q.sub.48                                                                               H    H         Me OMe      CH                                     1900 Q.sub.48                                                                               H    H         OMe                                                                               OMe      CH                                     1901 Q.sub.48                                                                               H    H         Me OMe      N                                      1902 Me      H    Q.sub.48  Me Me       CH                                     1903 Me      H    Q.sub.48  Me OMe      CH                                     1904 Me      H    Q.sub.48  OMe                                                                               OMe      CH                                     1905 Me      H    Q.sub.48  Me OMe      N                                      1906 Me      H    Q.sub.48  OMe                                                                               OMe      N                                      1907 Q.sub.49                                                                               H    COOMe     Me Me       CH                                     1908 Q.sub.49                                                                               H    COOMe     Me OMe      CH                                     1909 Q.sub.49                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1910 Q.sub.49                                                                               H    COOMe     Me OMe      N                                      1911 Q.sub.49                                                                               H    COOMe     OMe                                                                               OMe      N                                      1912 Q.sub.49                                                                               H    COOEt     Me Me       CH                                     1913 Q.sub.49                                                                               H    COOEt     Me OMe      CH                                     1914 Q49     H    COOEt     OMe                                                                               OMe      CH                                     1915 Q.sub.49                                                                               H    COOEt     Me OMe      N                                      1916 Q.sub.49                                                                               H    COOEt     OMe                                                                               OMe      N                                      1917 Q.sub.49                                                                               Me   COOMe     Me OMe      CH                                     1918 Q.sub.49                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1919 Q.sub.49                                                                               Me   COOMe     Me OMe      N                                      1920 Q.sub.49                                                                               Me   COOEt     Me OMe      CH                                     1921 Q.sub.49                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1922 Q.sub.49                                                                               Me   COOEt     Me OMe      N                                      1923 Q.sub.49                                                                               H    CN        Me OMe      CH                                     1924 Q.sub.49                                                                               H    CN        OMe                                                                               OMe      CH                                     1925 Q.sub.49                                                                               H    CN        Me OMe      N                                      1926 Q.sub.49                                                                               H    H         Me OMe      CH                                     1927 Q.sub.49                                                                               H    H         OMe                                                                               OMe      CH                                     1928 Q.sub.49                                                                               H    H         Me OMe      N                                      1929 Me      H    Q.sub.49  Me Me       CH                                     1930 Me      H    Q.sub.49  Me OMe      CH                                     1931 Me      H    Q.sub.49  OMe                                                                               OMe      CH                                     1932 Me      H    Q.sub.49  Me OMe      N                                      1933 Me      H    Q.sub.49  OMe                                                                               OMe      N                                      1934 Q.sub.50                                                                               H    COOMe     Me Me       CH                                     1935 Q.sub.50                                                                               H    COOMe     Me OMe      CH                                     1936 Q.sub.50                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1937 Q.sub.50                                                                               H    COOMe     Me OMe      N                                      1938 Q.sub.50                                                                               H    COOMe     OMe                                                                               OMe      N                                      1939 Q.sub.50                                                                               H    COOEt     Me Me       CH                                     1940 Q.sub.50                                                                               H    COOEt     Me OMe      CH                                     1941 Q.sub.50                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1942 Q.sub.50                                                                               H    COOEt     Me OMe      N                                      1943 Q.sub.50                                                                               H    COOEt     OMe                                                                               OMe      N                                      1944 Q.sub.50                                                                               Me   COOMe     Me OMe      CH                                     1945 Q.sub.50                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1946 Q.sub.50                                                                               Me   COOMe     Me OMe      N                                      1947 Q.sub.50                                                                               Me   COOEt     Me OMe      CH                                     1948 Q.sub.50                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1949 Q.sub.50                                                                               Me   COOEt     Me OMe      N                                      1950 Q.sub.50                                                                               H    CN        Me OMe      CH                                     1951 Q.sub.50                                                                               H    CN        OMe                                                                               OMe      CH                                     1952 Q.sub.50                                                                               H    CN        Me OMe      N                                      1953 Q.sub.50                                                                               H    H         Me OMe      CH                                     1954 Q.sub.50                                                                               H    H         OMe                                                                               OMe      CH                                     1955 Q.sub.50                                                                               H    H         Me OMe      N                                      1956 Me      H    Q.sub.50  Me Me       CH                                     1957 Me      H    Q.sub.50  Me OMe      CH                                     1958 Me      H    Q.sub.50  OMe                                                                               OMe      CH                                     1959 Me      H    Q.sub.50  Me OMe      N                                      1960 Me      H    Q.sub.50  OMe                                                                               OMe      N                                      1961 Q.sub.51                                                                               H    COOMe     Me Me       CH                                     1962 Q.sub.51                                                                               H    COOMe     Me OMe      CH                                     1963 Q.sub.51                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1964 Q.sub.51                                                                               H    COOMe     Me OMe      N                                      1965 Q.sub.51                                                                               H    COOMe     OMe                                                                               OMe      N                                      1966 Q.sub.51                                                                               H    COOEt     Me Me       CH                                     1967 Q.sub.51                                                                               H    COOEt     Me OMe      CH                                     1968 Q.sub.51                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1969 Q.sub.51                                                                               H    COOEt     Me OMe      N                                      1970 Q.sub.51                                                                               H    COOEt     OMe                                                                               OMe      N                                      1971 Q.sub.51                                                                               Me   COOMe     Me OMe      CH                                     1972 Q.sub.51                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1973 Q.sub.51                                                                               Me   COOMe     Me OMe      N                                      1974 Q.sub.51                                                                               Me   COOEt     Me OMe      CH                                     1975 Q.sub.51                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1976 Q.sub.51                                                                               Me   COOEt     Me OMe      N                                      1977 Q.sub.51                                                                               H    CN        Me OMe      CH                                     1978 Q.sub.51                                                                               H    CN        OMe                                                                               OMe      CH                                     1979 Q.sub.51                                                                               H    CN        Me OMe      N                                      1980 Q.sub.51                                                                               H    H         Me OMe      CH                                     1981 Q.sub.51                                                                               H    H         OMe                                                                               OMe      CH                                     1982 Q.sub.51                                                                               H    H         Me OMe      N                                      1983 Me      H    Q.sub.51  Me Me       CH                                     1984 Me      H    Q.sub.51  Me OMe      CH                                     1985 Me      H    Q.sub.51  OMe                                                                               OMe      CH                                     1986 Me      H    Q.sub.51  Me OMe      N                                      1987 Me      H    Q.sub.51  OMe                                                                               OMe      N                                      1988 Q.sub.52                                                                               H    COOMe     Me OMe      CH                                     1989 Q.sub.52                                                                               H    COOMe     OMe                                                                               OMe      CH                                     1990 Q.sub.52                                                                               H    COOEt     Me OMe      CH                                     1991 Q.sub.52                                                                               H    COOEt     OMe                                                                               OMe      CH                                     1992 Q.sub.52                                                                               Me   COOMe     Me OMe      CH                                     1993 Q.sub.52                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     1994 Q.sub.52                                                                               Me   COOEt     Me OMe      CH                                     1995 Q.sub.52                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     1996 Q.sub.52                                                                               H    H         Me OMe      CH                                     1997 Q.sub.52                                                                               H    H         OMe                                                                               OMe      CH                                     1998 Me      H    Q.sub. 52 Me OMe      CH                                     1999 Me      H    Q.sub.52  OMe                                                                               OMe      CH                                     2000 Q.sub.53                                                                               H    COOMe     Me OMe      CH                                     2001 Q.sub.53                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2002 Q.sub.53                                                                               H    COOEt     Me OMe      CH                                     2003 Q.sub.53                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2004 Q.sub.53                                                                               Me   COOMe     Me OMe      CH                                     2005 Q.sub.53                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2006 Q.sub.53                                                                               Me   COOEt     Me OMe      CH                                     2007 Q.sub.53                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2008 Q.sub.53                                                                               H    H         Me OMe      CH                                     2009 Q.sub.53                                                                               H    H         OMe                                                                               OMe      CH                                     2010 Me      H    Q.sub.53  Me OMe      CH                                     2011 Me      H    Q.sub.53  OMe                                                                               OMe      CH                                     2012 Q.sub.54                                                                               H    COOMe     Me Me       CH                                     2013 Q.sub.54                                                                               H    COOMe     Me OMe      CH                                     2014 Q.sub.54                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2015 Q.sub.54                                                                               H    COOMe     Me OMe      N                                      2016 Q.sub.54                                                                               H    COOMe     OMe                                                                               OMe      N                                      2017 Q.sub.54                                                                               H    COOEt     Me Me       CH                                     2018 Q.sub.54                                                                               H    COOEt     Me OMe      CH                                     2019 Q.sub.54                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2020 Q.sub.54                                                                               H    COOEt     Me OMe      N                                      2021 Q.sub.54                                                                               H    COOEt     OMe                                                                               OMe      N                                      2022 Q.sub.54                                                                               Me   COOMe     Me OMe      CH                                     2023 Q.sub.54                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2024 Q.sub.54                                                                               Me   COOMe     Me OMe      N                                      2025 Q.sub.54                                                                               Me   COOEt     Me OMe      CH                                     2026 Q.sub.54                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2027 Q.sub.54                                                                               Me   COOEt     Me OMe      N                                      2028 Q.sub.54                                                                               H    CN        Me OMe      CH                                     2029 Q.sub.54                                                                               H    CN        OMe                                                                               OMe      CH                                     2030 Q.sub.54                                                                               H    CN        Me OMe      N                                      2031 Q.sub.54                                                                               H    H         Me OMe      CH                                     2032 Q.sub.54                                                                               H    H         OMe                                                                               OMe      CH                                     2033 Q.sub.54                                                                               H    H         Me OMe      N                                      2034 Me      H    Q.sub.54  Me Me       CH                                     2035 Me      H    Q.sub.54  Me OMe      CH                                     2036 Me      H    Q.sub.54  OMe                                                                               OMe      CH                                     2037 Me      H    Q.sub.54  Me OMe      N                                      2038 Me      H    Q.sub.54  OMe                                                                               OMe      N                                      2039 Q.sub.55                                                                               H    COOMe     Me Me       CH                                     2040 Q.sub.55                                                                               H    COOMe     Me OMe      CH                                     2041 Q.sub.55                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2042 Q.sub.55                                                                               H    COOMe     Me OMe      N                                      2043 Q.sub.55                                                                               H    COOMe     OMe                                                                               OMe      N                                      2044 Q.sub.55                                                                               H    COOEt     Me Me       CH                                     2045 Q.sub.55                                                                               H    COOEt     Me OMe      CH                                     2046 Q.sub.55                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2047 Q.sub.55                                                                               H    COOEt     Me OMe      N                                      2048 Q.sub.55                                                                               H    COOEt     OMe                                                                               OMe      N                                      2049 Q.sub.55                                                                               Me   COOMe     Me OMe      CH                                     2050 Q.sub.55                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2051 Q.sub.55                                                                               Me   COOMe     Me OMe      N                                      2052 Q.sub.55                                                                               Me   COOEt     Me OMe      CH                                     2053 Q.sub.55                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2054 Q.sub.55                                                                               Me   COOEt     Me OMe      N                                      2055 Q.sub.55                                                                               H    CN        Me OMe      CH                                     2056 Q.sub.55                                                                               H    CN        OMe                                                                               OMe      CH                                     2057 Q.sub.55                                                                               H    CN        Me OMe      N                                      2058 Q.sub.55                                                                               H    H         Me OMe      CH                                     2059 Q.sub.55                                                                               H    H         OMe                                                                               OMe      CH                                     2060 Q.sub.55                                                                               H    H         Me OMe      N                                      2061 Me      H    Q.sub.55  Me Me       CH                                     2062 Me      H    Q.sub.55  Me OMe      CH                                     2063 Me      H    Q.sub.55  OMe                                                                               OMe      CH                                     2064 Me      H    Q.sub.55  Me OMe      N                                      2065 Me      H    Q.sub.55  OMe                                                                               OMe      N                                      2066 Q.sub.56                                                                               H    COOMe     Me Me       CH                                     2067 Q.sub.56                                                                               H    COOMe     Me OMe      CH                                     2068 Q.sub.56                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2069 Q.sub.56                                                                               H    COOMe     Me OMe      N                                      2070 Q.sub.56                                                                               H    COOMe     OMe                                                                               OMe      N                                      2071 Q.sub.56                                                                               H    COOEt     Me Me       CH                                     2072 Q.sub.56                                                                               H    COOEt     Me OMe      CH                                     2073 Q.sub.56                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2074 Q.sub.56                                                                               H    COOEt     Me OMe      N                                      2075 Q.sub.56                                                                               H    COOEt     OMe                                                                               OMe      N                                      2076 Q.sub.56                                                                               Me   COOMe     Me OMe      CH                                     2077 Q.sub.56                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2078 Q.sub.56                                                                               Me   COOMe     Me OMe      N                                      2079 Q.sub.56                                                                               Me   COOEt     Me OMe      CH                                     2080 Q.sub.56                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2081 Q.sub.56                                                                               Me   COOEt     Me OMe      N                                      2082 Q.sub.56                                                                               H    CN        Me OMe      CH                                     2083 Q.sub.56                                                                               H    CN        OMe                                                                               OMe      CH                                     2084 Q.sub.56                                                                               H    CN        Me OMe      N                                      2085 Q.sub.56                                                                               H    H         Me OMe      CH                                     2086 Q.sub.56                                                                               H    H         OMe                                                                               OMe      CH                                     2087 Q.sub.56                                                                               H    H         Me OMe      N                                      2088 Me      H    Q.sub.56  Me Me       CH                                     2089 Me      H    Q.sub.56  Me OMe      CH                                     2090 Me      H    Q.sub.56  OMe                                                                               OMe      CH                                     2091 Me      H    Q.sub.56  Me OMe      N                                      2092 Me      H    Q.sub.56  OMe                                                                               OMe      N                                      2093 Q.sub.57                                                                               H    COOMe     Me OMe      CH                                     2094 Q.sub.57                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2095 Q.sub.57                                                                               H    COOEt     Me OMe      CH                                     2096 Q.sub.57                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2097 Q.sub.57                                                                               Me   COOMe     Me OMe      CH                                     2098 Q.sub.57                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2099 Q.sub.57                                                                               Me   COOEt     Me OMe      CH                                     2100 Q.sub.57                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2101 Q.sub.57                                                                               H    H         Me OMe      CH                                     2102 Q.sub.57                                                                               H    H         OMe                                                                               OMe      CH                                     2103 Me      H    Q.sub.57  Me OMe      CH                                     2104 Me      H    Q.sub.57  OMe                                                                               OMe      CH                                     2105 Q.sub.58                                                                               H    COOMe     Me OMe      CH                                     2106 Q.sub.58                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2107 Q.sub.58                                                                               H    COOEt     Me OMe      CH                                     2108 Q.sub.58                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2109 Q.sub.58                                                                               Me   COOMe     Me OMe      CH                                     2110 Q.sub.58                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2111 Q.sub.58                                                                               Me   COOEt     Me OMe      CH                                     2112 Q.sub.58                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2113 Q.sub.58                                                                               H    H         Me OMe      CH                                     2114 Q.sub.58                                                                               H    H         OMe                                                                               OMe      CH                                     2115 Me      H    Q.sub.58  Me OMe      CH                                     2116 Me      H    Q.sub.58  OMe                                                                               OMe      CH                                     2117 Q.sub.59                                                                               H    COOMe     Me Me       CH                                     2118 Q.sub.59                                                                               H    COOMe     Me OMe      CH                                     2119 Q.sub.59                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2120 Q.sub.59                                                                               H    COOMe     Me Me       N                                      2121 Q.sub.59                                                                               H    COOMe     Me OMe      N                                      2122 Q.sub.59                                                                               H    COOMe     OMe                                                                               OMe      N                                      2123 Q.sub.59                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     2124 Q.sub.59                                                                               H    COOMe     Cl OMe      CH                                     2125 Q.sub.59                                                                               H    COOEt     Me Me       CH                                     2126 Q.sub.59                                                                               H    COOEt     Me OMe      CH                                     2127 Q.sub.59                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2128 Q.sub.59                                                                               H    COOEt     Me Me       N                                      2129 Q.sub.59                                                                               H    COOEt     Me OMe      N                                      2130 Q.sub.59                                                                               H    COOEt     OMe                                                                               OMe      N                                      2131 Q.sub.59                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     2132 Q.sub.59                                                                               H    COOEt     Cl OMe      CH                                     2133 Q.sub.59                                                                               H    COOPrn    Me OMe      CH                                     2134 Q.sub.59                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     2135 Q.sub.59                                                                               H    COOPrn    Me OMe      N                                      2136 Q.sub.59                                                                               H    COOPri    Me OMe      CH                                     2137 Q.sub.59                                                                               H    COOPri    OMe                                                                               OMe      CH                                     2138 Q.sub.59                                                                               H    COOPri    Me OMe      N                                      2139 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     2140 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     2141 Q.sub.59                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      2142 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     2143 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     2144 Q.sub.59                                                                               H    COOCH.sub.2 CHCH.sub. 2                                                                  Me OMe      N                                      2145 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     2146 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     2147 Q.sub.59                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      2148 Q.sub.59                                                                               Me   COOMe     Me Me       CH                                     2149 Q.sub.59                                                                               Me   COOMe     Me OMe      CH                                     2150 Q.sub.59                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2151 Q.sub.59                                                                               Me   COOMe     Me OMe      N                                      2152 Q.sub.59                                                                               Me   COOMe     OMe                                                                               OMe      N                                      2153 Q.sub.59                                                                               Me   COOEt     Me Me       CH                                     2154 Q.sub.59                                                                               Me   COOEt     Me OMe      CH                                     2155 Q.sub.59                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2156 Q.sub.59                                                                               Me   COOEt     Me OMe      N                                      2157 Q.sub.59                                                                               Me   COOEt     OMe                                                                               OMe      N                                      2158 Q.sub.59                                                                               Cl   COOMe     Me OMe      CH                                     2159 Q.sub.59                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     2160 Q.sub.59                                                                               Cl   COOMe     Me OMe      N                                      2161 Q.sub.59                                                                               Cl   COOEt     Me OMe      CH                                     2162 Q.sub.59                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     2163 Q.sub.59                                                                               Cl   COOEt     Me OMe      N                                      2164 Q.sub.59                                                                               OMe  COOMe     Me OMe      CH                                     2165 Q.sub.59                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     2166 Q.sub.59                                                                               OMe  COOMe     Me OMe      N                                      2167 Q.sub.59                                                                               OMe  COOEt     Me OMe      CH                                     2168 Q.sub.59                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     2169 Q.sub.59                                                                               OMe  COOEt     Me OMe      N                                      2170 Q.sub.59                                                                               H    Cl        Me OMe      CH                                     2171 Q.sub.59                                                                               H    Cl        OMe                                                                               OMe      CH                                     2172 Q.sub.59                                                                               H    Cl        Me OMe      N                                      2173 Q.sub.59                                                                               H    NO.sub.2  Me OMe      CH                                     2174 Q.sub.59                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     2175 Q.sub.59                                                                               H    NO.sub.2  Me OMe      N                                      2176 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     2177 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     2178 Q.sub.59                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      2179 Q.sub.59                                                                               H    CN        Me OMe      CH                                     2180 Q.sub.59                                                                               H    CN        OMe                                                                               OMe      CH                                     2181 Q.sub.59                                                                               H    CN        Me OMe      N                                      2182 Q.sub.59                                                                               Me   CN        Me OMe      CH                                     2183 Q.sub.59                                                                               Me   CN        OMe                                                                               OMe      CH                                     2184 Q.sub.59                                                                               Me   CN        Me OMe      N                                      2185 Q.sub.59                                                                               H    Me        Me OMe      CH                                     2186 Q.sub.59                                                                               H    Me        OMe                                                                               OMe      CH                                     2187 Q.sub.59                                                                               H    Me        Me OMe      N                                      2188 Q.sub.59                                                                               H    Et        Me OMe      CH                                     2189 Q.sub.59                                                                               H    Et        OMe                                                                               OMe      CH                                     2190 Q.sub.59                                                                               H    Et        Me OMe      N                                      2191 Q.sub.59                                                                               H    H         Me OMe      CH                                     2192 Q.sub.59                                                                               H    H         OMe                                                                               OMe      CH                                     2193 Q.sub.59                                                                               H    H         Me OMe      N                                      2194 Q.sub.59                                                                               H    COPh      Me OMe      CH                                     2195 Q.sub.59                                                                               H    COPh      OMe                                                                               OMe      CH                                     2196 Q.sub.59                                                                               H    COPh      Me OMe      N                                      2197 Me      Q.sub.59                                                                            COOMe     Me OMe      CH                                     2198 Me      Q.sub.59                                                                            COOMe     OMe                                                                               OMe      CH                                     2199 Me      Q.sub.59                                                                            COOMe     Me OMe      N                                      2200 H       H    Q.sub.59  Me OMe      CH                                     2201 H       H    Q.sub.59  OMe                                                                               OMe      CH                                     2202 H       H    Q.sub.59  Me OMe      N                                      2203 Me      H    Q.sub.59  Me Me       CH                                     2204 Me      H    Q.sub.59  Me OMe      CH                                     2205 Me      H    Q.sub.59  OMe                                                                               OMe      CH                                     2206 Me      H    Q.sub.59  Me OMe      N                                      2207 Me      H    Q.sub.59  OMe                                                                               OMe      N                                      2208 Me      Me   Q.sub.59  Me OMe      CH                                     2209 Me      Me   Q.sub.59  OMe                                                                               OMe      CH                                     2210 Me      Me   Q.sub.59  Me OMe      N                                      2211 Q.sub.60                                                                               H    COOMe     Me Me       CH                                     2212 Q.sub.60                                                                               H    COOMe     Me OMe      CH                                     2213 Q.sub.60                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2214 Q.sub.60                                                                               H    COOMe     Me OMe      N                                      2215 Q.sub.60                                                                               H    COOMe     OMe                                                                               OMe      N                                      2216 Q.sub.60                                                                               H    COOEt     Me Me       CH                                     2217 Q.sub.60                                                                               H    COOEt     Me OMe      CH                                     2218 Q.sub.60                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2219 Q.sub.60                                                                               H    COOEt     Me OMe      N                                      2220 Q.sub.60                                                                               H    COOEt     OMe                                                                               OMe      N                                      2221 Q.sub.60                                                                               Me   COOMe     Me OMe      CH                                     2222 Q.sub.60                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2223 Q.sub.60                                                                               Me   COOMe     Me OMe      N                                      2224 Q.sub.60                                                                               Me   COOEt     Me OMe      CH                                     2225 Q.sub.60                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2226 Q.sub.60                                                                               Me   COOEt     Me OMe      N                                      2227 Q.sub.60                                                                               H    CN        Me OMe      CH                                     2228 Q.sub.60                                                                               H    CN        OMe                                                                               OMe      CH                                     2229 Q.sub.60                                                                               H    CN        Me OMe      N                                      2230 Q.sub.60                                                                               H    H         Me OMe      CH                                     2231 Q.sub.60                                                                               H    H         OMe                                                                               OMe      CH                                     2232 Q.sub.60                                                                               H    H         Me OMe      N                                      2233 Me      H    Q.sub.60  Me Me       CH                                     2234 Me      H    Q.sub.60  Me OMe      CH                                     2235 Me      H    Q.sub.60  OMe                                                                               OMe      CH                                     2236 Me      H    Q.sub.60  Me OMe      N                                      2237 Me      H    Q.sub.60  OMe                                                                               OMe      N                                      2238 Q.sub.61                                                                               H    COOMe     Me Me       CH                                     2239 Q.sub.61                                                                               H    COOMe     Me OMe      CH                                     2240 Q.sub.61                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2241 Q.sub.61                                                                               H    COOMe     Me OMe      N                                      2242 Q.sub.61                                                                               H    COOMe     OMe                                                                               OMe      N                                      2243 Q.sub.61                                                                               H    COOEt     Me Me       CH                                     2244 Q.sub.61                                                                               H    COOEt     Me OMe      CH                                     2245 Q.sub.61                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2246 Q.sub.61                                                                               H    COOEt     Me OMe      N                                      2247 Q.sub.61                                                                               H    COOEt     OMe                                                                               OMe      N                                      2248 Q.sub.61                                                                               Me   COOMe     Me OMe      CH                                     2249 Q.sub.61                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2250 Q.sub.61                                                                               Me   COOMe     Me OMe      N                                      2251 Q.sub.61                                                                               Me   COOEt     Me OMe      CH                                     2252 Q.sub.61                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2253 Q.sub.61                                                                               Me   COOEt     Me OMe      N                                      2254 Q.sub.61                                                                               H    CN        Me OMe      CH                                     2255 Q.sub.61                                                                               H    CN        OMe                                                                               OMe      CH                                     2256 Q.sub.61                                                                               H    CN        Me OMe      N                                      2257 Q.sub.61                                                                               H    H         Me OMe      CH                                     2258 Q.sub.61                                                                               H    H         OMe                                                                               OMe      CH                                     2259 Q.sub.61                                                                               H    H         Me OMe      N                                      2260 Me      H    Q.sub.61  Me Me       CH                                     2261 Me      H    Q.sub.61  Me OMe      CH                                     2262 Me      H    Q.sub.61  OMe                                                                               OMe      CH                                     2263 Me      H    Q.sub. 61 Me OMe      N                                      2264 Me      H    Q.sub.61  OMe                                                                               OMe      N                                      2265 Q.sub.62                                                                               H    COOMe     Me Me       CH                                     2266 Q.sub.62                                                                               H    COOMe     Me OMe      CH                                     2267 Q.sub.62                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2268 Q.sub.62                                                                               H    COOMe     Me OMe      N                                      2269 Q.sub.62                                                                               H    COOMe     OMe                                                                               OMe      N                                      2270 Q.sub.62                                                                               H    COOEt     Me Me       CH                                     2271 Q.sub.62                                                                               H    COOEt     Me OMe      CH                                     2272 Q.sub.62                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2273 Q.sub.62                                                                               H    COOEt     Me OMe      N                                      2274 Q.sub.62                                                                               H    COOEt     OMe                                                                               OMe      N                                      2275 Q.sub.62                                                                               Me   COOMe     Me OMe      CH                                     2276 Q.sub.62                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2277 Q.sub.62                                                                               Me   COOMe     Me OMe      N                                      2278 Q.sub.62                                                                               Me   COOEt     Me OMe      CH                                     2279 Q.sub.62                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2280 Q.sub.62                                                                               Me   COOEt     Me OMe      N                                      2281 Q.sub.62                                                                               H    CN        Me OMe      CH                                     2282 Q.sub.62                                                                               H    CN        OMe                                                                               OMe      CH                                     2283 Q.sub.62                                                                               H    CN        Me OMe      N                                      2284 Q.sub.62                                                                               H    H         Me OMe      CH                                     2285 Q.sub.62                                                                               H    H         OMe                                                                               OMe      CH                                     2286 Q.sub.62                                                                               H    H         Me OMe      N                                      2287 Me      H    Q.sub.62  Me Me       CH                                     2288 Me      H    Q.sub. 62 Me OMe      CH                                     2289 Me      H    Q.sub.62  OMe                                                                               OMe      CH                                     2290 Me      H    Q.sub.62  Me OMe      N                                      2291 Me      H    Q.sub.62  OMe                                                                               OMe      N                                      2292 Q.sub.63                                                                               H    COOMe     Me OMe      CH                                     2293 Q.sub.63                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2294 Q.sub.63                                                                               H    COOEt     Me OMe      CH                                     2295 Q.sub.63                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2296 Q.sub.63                                                                               Me   COOMe     Me OMe      CH                                     2297 Q.sub.63                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2298 Q.sub.63                                                                               Me   COOEt     Me OMe      CH                                     2299 Q.sub.63                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2300 Q.sub.63                                                                               H    H         Me OMe      CH                                     2301 Q.sub.63                                                                               H    H         OMe                                                                               OMe      CH                                     2302 Me      H    Q.sub.63  Me OMe      CH                                     2303 Me      H    Q.sub.63  OMe                                                                               OMe      CH                                     2304 Q.sub.64                                                                               H    COOMe     Me OMe      CH                                     2305 Q.sub.64                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2306 Q.sub.64                                                                               H    COOEt     Me OMe      CH                                     2307 Q.sub.64                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2308 Q.sub.64                                                                               Me   COOMe     Me OMe      CH                                     2309 Q.sub.64                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2310 Q.sub.64                                                                               Me   COOEt     Me OMe      CH                                     2311 Q.sub.64                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2312 Q.sub.64                                                                               H    H         Me OMe      CH                                     2313 Q.sub.64                                                                               H    H         OMe                                                                               OMe      CH                                     2314 Me      H    Q.sub.64  Me OMe      CH                                     2315 Me      H    Q.sub.64  OMe                                                                               OMe      CH                                     2316 Q.sub.65                                                                               H    COOMe     Me Me       CH                                     2317 Q.sub.65                                                                               H    COOMe     Me OMe      CH                                     2318 Q.sub.65                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2319 Q.sub.65                                                                               H    COOMe     Me OMe      N                                      2320 Q.sub.65                                                                               H    COOMe     OMe                                                                               OMe      N                                      2321 Q.sub.65                                                                               H    COOEt     Me Me       CH                                     2322 Q.sub.65                                                                               H    COOEt     Me OMe      CH                                     2323 Q.sub.65                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2324 Q.sub.65                                                                               H    COOEt     Me OMe      N                                      2325 Q.sub.65                                                                               H    COOEt     OMe                                                                               OMe      N                                      2326 Q.sub.65                                                                               Me   COOMe     Me OMe      CH                                     2327 Q.sub.65                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2328 Q.sub.65                                                                               Me   COOMe     Me OMe      N                                      2329 Q.sub.65                                                                               Me   COOEt     Me OMe      CH                                     2330 Q.sub.65                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2331 Q.sub.65                                                                               Me   COOEt     Me OMe      N                                      2332 Q.sub.65                                                                               H    CN        Me OMe      CH                                     2333 Q.sub.65                                                                               H    CN        OMe                                                                               OMe      CH                                     2334 Q.sub.65                                                                               H    CN        Me OMe      N                                      2335 Q.sub.65                                                                               H    H         Me OMe      CH                                     2336 Q.sub.65                                                                               H    H         OMe                                                                               OMe      CH                                     2337 Q.sub.65                                                                               H    H         Me OMe      N                                      2338 Me      H    Q.sub. 65 Me Me       CH                                     2339 Me      H    Q.sub.65  Me OMe      CH                                     2340 Me      H    Q.sub.65  OMe                                                                               OMe      CH                                     2341 Me      H    Q.sub.65  Me OMe      N                                      2342 Me      H    Q.sub.65  OMe                                                                               OMe      N                                      2343 Q.sub.66                                                                               H    COOMe     Me OMe      CH                                     2344 Q.sub.66                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2345 Q.sub.66                                                                               H    COOEt     Me OMe      CH                                     2346 Q.sub.66                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2347 Q.sub.66                                                                               Me   COOMe     Me OMe      CH                                     2348 Q.sub.66                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2349 Q.sub.66                                                                               Me   COOEt     Me OMe      CH                                     2350 Q.sub.66                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2351 Q.sub.66                                                                               H    H         Me OMe      CH                                     2352 Q.sub.66                                                                               H    H         OMe                                                                               OMe      CH                                     2353 Me      H    Q.sub.66  Me OMe      CH                                     2354 Me      H    Q.sub.66  OMe                                                                               OMe      CH                                     2355 Q.sub.67                                                                               H    COOMe     Me OMe      CH                                     2356 Q.sub.67                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2357 Q.sub.67                                                                               H    COOEt     Me OMe      CH                                     2358 Q.sub.67                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2359 Q.sub.67                                                                               Me   COOMe     Me OMe      CH                                     2360 Q.sub.67                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2361 Q.sub.67                                                                               Me   COOEt     Me OMe      CH                                     2362 Q.sub.67                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2363 Q.sub.67                                                                               H    H         Me OMe      CH                                     2364 Q.sub.67                                                                               H    H         OMe                                                                               OMe      CH                                     2365 Me      H    Q.sub.67  Me OMe      CH                                     2366 Me      H    Q.sub.67  OMe                                                                               OMe      CH                                     2367 Q.sub.68                                                                               H    COOMe     Me OMe      CH                                     2368 Q.sub.68                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2369 Q.sub.68                                                                               H    COOEt     Me OMe      CH                                     2370 Q.sub.68                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2371 Q.sub.68                                                                               Me   COOMe     Me OMe      CH                                     2372 Q.sub.68                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2373 Q.sub.68                                                                               Me   COOEt     Me OMe      CH                                     2374 Q.sub.68                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2375 Q.sub.68                                                                               H    H         Me OMe      CH                                     2376 Q.sub.68                                                                               H    H         OMe                                                                               OMe      CH                                     2377 Me      H    Q.sub.68  Me OMe      CH                                     2378 Me      H    Q.sub.68  Me OMe      CH                                     2379 Q.sub.69                                                                               H    COOMe     Me OMe      CH                                     2380 Q.sub.69                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2381 Q.sub.69                                                                               H    COOEt     Me OMe      CH                                     2382 Q.sub.69                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2383 Q.sub.69                                                                               Me   COOMe     Me OMe      CH                                     2384 Q.sub.69                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2385 Q.sub.69                                                                               Me   COOEt     Me OMe      CH                                     2386 Q.sub.69                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2387 Q.sub.69                                                                               H    H         Me OMe      CH                                     2388 Q.sub.69                                                                               H    H         OMe                                                                               OMe      CH                                     2389 Me      H    Q.sub.69  Me OMe      CH                                     2390 Me      H    Q.sub.69  OMe                                                                               OMe      CH                                     2391 Q.sub.70                                                                               H    COOMe     Me Me       CH                                     2392 Q.sub.70                                                                               H    COOMe     Me OMe      CH                                     2393 Q.sub.70                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2394 Q.sub.70                                                                               H    COOMe     Me OMe      N                                      2395 Q.sub.70                                                                               H    COOMe     OMe                                                                               OMe      N                                      2396 Q.sub.70                                                                               H    COOEt     Me Me       CH                                     2397 Q.sub.70                                                                               H    COOEt     Me OMe      CH                                     2398 Q.sub.70                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2399 Q.sub.70                                                                               H    COOEt     Me OMe      N                                      2400 Q.sub.70                                                                               H    COOEt     OMe                                                                               OMe      N                                      2401 Q.sub.70                                                                               Me   COOMe     Me OMe      CH                                     2402 Q.sub.70                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2403 Q.sub.70                                                                               Me   COOMe     Me OMe      N                                      2404 Q.sub.70                                                                               Me   COOEt     Me OMe      CH                                     2405 Q.sub.70                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2406 Q.sub.70                                                                               Me   COOEt     Me OMe      N                                      2407 Q.sub.70                                                                               H    CN        Me OMe      CH                                     2408 Q.sub.70                                                                               H    CN        OMe                                                                               OMe      CH                                     2409 Q.sub.70                                                                               H    CN        Me OMe      N                                      2410 Q.sub.70                                                                               H    H         Me OMe      CH                                     2411 Q.sub.70                                                                               H    H         OMe                                                                               OMe      CH                                     2412 Q.sub.70                                                                               H    H         Me OMe      N                                      2413 Me      H    Q.sub. 70 Me Me       CH                                     2414 Me      H    Q.sub.70  Me OMe      CH                                     2415 Me      H    Q.sub.70  OMe                                                                               OMe      CH                                     2416 Me      H    Q.sub.70  Me OMe      N                                      2417 Me      H    Q.sub.70  OMe                                                                               OMe      N                                      2418 Q.sub.71                                                                               H    COOMe     Me OMe      CH                                     2419 Q.sub.71                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2420 Q.sub.71                                                                               H    COOEt     Me OMe      CH                                     2421 Q.sub.71                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2422 Q.sub.71                                                                               Me   COOMe     Me OMe      CH                                     2423 Q.sub.71                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2424 Q.sub.71                                                                               Me   COOEt     Me OMe      CH                                     2425 Q.sub.71                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2426 Q.sub.71                                                                               H    H         Me OMe      CH                                     2427 Q.sub.71                                                                               H    H         OMe                                                                               OMe      CH                                     2428 Me      H    Q.sub.71  Me OMe      CH                                     2429 Me      H    Q.sub.71  OMe                                                                               OMe      CH                                     2430 Q.sub.72                                                                               H    COOMe     Me OMe      CH                                     2431 Q.sub.72                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2432 Q.sub.72                                                                               H    COOEt     Me OMe      CH                                     2433 Q.sub.72                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2434 Q.sub.72                                                                               Me   COOMe     Me OMe      CH                                     2435 Q.sub.72                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2436 Q.sub.72                                                                               Me   COOEt     Me OMe      CH                                     2437 Q.sub.72                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2438 Q.sub.72                                                                               H    H         Me OMe      CH                                     2439 Q.sub.72                                                                               H    H         OMe                                                                               OMe      CH                                     2440 Me      H    Q.sub.72  Me OMe      CH                                     2441 Me      H    Q.sub.72  OMe                                                                               OMe      CH                                     2442 Q.sub.73                                                                               H    COOMe     Me OMe      CH                                     2443 Q.sub.73                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2444 Q.sub.73                                                                               H    COOEt     Me OMe      CH                                     2445 Q.sub.73                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2446 Q.sub.73                                                                               Me   COOMe     Me OMe      CH                                     2447 Q.sub.73                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2448 Q.sub.73                                                                               Me   COOEt     Me OMe      CH                                     2449 Q.sub.73                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2450 Q.sub.73                                                                               H    H         Me OMe      CH                                     2451 Q.sub.73                                                                               H    H         OMe                                                                               OMe      CH                                     2452 Me      H    Q.sub.73  Me OMe      CH                                     2453 Me      H    Q.sub.73  OMe                                                                               OMe      CH                                     2454 Q.sub.74                                                                               H    COOMe     Me OMe      CH                                     2455 Q.sub.74                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2456 Q.sub.74                                                                               H    COOEt     Me OMe      CH                                     2457 Q.sub.74                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2458 Q.sub.74                                                                               Me   COOMe     Me OMe      CH                                     2459 Q.sub.74                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2460 Q.sub.74                                                                               Me   COOEt     Me OMe      CH                                     2461 Q.sub.74                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2462 Q.sub.74                                                                               H    H         Me OMe      CH                                     2463 Q.sub.74                                                                               H    H         OMe                                                                               OMe      CH                                     2464 Me      H    Q.sub.74  Me OMe      CH                                     2465 Me      H    Q.sub.74  OMe                                                                               OMe      CH                                     2466 Q.sub.75                                                                               H    COOMe     Me OMe      CH                                     2467 Q.sub.75                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2468 Q.sub.75                                                                               H    COOEt     Me OMe      CH                                     2469 Q.sub.75                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2470 Q.sub.75                                                                               Me   COOMe     Me OMe      CH                                     2471 Q.sub.75                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2472 Q.sub.75                                                                               Me   COOEt     Me OMe      CH                                     2473 Q.sub.75                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2474 Q.sub.75                                                                               H    H         Me OMe      CH                                     2475 Q.sub.75                                                                               H    H         OMe                                                                               OMe      CH                                     2476 Me      H    Q.sub.75  Me OMe      CH                                     2477 Me      H    Q.sub.75  OMe                                                                               OMe      CH                                     2478 Q.sub.76                                                                               H    COOMe     Me OMe      CH                                     2479 Q.sub.76                                                                               H    COOMe     OMe                                                                               OMe      CH                                     2480 Q.sub.76                                                                               H    COOEt     Me OMe      CH                                     2481 Q.sub.76                                                                               H    COOEt     OMe                                                                               OMe      CH                                     2482 Q.sub.76                                                                               Me   COOMe     Me OMe      CH                                     2483 Q.sub.76                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     2484 Q.sub.76                                                                               Me   COOEt     Me OMe      CH                                     2485 Q.sub.76                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     2486 Q.sub.76                                                                               H    H         Me OMe      CH                                     2487 Q.sub.76                                                                               H    H         OMe                                                                               OMe      CH                                     2488 Me      H    Q.sub. 76 Me OMe      CH                                     2489 Me      H    Q.sub.76  OMe                                                                               OMe      CH                                     5347 Q.sub.10                                                                               Me   COOMe     Me Me       CH                                     5348 Q.sub.77                                                                               H    COOMe     Me OMe      CH                                     5349 Q.sub.77                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5350 Q.sub.77                                                                               H    COOEt     Me OMe      CH                                     5351 Q.sub.77                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5352 Q.sub.77                                                                               Me   COOMe     Me OMe      CH                                     5353 Q.sub.77                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5354 Q.sub.77                                                                               Me   COOEt     Me OMe      CH                                     5355 Q.sub.77                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5356 Q.sub.77                                                                               H    H         Me OMe      CH                                     5357 Q.sub.77                                                                               H    H         OMe                                                                               OMe      CH                                     5358 Me      H    Q.sub.77  Me OMe      CH                                     5359 Me      H    Q.sub.77  OMe                                                                               OMe      CH                                     5360 Q.sub.78                                                                               H    COOMe     Me Me       CH                                     5361 Q.sub.78                                                                               H    COOMe     Me OMe      CH                                     5362 Q.sub.78                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5363 Q.sub.78                                                                               H    COOMe     Me Me       N                                      5364 Q.sub.78                                                                               H    COOMe     Me OMe      N                                      5365 Q.sub.78                                                                               H    COOMe     OMe                                                                               OMe      N                                      5366 Q.sub.78                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     5367 Q.sub.78                                                                               H    COOMe     Cl OMe      CH                                     5368 Q.sub.78                                                                               H    COOEt     Me Me       CH                                     5369 Q.sub.78                                                                               H    COOEt     Me OMe      CH                                     5370 Q.sub.78                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5371 Q.sub.78                                                                               H    COOEt     Me Me       N                                      5372 Q.sub.78                                                                               H    COOEt     Me OMe      N                                      5373 Q.sub.78                                                                               H    COOEt     OMe                                                                               OMe      N                                      5374 Q.sub.78                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     5375 Q.sub.78                                                                               H    COOEt     Cl OMe      CH                                     5376 Q.sub.78                                                                               H    COOPrn    Me OMe      CH                                     5377 Q.sub.78                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     5378 Q.sub.78                                                                               H    COOPrn    Me OMe      N                                      5379 Q.sub.78                                                                               H    COOPri    Me OMe      CH                                     5380 Q.sub.78                                                                               H    COOPri    OMe                                                                               OMe      CH                                     5381 Q.sub.78                                                                               H    COOPri    Me OMe      N                                      5382 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     5383 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     5384 Q.sub.78                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      5385 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     5386 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     5387 Q.sub.78                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      N                                      5388 Q.sub.78                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     5389 Q.sub.78                                                                               H    COOCH.sub.2 C CH                                                                         OMe                                                                               OMe      CH                                     5390 Q.sub.78                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      5391 Q.sub.78                                                                               Me   COOMe     Me Me       CH                                     5392 Q.sub.78                                                                               Me   COOMe     Me OMe      CH                                     5393 Q.sub.78                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5394 Q.sub.78                                                                               Me   COOMe     Me OMe      N                                      5395 Q.sub.78                                                                               Me   COOMe     OMe                                                                               OMe      N                                      5396 Q.sub.78                                                                               Me   COOEt     Me Me       CH                                     5397 Q.sub.78                                                                               Me   COOEt     Me OMe      CH                                     5398 Q.sub.78                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5399 Q.sub.78                                                                               Me   COOEt     Me OMe      N                                      5400 Q.sub.78                                                                               Me   COOEt     OMe                                                                               OMe      N                                      5401 Q.sub.78                                                                               Cl   COOMe     Me OMe      CH                                     5402 Q.sub.78                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     5403 Q.sub.78                                                                               Cl   COOMe     Me OMe      N                                      5404 Q.sub.78                                                                               Cl   COOEt     Me OMe      CH                                     5405 Q.sub.78                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     5406 Q.sub.78                                                                               Cl   COOEt     Me OMe      N                                      5407 Q.sub.78                                                                               OMe  COOMe     Me OMe      CH                                     5408 Q.sub.78                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     5409 Q.sub.78                                                                               OMe  COOMe     Me OMe      N                                      5410 Q.sub.78                                                                               OMe  COOEt     Me OMe      CH                                     5411 Q.sub.78                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     5412 Q.sub.78                                                                               OMe  COOEt     Me OMe      N                                      5413 Q.sub.78                                                                               H    Cl        Me OMe      CH                                     5414 Q.sub.78                                                                               H    Cl        OMe                                                                               OMe      CH                                     5415 Q.sub.78                                                                               H    Cl        Me OMe      N                                      5416 Q.sub.78                                                                               H    NO.sub.2  Me OMe      CH                                     5417 Q.sub.78                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     5418 Q.sub.78                                                                               H    NO.sub.2  Me OMe      N                                      5419 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     5420 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     5421 Q.sub.78                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      5422 Q.sub.78                                                                               H    CN        Me OMe      CH                                     5423 Q.sub.78                                                                               H    CN        OMe                                                                               OMe      CH                                     5424 Q.sub.78                                                                               H    CN        Me OMe      N                                      5425 Q.sub.78                                                                               Me   CN        Me OMe      CH                                     5426 Q.sub.78                                                                               Me   CN        OMe                                                                               OMe      CH                                     5427 Q.sub.78                                                                               Me   CN        Me OMe      N                                      5428 Q.sub.78                                                                               H    Me        Me OMe      CH                                     5429 Q.sub.78                                                                               H    Me        OMe                                                                               OMe      CH                                     5430 Q.sub.78                                                                               H    Me        Me OMe      N                                      5431 Q.sub.78                                                                               H    Et        Me OMe      CH                                     5432 Q.sub.78                                                                               H    Et        OMe                                                                               OMe      CH                                     5433 Q.sub.78                                                                               H    Et        Me OMe      N                                      5434 Q.sub.78                                                                               H    H         Me OMe      CH                                     5435 Q.sub.78                                                                               H    H         OMe                                                                               OMe      CH                                     5436 Q.sub.78                                                                               H    H         Me OMe      N                                      5437 Q.sub.78                                                                               H    COPh      Me OMe      CH                                     5438 Q.sub.78                                                                               H    COPh      OMe                                                                               OMe      CH                                     5439 Q.sub.78                                                                               H    COPh      Me OMe      N                                      5440 Me      Q.sub.78                                                                            COOMe     Me OMe      CH                                     5441 Me      Q.sub.78                                                                            COOMe     OMe                                                                               OMe      CH                                     5442 Me      Q.sub.78                                                                            COOMe     Me OMe      N                                      5443 H       H    Q.sub.78  Me OMe      CH                                     5444 H       H    Q.sub.78  OMe                                                                               OMe      CH                                     5445 H       H    Q.sub.78  Me OMe      N                                      5446 Me      H    Q.sub.78  Me Me       CH                                     5447 Me      H    Q.sub.78  Me OMe      CH                                     5448 Me      H    Q.sub.78  OMe                                                                               OMe      CH                                     5449 Me      H    Q.sub.78  Me OMe      N                                      5450 Me      H    Q.sub.78  OMe                                                                               OMe      N                                      5451 Me      Me   Q.sub.78  Me OMe      CH                                     5452 Me      Me   Q.sub.78  OMe                                                                               OMe      CH                                     5453 Me      Me   Q.sub.78  Me OMe      N                                      5454 Q.sub.79                                                                               H    COOMe     Me Me       CH                                     5455 Q.sub.79                                                                               H    COOMe     Me OMe      CH                                     5456 Q.sub.79                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5457 Q.sub.79                                                                               H    COOMe     Me Me       N                                      5458 Q.sub.79                                                                               H    COOMe     Me OMe      N                                      5459 Q.sub.79                                                                               H    COOMe     OMe                                                                               OMe      N                                      5460 Q.sub.79                                                                               H    COOMe     Me OCHF.sub.2                                                                              CH                                     5461 Q.sub.79                                                                               H    COOMe     Cl OMe      CH                                     5462 Q.sub.79                                                                               H    COOEt     Me Me       CH                                     5463 Q.sub.79                                                                               H    COOEt     Me OMe      CH                                     5464 Q.sub.79                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5465 Q.sub.79                                                                               H    COOEt     Me Me       N                                      5466 Q.sub.79                                                                               H    COOEt     Me OMe      N                                      5467 Q.sub.79                                                                               H    COOEt     OMe                                                                               OMe      N                                      5468 Q.sub.79                                                                               H    COOEt     Me OCHF.sub.2                                                                              CH                                     5469 Q.sub.79                                                                               H    COOEt     Cl OMe      CH                                     5470 Q.sub.79                                                                               H    COOPrn    Me OMe      CH                                     5471 Q.sub.79                                                                               H    COOPrn    OMe                                                                               OMe      CH                                     5472 Q.sub.79                                                                               H    COOPrn    Me OMe      N                                      5473 Q.sub.79                                                                               H    COOPri    Me OMe      CH                                     5474 Q.sub.79                                                                               H    COOPri    OMe                                                                               OMe      CH                                     5475 Q.sub.79                                                                               H    COOPri    Me OMe      N                                      5476 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      CH                                     5477 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  OMe                                                                               OMe      CH                                     5478 Q.sub.79                                                                               H    COOCH.sub.2 CH.sub.2 Cl                                                                  Me OMe      N                                      5479 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   Me OMe      CH                                     5480 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub.2                                                                   OMe                                                                               OMe      CH                                     5481 Q.sub.79                                                                               H    COOCH.sub.2 CHCH.sub. 2                                                                  Me OMe      N                                      5482 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      CH                                     5483 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          OMe                                                                               OMe      CH                                     5484 Q.sub.79                                                                               H    COOCH.sub.2 CCH                                                                          Me OMe      N                                      5485 Q.sub.79                                                                               Me   COOMe     Me Me       CH                                     5486 Q.sub.79                                                                               Me   COOMe     Me OMe      CH                                     5487 Q.sub.79                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5488 Q.sub.79                                                                               Me   COOMe     Me OMe      N                                      5489 Q.sub.79                                                                               Me   COOMe     OMe                                                                               OMe      N                                      5490 Q.sub.79                                                                               Me   COOEt     Me Me       CH                                     5491 Q.sub.79                                                                               Me   COOEt     Me OMe      CH                                     5492 Q.sub.79                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5493 Q.sub.79                                                                               Me   COOEt     Me OMe      N                                      5494 Q.sub.79                                                                               Me   COOEt     OMe                                                                               OMe      N                                      5495 Q.sub.79                                                                               Cl   COOMe     Me OMe      CH                                     5496 Q.sub.79                                                                               Cl   COOMe     OMe                                                                               OMe      CH                                     5497 Q.sub.79                                                                               Cl   COOMe     Me OMe      N                                      5498 Q.sub.79                                                                               Cl   COOEt     Me OMe      CH                                     5499 Q.sub.79                                                                               Cl   COOEt     OMe                                                                               OMe      CH                                     5500 Q.sub.79                                                                               Cl   COOEt     Me OMe      N                                      5501 Q.sub.79                                                                               OMe  COOMe     Me OMe      CH                                     5502 Q.sub.79                                                                               OMe  COOMe     OMe                                                                               OMe      CH                                     5503 Q.sub.79                                                                               OMe  COOMe     Me OMe      N                                      5504 Q.sub.79                                                                               OMe  COOEt     Me OMe      CH                                     5505 Q.sub.79                                                                               OMe  COOEt     OMe                                                                               OMe      CH                                     5506 Q.sub.79                                                                               OMe  COOEt     Me OMe      N                                      5507 Q.sub.79                                                                               H    Cl        Me OMe      CH                                     5508 Q.sub.79                                                                               H    Cl        OMe                                                                               OMe      CH                                     5509 Q.sub.79                                                                               H    Cl        Me OMe      N                                      5510 Q.sub.79                                                                               H    NO.sub.2  Me OMe      CH                                     5511 Q.sub.79                                                                               H    NO.sub.2  OMe                                                                               OMe      CH                                     5512 Q.sub.79                                                                               H    NO.sub.2  Me OMe      N                                      5513 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      CH                                     5514 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       OMe                                                                               OMe      CH                                     5515 Q.sub.79                                                                               H    SO.sub.2 NMe.sub.2                                                                       Me OMe      N                                      5516 Q.sub.79                                                                               H    CN        Me OMe      CH                                     5517 Q.sub.79                                                                               H    CN        OMe                                                                               OMe      CH                                     5518 Q.sub.79                                                                               H    CN        Me OMe      N                                      5519 Q.sub.79                                                                               Me   CN        Me OMe      CH                                     5520 Q.sub.79                                                                               Me   CN        OMe                                                                               OMe      CH                                     5521 Q.sub.79                                                                               Me   CN        Me OMe      N                                      5522 Q.sub.79                                                                               H    Me        Me OMe      CH                                     5523 Q.sub.79                                                                               H    Me        OMe                                                                               OMe      CH                                     5524 Q.sub.79                                                                               H    Me        Me OMe      N                                      5525 Q.sub.79                                                                               H    Et        Me OMe      CH                                     5526 Q.sub.79                                                                               H    Et        OMe                                                                               OMe      CH                                     5527 Q.sub.79                                                                               H    Et        Me OMe      N                                      5528 Q.sub.79                                                                               H    H         Me OMe      CH                                     5529 Q.sub.79                                                                               H    H         OMe                                                                               OMe      CH                                     5530 Q.sub.79                                                                               H    H         Me OMe      N                                      5531 Q.sub.79                                                                               H    COPh      Me OMe      CH                                     5532 Q.sub.79                                                                               H    COPh      OMe                                                                               OMe      CH                                     5533 Q.sub.79                                                                               H    COPh      Me OMe      N                                      5534 Me      Q.sub.79                                                                            COOMe     Me OMe      CH                                     5535 Me      Q.sub.79                                                                            COOMe     OMe                                                                               OMe      CH                                     5536 Me      Q.sub.79                                                                            COOMe     Me OMe      N                                      5537 H       H    Q.sub.79  Me OMe      CH                                     5538 H       H    Q.sub.79  OMe                                                                               OMe      CH                                     5539 H       H    Q.sub.79  Me OMe      N                                      5540 Me      H    Q.sub.79  Me Me       CH                                     5541 Me      H    Q.sub.79  Me OMe      CH                                     5542 Me      H    Q.sub.79  OMe                                                                               OMe      CH                                     5543 Me      H    Q.sub.79  Me OMe      N                                      5544 Me      H    Q.sub.79  OMe                                                                               OMe      N                                      5545 Me      Me   Q.sub.79  Me OMe      CH                                     5546 Me      Me   Q.sub.79  OMe                                                                               OMe      CH                                     5547 Me      Me   Q.sub.79  Me OMe      N                                      5548 Q.sub.80                                                                               H    COOMe     Me Me       CH                                     5549 Q.sub.80                                                                               H    COOMe     Me OMe      CH                                     5550 Q.sub.80                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5551 Q.sub.80                                                                               H    COOMe     Me OMe      N                                      5552 Q.sub.80                                                                               H    COOMe     OMe                                                                               OMe      N                                      5553 Q.sub.80                                                                               H    COOEt     Me Me       CH                                     5554 Q.sub.80                                                                               H    COOEt     Me OMe      CH                                     5555 Q.sub.80                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5556 Q.sub.80                                                                               H    COOEt     Me OMe      N                                      5557 Q.sub.80                                                                               H    COOEt     OMe                                                                               OMe      N                                      5558 Q.sub.80                                                                               Me   COOMe     Me OMe      CH                                     5559 Q.sub.80                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5560 Q.sub.80                                                                               Me   COOMe     Me OMe      N                                      5561 Q.sub.80                                                                               Me   COOEt     Me OMe      CH                                     5562 Q.sub.80                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5563 Q.sub.80                                                                               Me   COOEt     Me OMe      N                                      5564 Q.sub.80                                                                               H    CN        Me OMe      CH                                     5565 Q.sub.80                                                                               H    CN        OMe                                                                               OMe      CH                                     5566 Q.sub.80                                                                               H    CN        Me OMe      N                                      5567 Q.sub.80                                                                               H    H         Me OMe      CH                                     5568 Q.sub.80                                                                               H    H         OMe                                                                               OMe      CH                                     5569 Q.sub.80                                                                               H    H         Me OMe      N                                      5570 Me      H    Q.sub.80  Me Me       CH                                     5571 Me      H    Q.sub.80  Me OMe      CH                                     5572 Me      H    Q.sub.80  OMe                                                                               OMe      CH                                     5573 Me      H    Q.sub.80  Me OMe      N                                      5574 Me      H    Q.sub.80  OMe                                                                               OMe      N                                      5575 Q.sub.81                                                                               H    COOMe     Me OMe      CH                                     5576 Q.sub.81                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5577 Q.sub.81                                                                               H    COOEt     Me OMe      CH                                     5578 Q.sub.81                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5579 Q.sub.81                                                                               Me   COOMe     Me OMe      CH                                     5580 Q.sub.81                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5581 Q.sub.81                                                                               Me   COOEt     Me OMe      CH                                     5582 Q.sub.81                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5583 Q.sub.81                                                                               H    H         Me OMe      CH                                     5584 Q.sub.81                                                                               H    H         OMe                                                                               OMe      CH                                     5585 Me      H    Q.sub.81  Me OMe      CH                                     5586 Me      H    Q.sub.81  OMe                                                                               OMe      CH                                     5587 Q.sub.82                                                                               H    COOMe     Me OMe      CH                                     5588 Q.sub.82                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5589 Q.sub.82                                                                               H    COOEt     Me OMe      CH                                     5590 Q.sub.82                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5591 Q.sub.82                                                                               Me   COOMe     Me OMe      CH                                     5592 Q.sub.82                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5593 Q.sub.82                                                                               Me   COOEt     Me OMe      CH                                     5594 Q.sub.82                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5595 Q.sub.82                                                                               H    H         Me OMe      CH                                     5596 Q.sub.82                                                                               H    H         OMe                                                                               OMe      CH                                     5597 Me      H    Q.sub.82  Me OMe      CH                                     5598 Me      H    Q.sub.82  OMe                                                                               OMe      CH                                     5599 Q.sub.83                                                                               H    COOMe     Me OMe      CH                                     5600 Q.sub.83                                                                               H    COOMe     OMe                                                                               OMe      CH                                     5601 Q.sub.83                                                                               H    COOEt     Me OMe      CH                                     5602 Q.sub.83                                                                               H    COOEt     OMe                                                                               OMe      CH                                     5603 Q.sub.83                                                                               Me   COOMe     Me OMe      CH                                     5604 Q.sub.83                                                                               Me   COOMe     OMe                                                                               OMe      CH                                     5605 Q.sub.83                                                                               Me   COOEt     Me OMe      CH                                     5606 Q.sub.83                                                                               Me   COOEt     OMe                                                                               OMe      CH                                     5607 Q.sub.83                                                                               H    H         Me OMe      CH                                     5608 Q.sub.83                                                                               H    H         OMe                                                                               OMe      CH                                     5609 Me      H    Q.sub.83  Me OMe      CH                                     5610 Me      H    Q.sub.83  OMe                                                                               OMe      CH                                     __________________________________________________________________________

In the above, Q₁ to Q₈₃ each represent the following heterocyclic group. ##STR19##

                                      TABLE 2                                      __________________________________________________________________________     No.                                                                               A       B    D         X   Y    Z                                           __________________________________________________________________________     2490                                                                              Q.sub.1 H    H         Me  Me   CH                                          2491                                                                              Q.sub.1 H    H         Me  OMe  CH                                          2492                                                                              Q.sub.1 H    H         OMe OMe  CH                                          2493                                                                              Q.sub.1 H    H         Me  OMe  N                                           2494                                                                              Q.sub.1 H    H         OMe OMe  N                                           2495                                                                              Q.sub.1 Me   H         Me  Me   CH                                          2496                                                                              Q.sub.1 Me   H         Me  OMe  CH                                          2497                                                                              Q.sub.1 Me   H         OMe OMe  CH                                          2498                                                                              Q.sub.1 Me   H         Me  OMe  N                                           2499                                                                              Q.sub.1 Me   H         OMe OMe  N                                           2500                                                                              Q.sub.1 H    Me        Me  Me   CH                                          2501                                                                              Q.sub.1 H    Me        Me  OMe  CH                                          2502                                                                              Q.sub.1 H    Me        OMe OMe  CH                                          2503                                                                              Q.sub.1 H    Me        Me  OMe  N                                           2504                                                                              Q.sub.1 H    Me        OMe OMe  N                                           2505                                                                              Q.sub.1 Me   Cl        Me  Me   CH                                          2506                                                                              Q.sub.1 Me   Cl        Me  OMe  CH                                          2507                                                                              Q.sub.1 Me   Cl        OMe OMe  CH                                          2508                                                                              Q.sub.1 Me   Cl        Me  OMe  N                                           2509                                                                              Q.sub.1 Me   Cl        OMe OMe  N                                           2510                                                                              Q.sub.1 Me   OMe       Me  Me   CH                                          2511                                                                              Q.sub.1 Me   OMe       Me  OMe  CH                                          2512                                                                              Q.sub.1 Me   OMe       OMe OMe  CH                                          2513                                                                              Q.sub.1 Me   OMe       Me  OMe  N                                           2514                                                                              Q.sub.1 Me   OMe       OMe OMe  N                                           2515                                                                              Q.sub.1 Cl   H         Me  Me   CH                                          2516                                                                              Q.sub.1 Cl   H         Me  OMe  CH                                          2517                                                                              Q.sub.1 Cl   H         OMe OMe  CH                                          2518                                                                              Q.sub.1 Cl   H         Me  OMe  N                                           2519                                                                              Q.sub.1 Cl   H         OMe OMe  N                                           2520                                                                              Q.sub.1 Br   H         Me  Me   CH                                          2521                                                                              Q.sub.1 Br   H         Me  OMe  CH                                          2522                                                                              Q.sub.1 Br   H         OMe OMe  N                                           2523                                                                              Q.sub.1 CF.sub.3                                                                            H         Me  OMe  CH                                          2524                                                                              Q.sub.1 CF.sub.3                                                                            H         OMe OMe  CH                                          2525                                                                              Q.sub.1 CF.sub.3                                                                            H         Me  Me   CH                                          2526                                                                              Q.sub.1 CF.sub.3                                                                            H         Me  OMe  N                                           2527                                                                              Q.sub.1 CF.sub.3                                                                            H         OMe OMe  N                                           2528                                                                              Q.sub. 1                                                                               H    CF.sub.3  Me  OMe  CH                                          2529                                                                              Q.sub.1 H    CF.sub.3  OMe OMe  CH                                          2530                                                                              Q.sub.1 H    CF.sub.3  OMe OMe  CH                                          2531                                                                              Q.sub.1 H    CF.sub.3  Me  OMe  N                                           2532                                                                              Q.sub.1 H    CF.sub.3  OMe OMe  N                                           2533                                                                              Q.sub.1 CF.sub.3                                                                            CH.sub.3  Me  Me   CH                                          2534                                                                              Q.sub.1 CF.sub.3                                                                            CH.sub.3  Me  OMe  CH                                          2535                                                                              Q.sub.1 CF.sub.3                                                                            CH.sub.3  OMe OMe  CH                                          2536                                                                              Q.sub.1 CF.sub.3                                                                            CH.sub.3  Me  OMe  N                                           2537                                                                              Q.sub.1 CF.sub.3                                                                            CH.sub.3  OMe OMe  N                                           2538                                                                              Q.sub.1 CH.sub.3                                                                            CF.sub.3  Me  Me   CH                                          2539                                                                              Q.sub.1 CH.sub.3                                                                            CF.sub.3  Me  OMe  CH                                          2540                                                                              Q.sub.1 CH.sub.3                                                                            CF.sub.3  OMe OMe  CH                                          2541                                                                              Q.sub.1 CH.sub.3                                                                            CF.sub.3  Me  OMe  N                                           2542                                                                              Q.sub.1 CH.sub.3                                                                            CF.sub.3  OMe OMe  N                                           2543                                                                              Q.sub.1 H    COOMe     Me  Me   CH                                          2544                                                                              Q.sub.1 H    COOMe     Me  OMe  CH                                          2545                                                                              Q.sub.1 H    COOMe     OMe OMe  CH                                          2546                                                                              Q.sub.1 H    COOMe     Me  OMe  N                                           2547                                                                              Q.sub.1 H    COOMe     OMe OMe  N                                           2548                                                                              Q.sub.1 Me   COOMe     Me  Me   CH                                          2549                                                                              Q.sub.1 Me   COOMe     Me  OMe  CH                                          2550                                                                              Q.sub.1 Me   COOMe     OMe OMe  CH                                          2551                                                                              Q.sub.1 Me   COOMe     Me  OMe  N                                           2552                                                                              Q.sub.1 Me   COOMe     OMe OMe  N                                           2553                                                                              Q.sub.1 Me   COOMe     Me  Cl   CH                                          2554                                                                              Q.sub.1 Me   COOMe     Me  CH.sub.2 OMe                                                                        CH                                          2555                                                                              Q.sub.1 Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          2556                                                                              Q.sub.1 Me   COOMe     Me                                                                                  ##STR20##                                                                          CH                                          2557                                                                              Q.sub.1 Me   COOMe     OMe OMe  CCl                                         2558                                                                              Q.sub.1 Me   COOMe     Me  NMe.sub.2                                                                           N                                           2559                                                                              Q.sub.1 Me   COOMe     Me  Me   N                                           2560                                                                              Q.sub.1 Me   COOH      Me  Me   CH                                          2561                                                                              Q.sub.1 Me   COOH      Me  OMe  CH                                          2562                                                                              Q.sub.1 Me   COOH      OMe OMe  CH                                          2563                                                                              Q.sub.1 Me   COOH      Me  OMe  N                                           2564                                                                              Q.sub.1 Me   COOH      OMe OMe  N                                           2565                                                                              Q.sub.1 Me   COOEt     Me  Me   CH                                          2566                                                                              Q.sub.1 Me   COOEt     Me  OMe  CH                                          2567                                                                              Q.sub.1 Me   COOEt     OMe OMe  CH                                          2568                                                                              Q.sub.1 Me   COOEt     Me  OMe  N                                           2569                                                                              Q.sub.1 Me   COOEt     OMe OMe  N                                           2570                                                                              Q.sub.1 Me   COOPrn    Me  Me   CH                                          2571                                                                              Q.sub.1 Me   COOPrn    Me  OMe  CH                                          2572                                                                              Q.sub.1 Me   COOPrn    OMe OMe  CH                                          2573                                                                              Q.sub.1 Me   COOPrn    Me  OMe  N                                           2574                                                                              Q.sub.1 Me   COOPrn    OMe OMe  N                                           2575                                                                              Q.sub.1 Me   COOPri    Me  Me   CH                                          2576                                                                              Q.sub.1 Me   COOPri    Me  OMe  CH                                          2577                                                                              Q.sub.1 Me   COOPri    OMe OMe  CH                                          2578                                                                              Q.sub.1 Me   COOPri    Me  OMe  N                                           2579                                                                              Q.sub.1 Me   COOPri    OMe OMe  N                                           2580                                                                              Q.sub.1 Me   COOCH.sub.2 CHCH.sub.2                                                                   Me  Me   CH                                          2581                                                                              Q.sub.1 Me   COOCH.sub.2 CHCH.sub.2                                                                   Me  OMe  CH                                          2582                                                                              Q.sub.1 Me   COOCH.sub.2 CHCH.sub.2                                                                   OMe OMe  CH                                          2583                                                                              Q.sub.1 Me   COOCH.sub.2 CHCH.sub.2                                                                   Me  OMe  N                                           2584                                                                              Q.sub.1 Me   COOCH.sub.2 CHCH.sub.2                                                                   OMe OMe  N                                           2585                                                                              Q.sub.1 Me   COOCH.sub.2 CCH                                                                          Me  Me   CH                                          2586                                                                              Q.sub.1 Me   COOCH.sub.2 CCH                                                                          Me  OMe  CH                                          2587                                                                              Q.sub.1 Me   COOCH.sub.2 CCH                                                                          OMe OMe  CH                                          2588                                                                              Q.sub.1 Me   COOCH.sub.2 CCH                                                                          Me  OMe  N                                           2589                                                                              Q.sub.1 Me   COOCH.sub.2 CCH                                                                          OMe OMe  N                                           2590                                                                              Q.sub.1 Cl   COOMe     Me  OMe  CH                                          2591                                                                              Q.sub.1 Cl   COOMe     OMe OMe  CH                                          2592                                                                              Q.sub.1 Cl   COOMe     Me  OMe  N                                           2593                                                                              Q.sub.1 Et   COOMe     Me  OMe  CH                                          2594                                                                              Q.sub.1 Et   COOMe     OMe OMe  CH                                          2595                                                                              Q.sub.1 Et   COOMe     Me  OMe  N                                           2596                                                                              Q.sub.1 Me   CONMe.sub.2                                                                              Me  OMe  CH                                          2597                                                                              Q.sub.1 Me   CONMe.sub.2                                                                              OMe OMe  CH                                          2598                                                                              Q.sub.1 Me   CONMe.sub.2                                                                              Me  OMe  N                                           2599                                                                              Q.sub.1 Me   SMe       Me  OMe  CH                                          2600                                                                              Q.sub.1 Me   SMe       OMe OMe  CH                                          2601                                                                              Q.sub.1 Me   SMe       Me  OMe  N                                           2602                                                                              Q.sub.1 Me   SOMe      Me  OMe  CH                                          2603                                                                              Q.sub.1 Me   SOMe      OMe OMe  CH                                          2604                                                                              Q.sub.1 Me   SOMe      Me  OMe  N                                           2605                                                                              Q.sub.1 Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          2606                                                                              Q.sub.1 Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          2607                                                                              Q.sub.1 Me   SO.sub.2 Me                                                                              Me  OMe  N                                           2608                                                                              Q.sub.1 Me   SO.sub.2 Et                                                                              Me  OMe  CH                                          2609                                                                              Q.sub.1 Me   SO.sub.2 Et                                                                              OMe OMe  CH                                          2610                                                                              Q.sub.1 Me   SO.sub.2 Et                                                                              Me  OMe  N                                           2611                                                                              Q.sub.1 Me   SO.sub.2 Prn                                                                             Me  Me   CH                                          2612                                                                              Q.sub.1 Me   SO.sub.2 Prn                                                                             Me  OMe  CH                                          2613                                                                              Q.sub.1 Me   SO.sub.2 Prn                                                                             OMe OMe  CH                                          2614                                                                              Q.sub.1 Me   SO.sub.2 Prn                                                                             Me  OMe  N                                           2615                                                                              Q.sub.1 Me   SO.sub.2 Prn                                                                             OMe OMe  N                                           2616                                                                              Q.sub.1 Me   SO.sub.2 Ph                                                                              Me  OMe  CH                                          2617                                                                              Q.sub.1 Me   SO.sub.2 Ph                                                                              OMe OMe  CH                                          2618                                                                              Q.sub.1 Me   SO.sub.2 Ph                                                                              Me  OMe  N                                           2619                                                                              Q.sub.1 Me   SO.sub.2 CH.sub.2 CF.sub.3                                                               Me  OMe  CH                                          2620                                                                              Q.sub.1 Me   SO.sub.2 CH.sub.2 CF.sub.3                                                               OMe OMe  CH                                          2621                                                                              Q.sub.1 Me   SO.sub.2 CH.sub.2 CF.sub.3                                                               Me  OMe  N                                           2622                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.3                                                                        Me  OMe  CH                                          2623                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.3                                                                        OMe OMe  CH                                          2624                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.3                                                                        Me  OMe  N                                           2625                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CHCH.sub.2                                                             Me  OMe  CH                                          2626                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CHCH.sub.2                                                             OMe OMe  CH                                          2627                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CHCH.sub.2                                                             Me  OMe  N                                           2628                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CCH                                                                    Me  OMe  CH                                          2629                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CCH                                                                    OMe OMe  CH                                          2630                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 C CH                                                                   Me  OMe  N                                           2631                                                                              Q.sub.1 Me   SO.sub.3 CH.sub.2 CCH                                                                    Me  OMe  CH                                          2632                                                                              Q.sub.1 Me   SO.sub.2 NMe.sub.2                                                                       OMe OMe  CH                                          2633                                                                              Q.sub.1 Me   SO.sub.2 NMe.sub.2                                                                       Me  OMe  N                                           2634                                                                              Q.sub.1 Me   CN        Me  OMe  CH                                          2635                                                                              Q.sub.1 Me   CN        OMe OMe  CH                                          2636                                                                              Q.sub.1 Me   CN        Me  OMe  N                                           2637                                                                              Q.sub.1 Me   OH        Me  OMe  CH                                          2638                                                                              Q.sub.1 Me   OH        OMe OMe  CH                                          2639                                                                              Q.sub.1 Me   OH        Me  OMe  N                                           2640                                                                              Q.sub.1 Ph   COOMe     Me  Me   CH                                          2641                                                                              Q.sub.1 Ph   COOMe     Me  OMe  CH                                          2642                                                                              Q.sub.1 Ph   COOMe     OMe OMe  CH                                          2643                                                                              Q.sub.1 Ph   COOMe     Me  OMe  N                                           2644                                                                              Q.sub.1 Ph   COOMe     OMe OMe  N                                           2645                                                                              Q.sub.1 Me   Ph        Me  OMe  CH                                          2646                                                                              Q.sub.1 Me   Ph        OMe OMe  CH                                          2647                                                                              Q.sub.1 Me   Ph        Me  OMe  N                                           2648                                                                              Q.sub.1 COOMe                                                                               Me        Me  Me   CH                                          2649                                                                              Q.sub.1 COOMe                                                                               Me        Me  OMe  CH                                          2650                                                                              Q.sub.1 COOMe                                                                               Me        OMe OMe  CH                                          2651                                                                              Q.sub.1 COOMe                                                                               Me        Me  OMe  N                                           2652                                                                              Q.sub. 1                                                                               COOMe                                                                               Me        OMe OMe  N                                           2653                                                                              H       Q.sub.1                                                                             Me        Me  Me   CH                                          2654                                                                              H       Q.sub.1                                                                             Me        Me  OMe  CH                                          2655                                                                              H       Q.sub.1                                                                             Me        OMe OMe  CH                                          2656                                                                              H       Q.sub.1                                                                             Me        Me  OMe  N                                           2657                                                                              H       Q.sub.1                                                                             Me        OMe OMe  N                                           2658                                                                              H       Q.sub.1                                                                             Cl        Me  Me   CH                                          2659                                                                              H       Q.sub.1                                                                             Cl        Me  OMe  CH                                          2660                                                                              H       Q.sub.1                                                                             Cl        OMe OMe  CH                                          2661                                                                              H       Q.sub.1                                                                             Cl        Me  OMe  N                                           2662                                                                              H       Q.sub.1                                                                             Cl        OMe OMe  N                                           2663                                                                              H       Q.sub.1                                                                             OMe       Me  Me   CH                                          2664                                                                              H       Q.sub.1                                                                             OMe       Me  OMe  CH                                          2665                                                                              H       Q.sub.1                                                                             OMe       OMe OMe  CH                                          2666                                                                              H       Q.sub.1                                                                             OMe       Me  OMe  N                                           2667                                                                              H       Q.sub.1                                                                             OMe       OMe OMe  N                                           2668                                                                              H       Q.sub.1                                                                             COOMe     Me  Me   CH                                          2669                                                                              H       Q.sub.1                                                                             COOMe     Me  OMe  CH                                          2670                                                                              H       Q.sub.1                                                                             COOMe     OMe OMe  CH                                          2671                                                                              H       Q.sub.1                                                                             COOMe     Me  OMe  N                                           2672                                                                              H       Q.sub.1                                                                             COOMe     OMe OMe  N                                           2673                                                                              H       Q.sub.1                                                                             SO.sub.2 Me                                                                              Me  Me   CH                                          2674                                                                              H       Q.sub.1                                                                             SO.sub.2 Me                                                                              Me  OMe  CH                                          2675                                                                              H       Q.sub.1                                                                             SO.sub.2 Me                                                                              OMe OMe  CH                                          2676                                                                              H       Q.sub.1                                                                             SO.sub.2 Me                                                                              Me  OMe  N                                           2677                                                                              H       Q.sub.1                                                                             SO.sub.2 Me                                                                              OMe OMe  N                                           2678                                                                              Me      Q.sub.1                                                                             Me        Me  Me   CH                                          2679                                                                              Me      Q.sub.1                                                                             Me        Me  OMe  CH                                          2680                                                                              Me      Q.sub.1                                                                             Me        OMe OMe  CH                                          2681                                                                              Me      Q.sub.1                                                                             Me        Me  OMe  N                                           2682                                                                              Me      Q.sub.1                                                                             Me        OMe OMe  N                                           2683                                                                              Me      Q.sub.1                                                                             Cl        Me  Me   CH                                          2684                                                                              Me      Q.sub.1                                                                             Cl        Me  OMe  CH                                          2685                                                                              Me      Q.sub.1                                                                             Cl        OMe OMe  CH                                          2686                                                                              Me      Q.sub.1                                                                             Cl        Me  OMe  N                                           2687                                                                              Me      Q.sub.1                                                                             Cl        OMe OMe  N                                           2688                                                                              Me      Q.sub.1                                                                             OMe       Me  Me   CH                                          2689                                                                              Me      Q.sub.1                                                                             OMe       Me  OMe  CH                                          2690                                                                              Me      Q.sub.1                                                                             OMe       OMe OMe  CH                                          2691                                                                              Me      Q.sub.1                                                                             OMe       Me  OMe  N                                           2692                                                                              Me      Q.sub.1                                                                             OMe       OMe OMe  N                                           2693                                                                              Me      Q.sub.1                                                                             COOMe     Me  Me   CH                                          2694                                                                              Me      Q.sub.1                                                                             COOMe     Me  OMe  CH                                          2695                                                                              Me      Q.sub.1                                                                             COOMe     OMe OMe  CH                                          2696                                                                              Me      Q.sub.1                                                                             COOMe     Me  OMe  N                                           2697                                                                              Me      Q.sub.1                                                                             COOMe     OMe OMe  N                                           2698                                                                              Me      Q.sub.1                                                                             COOEt     Me  OMe  CH                                          2699                                                                              Me      Q.sub.1                                                                             COOEt     OMe OMe  CH                                          2700                                                                              Me      Q.sub.1                                                                             COOEt     Me  OMe  N                                           2701                                                                              Me      Q.sub.1                                                                             SMe       Me  OMe  CH                                          2702                                                                              Me      Q.sub.1                                                                             SMe       OMe OMe  CH                                          2703                                                                              Me      Q.sub.1                                                                             SMe       Me  OMe  N                                           2704                                                                              Me      Q.sub.1                                                                             SO.sub.2 Me                                                                              Me  OMe  CH                                          2705                                                                              Me      Q.sub.1                                                                             SO.sub.2 Me                                                                              OMe OMe  CH                                          2706                                                                              Me      Q.sub.1                                                                             SO.sub.2 Me                                                                              Me  OMe  N                                           2707                                                                              Me      Q.sub.1                                                                             SO.sub.2 Et                                                                              Me  OMe  CH                                          2708                                                                              Me      Q.sub.1                                                                             SO.sub.2 Et                                                                              OMe OMe  CH                                          2709                                                                              Me      Q.sub.1                                                                             SO.sub.2 Et                                                                              Me  OMe  N                                           2710                                                                              Me      Q.sub.1                                                                             SO.sub.2 Prn                                                                             Me  OMe  CH                                          2711                                                                              Me      Q.sub.1                                                                             SO.sub.2 Prn                                                                             OMe OMe  CH                                          2712                                                                              Me      Q.sub.1                                                                             SO.sub.2 Prn                                                                             Me  OMe  N                                           2713                                                                              Me      Q.sub.1                                                                             SO.sub.2 Pri                                                                             Me  OMe  CH                                          2714                                                                              Me      Q.sub.1                                                                             SO.sub.2 Pri                                                                             OMe OMe  CH                                          2715                                                                              Me      Q.sub.1                                                                             SO.sub.2 Pri                                                                             Me  OMe  N                                           2716                                                                              Me      Q.sub.1                                                                             Br        Me  Me   CH                                          2717                                                                              Me      Q.sub.1                                                                             Br        Me  OMe  CH                                          2718                                                                              Me      Q.sub.1                                                                             Br        OMe OMe  CH                                          2719                                                                              Me      Q.sub.1                                                                             Br        Me  OMe  N                                           2720                                                                              Me      Q.sub.1                                                                             Br        OMe OMe  N                                           2721                                                                              Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       Me  Me   CH                                          2722                                                                              Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       Me  OMe  CH                                          2723                                                                              Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       OMe OMe  CH                                          2724                                                                              Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       Me  OMe  N                                           2725                                                                              Me      Q.sub.1                                                                             SO.sub.2 NMe.sub.2                                                                       OMe OMe  N                                           2726                                                                              Me      Q.sub.1                                                                             Ph        Me  Me   CH                                          2727                                                                              Me      Q.sub.1                                                                             Ph        Me  OMe  CH                                          2728                                                                              Me      Q.sub.1                                                                             Ph        OMe OMe  CH                                          2729                                                                              Me      Q.sub.1                                                                             Ph        Me  OMe  N                                           2730                                                                              Me      Q.sub.1                                                                             Ph        OMe OMe  N                                           2731                                                                              Me      Q.sub.1                                                                             Ph2-Cl    Me  OMe  CH                                          2732                                                                              Me      Q.sub.1                                                                             Ph2-Cl    OMe OMe  CH                                          2733                                                                              Me      Q.sub.1                                                                             Ph2-Cl    Me  OMe  N                                           2734                                                                              Me      Q.sub.1                                                                             Ph2-Me    Me  OMe  CH                                          2735                                                                              Me      Q.sub.1                                                                             Ph2-Me    OMe OMe  CH                                          2736                                                                              Me      Q.sub.1                                                                             Ph2-Me    Me  OMe  N                                           2737                                                                              Me      Q.sub.1                                                                             Ph2-NO.sub.2                                                                             Me  OMe  CH                                          2738                                                                              Me      Q.sub.1                                                                             Ph2-NO.sub.2                                                                             OMe OMe  CH                                          2739                                                                              Me      Q.sub.1                                                                             Ph2-NO.sub.2                                                                             Me  OMe  N                                           2740                                                                              Me      Q.sub.1                                                                             Ph4-Cl    Me  OMe  CH                                          2741                                                                              Me      Q.sub.1                                                                             Ph4-Cl    OMe OMe  CH                                          2742                                                                              Me      Q.sub.1                                                                             Ph4-Cl    Me  OMe  N                                           2743                                                                              Et      Q.sub.1                                                                             Me        Me  OMe  CH                                          2744                                                                              Et      Q.sub.1                                                                             Me        OMe OMe  CH                                          2745                                                                              Et      Q.sub.1                                                                             Me        Me  OMe  N                                           2746                                                                              CH.sub.2 CHCH.sub.2                                                                    Q.sub.1                                                                             Me        Me  OMe  CH                                          2747                                                                              CH.sub.2 CHCH.sub.2                                                                    Q.sub.1                                                                             Me        OMe OMe  CH                                          2748                                                                              CH.sub.2 CHCH.sub.2                                                                    Q.sub.1                                                                             Me        Me  OMe  N                                           2749                                                                              CH.sub.2 CCH                                                                           Q.sub.1                                                                             Me        Me  OMe  CH                                          2750                                                                              CH.sub.2 CCH                                                                           Q.sub.1                                                                             Me        OMe OMe  CH                                          2751                                                                              CH.sub.2 CCH                                                                           Q.sub.1                                                                             Me        Me  OMe  N                                           2752                                                                              CH.sub.2 CN                                                                            Q.sub.1                                                                             Me        Me  OMe  CH                                          2753                                                                              CH.sub.2 CN                                                                            Q.sub.1                                                                             Me        OMe OMe  CH                                          2754                                                                              CH.sub.2 CN                                                                            Q.sub.1                                                                             Me        Me  OMe  N                                           2755                                                                              CH.sub.2 OMe                                                                           Q.sub.1                                                                             Me        Me  OMe  CH                                          2756                                                                              CH.sub.2 OMe                                                                           Q.sub.1                                                                             Me        OMe OMe  CH                                          2757                                                                              CH.sub.2 OMe                                                                           Q.sub.1                                                                             Me        Me  OMe  N                                           2758                                                                              Ph      Q.sub.1                                                                             Me        Me  OME  CH                                          2759                                                                              Ph      Q.sub.1                                                                             Me        OMe OMe  CH                                          2760                                                                              Ph      Q.sub.1                                                                             Me        Me  OMe  N                                           2761                                                                              Me      Me   Q.sub.1   Me  Me   CH                                          2762                                                                              Me      Me   Q.sub.1   Me  OMe  CH                                          2763                                                                              Me      Me   Q.sub.1   OMe OMe  CH                                          2764                                                                              Me      Me   Q.sub.1   Me  OMe  N                                           2765                                                                              Me      Me   Q.sub.1   OMe OMe  N                                           2766                                                                              Me      Cl   Q.sub.1   Me  Me   CH                                          2767                                                                              Me      Cl   Q.sub.1   Me  OMe  CH                                          2768                                                                              Me      Cl   Q.sub.1   OMe OMe  CH                                          2769                                                                              Me      Cl   Q.sub.1   Me  OMe  N                                           2770                                                                              Me      Cl   Q.sub.1   OMe OMe  N                                           2771                                                                              Me      OMe  Q.sub.1   Me  OMe  CH                                          2772                                                                              Me      OMe  Q.sub.1   OMe OMe  CH                                          2773                                                                              Me      OMe  Q.sub.1   Me  OMe  N                                           2774                                                                              Me      COOMe                                                                               Q.sub.1   Me  Me   CH                                          2775                                                                              Me      COOMe                                                                               Q.sub.1   Me  OMe  CH                                          2776                                                                              Me      COOMe                                                                               Q.sub.1   OMe OMe  CH                                          2777                                                                              Me      COOMe                                                                               Q.sub.1   Me  OMe  N                                           2778                                                                              Me      COOMe                                                                               Q.sub.1   OMe OMe  N                                           2779                                                                              Me      SMe  Q.sub.1   Me  OMe  CH                                          2780                                                                              Me      SMe  Q.sub.1   OMe OMe  CH                                          2781                                                                              Me      SMe  Q.sub.1   Me  OMe  N                                           2782                                                                              Me      SO.sub.2 Me                                                                         Q.sub.1   Me  OMe  CH                                          2783                                                                              Me      SO.sub.2 Me                                                                         Q.sub.1   OMe OMe  CH                                          2784                                                                              Me      SO.sub.2 Me                                                                         Q.sub.1   Me  OMe  N                                           2785                                                                              Me      Ph   Q.sub.1   Me  Me   CH                                          2786                                                                              Me      Ph   Q.sub.1   Me  OMe  CH                                          2787                                                                              Me      Ph   Q.sub.1   OMe OMe  CH                                          2788                                                                              Me      Ph   Q.sub.1   Me  OMe  N                                           2789                                                                              Me      Ph   Q.sub.1   OMe OMe  N                                           2790                                                                              Me      Ph2-Cl                                                                              Q.sub.1   Me  OMe  CH                                          2791                                                                              Me      Ph2-Cl                                                                              Q.sub.1   OMe OMe  CH                                          2792                                                                              Me      Ph2-Cl                                                                              Q.sub.1   Me  OMe  N                                           2793                                                                              Ph      Me   Q.sub.1   Me  OMe  CH                                          2794                                                                              Ph      Me   Q.sub.1   OMe OMe  CH                                          2795                                                                              Ph      Me   Q.sub.1   Me  OMe  N                                           2796                                                                              Q.sub.2 Me   Cl        Me  Me   CH                                          2797                                                                              Q.sub.2 Me   Cl        Me  OMe  CH                                          2798                                                                              Q.sub.2 Me   Cl        OMe OMe  CH                                          2799                                                                              Q.sub.2 Me   Cl        Me  OMe  N                                           2800                                                                              Q.sub.2 Me   Cl        OMe OMe  N                                           2801                                                                              Q.sub.2 Me   OMe       Me  OMe  CH                                          2802                                                                              Q.sub.2 Me   OMe       OMe OMe  CH                                          2803                                                                              Q.sub.2 Me   OMe       Me  OMe  N                                           2804                                                                              Q.sub.2 CF.sub.3                                                                            Me        Me  OMe  CH                                          2805                                                                              Q.sub.2 CF.sub.3                                                                            Me        OMe OMe  CH                                          2806                                                                              Q.sub.2 CF.sub.3                                                                            Me        Me  OMe  N                                           2807                                                                              Q.sub.2 Me   COOMe     Me  Me   CH                                          2808                                                                              Q.sub.2 Me   COOMe     Me  OMe  CH                                          2809                                                                              Q.sub.2 Me   COOMe     OMe OMe  CH                                          2810                                                                              Q.sub.2 Me   COOMe     Me  OMe  N                                           2811                                                                              Q.sub.2 Me   COOMe     OMe OMe  N                                           2812                                                                              Q.sub.2 Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          2813                                                                              Q.sub.2 Me   COOMe     Me                                                                                  ##STR21##                                                                          CH                                          2814                                                                              Q.sub.2 Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          2815                                                                              Q.sub.2 Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          2816                                                                              Q.sub.2 Me   SO.sub.2 Me                                                                              Me  OMe  N                                           2817                                                                              H       Q.sub.2                                                                             Me        Me  OMe  CH                                          2818                                                                              H       Q.sub.2                                                                             Me        OMe OMe  CH                                          2819                                                                              H       Q.sub.2                                                                             Me        Me  OMe  N                                           2820                                                                              Me      Q.sub.2                                                                             Me        Me  OMe  CH                                          2821                                                                              Me      Q.sub.2                                                                             Me        OMe OMe  CH                                          2822                                                                              Me      Q.sub.2                                                                             Me        Me  OMe  N                                           2823                                                                              Me      Q.sub.2                                                                             Cl        Me  OMe  CH                                          2824                                                                              Me      Q.sub.2                                                                             Cl        OMe OMe  CH                                          2825                                                                              Me      Q.sub.2                                                                             Cl        Me  OMe  N                                           2826                                                                              Me      Q.sub.2                                                                             COOMe     Me  OMe  CH                                          2827                                                                              Me      Q.sub.2                                                                             COOMe     OMe OMe  CH                                          2828                                                                              Me      Q.sub.2                                                                             COOMe     Me  OMe  N                                           2829                                                                              Me      Q.sub.2                                                                             Ph        Me  OMe  CH                                          2830                                                                              Me      Q.sub.2                                                                             Ph        OMe OMe  CH                                          2831                                                                              Me      Q.sub.2                                                                             Ph        Me  OMe  N                                           2832                                                                              Me      Me   Q.sub.2   Me  OMe  CH                                          2833                                                                              Me      Me   Q.sub.2   OMe OMe  CH                                          2834                                                                              Me      Me   Q.sub.2   Me  OMe  N                                           2835                                                                              Q.sub.3 Me   COOMe     Me  Me   CH                                          2836                                                                              Q.sub.3 Me   COOMe     Me  OMe  CH                                          2837                                                                              Q.sub.3 Me   COOMe     OMe OMe  CH                                          2838                                                                              Q.sub.3 Me   COOMe     Me  OMe  N                                           2839                                                                              Q.sub.3 Me   COOMe     OMe OMe  N                                           2840                                                                              Me      Q.sub.3                                                                             Me        Me  OMe  CH                                          2841                                                                              Me      Q.sub.3                                                                             Me        OMe OMe  CH                                          2842                                                                              Me      Q.sub.3                                                                             Me        Me  OMe  N                                           2843                                                                              Me      Me   Q.sub.3   Me  OMe  CH                                          2844                                                                              Me      Me   Q.sub.3   OMe OMe  CH                                          2845                                                                              Me      Me   Q.sub.3   Me  OMe  N                                           2846                                                                              Q.sub.4 Me   COOMe     Me  Me   CH                                          2847                                                                              Q.sub.4 Me   COOMe     Me  OMe  CH                                          2848                                                                              Q.sub.4 Me   COOMe     OMe OMe  CH                                          2849                                                                              Q.sub.4 Me   COOMe     Me  OMe  N                                           2850                                                                              Q.sub.4 Me   COOMe     OMe OMe  N                                           2851                                                                              Me      Q.sub.4                                                                             Me        Me  OMe  CH                                          2852                                                                              Me      Q.sub.4                                                                             Me        OMe OMe  CH                                          2853                                                                              Me      Q.sub.4                                                                             Me        Me  OMe  N                                           2854                                                                              Me      Me   Q.sub.4   OMe OMe  CH                                          2855                                                                              Me      Me   Q.sub.4   Me  OMe  CH                                          2856                                                                              Me      Me   Q.sub.4   Me  OMe  N                                           2857                                                                              Q.sub.5 Me   Cl        Me  Me   CH                                          2858                                                                              Q.sub.5 Me   Cl        Me  OMe  CH                                          2859                                                                              Q.sub.5 Me   Cl        OMe OMe  CH                                          2860                                                                              Q.sub.5 Me   Cl        Me  OMe  N                                           2861                                                                              Q.sub.5 Me   Cl        OMe OMe  N                                           2862                                                                              Q.sub.5 Me   OMe       Me  OMe  CH                                          2863                                                                              Q.sub.5 Me   OMe       OMe OMe  CH                                          2864                                                                              Q.sub.5 Me   OMe       Me  OMe  N                                           2865                                                                              Q.sub.5 CF.sub.3                                                                            Me        Me  OMe  CH                                          2866                                                                              Q.sub.5 CF.sub.3                                                                            Me        OMe OMe  CH                                          2867                                                                              Q.sub.5 CF.sub.3                                                                            Me        Me  OMe  N                                           2868                                                                              Q.sub.5 Me   COOMe     Me  Me   CH                                          2869                                                                              Q.sub.5 Me   COOMe     Me  OMe  CH                                          2870                                                                              Q.sub.5 Me   COOMe     OMe OMe  CH                                          2871                                                                              Q.sub.5 Me   COOMe     Me  OMe  N                                           2872                                                                              Q.sub.5 Me   COOMe     OMe OMe  N                                           2873                                                                              Q.sub.5 Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          2874                                                                              Q.sub.5 Me   COOMe     Me                                                                                  ##STR22##                                                                          CH                                          2875                                                                              Q.sub.5 Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          2876                                                                              Q.sub.5 Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          2877                                                                              Q.sub.5 Me   SO.sub.2 Me                                                                              Me  OMe  N                                           2878                                                                              H       Q.sub.5                                                                             Me        Me  OMe  CH                                          2879                                                                              H       Q.sub.5                                                                             Me        OMe OMe  CH                                          2880                                                                              H       Q.sub.5                                                                             Me        Me  OMe  N                                           2881                                                                              Me      Q.sub.5                                                                             Me        Me  OMe  CH                                          2882                                                                              Me      Q.sub.5                                                                             Me        OMe OMe  CH                                          2883                                                                              Me      Q.sub.5                                                                             Me        Me  OMe  N                                           2884                                                                              Me      Q.sub.5                                                                             Cl        Me  OMe  CH                                          2885                                                                              Me      Q.sub.5                                                                             Cl        OMe OMe  CH                                          2886                                                                              Me      Q.sub.5                                                                             Cl        Me  OMe  N                                           2887                                                                              Me      Q.sub.5                                                                             COOMe     Me  OMe  CH                                          2888                                                                              Me      Q.sub.5                                                                             COOMe     OMe OMe  CH                                          2889                                                                              Me      Q.sub.5                                                                             COOMe     Me  OMe  N                                           2890                                                                              Me      Q.sub.5                                                                             Ph        Me  OMe  CH                                          2891                                                                              Me      Q.sub.5                                                                             Ph        OMe OMe  CH                                          2892                                                                              Me      Q.sub.5                                                                             Ph        Me  OMe  N                                           2893                                                                              Me      Me   Q.sub.5   Me  OMe  CH                                          2894                                                                              Me      Me   Q.sub.5   OMe OMe  CH                                          2895                                                                              Me      Me   Q.sub.5   Me  OMe  N                                           2896                                                                              Q.sub.6 Me   COOMe     Me  Me   CH                                          2897                                                                              Q.sub.6 Me   COOMe     Me  OMe  CH                                          2898                                                                              Q.sub.6 Me   COOMe     OMe OMe  CH                                          2899                                                                              Q.sub.6 Me   COOMe     Me  OMe  N                                           2900                                                                              Q.sub.6 Me   COOMe     OMe OMe  N                                           2901                                                                              Me      Q.sub.6                                                                             Me        Me  OMe  CH                                          2902                                                                              Me      Q.sub.6                                                                             Me        OMe OMe  CH                                          2903                                                                              Me      Q.sub.6                                                                             Me        Me  OMe  N                                           2904                                                                              Me      Me   Q.sub.6   Me  OMe  CH                                          2905                                                                              Me      Me   Q.sub.6   OMe OMe  CH                                          2906                                                                              Me      Me   Q.sub.6   Me  OMe  N                                           2907                                                                              Q.sub.7 Me   COOMe     Me  OMe  CH                                          2908                                                                              Q.sub.7 Me   COOMe     OMe OMe  CH                                          2909                                                                              Q.sub.7 Me   COOMe     Me  OMe  N                                           2910                                                                              Me      Me   Q.sub.7   OMe OMe  CH                                          2911                                                                              Me      Me   Q.sub.7   Me  OMe  N                                           2912                                                                              Q.sub.8 Me   Cl        Me  Me   CH                                          2913                                                                              Q.sub.8 Me   Cl        Me  OMe  CH                                          2914                                                                              Q.sub.8 Me   Cl        OMe OMe  CH                                          2915                                                                              Q.sub.8 Me   Cl        Me  OMe  N                                           2916                                                                              Q.sub.8 Me   Cl        OMe OMe  N                                           2917                                                                              Q.sub.8 Me   OMe       Me  OMe  CH                                          2918                                                                              Q.sub.8 Me   OMe       OMe OMe  CH                                          2919                                                                              Q.sub.8 Me   OMe       Me  OMe  N                                           2920                                                                              Q.sub.8 CF.sub.3                                                                            Me        Me  OMe  CH                                          2921                                                                              Q.sub.8 CF.sub.3                                                                            Me        OMe OMe  CH                                          2922                                                                              Q.sub.8 CF.sub.3                                                                            Me        Me  OMe  N                                           2923                                                                              Q.sub.8 Me   COOMe     Me  Me   CH                                          2924                                                                              Q.sub.8 Me   COOMe     Me  OMe  CH                                          2925                                                                              Q.sub.8 Me   COOMe     OMe OMe  CH                                          2926                                                                              Q.sub.8 Me   COOMe     Me  OMe  N                                           2927                                                                              Q.sub.8 Me   COOMe     OMe OMe  N                                           2928                                                                              Q.sub.8 Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          2929                                                                              Q.sub.8 Me   COOMe     Me                                                                                  ##STR23##                                                                          CH                                          2930                                                                              Q.sub.8 Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          2931                                                                              Q.sub.8 Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          2932                                                                              Q.sub.8 Me   SO.sub.2 Me                                                                              Me  OMe  N                                           2933                                                                              H       Q.sub.8                                                                             Me        Me  OMe  CH                                          2934                                                                              H       Q.sub.8                                                                             Me        OMe OMe  CH                                          2935                                                                              H       Q.sub.8                                                                             Me        Me  OMe  N                                           2936                                                                              Me      Q.sub.8                                                                             Me        Me  OMe  CH                                          2937                                                                              Me      Q.sub.8                                                                             Me        OMe OMe  CH                                          2938                                                                              Me      Q.sub.8                                                                             Me        Me  OMe  N                                           2939                                                                              Me      Q.sub.8                                                                             Cl        Me  OMe  CH                                          2940                                                                              Me      Q.sub.8                                                                             Cl        OMe OMe  CH                                          2941                                                                              Me      Q.sub.8                                                                             Cl        Me  OMe  N                                           2942                                                                              Me      Q.sub.8                                                                             COOMe     Me  OMe  CH                                          2943                                                                              Me      Q.sub.8                                                                             COOMe     OMe OMe  CH                                          2944                                                                              Me      Q.sub.8                                                                             COOMe     Me  OMe  N                                           2945                                                                              Me      Q.sub.8                                                                             Ph        Me  OMe  CH                                          2946                                                                              Me      Q.sub.8                                                                             Ph        OMe OMe  CH                                          2947                                                                              Me      Q.sub.8                                                                             Ph        Me  OMe  N                                           2948                                                                              Me      Me   Q.sub.8   Me  OMe  CH                                          2949                                                                              Me      Me   Q.sub.8   OMe OMe  CH                                          2950                                                                              Me      Me   Q.sub.8   Me  OMe  N                                           2951                                                                              Q.sub.9 Me   COOMe     Me  Me   CH                                          2952                                                                              Q.sub.9 Me   COOMe     Me  OMe  CH                                          2953                                                                              Q.sub.9 Me   COOMe     OMe OMe  CH                                          2954                                                                              Q.sub.9 Me   COOMe     Me  OMe  N                                           2955                                                                              Q.sub.9 Me   COOMe     OMe OMe  N                                           2956                                                                              Me      Q.sub.9                                                                             Me        Me  OMe  CH                                          2957                                                                              Me      Q.sub.9                                                                             Me        OMe OMe  CH                                          2958                                                                              Me      Q.sub.9                                                                             Me        Me  OMe  N                                           2959                                                                              Me      Me   Q.sub.9   Me  OMe  CH                                          2960                                                                              Me      Me   Q.sub.9   OMe OMe  CH                                          2961                                                                              Me      Me   Q.sub.9   Me  OMe  N                                           2962                                                                              Q.sub.10                                                                               Me   COOMe     Me  Me   CH                                          2963                                                                              Q.sub.10                                                                               Me   COOMe     Me  OMe  CH                                          2964                                                                              Q.sub.10                                                                               Me   COOMe     OMe OMe  CH                                          2965                                                                              Q.sub.10                                                                               Me   COOMe     Me  OMe  N                                           2966                                                                              Q.sub.10                                                                               Me   COOMe     OMe OMe  N                                           2967                                                                              Me      Q.sub.10                                                                            Me        Me  OMe  CH                                          2968                                                                              Me      Q.sub.10                                                                            Me        OMe OMe  CH                                          2969                                                                              Me      Q.sub.10                                                                            Me        Me  OMe  N                                           2970                                                                              Me      Me   Q.sub.10  Me  OMe  CH                                          2971                                                                              Me      Me   Q.sub.10  OMe OMe  CH                                          2972                                                                              Me      Me   Q.sub.10  Me  OMe  N                                           2973                                                                              Q.sub.11                                                                               Me   COOMe     Me  Me   CH                                          2974                                                                              Q.sub.11                                                                               Me   COOMe     Me  OMe  CH                                          2975                                                                              Q.sub.11                                                                               Me   COOMe     OMe OMe  CH                                          2976                                                                              Q.sub.11                                                                               Me   COOMe     Me  OMe  N                                           2977                                                                              Q.sub.11                                                                               Me   COOMe     OMe OMe  N                                           2978                                                                              Me      Q.sub. 11                                                                           Me        Me  OMe  CH                                          2979                                                                              Me      Q.sub.11                                                                            Me        OMe OMe  CH                                          2980                                                                              Me      Q.sub.11                                                                            Me        Me  OMe  N                                           2981                                                                              Me      Me   Q.sub.11  Me  OMe  CH                                          2982                                                                              Me      Me   Q.sub.11  OMe OMe  CH                                          2983                                                                              Me      Me   Q.sub.11  Me  OMe  N                                           2984                                                                              Q.sub.12                                                                               Me   COOMe     Me  Me   CH                                          2985                                                                              Q.sub.12                                                                               Me   COOMe     Me  OMe  CH                                          2986                                                                              Q.sub.12                                                                               Me   COOMe     OMe OMe  CH                                          2987                                                                              Q.sub.12                                                                               Me   COOMe     Me  OMe  N                                           2988                                                                              Q.sub.12                                                                               Me   COOMe     OMe OMe  N                                           2989                                                                              Me      Q.sub.12                                                                            Me        Me  OMe  CH                                          2990                                                                              Me      Q.sub.12                                                                            Me        OMe OMe  CH                                          2991                                                                              Me      Q.sub.12                                                                            Me        Me  OMe  N                                           2992                                                                              Me      Me   Q.sub.12  Me  OMe  CH                                          2993                                                                              Me      Me   Q.sub.12  OMe OMe  CH                                          2994                                                                              Me      Me   Q.sub.12  Me  OMe  N                                           2995                                                                              Q.sub.13                                                                               Me   COOMe     Me  OMe  CH                                          2996                                                                              Q.sub.13                                                                               Me   COOMe     OMe OMe  CH                                          2997                                                                              Q.sub.13                                                                               Me   COOMe     Me  OMe  N                                           2998                                                                              Me      Me   Q.sub.13  OMe OMe  CH                                          2999                                                                              Me      Me   Q.sub.13  Me  OMe  N                                           3000                                                                              Q.sub.14                                                                               Me   COOMe     Me  Me   CH                                          3001                                                                              Q.sub.14                                                                               Me   COOMe     Me  OMe  CH                                          3002                                                                              Q.sub.14                                                                               Me   COOMe     OMe OMe  CH                                          3003                                                                              Q.sub.14                                                                               Me   COOMe     Me  OMe  N                                           3004                                                                              Q.sub.14                                                                               Me   COOMe     OMe OMe  N                                           3005                                                                              Me      Q.sub.14                                                                            Me        Me  OMe  CH                                          3006                                                                              Me      Q.sub.14                                                                            Me        OMe OMe  CH                                          3007                                                                              Me      Q.sub.14                                                                            Me        Me  OMe  N                                           3008                                                                              Me      Me   Q.sub.14  Me  OMe  CH                                          3009                                                                              Me      Me   Q.sub.14  OMe OMe  CH                                          3010                                                                              Me      Me   Q.sub.14  Me  OMe  N                                           3011                                                                              Q.sub.15                                                                               Me   COOMe     Me  Me   CH                                          3012                                                                              Q.sub.15                                                                               Me   COOMe     Me  OMe  CH                                          3013                                                                              Q.sub.15                                                                               Me   COOMe     OMe OMe  CH                                          3014                                                                              Q.sub.15                                                                               Me   COOMe     Me  OMe  N                                           3015                                                                              Q.sub.15                                                                               Me   COOMe     OMe OMe  N                                           3016                                                                              Me      Q.sub.15                                                                            Me        Me  OMe  CH                                          3017                                                                              Me      Q.sub.15                                                                            Me        OMe OMe  CH                                          3018                                                                              Me      Q.sub.15                                                                            Me        Me  OMe  N                                           3019                                                                              Me      Me   Q.sub.15  Me  OMe  CH                                          3020                                                                              Me      Me   Q.sub.15  OMe OMe  CH                                          3021                                                                              Me      Me   Q.sub.15  Me  OMe  N                                           3022                                                                              Q.sub.16                                                                               Me   COOMe     Me  Me   CH                                          3023                                                                              Q.sub.16                                                                               Me   COOMe     Me  OMe  CH                                          3024                                                                              Q.sub.16                                                                               Me   COOMe     OMe OMe  CH                                          3025                                                                              Q.sub.16                                                                               Me   COOMe     Me  OMe  N                                           3026                                                                              Q.sub.16                                                                               Me   COOMe     OMe OMe  N                                           3027                                                                              Me      Q.sub.16                                                                            Me        Me  OMe  CH                                          3028                                                                              Me      Q.sub. 16                                                                           Me        OMe OMe  CH                                          3029                                                                              Me      Q.sub.16                                                                            Me        Me  OMe  N                                           3030                                                                              Me      Me   Q.sub.16  Me  OMe  CH                                          3031                                                                              Me      Me   Q.sub.16  OMe OMe  CH                                          3032                                                                              Me      Me   Q.sub.16  Me  OMe  N                                           3033                                                                              Q.sub.17                                                                               Me   COMe      Me  OMe  CH                                          3034                                                                              Q.sub.17                                                                               Me   COOMe     OMe OMe  CH                                          3035                                                                              Q.sub.17                                                                               Me   COOMe     Me  OMe  N                                           3036                                                                              Me      Me   Q.sub.17  OMe OMe  CH                                          3037                                                                              Me      Me   Q.sub.17  Me  OMe  N                                           3038                                                                              Q.sub.18                                                                               Me   COOMe     Me  Me   CH                                          3039                                                                              Q.sub.18                                                                               Me   COOMe     Me  OMe  CH                                          3040                                                                              Q.sub.18                                                                               Me   COOMe     OMe OMe  CH                                          3041                                                                              Q.sub.18                                                                               Me   COOMe     Me  OMe  N                                           3042                                                                              Q.sub.18                                                                               Me   COOMe     OMe OMe  N                                           3043                                                                              Me      Q.sub.18                                                                            Me        Me  OMe  CH                                          3044                                                                              Me      Q.sub.18                                                                            Me        OMe OMe  CH                                          3045                                                                              Me      Q.sub.18                                                                            Me        Me  OMe  N                                           3046                                                                              Me      Me   Q.sub.18  Me  OMe  CH                                          3047                                                                              Me      Me   Q.sub.18  OMe OMe  CH                                          3048                                                                              Me      Me   Q.sub.18  Me  OMe  N                                           3049                                                                              Q.sub.19                                                                               Me   COOMe     Me  Me   CH                                          3050                                                                              Q.sub.19                                                                               Me   COOMe     Me  OMe  CH                                          3051                                                                              Q.sub.19                                                                               Me   COOMe     OMe OMe  CH                                          3052                                                                              Q.sub.19                                                                               Me   COOMe     Me  OMe  N                                           3053                                                                              Q.sub.19                                                                               Me   COOMe     OMe OMe  N                                           3054                                                                              Me      Q.sub.19                                                                            Me        Me  OMe  CH                                          3055                                                                              Me      Q.sub.19                                                                            Me        OMe OMe  CH                                          3056                                                                              Me      Q.sub.19                                                                            Me        Me  OMe  N                                           3057                                                                              Me      Me   Q.sub.19  Me  OMe  CH                                          3058                                                                              Me      Me   Q.sub.19  OMe OMe  CH                                          3059                                                                              Me      Me   Q.sub.19  Me  OMe  N                                           3060                                                                              Q.sub.20                                                                               Me   COOMe     Me  Me   CH                                          3061                                                                              Q.sub.20                                                                               Me   COOMe     Me  OMe  CH                                          3062                                                                              Q.sub.20                                                                               Me   COOMe     OMe OMe  CH                                          3063                                                                              Q.sub.20                                                                               Me   COOMe     Me  OMe  N                                           3064                                                                              Q.sub.20                                                                               Me   COOMe     OMe OMe  N                                           3065                                                                              Me      Q.sub.20                                                                            Me        Me  OMe  CH                                          3066                                                                              Me      Q.sub.20                                                                            Me        OMe OMe  CH                                          3067                                                                              Me      Q.sub.20                                                                            Me        Me  OMe  N                                           3068                                                                              Me      Me   Q.sub.20  Me  OMe  CH                                          3069                                                                              Me      Me   Q.sub.20  OMe OMe  CH                                          3070                                                                              Me      Me   Q.sub.20  Me  OMe  N                                           3071                                                                              Q.sub.21                                                                               Me   COOMe     Me  Me   CH                                          3072                                                                              Q.sub.21                                                                               Me   COOMe     Me  OMe  CH                                          3073                                                                              Q.sub.21                                                                               Me   COOMe     OMe OMe  CH                                          3074                                                                              Q.sub.21                                                                               Me   COOMe     Me  OMe  N                                           3075                                                                              Q.sub.21                                                                               Me   COOMe     OMe OMe  N                                           3076                                                                              Me      Q.sub.21                                                                            Me        Me  OMe  CH                                          3077                                                                              Me      Q.sub.21                                                                            Me        OMe OMe  CH                                          3078                                                                              Me      Q.sub.21                                                                            Me        Me  OMe  N                                           3079                                                                              Me      Me   Q.sub.21  Me  OMe  CH                                          3080                                                                              Me      Me   Q.sub.21  OMe OMe  CH                                          3081                                                                              Me      Me   Q.sub.21  Me  OMe  N                                           3082                                                                              Q.sub.22                                                                               Me   COOMe     Me  Me   CH                                          3083                                                                              Q.sub.22                                                                               Me   COOMe     Me  OMe  CH                                          3084                                                                              Q.sub.22                                                                               Me   COOMe     OMe OMe  CH                                          3085                                                                              Q.sub.22                                                                               Me   COOMe     Me  OMe  N                                           3086                                                                              Q.sub.22                                                                               Me   COOMe     OMe OMe  N                                           3087                                                                              Me      Q.sub.22                                                                            Me        Me  OMe  CH                                          3088                                                                              Me      Q.sub.22                                                                            Me        OMe OMe  CH                                          3089                                                                              Me      Q.sub.22                                                                            Me        Me  OMe  N                                           3090                                                                              Me      Me   Q.sub.22  Me  OMe  CH                                          3091                                                                              Me      Me   Q.sub.22  OMe OMe  CH                                          3092                                                                              Me      Me   Q.sub.22  Me  OMe  N                                           3093                                                                              Q.sub.23                                                                               Me   COOMe     Me  OMe  CH                                          3094                                                                              Q.sub.23                                                                               Me   COOMe     OMe OMe  CH                                          3095                                                                              Q.sub.23                                                                               Me   COOMe     Me  OMe  N                                           3096                                                                              Me      Me   Q.sub.23  OMe OMe  CH                                          3097                                                                              Me      Me   Q.sub.23  Me  OMe  N                                           3098                                                                              Q.sub.24                                                                               Me   COOMe     Me  Me   CH                                          3099                                                                              Q.sub.24                                                                               Me   COOMe     Me  OMe  CH                                          3100                                                                              Q.sub.24                                                                               Me   COOMe     OMe OMe  CH                                          3101                                                                              Q.sub.242                                                                              Me   COOMe     Me  OMe  N                                           3102                                                                              Q.sub.24                                                                               Me   COOMe     OMe OMe  N                                           3103                                                                              Me      Q.sub.24                                                                            Me        Me  OMe  CH                                          3104                                                                              Me      Q.sub.24                                                                            Me        OMe OMe  CH                                          3105                                                                              Me      Q.sub.24                                                                            Me        Me  OMe  N                                           3106                                                                              Me      Me   Q.sub.24  Me  OMe  CH                                          3107                                                                              Me      Me   Q.sub.24  OMe OMe  CH                                          3108                                                                              Me      Me   Q.sub.24  Me  OMe  N                                           3109                                                                              Q.sub.25                                                                               Me   COOMe     Me  Me   CH                                          3110                                                                              Q.sub.25                                                                               Me   COOMe     Me  OMe  CH                                          3111                                                                              Q.sub.25                                                                               Me   COOMe     OMe OMe  CH                                          3112                                                                              Q.sub.25                                                                               Me   COOMe     Me  OMe  N                                           3113                                                                              Q.sub.25                                                                               Me   COOMe     OMe OMe  N                                           3114                                                                              Me      Q.sub.25                                                                            Me        Me  OMe  CH                                          3115                                                                              Me      Q.sub.25                                                                            Me        OMe OMe  CH                                          3116                                                                              Me      Q.sub.25                                                                            Me        Me  OMe  N                                           3117                                                                              Me      Me   Q.sub.25  Me  OMe  CH                                          3118                                                                              Me      Me   Q.sub.25  OMe OMe  CH                                          3119                                                                              Me      Me   Q.sub.25  Me  OMe  N                                           3120                                                                              Q.sub.26                                                                               Me   COOMe     Me  OMe  CH                                          3121                                                                              Q.sub.26                                                                               Me   COOMe     OMe OMe  CH                                          3122                                                                              Q.sub.26                                                                               Me   COOMe     Me  OMe  N                                           3123                                                                              Me      Me   Q.sub.26  OMe OMe  CH                                          3124                                                                              Me      Me   Q.sub.26  Me  OMe  N                                           3125                                                                              Q.sub.27                                                                               Me   COOMe     Me  OMe  CH                                          3126                                                                              Q.sub.27                                                                               Me   COOMe     OMe OMe  CH                                          3127                                                                              Q.sub.27                                                                               Me   COOMe     Me  OMe  N                                           3128                                                                              Me      Me   Q.sub.27  OMe OMe  CH                                          3129                                                                              Me      Me   Q.sub.27  Me  OMe  N                                           3130                                                                              Q.sub.28                                                                               Me   COOMe     Me  Me   CH                                          3131                                                                              Q.sub.28                                                                               Me   COOMe     Me  OMe  CH                                          3132                                                                              Q.sub.28                                                                               Me   COOMe     OMe OMe  CH                                          3133                                                                              Q.sub.28                                                                               Me   COOMe     Me  OMe  N                                           3134                                                                              Q.sub.28                                                                               Me   COOMe     OMe OMe  N                                           3135                                                                              Me      Q.sub.28                                                                            Me        Me  OMe  CH                                          3136                                                                              Me      Q.sub.28                                                                            Me        OMe OMe  CH                                          3137                                                                              Me      Q.sub.28                                                                            Me        Me  OMe  N                                           3138                                                                              Me      Me   Q.sub.28  Me  OMe  CH                                          3139                                                                              Me      Me   Q.sub.28  OMe OMe  CH                                          3140                                                                              Me      Me   Q.sub.28  Me  OMe  N                                           3141                                                                              Q.sub.29                                                                               Me   COOMe     Me  OMe  CH                                          3142                                                                              Q.sub.29                                                                               Me   COOMe     OMe OMe  CH                                          3143                                                                              Q.sub.29                                                                               Me   COOMe     Me  OMe  N                                           3144                                                                              Me      Me   Q.sub.29  OMe OMe  CH                                          3145                                                                              Me      Me   Q.sub.29  Me  OMe  N                                           3146                                                                              Q.sub.30                                                                               Me   COOMe     Me  OMe  CH                                          3147                                                                              Q.sub.30                                                                               Me   COOMe     OMe OMe  CH                                          3148                                                                              Q.sub.30                                                                               Me   COOMe     Me  OMe  N                                           3149                                                                              Me      Me   Q.sub.30  OMe OMe  CH                                          3150                                                                              Me      Me   Q.sub.30  Me  OMe  N                                           3151                                                                              Q.sub.31                                                                               Me   COOMe     Me  OMe  CH                                          3152                                                                              Q.sub.31                                                                               Me   COOMe     OMe OMe  CH                                          3153                                                                              Q.sub.31                                                                               Me   COOMe     Me  OMe  N                                           3154                                                                              Me      Me   Q.sub.31  OMe OMe  CH                                          3155                                                                              Me      Me   Q.sub.31  Me  OMe  N                                           3156                                                                              Q.sub.32                                                                               Me   Cl        Me  Me   CH                                          3157                                                                              Q.sub.32                                                                               Me   Cl        Me  OMe  CH                                          3158                                                                              Q.sub.32                                                                               Me   Cl        OMe OMe  N                                           3159                                                                              Q.sub.32                                                                               Me   Cl        Me  OMe  N                                           3160                                                                              Q.sub.32                                                                               Me   Cl        OMe OMe  N                                           3161                                                                              Q.sub.32                                                                               Me   OMe       Me  OMe  CH                                          3162                                                                              Q.sub.32                                                                               Me   OMe       OMe OMe  CH                                          3163                                                                              Q.sub.32                                                                               Me   OMe       Me  OMe  N                                           3164                                                                              Q.sub.32                                                                               CF.sub.3                                                                            Me        Me  OMe  CH                                          3165                                                                              Q.sub.32                                                                               CF.sub.3                                                                            Me        OMe OMe  CH                                          3166                                                                              Q.sub.32                                                                               CF.sub.3                                                                            Me        Me  OMe  N                                           3167                                                                              Q.sub.32                                                                               Me   COOMe     Me  Me   CH                                          3168                                                                              Q.sub.32                                                                               Me   COOMe     Me  OMe  CH                                          3169                                                                              Q.sub.32                                                                               Me   COOMe     OMe OMe  CH                                          3170                                                                              Q.sub.32                                                                               Me   COOMe     Me  OMe  N                                           3171                                                                              Q.sub.32                                                                               Me   COOMe     OMe OMe  N                                           3172                                                                              Q.sub.32                                                                               Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          3173                                                                              Q.sub.32                                                                               Me   COOMe     Me                                                                                  ##STR24##                                                                          CH                                          3174                                                                              Q.sub.32                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          3175                                                                              Q.sub.32                                                                               Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          3176                                                                              Q.sub.32                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  N                                           3177                                                                              H       Q.sub.32                                                                            Me        Me  OMe  CH                                          3178                                                                              H       Q.sub.32                                                                            Me        OMe OMe  CH                                          3179                                                                              H       Q.sub.32                                                                            Me        Me  OMe  N                                           3180                                                                              Me      Q.sub.32                                                                            Me        Me  OMe  CH                                          3181                                                                              Me      Q.sub.32                                                                            Me        OMe OMe  CH                                          3182                                                                              Me      Q.sub.32                                                                            Me        Me  OMe  N                                           3183                                                                              Me      Q.sub.32                                                                            Cl        Me  OMe  CH                                          3184                                                                              Me      Q.sub.32                                                                            Cl        OMe OMe  CH                                          3185                                                                              Me      Q.sub.32                                                                            Cl        Me  OMe  N                                           3186                                                                              Me      Q.sub.32                                                                            COOMe     Me  OMe  CH                                          3187                                                                              Me      Q.sub.32                                                                            COOMe     OMe OMe  CH                                          3188                                                                              Me      Q.sub.32                                                                            COOMe     Me  OMe  N                                           3189                                                                              Me      Q.sub.32                                                                            Ph        Me  OMe  CH                                          3190                                                                              Me      Q.sub.32                                                                            Ph        OMe OMe  CH                                          3191                                                                              Me      Q.sub.32                                                                            Ph        Me  OMe  N                                           3192                                                                              Me      Me   Q.sub.32  Me  OMe  CH                                          3193                                                                              Me      Me   Q.sub.32  OMe OMe  CH                                          3194                                                                              Me      Me   Q.sub.32  Me  OMe  N                                           3195                                                                              Q.sub.33                                                                               Me   COOMe     Me  Me   CH                                          3196                                                                              Q.sub.33                                                                               Me   COOMe     Me  OMe  CH                                          3197                                                                              Q.sub.33                                                                               Me   COOMe     OMe OMe  CH                                          3198                                                                              Q.sub.33                                                                               Me   COOMe     Me  OMe  N                                           3199                                                                              Q.sub.33                                                                               Me   COOMe     OMe OMe  N                                           3200                                                                              Me      Q.sub.33                                                                            Me        Me  OMe  CH                                          3201                                                                              Me      Q.sub.33                                                                            Me        OMe OMe  CH                                          3202                                                                              Me      Q.sub.33                                                                            Me        Me  OMe  N                                           3203                                                                              Me      Me   Q.sub.33  Me  OMe  CH                                          3204                                                                              Me      Me   Q.sub.33  OMe OMe  CH                                          3205                                                                              Me      Me   Q.sub.33  Me  OMe  N                                           3206                                                                              Q.sub.34                                                                               Me   COOMe     Me  Me   CH                                          3207                                                                              Q.sub.34                                                                               Me   COOMe     Me  OMe  CH                                          3208                                                                              Q.sub.34                                                                               Me   COOMe     OMe OMe  CH                                          3209                                                                              Q.sub.34                                                                               Me   COOMe     Me  OMe  N                                           3210                                                                              Q.sub.34                                                                               Me   COOMe     OMe OMe  N                                           3211                                                                              Me      Q.sub.34                                                                            Me        Me  OMe  CH                                          3212                                                                              Me      Q.sub.34                                                                            Me        Me  OMe  CH                                          3213                                                                              Me      Q.sub.34                                                                            Me        Me  OMe  N                                           3214                                                                              Me      Me   Q.sub.34  Me  OMe  CH                                          3215                                                                              Me      Me   Q.sub.34  OMe OMe  CH                                          3216                                                                              Me      Me   Q.sub.34  Me  OMe  N                                           3217                                                                              Q.sub.35                                                                               Me   COOMe     Me  Me   CH                                          3218                                                                              Q.sub.35                                                                               Me   COOMe     Me  OMe  CH                                          3219                                                                              Q.sub.35                                                                               Me   COOMe     OMe OMe  CH                                          3220                                                                              Q.sub.35                                                                               Me   COOMe     Me  OMe  N                                           3221                                                                              Q.sub.35                                                                               Me   COOMe     OMe OMe  N                                           3222                                                                              Me      Q.sub.35                                                                            Me        Me  OMe  CH                                          3223                                                                              Me      Q.sub.35                                                                            Me        OMe OMe  CH                                          3224                                                                              Me      Q.sub.35                                                                            Me        Me  OMe  N                                           3225                                                                              Me      Me   Q.sub.35  Me  OMe  CH                                          3226                                                                              Me      Me   Q.sub.35  OMe OMe  CH                                          3227                                                                              Me      Me   Q.sub.35  Me  OMe  N                                           3228                                                                              Q.sub.36                                                                               Me   COOMe     Me  OMe  CH                                          3229                                                                              Q.sub.36                                                                               Me   COOMe     OMe OMe  CH                                          3230                                                                              Q.sub.36                                                                               Me   COOMe     Me  OMe  N                                           3231                                                                              Me      Me   Q.sub.36  OMe OMe  CH                                          3232                                                                              Me      Me   Q.sub.36  Me  OMe  N                                           3233                                                                              Q.sub.37                                                                               Me   COOMe     Me  Me   CH                                          3234                                                                              Q.sub.37                                                                               Me   COOMe     Me  OMe  CH                                          3235                                                                              Q.sub.37                                                                               Me   COOMe     OMe OMe  CH                                          3236                                                                              Q.sub.37                                                                               Me   COOMe     Me  OMe  N                                           3237                                                                              Q.sub.37                                                                               Me   COOMe     OMe OMe  N                                           3238                                                                              Me      Q.sub.37                                                                            Me        Me  OMe  CH                                          3239                                                                              Me      Q.sub.37                                                                            Me        OMe OMe  CH                                          3240                                                                              Me      Q.sub.37                                                                            Me        Me  OMe  N                                           3241                                                                              Me      Me   Q.sub.37  Me  OMe  CH                                          3242                                                                              Me      Me   Q.sub.37  OMe OMe  CH                                          3243                                                                              Me      Me   Q.sub.37  Me  OMe  N                                           3244                                                                              Q.sub.38                                                                               Me   COOMe     Me  Me   CH                                          3245                                                                              Q.sub.38                                                                               Me   COOMe     Me  OMe  CH                                          3246                                                                              Q.sub.38                                                                               Me   COOMe     OMe OMe  CH                                          3247                                                                              Q.sub.38                                                                               Me   COOMe     Me  OMe  N                                           3248                                                                              Q.sub.38                                                                               Me   COOMe     OMe OMe  N                                           3249                                                                              Me      Q.sub.38                                                                            Me        Me  OMe  CH                                          3250                                                                              Me      Q.sub.38                                                                            Me        OMe OMe  CH                                          3251                                                                              Me      Q.sub.38                                                                            Me        Me  OMe  N                                           3152                                                                              Me      Me   Q.sub.38  Me  OMe  CH                                          3253                                                                              Me      Me   Q.sub.38  OMe OMe  CH                                          3254                                                                              Me      Me   Q.sub.38  Me  OMe  N                                           3255                                                                              Q.sub.39                                                                               Me   COOMe     Me  Me   CH                                          3256                                                                              Q.sub.39                                                                               Me   COOMe     Me  OMe  CH                                          3257                                                                              Q.sub.39                                                                               Me   COOMe     OMe OMe  CH                                          3258                                                                              Q.sub.39                                                                               Me   COOMe     Me  OMe  N                                           3259                                                                              Q.sub.39                                                                               Me   COOMe     OMe OMe  N                                           3260                                                                              Me      Q.sub.39                                                                            Me        Me  OMe  CH                                          3261                                                                              Me      Q.sub.39                                                                            Me        OMe OMe  CH                                          3262                                                                              Me      Q.sub.39                                                                            Me        Me  OMe  N                                           3263                                                                              Me      Me   Q.sub.39  Me  OMe  CH                                          3264                                                                              Me      Me   Q.sub.39  OMe OMe  CH                                          3265                                                                              Me      Me   Q.sub.39  Me  OMe  N                                           3266                                                                              Q.sub.40                                                                               Me   COOMe     Me  OMe  CH                                          3267                                                                              Q.sub.40                                                                               Me   COOMe     OMe OMe  CH                                          3268                                                                              Q.sub.40                                                                               Me   COOMe     Me  OMe  N                                           3269                                                                              Me      Me   Q.sub.40  OMe OMe  CH                                          3270                                                                              Me      Me   Q.sub.40  Me  OMe  N                                           3271                                                                              Q.sub.41                                                                               Me   COOMe     Me  Me   CH                                          3272                                                                              Q.sub.41                                                                               Me   COOMe     Me  OMe  CH                                          3273                                                                              Q.sub.41                                                                               Me   COOMe     OMe OMe  CH                                          3274                                                                              Q.sub.41                                                                               Me   COOMe     Me  OMe  N                                           3275                                                                              Q.sub.41                                                                               Me   COOMe     OMe OMe  N                                           3276                                                                              Me      Q.sub.41                                                                            Me        Me  OMe  CH                                          3277                                                                              Me      Q.sub.41                                                                            Me        OMe OMe  CH                                          3278                                                                              Me      Q.sub.41                                                                            Me        Me  OMe  N                                           3279                                                                              Me      Me   Q.sub.41  Me  OMe  CH                                          3280                                                                              Me      Me   Q.sub.41  OMe OMe  CH                                          3281                                                                              Me      Me   Q.sub.41  Me  OMe  N                                           3282                                                                              Q.sub.42                                                                               Me   COOMe     Me  Me   CH                                          3283                                                                              Q.sub.42                                                                               Me   COOMe     Me  OMe  CH                                          3284                                                                              Q.sub.42                                                                               Me   COOMe     OMe OMe  CH                                          3285                                                                              Q.sub.42                                                                               Me   COOMe     Me  OMe  N                                           3286                                                                              Q.sub.42                                                                               Me   COOMe     OMe OMe  N                                           3287                                                                              Me      Q.sub.42                                                                            Me        Me  OMe  CH                                          3288                                                                              Me      Q.sub.42                                                                            Me        OMe OMe  CH                                          3289                                                                              Me      Q.sub.42                                                                            Me        Me  OMe  N                                           3290                                                                              Me      Me   Q.sub.42  Me  OMe  CH                                          3291                                                                              Me      Me   Q.sub.42  OMe OMe  CH                                          3292                                                                              Me      Me   Q.sub.42  Me  OMe  N                                           3293                                                                              Q.sub.43                                                                               Me   COOMe     Me  Me   CH                                          3294                                                                              Q.sub.43                                                                               Me   COOMe     Me  OMe  CH                                          3295                                                                              Q.sub.43                                                                               Me   COOMe     OMe OMe  CH                                          3296                                                                              Q.sub.43                                                                               Me   COOMe     Me  OMe  N                                           3297                                                                              Q.sub.43                                                                               Me   COOMe     OMe OMe  N                                           3298                                                                              Me      Q.sub.43                                                                            Me        Me  OMe  CH                                          3299                                                                              Me      Q.sub.43                                                                            Me        OMe OMe  CH                                          3300                                                                              Me      Q.sub.43                                                                            Me        Me  OMe  N                                           3301                                                                              Me      Me   Q.sub.43  Me  OMe  CH                                          3302                                                                              Me      Me   Q.sub. 43 OMe OMe  CH                                          3303                                                                              Me      Me   Q.sub.43  Me  OMe  N                                           3304                                                                              Q.sub.44                                                                               Me   COOMe     Me  OMe  CH                                          3305                                                                              Q.sub.44                                                                               Me   COOMe     OMe OMe  CH                                          3306                                                                              Q.sub.44                                                                               Me   COOMe     Me  OMe  N                                           3307                                                                              Me      Me   Q.sub.44  OMe OMe  CH                                          3308                                                                              Me      Me   Q.sub.44  Me  OMe  N                                           3309                                                                              Q.sub.45                                                                               Me   Cl        Me  Me   CH                                          3310                                                                              Q.sub.45                                                                               Me   Cl        Me  OMe  CH                                          3311                                                                              Q.sub.45                                                                               Me   Cl        OMe OMe  CH                                          3312                                                                              Q.sub.45                                                                               Me   Cl        Me  OMe  N                                           3313                                                                              Q.sub.45                                                                               Me   Cl        OMe OMe  N                                           3314                                                                              Q.sub.45                                                                               Me   OMe       Me  OMe  CH                                          3315                                                                              Q.sub.45                                                                               Me   OMe       OMe OMe  CH                                          3316                                                                              Q.sub.45                                                                               Me   OMe       Me  OMe  N                                           3317                                                                              Q.sub.45                                                                               CF.sub.3                                                                            Me        Me  OMe  CH                                          3318                                                                              Q.sub.45                                                                               CF.sub.3                                                                            Me        OMe OMe  CH                                          3319                                                                              Q.sub.45                                                                               CF.sub.3                                                                            Me        Me  OMe  N                                           3320                                                                              Q.sub.45                                                                               Me   COOMe     Me  Me   CH                                          3321                                                                              Q.sub.45                                                                               Me   COOMe     Me  OMe  CH                                          3322                                                                              Q.sub.45                                                                               Me   COOMe     OMe OMe  CH                                          3323                                                                              Q.sub.45                                                                               Me   COOMe     Me  OMe  N                                           3324                                                                              Q.sub.45                                                                               Me   COOMe     OMe OMe  N                                           3325                                                                              Q.sub.45                                                                               Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          3326                                                                              Q.sub.45                                                                               Me   COOMe     Me                                                                                  ##STR25##                                                                          CH                                          3327                                                                              Q.sub.45                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          3328                                                                              Q.sub.45                                                                               Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          3329                                                                              Q.sub.45                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  N                                           3330                                                                              H       Q.sub.45                                                                            Me        Me  OMe  CH                                          3331                                                                              H       Q.sub.45                                                                            Me        OMe OMe  CH                                          3332                                                                              H       Q.sub.45                                                                            Me        Me  OMe  N                                           3333                                                                              Me      Q.sub.45                                                                            Me        Me  OMe  CH                                          3334                                                                              Me      Q.sub.45                                                                            Me        OMe OMe  CH                                          3335                                                                              Me      Q.sub.45                                                                            Me        Me  OMe  N                                           3336                                                                              Me      Q.sub.45                                                                            Cl        Me  OMe  CH                                          3337                                                                              Me      Q.sub.45                                                                            Cl        OMe OMe  CH                                          3338                                                                              Me      Q.sub.45                                                                            Cl        Me  OMe  N                                           3339                                                                              Me      Q.sub.45                                                                            COOMe     Me  OMe  CH                                          3340                                                                              Me      Q.sub.45                                                                            COOMe     OMe OMe  CH                                          3341                                                                              Me      Q.sub.45                                                                            COOMe     Me  OMe  N                                           3342                                                                              Me      Q.sub.45                                                                            Ph        Me  OMe  CH                                          3343                                                                              Me      Q.sub.45                                                                            Ph        OMe OMe  CH                                          3344                                                                              Me      Q.sub.45                                                                            Ph        Me  OMe  N                                           3345                                                                              Me      Me   Q.sub.45  Me  OMe  CH                                          3346                                                                              Me      Me   Q.sub.45  OMe OMe  CH                                          3347                                                                              Me      Me   Q.sub.45  Me  OMe  N                                           3348                                                                              Q.sub.46                                                                               Me   COOMe     Me  Me   CH                                          3349                                                                              Q.sub.46                                                                               Me   COOMe     Me  OMe  CH                                          3350                                                                              Q.sub.46                                                                               Me   COOMe     OMe OMe  CH                                          3351                                                                              Q.sub.46                                                                               Me   COOMe     Me  OMe  N                                           3352                                                                              Q.sub.46                                                                               Me   COOMe     OMe OMe  N                                           3353                                                                              Me      Q.sub.46                                                                            Me        Me  OMe  CH                                          3354                                                                              Me      Q.sub.46                                                                            Me        OMe OMe  CH                                          3355                                                                              Me      Q.sub.46                                                                            Me        Me  OMe  N                                           3356                                                                              Me      Me   Q.sub.46  Me  OMe  CH                                          3357                                                                              Me      Me   Q.sub.46  OMe OMe  CH                                          3358                                                                              Me      Me   Q.sub.46  Me  OMe  N                                           3359                                                                              Q.sub.47                                                                               Me   COOMe     Me  Me   CH                                          3360                                                                              Q.sub.47                                                                               Me   COOMe     Me  OMe  CH                                          3361                                                                              Q.sub.47                                                                               Me   COOMe     OMe OMe  CH                                          3362                                                                              Q.sub.47                                                                               Me   COOMe     Me  OMe  N                                           3363                                                                              Q.sub.47                                                                               Me   COOMe     OMe OMe  N                                           3364                                                                              Me      Q.sub.47                                                                            Me        Me  OMe  CH                                          3365                                                                              Me      Q.sub.47                                                                            Me        OMe OMe  CH                                          3366                                                                              Me      Q.sub.47                                                                            Me        Me  OMe  N                                           3367                                                                              Me      Me   Q.sub.47  Me  OMe  CH                                          3368                                                                              Me      Me   Q.sub.47  OMe OMe  CH                                          3369                                                                              Me      Me   Q.sub.47  Me  OMe  N                                           3370                                                                              Q.sub.48                                                                               Me   COOMe     Me  Me   CH                                          3371                                                                              Q.sub.48                                                                               Me   COOMe     Me  OMe  CH                                          3372                                                                              Q.sub.48                                                                               Me   COOMe     OMe OMe  CH                                          3373                                                                              Q.sub.48                                                                               Me   COOMe     Me  OMe  N                                           3374                                                                              Q.sub.48                                                                               Me   COOMe     OMe OMe  N                                           3375                                                                              Me      Q.sub.48                                                                            Me        Me  OMe  CH                                          3376                                                                              Me      Q.sub.48                                                                            Me        OMe OMe  CH                                          3377                                                                              Me      Q.sub.48                                                                            Me        Me  OMe  CH                                          3378                                                                              Me      Me   Q.sub.48  Me  OMe  CH                                          3379                                                                              Me      Me   Q.sub.48  OMe OMe  CH                                          3380                                                                              Me      Me   Q.sub.48  Me  OMe  N                                           3381                                                                              Q.sub.49                                                                               Me   COOMe     Me  Me   CH                                          3382                                                                              Q.sub.49                                                                               Me   COOMe     Me  OMe  CH                                          3383                                                                              Q.sub.49                                                                               Me   COOMe     OMe OMe  CH                                          3384                                                                              Q.sub.49                                                                               Me   COOMe     Me  OMe  N                                           3385                                                                              Q.sub.49                                                                               Me   COOMe     OMe OMe  N                                           3386                                                                              Me      Q.sub.49                                                                            Me        Me  OMe  CH                                          3387                                                                              Me      Q.sub.49                                                                            Me        OMe OMe  CH                                          3388                                                                              Me      Q.sub.49                                                                            Me        Me  OMe  N                                           3389                                                                              Me      Me   Q.sub.49  Me  OMe  CH                                          3390                                                                              Me      Me   Q.sub.49  OMe OMe  CH                                          3391                                                                              Me      Me   Q.sub.49  Me  OMe  N                                           3392                                                                              Q.sub.50                                                                               Me   COOMe     Me  Me   CH                                          3393                                                                              Q.sub.50                                                                               Me   COOMe     Me  OMe  CH                                          3394                                                                              Q.sub.50                                                                               Me   COOMe     OMe OMe  CH                                          3395                                                                              Q.sub.50                                                                               Me   COOMe     Me  OMe  N                                           3396                                                                              Q.sub.50                                                                               Me   COOMe     OMe OMe  N                                           3397                                                                              Me      Q.sub.50                                                                            Me        Me  OMe  CH                                          3398                                                                              Me      Q.sub.50                                                                            Me        OMe OMe  CH                                          3399                                                                              Me      Q.sub.50                                                                            Me        Me  OMe  N                                           3400                                                                              Me      Me   Q.sub.50  Me  OMe  CH                                          3401                                                                              Me      Me   Q.sub.50  OMe OMe  CH                                          3402                                                                              Me      Me   Q.sub.50  Me  OMe  N                                           3403                                                                              Q.sub.51                                                                               Me   COOMe     Me  Me   CH                                          3404                                                                              Q.sub.51                                                                               Me   COOMe     Me  OMe  CH                                          3405                                                                              Q.sub.51                                                                               Me   COOMe     OMe OMe  CH                                          3406                                                                              Q.sub.51                                                                               Me   COOMe     Me  OMe  N                                           3407                                                                              Q.sub.51                                                                               Me   COOMe     OMe OMe  N                                           3408                                                                              Me      Q.sub.51                                                                            Me        Me  OMe  CH                                          3409                                                                              Me      Q.sub.51                                                                            Me        OMe OMe  CH                                          3410                                                                              Me      Q.sub.51                                                                            Me        Me  OMe  N                                           3411                                                                              Me      Me   Q.sub.51  Me  OMe  CH                                          3412                                                                              Me      Me   Q.sub.51  OMe OMe  CH                                          3413                                                                              Me      Me   Q.sub.51  Me  OMe  N                                           3414                                                                              Q.sub.52                                                                               Me   COOMe     Me  OMe  CH                                          3415                                                                              Q.sub.52                                                                               Me   COOMe     OMe OMe  CH                                          3416                                                                              Q.sub.52                                                                               Me   COOMe     Me  OMe  N                                           3417                                                                              Me      Me   Q.sub.52  OMe OMe  CH                                          3418                                                                              Me      Me   Q.sub.52  Me  OMe  N                                           3419                                                                              Q.sub.53                                                                               Me   COOMe     Me  OMe  CH                                          3420                                                                              Q.sub.53                                                                               Me   COOMe     OMe OMe  CH                                          3421                                                                              Q.sub.53                                                                               Me   COOMe     Me  OMe  N                                           3422                                                                              Me      Me   Q.sub.53  OMe OMe  CH                                          3423                                                                              Me      Me   Q.sub.53  Me  OMe  N                                           3424                                                                              Q.sub.54                                                                               Me   COOMe     Me  Me   CH                                          3425                                                                              Q.sub.54                                                                               Me   COOMe     Me  OMe  CH                                          3426                                                                              Q.sub.54                                                                               Me   COOMe     OMe OMe  CH                                          3427                                                                              Q.sub.54                                                                               Me   COOMe     Me  OMe  N                                           3428                                                                              Q.sub.54                                                                               Me   COOMe     OMe OMe  N                                           3429                                                                              Me      Q.sub.54                                                                            Me        Me  OMe  CH                                          3430                                                                              Me      Q.sub.54                                                                            Me        OMe OMe  CH                                          3431                                                                              Me      Q.sub.54                                                                            Me        Me  OMe  N                                           3432                                                                              Me      Me   Q.sub.54  Me  OMe  CH                                          3433                                                                              Me      Me   Q.sub.54  OMe OMe  CH                                          3434                                                                              Me      Me   Q.sub.54  Me  OMe  N                                           3435                                                                              Q.sub.55                                                                               Me   COOMe     Me  Me   CH                                          3436                                                                              Q.sub.55                                                                               Me   COOMe     Me  OMe  CH                                          3437                                                                              Q.sub.55                                                                               Me   COOMe     OMe OMe  CH                                          3438                                                                              Q.sub.55                                                                               Me   COOMe     Me  OMe  N                                           3439                                                                              Q.sub.55                                                                               Me   COOMe     OMe OMe  N                                           3440                                                                              Me      Q.sub.55                                                                            Me        Me  OMe  CH                                          3441                                                                              Me      Q.sub.55                                                                            Me        OMe OMe  CH                                          3442                                                                              Me      Q.sub.55                                                                            Me        Me  OMe  N                                           3443                                                                              Me      Me   Q.sub.55  Me  OMe  CH                                          3444                                                                              Me      Me   Q.sub.55  OMe OMe  CH                                          3445                                                                              Me      Me   Q.sub.55  Me  OMe  N                                           3446                                                                              Q.sub.56                                                                               Me   COOMe     Me  Me   CH                                          3447                                                                              Q.sub.56                                                                               Me   COOMe     Me  OMe  CH                                          3448                                                                              Q.sub.56                                                                               Me   COOMe     OMe OMe  CH                                          3449                                                                              Q.sub.56                                                                               Me   COOMe     Me  OMe  N                                           3450                                                                              Q.sub.56                                                                               Me   COOMe     OMe OMe  N                                           3451                                                                              Me      Q.sub.56                                                                            Me        Me  OMe  CH                                          3452                                                                              Me      Q.sub.56                                                                            Me        OMe OMe  CH                                          3453                                                                              Me      Q.sub.56                                                                            Me        Me  OMe  N                                           3454                                                                              Me      Me   Q.sub.56  Me  OMe  CH                                          3455                                                                              Me      Me   Q.sub.56  OMe OMe  CH                                          3456                                                                              Me      Me   Q.sub.56  Me  OMe  N                                           3457                                                                              Q.sub.57                                                                               Me   COOMe     Me  OMe  CH                                          3458                                                                              Q.sub.57                                                                               Me   COOMe     OMe OMe  CH                                          3459                                                                              Q.sub.57                                                                               Me   COOMe     Me  OMe  N                                           3460                                                                              Me      Me   Q.sub.57  OMe OMe  CH                                          3461                                                                              Me      Me   Q.sub.57  Me  OMe  N                                           3462                                                                              Q.sub.58                                                                               Me   COOMe     Me  OMe  CH                                          3463                                                                              Q.sub.58                                                                               Me   COOMe     OMe OMe  CH                                          3464                                                                              Q.sub.58                                                                               Me   COOMe     Me  OMe  N                                           3465                                                                              Me      Me   Q.sub.58  OMe OMe  CH                                          3466                                                                              Me      Me   Q.sub.58  Me  OMe  N                                           3467                                                                              Q.sub.59                                                                               Me   Cl        Me  Me   CH                                          3468                                                                              Q.sub.59                                                                               Me   Cl        Me  OMe  CH                                          3469                                                                              Q.sub.59                                                                               Me   Cl        OMe OMe  CH                                          3470                                                                              Q.sub.59                                                                               Me   Cl        Me  OMe  N                                           3471                                                                              Q.sub.59                                                                               Me   Cl        OMe OMe  N                                           3472                                                                              Q.sub.59                                                                               Me   OMe       Me  OMe  CH                                          3473                                                                              Q.sub.59                                                                               Me   OMe       OMe OMe  CH                                          3474                                                                              Q.sub.59                                                                               Me   OMe       Me  OMe  N                                           3475                                                                              Q.sub.59                                                                               CF.sub.3                                                                            Me        Me  OMe  CH                                          3476                                                                              Q.sub.59                                                                               CF.sub.3                                                                            Me        OMe OMe  CH                                          3477                                                                              Q.sub.59                                                                               CF.sub.3                                                                            Me        Me  OMe  N                                           3478                                                                              Q.sub.59                                                                               Me   COOMe     Me  Me   CH                                          3479                                                                              Q.sub.59                                                                               Me   COOMe     Me  OMe  CH                                          3480                                                                              Q.sub.59                                                                               Me   COOMe     OMe OMe  CH                                          3481                                                                              Q.sub.59                                                                               Me   COOMe     Me  OMe  N                                           3482                                                                              Q.sub.59                                                                               Me   COOMe     OMe OMe  N                                           3483                                                                              Q.sub.59                                                                               Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          3484                                                                              Q.sub.59                                                                               Me   COOMe     Me                                                                                  ##STR26##                                                                          CH                                          3485                                                                              Q.sub.59                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          3486                                                                              Q.sub.59                                                                               Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          3487                                                                              Q.sub.59                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  N                                           3488                                                                              H       Q.sub.59                                                                            Me        Me  OMe  CH                                          3489                                                                              H       Q.sub.59                                                                            Me        OMe OMe  CH                                          3490                                                                              H       Q.sub.59                                                                            Me        Me  OMe  N                                           3491                                                                              Me      Q.sub.59                                                                            Me        Me  OMe  CH                                          3492                                                                              Me      Q.sub.59                                                                            Me        OMe OMe  CH                                          3493                                                                              Me      Q.sub.59                                                                            Me        Me  OMe  N                                           3494                                                                              Me      Q.sub.59                                                                            Cl        Me  OMe  CH                                          3495                                                                              Me      Q.sub.59                                                                            Cl        OMe OMe  CH                                          3496                                                                              Me      Q.sub.59                                                                            Cl        Me  OMe  N                                           3497                                                                              Me      Q.sub.59                                                                            COOMe     Me  OMe  CH                                          3498                                                                              Me      Q.sub.59                                                                            COOMe     OMe OMe  CH                                          3499                                                                              Me      Q.sub.59                                                                            COOMe     Me  OMe  N                                           3500                                                                              Me      Q.sub.59                                                                            Ph        Me  OMe  CH                                          3501                                                                              Me      Q.sub.59                                                                            Ph        OMe OMe  CH                                          3502                                                                              Me      Q.sub.59                                                                            Ph        Me  OMe  N                                           3503                                                                              Me      Me   Q.sub.59  Me  OMe  CH                                          3504                                                                              Me      Me   Q.sub.59  OMe OMe  CH                                          3505                                                                              Me      Me   Q.sub.59  Me  OMe  N                                           3506                                                                              Q.sub.60                                                                               Me   COOMe     Me  Me   CH                                          3507                                                                              Q.sub.60                                                                               Me   COOMe     Me  OMe  CH                                          3508                                                                              Q.sub.60                                                                               Me   COOMe     OMe OMe  CH                                          3509                                                                              Q.sub.60                                                                               Me   COOMe     Me  OMe  N                                           3510                                                                              Q.sub.60                                                                               Me   COOMe     OMe OMe  N                                           3511                                                                              Me      Q.sub.60                                                                            Me        Me  OMe  CH                                          3512                                                                              Me      Q.sub.60                                                                            Me        OMe OMe  CH                                          3513                                                                              Me      Q.sub.60                                                                            Me        Me  OMe  N                                           3514                                                                              Me      Me   Q.sub.60  Me  OMe  CH                                          3515                                                                              Me      Me   Q.sub.60  OMe OMe  CH                                          3516                                                                              Me      Me   Q.sub.60  Me  OMe  N                                           3517                                                                              Q.sub.61                                                                               Me   COOMe     Me  Me   CH                                          3518                                                                              Q.sub.61                                                                               Me   COOMe     Me  OMe  CH                                          3519                                                                              Q.sub.61                                                                               Me   COOMe     OMe OMe  CH                                          3520                                                                              Q.sub.61                                                                               Me   COOMe     Me  OMe  N                                           3521                                                                              Q.sub.61                                                                               Me   COOMe     OMe OMe  N                                           3522                                                                              Me      Q.sub.61                                                                            Me        Me  OMe  CH                                          3523                                                                              Me      Q.sub.61                                                                            Me        OMe OMe  CH                                          3524                                                                              Me      Q.sub.61                                                                            Me        Me  OMe  N                                           3525                                                                              Me      Me   Q.sub.61  Me  OMe  CH                                          3526                                                                              Me      Me   Q.sub.61  OMe OMe  CH                                          3527                                                                              Me      Me   Q.sub.61  Me  OMe  N                                           3528                                                                              Q.sub.62                                                                               Me   COOMe     Me  Me   CH                                          3529                                                                              Q.sub.62                                                                               Me   COOMe     Me  OMe  CH                                          3530                                                                              Q.sub.62                                                                               Me   COOMe     OMe OMe  CH                                          3531                                                                              Q.sub.62                                                                               Me   COOMe     Me  OMe  N                                           3532                                                                              Q.sub.62                                                                               Me   COOMe     OMe OMe  N                                           3533                                                                              Me      Q.sub.62                                                                            Me        Me  OMe  CH                                          3534                                                                              Me      Q.sub.62                                                                            Me        OMe OMe  CH                                          3535                                                                              Me      Q.sub.62                                                                            Me        Me  OMe  N                                           3536                                                                              Me      Me   Q.sub.62  Me  OMe  CH                                          3537                                                                              Me      Me   Q.sub.62  OMe OMe  CH                                          3538                                                                              Me      Me   Q.sub.62  Me  OMe  N                                           3539                                                                              Q.sub.63                                                                               Me   COOMe     Me  OMe  CH                                          3540                                                                              Q.sub.63                                                                               Me   COOMe     OMe OMe  CH                                          3541                                                                              Q.sub.63                                                                               Me   COOMe     Me  OMe  N                                           3542                                                                              Me      Me   Q.sub.63  OMe OMe  CH                                          3543                                                                              Me      Me   Q.sub.63  Me  OMe  N                                           3544                                                                              Q.sub.64                                                                               Me   COOMe     Me  OMe  CH                                          3545                                                                              Q.sub.64                                                                               Me   COOMe     OMe OMe  CH                                          3546                                                                              Q.sub.64                                                                               Me   COOMe     Me  OMe  N                                           3547                                                                              Me      Me   Q.sub.64  OMe OMe  CH                                          3548                                                                              Me      Me   Q.sub.64  Me  OMe  N                                           3549                                                                              Q.sub.65                                                                               Me   COOMe     Me  Me   CH                                          3550                                                                              Q.sub.65                                                                               Me   COOMe     Me  OMe  CH                                          3551                                                                              Q.sub.65                                                                               Me   COOMe     OMe OMe  CH                                          3552                                                                              Q.sub.65                                                                               Me   COOMe     Me  OMe  N                                           3553                                                                              Q.sub.65                                                                               Me   COOMe     OMe OMe  N                                           3554                                                                              Me      Q.sub.65                                                                            Me        Me  OMe  CH                                          3555                                                                              Me      Q.sub.65                                                                            Me        OMe OMe  CH                                          3556                                                                              Me      Q.sub.65                                                                            Me        Me  OMe  N                                           3557                                                                              Me      Me   Q.sub.65  Me  OMe  CH                                          3558                                                                              Me      Me   Q.sub.65  OMe OMe  CH                                          3559                                                                              Me      Me   Q.sub.65  Me  OMe  N                                           3560                                                                              Q.sub.66                                                                               Me   COOMe     Me  OMe  CH                                          3561                                                                              Q.sub.66                                                                               Me   COOMe     OMe OMe  CH                                          3562                                                                              Q.sub.66                                                                               Me   COOMe     Me  OMe  N                                           3563                                                                              Me      Me   Q.sub.66  OMe OMe  CH                                          3564                                                                              Me      Me   Q.sub.66  Me  OMe  N                                           3565                                                                              Q.sub.67                                                                               Me   COOMe     Me  OMe  CH                                          3566                                                                              Q.sub.67                                                                               Me   COOMe     OMe OMe  CH                                          3567                                                                              Q.sub.67                                                                               Me   COOMe     Me  OMe  N                                           3568                                                                              Me      Me   Q.sub.67  OMe OMe  CH                                          3569                                                                              Me      Me   Q.sub.67  Me  OMe  N                                           3570                                                                              Q.sub.68                                                                               Me   COOMe     Me  OMe  CH                                          3571                                                                              Q.sub.68                                                                               Me   COOMe     OMe OMe  CH                                          3572                                                                              Q.sub.68                                                                               Me   COOMe     Me  OMe  N                                           3573                                                                              Me      Me   Q.sub.68  OMe OMe  CH                                          3574                                                                              Me      Me   Q.sub.68  Me  OMe  N                                           3575                                                                              Q.sub.69                                                                               Me   COOMe     Me  OMe  CH                                          3576                                                                              Q.sub.69                                                                               Me   COOMe     OMe OMe  CH                                          3577                                                                              Q.sub.69                                                                               Me   COOMe     Me  OMe  N                                           3578                                                                              Me      Me   Q.sub.69  OMe OMe  CH                                          3579                                                                              Me      Me   Q.sub.69  Me  OMe  N                                           3580                                                                              Q.sub.70                                                                               Me   COOMe     Me  Me   CH                                          3581                                                                              Q.sub.70                                                                               Me   COOMe     Me  OMe  CH                                          3582                                                                              Q.sub.70                                                                               Me   COOMe     OMe OMe  CH                                          3583                                                                              Q.sub.70                                                                               Me   COOMe     Me  OMe  N                                           3584                                                                              Q.sub.70                                                                               Me   COOMe     OMe OMe  N                                           3585                                                                              Me      Q.sub.70                                                                            Me        Me  OMe  CH                                          3586                                                                              Me      Q.sub.70                                                                            Me        OMe OMe  CH                                          3587                                                                              Me      Q.sub.70                                                                            Me        Me  OMe  N                                           3588                                                                              Me      Me   Q.sub.70  Me  OMe  CH                                          3589                                                                              Me      Me   Q.sub.70  OMe OMe  CH                                          3590                                                                              Me      Me   Q.sub.70  Me  OMe  N                                           3591                                                                              Q.sub.71                                                                               Me   COOMe     Me  OMe  CH                                          3592                                                                              Q.sub.71                                                                               Me   COOMe     OMe OMe  CH                                          3593                                                                              Q.sub.71                                                                               Me   COOMe     Me  OMe  CH                                          3594                                                                              Me      Me   Q.sub.71  OMe OMe  CH                                          3595                                                                              Me      Me   Q.sub.71  Me  OMe  N                                           3596                                                                              Q.sub.72                                                                               Me   COOMe     Me  OMe  CH                                          3597                                                                              Q.sub.72                                                                               Me   COOMe     OMe OMe  CH                                          3598                                                                              Q.sub.72                                                                               Me   COOMe     Me  OMe  N                                           3599                                                                              Me      Me   Q.sub.72  OMe OMe  CH                                          3600                                                                              Me      Me   Q.sub.72  Me  OMe  N                                           3601                                                                              Q.sub.73                                                                               Me   COOMe     Me  OMe  CH                                          3602                                                                              Q.sub.73                                                                               Me   COOMe     OMe OMe  CH                                          3603                                                                              Q.sub.73                                                                               Me   COOMe     Me  OMe  N                                           3604                                                                              Me      Me   Q.sub.73  OMe OMe  CH                                          3605                                                                              Me      Me   Q.sub.73  Me  OMe  N                                           3606                                                                              Q.sub.74                                                                               Me   COOMe     Me  OMe  CH                                          3607                                                                              Q.sub.74                                                                               Me   COOMe     OMe OMe  CH                                          3608                                                                              Q.sub.74                                                                               Me   COOMe     Me  OMe  N                                           3609                                                                              Me      Me   Q.sub.74  OMe OMe  CH                                          3610                                                                              Me      Me   Q.sub.74  Me  OMe  N                                           3611                                                                              Q.sub.75                                                                               Me   COOMe     Me  OMe  CH                                          3612                                                                              Q.sub.75                                                                               Me   COOMe     OMe OMe  CH                                          3613                                                                              Q.sub.75                                                                               Me   COOMe     Me  OMe  N                                           3614                                                                              Me      Me   Q.sub.75  OMe OMe  CH                                          3615                                                                              Me      Me   Q.sub.75  Me  OMe  N                                           3616                                                                              Q.sub.76                                                                               Me   COOMe     Me  OMe  CH                                          3617                                                                              Q.sub.76                                                                               Me   COOMe     OMe OMe  CH                                          3618                                                                              Q.sub.76                                                                               Me   COOMe     Me  OMe  N                                           3619                                                                              Me      Me   Q.sub.76  OMe OMe  CH                                          3620                                                                              Me      Me   Q.sub.76  Me  OMe  N                                           3621                                                                              Q.sub.1 Me   Me        Me  Me   CH                                          3622                                                                              Q.sub.1 Me   Me        Me  OMe  CH                                          3623                                                                              Q.sub.1 Me   Me        OMe OMe  CH                                          3624                                                                              Q.sub.1 Me   Me        Me  OMe  N                                           3625                                                                              Q.sub.1 Me   Me        OMe OMe  N                                           3626                                                                              Q.sub.2 Me   Me        Me  Me   CH                                          3627                                                                              Q.sub.2 Me   Me        Me  OMe  CH                                          3628                                                                              Q.sub.2 Me   Me        OMe OMe  CH                                          3629                                                                              Q.sub.2 Me   Me        Me  OMe  N                                           3630                                                                              Q.sub.2 Me   Me        OMe OMe  N                                           3631                                                                              Q.sub.3 Me   Me        Me  Me   CH                                          3632                                                                              Q.sub.3 Me   Me        Me  OMe  CH                                          3633                                                                              Q.sub.3 Me   Me        OMe OMe  CH                                          3634                                                                              Q.sub.3 Me   Me        Me  OMe  N                                           3635                                                                              Q.sub.3 Me   Me        OMe OMe  N                                           3636                                                                              Q.sub.4 Me   Me        Me  Me   CH                                          3637                                                                              Q.sub.4 Me   Me        Me  OMe  CH                                          3638                                                                              Q.sub.4 Me   Me        OMe OMe  CH                                          3639                                                                              Q.sub.4 Me   Me        Me  OMe  N                                           3640                                                                              Q.sub.4 Me   Me        OMe OMe  N                                           3641                                                                              Q.sub.5 Me   Me        Me  Me   CH                                          3642                                                                              Q.sub.5 Me   Me        Me  OMe  CH                                          3643                                                                              Q.sub.5 Me   Me        OMe OMe  CH                                          3644                                                                              Q.sub.5 Me   Me        Me  OMe  N                                           3645                                                                              Q.sub.5 Me   Me        OMe OMe  N                                           3646                                                                              Q.sub.6 Me   Me        Me  Me   CH                                          3647                                                                              Q.sub.6 Me   Me        Me  OMe  CH                                          3648                                                                              Q.sub.6 Me   Me        OMe OMe  CH                                          3649                                                                              Q.sub.6 Me   Me        Me  OMe  N                                           3650                                                                              Q.sub.6 Me   Me        OMe OMe  N                                           3651                                                                              Q.sub.7 Me   Me        Me  OMe  CH                                          3652                                                                              Q.sub.7 Me   Me        OMe OMe  CH                                          3653                                                                              Q.sub.7 Me   Me        Me  OMe  N                                           3654                                                                              Q.sub.8 Me   Me        Me  Me   CH                                          3655                                                                              Q.sub.8 Me   Me        Me  OMe  CH                                          3656                                                                              Q.sub.8 Me   Me        OMe OMe  CH                                          3657                                                                              Q.sub.8 Me   Me        Me  OMe  N                                           3658                                                                              Q.sub.8 Me   Me        OMe OMe  N                                           3659                                                                              Q.sub.9 Me   Me        Me  Me   CH                                          3660                                                                              Q.sub.9 Me   Me        Me  OMe  CH                                          3661                                                                              Q.sub.9 Me   Me        OMe OMe  CH                                          3662                                                                              Q.sub.9 Me   Me        Me  OMe  N                                           3663                                                                              Q.sub.9 Me   Me        OMe OMe  N                                           3664                                                                              Q.sub.10                                                                               Me   Me        Me  Me   CH                                          3665                                                                              Q.sub.10                                                                               Me   Me        Me  OMe  CH                                          3666                                                                              Q.sub.10                                                                               Me   Me        OMe OMe  CH                                          3667                                                                              Q.sub.10                                                                               Me   Me        Me  OMe  N                                           3668                                                                              Q.sub.10                                                                               Me   Me        OMe OMe  N                                           3669                                                                              Q.sub.11                                                                               Me   Me        Me  Me   CH                                          3670                                                                              Q.sub.11                                                                               Me   Me        Me  OMe  CH                                          3671                                                                              Q.sub.11                                                                               Me   Me        OMe OMe  CH                                          3672                                                                              Q.sub.11                                                                               Me   Me        Me  OMe  N                                           3673                                                                              Q.sub.11                                                                               Me   Me        OMe OMe  N                                           3674                                                                              Q.sub.12                                                                               Me   Me        Me  Me   CH                                          3675                                                                              Q.sub.12                                                                               Me   Me        Me  OMe  CH                                          3676                                                                              Q.sub.12                                                                               Me   Me        OMe OMe  CH                                          3677                                                                              Q.sub.12                                                                               Me   Me        Me  OMe  N                                           3678                                                                              Q.sub.12                                                                               Me   Me        OMe OMe  N                                           3679                                                                              Q.sub.13                                                                               Me   Me        Me  OMe  CH                                          3680                                                                              Q.sub.13                                                                               Me   Me        OMe OMe  CH                                          3681                                                                              Q.sub.13                                                                               Me   Me        Me  OMe  N                                           3682                                                                              Q.sub.14                                                                               Me   Me        Me  Me   CH                                          3683                                                                              Q.sub.14                                                                               Me   Me        Me  OMe  CH                                          3684                                                                              Q.sub.14                                                                               Me   Me        OMe OMe  CH                                          3685                                                                              Q.sub.14                                                                               Me   Me        Me  OMe  N                                           3686                                                                              Q.sub.14                                                                               Me   Me        OMe OMe  N                  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                                                      Q.sub.15                                                                               Me   Me        OMe OMe  N                                           3692                                                                              Q.sub.16                                                                               Me   Me        Me  Me   CH                                          3693                                                                              Q.sub.16                                                                               Me   Me        Me  OMe  CH                                          3694                                                                              Q.sub.16                                                                               Me   Me        OMe OMe  CH                                          3695                                                                             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                                   Me   Me        Me  OMe  N                                           3700                                                                              Q.sub.18                                                                               Me   Me        Me  Me   CH                                          3701                                                                              Q.sub.18                                                                               Me   Me        Me  OMe  CH                                          3702                                                                              Q.sub.18                                                                               Me   Me        OMe OMe  CH                                          3703                                                                              Q.sub.18                                                                               Me   Me        Me  OMe  N                                           3704                                                                              Q.sub.18                                                                               Me   Me        OMe OMe  N                                           3705                                                                              Q.sub.19                                                                               Me   Me        Me  Me   CH                                          3706                                                                              Q.sub.19                                                                               Me   Me        Me  OMe  CH                                          3707                                                                              Q.sub.19                                                                               Me   Me        OMe OMe  CH                                          3708                                                                              Q.sub.19                                                                               Me   Me        Me  OMe  N                                           3709                                                                              Q.sub.19                                                                               Me   Me        OMe OMe  N                                           3710                                                                              Q.sub.20                                                                               Me   Me        Me  Me   CH                                          3711                                                                              Q.sub.20                                                                               Me   Me        Me  OMe  CH                                          3712                                                                              Q.sub.20                                                                               Me   Me        OMe OMe  CH                                          3713                                                                              Q.sub.20                                                                               Me   Me        Me  OMe  N                                           3714                                                                              Q.sub.20                                                                               Me   Me        OMe OMe  N                                           3715                                                                              Q.sub.21                                                                               Me   Me        Me  Me   CH                                          3716                                                                              Q.sub.21                                                                               Me   Me        Me  OMe  CH                                          3717                                                                              Q.sub.21                                                                               Me   Me        OMe OMe  CH                                          3718                                                                              Q.sub.21                                                                               Me   Me        Me  OMe  N                                           3719                                                                              Q.sub.21                                                                               Me   Me        OMe OMe  N                                           3720                                                                              Q.sub.22                                                                               Me   Me        Me  Me   CH                                          3721                                                                              Q.sub.22                                                                               Me   Me        Me  OMe  CH                                          3722                                                                              Q.sub.22                                                                               Me   Me        OMe OMe  CH                                          3723                                                                              Q.sub.22                                                                               Me   Me        Me  OMe  N                                           3724                                                                              Q.sub.22                                                                               Me   Me        OMe OMe  N                  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                                   Me   Me        OMe OMe  N                                           3738                                                                              Q.sub.26                                                                               Me   Me        Me  OMe  CH                                          3739                                                                              Q.sub.26                                                                               Me   Me        OMe OMe  CH                                          3740                                                                              Q.sub.26                                                                               Me   Me        Me  OMe  N                                           3741                                                                              Q.sub.27                                                                               Me   Me        Me  OMe  CH                                          3742                                                                              Q.sub.27                                                                               Me   Me        OMe OMe  CH                                          3743                                                                              Q.sub.27                                                                               Me   Me        Me  OMe  N                                           3744                                                                              Q.sub.28                                                                               Me   Me        Me  Me   CH                                          3745                                                                              Q.sub.28                                                                               Me   Me        Me  OMe  CH                                          3746                                                                              Q.sub.28                                                                               Me   Me        OMe OMe  CH                                          3747                                                                              Q.sub.28                                                                               Me   Me        Me  OMe  N                                           3748                                                                              Q.sub.28                                                                               Me   Me        OMe OMe  N                                           3749                                                                              Q.sub.29                                                                               Me   Me        Me  OMe  CH                                          3750                                                                              Q.sub.29                                                                               Me   Me        OMe OMe  CH                                          3751                                                                              Q.sub.29                                                                               Me   Me        Me  OMe  N                                           3752                                                                              Q.sub.30                                                                               Me   Me        Me  OMe  CH                                          3753                                                                              Q.sub.30                                                                               Me   Me        OMe OMe  CH                                          3754                                                                              Q.sub.30                                                                               Me   Me        Me  OMe  N                                           3755                                                                              Q.sub.31                                                                               Me   Me        Me  OMe  CH                                          3756                                                                              Q.sub.31                                                                               Me   Me        OMe OMe  CH                                          3757                                                                              Q.sub.31                                                                               Me   Me        Me  OMe  N                                           3758                                                                              Q.sub.32                                                                               Me   Me        Me  Me   CH                                          3759                                                                              Q.sub.32                                                                               Me   Me        Me  OMe  CH                                          3760                                                                              Q.sub.32                                                                               Me   Me        OMe OMe  CH                                          3761                                                                              Q.sub.32                                                                               Me   Me        Me  OMe  N                                           3762                                                                              Q.sub.32                                                                               Me   Me        OMe OMe  N                  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                                   Me   Me        OMe OMe  CH                                          3776                                                                              Q.sub.35                                                                               Me   Me        Me  OMe  N                                           3777                                                                              Q.sub.35                                                                               Me   Me        OMe OMe  N                                           3778                                                                              Q.sub.36                                                                               Me   Me        Me  OMe  CH                                          3779                                                                              Q.sub.36                                                                               Me   Me        OMe OMe  CH                                          3780                                                                              Q.sub.36                                                                               Me   Me        Me  OMe  N                                           3781                                                                              Q.sub.37                                                                               Me   Me        Me  Me   CH                                          3782                                                                              Q.sub.37                                                                               Me   Me        Me  OMe  CH                                          3783                                                                              Q.sub.37                                                                               Me   Me        OMe OMe  CH                                          3784                                                                              Q.sub.37                                                                               Me   Me        Me  OMe  N                                           3785                                                                              Q.sub.37                                                                               Me   Me        OMe OMe  N                                           3786                                                                              Q.sub.38                                                                               Me   Me        Me  Me   CH                                          3787                                                                              Q.sub.38                                                                               Me   Me        Me  OMe  CH                                          3788                                                                              Q.sub.38                                                                               Me   Me        OMe OMe  CH                                          3789                                                                              Q.sub.38                                                                               Me   Me        Me  OMe  N                                           3790                                                                              Q.sub.38                                                                               Me   Me        OMe OMe  N                                           3791                                                                              Q.sub.39                                                                               Me   Me        Me  Me   CH                                          3792                                                                              Q.sub.39                                                                               Me   Me        Me  OMe  CH                                          3793                                                                              Q.sub.39                                                                               Me   Me        OMe OMe  CH                                          3794                                                                              Q.sub.39                                                                               Me   Me        Me  OMe  N                                           3795                                                                              Q.sub.39                                                                               Me   Me        OMe OMe  N                                           3796                                                                              Q.sub.40                                                                               Me   Me        Me  OMe  CH                                          3797                                                                              Q.sub.40                                                                               Me   Me        OMe OMe  CH                                          3798                                                                              Q.sub.40                                                                               Me   Me        Me  OMe  N                                           3799                                                                              Q.sub.41                                                                               Me   Me        Me  Me   CH                                          3800                                                                              Q.sub.41                                                                               Me   Me        Me  OMe  CH                                          3801                                                                              Q.sub.41                                                                               Me   Me        OMe OMe  CH                                          3802                                                                              Q.sub.41                                                                               Me   Me        Me  OMe  N                                           3803                                                                              Q.sub.41                                                                               Me   Me        OMe OMe  N                                           3804                                                                              Q.sub.42                                                                               Me   Me        Me  Me   CH                                          3805                                                                              Q.sub.42                                                                               Me   Me        Me  OMe  CH                                          3806                                                                              Q.sub.42                                                                               Me   Me        OMe OMe  CH                                          3807                                                                              Q.sub.42                                                                               Me   Me        Me  OMe  N                                           3808                                                                              Q.sub.42                                                                               Me   Me        OMe OMe  N                                           3809                                                                              Q.sub.43                                                                               Me   Me        Me  Me   CH                                          3810                                                                              Q.sub.43                                                                               Me   Me        Me  OMe  CH                                          3811                                                                              Q.sub.43                                                                               Me   Me        OMe OMe  CH                                          3812                                                                              Q.sub.43                                                                               Me   Me        Me  OMe  N                                           3813                                                                              Q.sub.43                                                                               Me   Me        OMe OMe  N                                           3814                                                                              Q.sub.44                                                                               Me   Me        Me  OMe  CH                                          3815                                                                              Q.sub.44                                                                               Me   Me        OMe OMe  CH                                          3816                                                                              Q.sub.44                                                                               Me   Me        Me  OMe  N                                           3817                                                                              Q.sub.45                                                                               Me   Me        Me  Me   CH                                          3818                                                                              Q.sub.45                                                                               Me   Me        Me  OMe  CH                                          3819                                                                              Q.sub.45                                                                               Me   Me        OMe OMe  CH                                          3820                                                                              Q.sub.45                                                                               Me   Me        Me  OMe  N                                           3821                                                                              Q.sub.45                                                                               Me   Me        OMe OMe  N                                           3822                                                                              Q.sub.46                                                                               Me   Me        Me  Me   CH                                          3823                                                                              Q.sub.46                                                                               Me   Me        Me  OMe  CH                                          3824                                                                              Q.sub.46                                                                               Me   Me        OMe OMe  CH                                          3825                                                                              Q.sub.46                                                                               Me   Me        Me  OMe  N                                           3826                                                                              Q.sub.46                                                                               Me   Me        OMe OMe  N                                           3827                                                                              Q.sub.47                                                                               Me   Me        Me  Me   CH                                          3828                                                                              Q.sub.47                                                                               Me   Me        Me  OMe  CH                                          3829                                                                              Q.sub.47                                                                               Me   Me        OMe OMe  CH                                          3830                                                                              Q.sub.47                                                                               Me   Me        Me  OMe  N                                           3831                                                                              Q.sub.47                                                                               Me   Me        OMe OMe  N                                           3832                                                                              Q.sub.48                                                                               Me   Me        Me  Me   CH                                          3833                                                                              Q.sub.48                                                                               Me   Me        Me  OMe  CH                                          3834                                                                              Q.sub.48                                                                               Me   Me        OMe OMe  CH                                          3835                                                                              Q.sub.48                                                                               Me   Me        Me  OMe  N                                           3836                                                                              Q.sub.48                                                                               Me   Me        OMe OMe  N                                           3837                                                                              Q.sub.49                                                                               Me   Me        Me  Me   CH                                          3838                                                                              Q.sub.49                                                                               Me   Me        Me  OMe  CH                                          3839                                                                              Q.sub.49                                                                               Me   Me        OMe OMe  CH                                          3840                                                                              Q.sub.49                                                                               Me   Me        Me  OMe  N                                           3841                                                                              Q.sub.49                                                                               Me   Me        OMe OMe  N                                           3842                                                                              Q.sub.50                                                                               Me   Me        Me  Me   CH                                          3843                                                                              Q.sub.50                                                                               Me   Me        Me  OMe  CH                                          3844                                                                              Q.sub.50                                                                               Me   Me        OMe OMe  CH                                          3845                                                                              Q.sub.50                                                                               Me   Me        Me  OMe  N                                           3846                                                                              Q.sub.50                                                                               Me   Me        OMe OMe  N                                           3847                                                                              Q.sub.51                                                                               Me   Me        Me  Me   CH                                          3848                                                                              Q.sub.51                                                                               Me   Me        Me  OMe  CH                                          3849                                                                              Q.sub.51                                                                               Me   Me        OMe OMe  CH                                          3850                                                                              Q.sub.51                                                                               Me   Me        Me  OMe  N                                           3851                                                                              Q.sub.51                                                                               Me   Me        OMe OMe  N                                           3852                                                                              Q.sub.52                                                                               Me   Me        Me  OMe  CH                                          3853                                                                              Q.sub.52                                                                               Me   Me        OMe OMe  CH                                          3854                                                                              Q.sub.52                                                                               Me   Me        Me  OMe  N                                           3855                                                                              Q.sub.53                                                                               Me   Me        Me  OMe  CH                                          3856                                                                              Q.sub.53                                                                               Me   Me        OMe OMe  CH                                          3857                                                                              Q.sub.53                                                                               Me   Me        Me  OMe  N                                           3858                                                                              Q.sub.54                                                                               Me   Me        Me  Me   CH                                          3859                                                                              Q.sub.54                                                                               Me   Me        Me  OMe  CH                                          3860                                                                              Q.sub.54                                                                               Me   Me        OMe OMe  CH                                          3861                                                                              Q.sub.54                                                                               Me   Me        Me  OMe  N                                           3862                                                                              Q.sub.54                                                                               Me   Me        OMe OMe  N                                           3863                                                                              Q.sub.55                                                                               Me   Me        Me  Me   CH                                          3864                                                                              Q.sub.55                                                                               Me   Me        Me  OMe  CH                                          3865                                                                              Q.sub.55                                                                               Me   Me        OMe OMe  CH                                          3866                                                                              Q.sub.55                                                                               Me   Me        Me  OMe  N                                           3867                                                                              Q.sub.55                                                                               Me   Me        OMe OMe  N                                           3868                                                                              Q.sub.56                                                                               Me   Me        Me  Me   CH                                          3869                                                                              Q.sub.56                                                                               Me   Me        Me  OMe  CH                                          3870                                                                              Q.sub.56                                                                               Me   Me        OMe OMe  CH                                          3871                                                                              Q.sub.56                                                                               Me   Me        Me  OMe  N                                           3872                                                                              Q.sub.56                                                                               Me   Me        OMe OMe  N                                           3873                                                                              Q.sub.57                                                                               Me   Me        Me  OMe  CH                                          3874                                                                              Q.sub.57                                                                               Me   Me        OMe OMe  CH                                          3875                                                                              Q.sub.57                                                                               Me   Me        Me  OMe  N                                           3876                                                                              Q.sub.58                                                                               Me   Me        Me  OMe  CH                 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                                                      Q.sub.59                                                                               Me   Me        OMe OMe  CH                                          3882                                                                              Q.sub.59                                                                               Me   Me        Me  OMe  N                                           3883                                                                              Q.sub.59                                                                               Me   Me        OMe OMe  N                                           3884                                                                              Q.sub.60                                                                               Me   Me        Me  Me   CH                                          3885                                                                              Q.sub.60                                                                               Me   Me        OMe OMe  CH                                          3886                                                                              Q.sub.60                                                                               Me   Me        OMe OMe  CH                                          3887                                                                              Q.sub.60                                                                               Me   Me        Me  OMe  N                                           3888                                                                              Q.sub.60                                                                               Me   Me        OMe OMe  N                                           3889                                                                              Q.sub.61                                                                               Me   Me        Me  Me   CH                                          3890                                                                              Q.sub.61                                                                               Me   Me        Me  OMe  CH                                          3891                                                                              Q.sub.61                                                                               Me   Me        OMe OMe  CH                                          3892                                                                              Q.sub.61                                                                               Me   Me        Me  OMe  N                                           3893                                                                              Q.sub.61                                                                               Me   Me        OMe OMe  N                                           3894                                                                              Q.sub.62                                                                               Me   Me        Me  Me   CH                                          3895                                                                              Q.sub.62                                                                               Me   Me        OMe OMe  CH                                          3896                                                                              Q.sub.62                                                                               Me   Me        OMe OMe  CH                                          3897                                                                              Q.sub.62                                                                               Me   Me        Me  OMe  N                                           3898                                                                              Q.sub.62                                                                               Me   Me        OMe OMe  N                                           3899                                                                              Q.sub.63                                                                               Me   Me        OMe OMe  CH                                          3900                                                                              Q.sub.63                                                                               Me   Me        OMe OMe  CH                                          3901                                                                              Q.sub.63                                                                               Me   Me        Me  OMe  N                                           3902                                                                              Q.sub.64                                                                               Me   Me        Me  OMe  CH                                          3903                                                                              Q.sub.64                                                                               Me   Me        OMe OMe  CH                                          3904                                                                              Q.sub.64                                                                               Me   Me        Me  OMe  N                                           3905                                                                              Q.sub.65                                                                               Me   Me        Me  Me   CH                                          3906                                                                              Q.sub.65                                                                               Me   Me        Me  OMe  CH                                          3907                                                                              Q.sub.65                                                                               Me   Me        OMe OMe  CH                                          3908                                                                              Q.sub.65                                                                               Me   Me        Me  OMe  N                                           3909                                                                              Q.sub.65                                                                               Me   Me        OMe OMe  N                                           3910                                                                              Q.sub.66                                                                               Me   Me        Me  OMe  CH                                          3911                                                                              Q.sub.66                                                                               Me   Me        OMe OMe  CH                                          3912                                                                              Q.sub.66                                                                               Me   Me        Me  OMe  N                                           3913                                                                              Q.sub.67                                                                               Me   Me        OMe OMe  CH                                          3914                                                                              Q.sub.67                                                                               Me   Me        OMe OMe  CH                                          3915                                                                              Q.sub.67                                                                               Me   Me        Me  OMe  N                                           3916                                                                              Q.sub.68                                                                               Me   Me        Me  OMe  CH                                          3917                                                                              Q.sub.68                                                                               Me   Me        OMe OMe  CH                                          3918                                                                              Q.sub.68                                                                               Me   Me        Me  OMe  N                                           3919                                                                              Q.sub.69                                                                               Me   Me        Me  OMe  CH                                          3920                                                                              Q.sub.69                                                                               Me   Me        OMe OMe  CH                                          3921                                                                              Q.sub.69                                                                               Me   Me        Me  OMe  N                                           3922                                                                              Q.sub.70                                                                               Me   Me        Me  Me   CH                                          3923                                                                              Q.sub.70                                                                               Me   Me        Me  OMe  CH                                          3924                                                                              Q.sub.70                                                                               Me   Me        OMe OMe  CH                                          3925                                                                              Q.sub.70                                                                               Me   Me        Me  OMe  N                                           3926                                                                              Q.sub.70                                                                               Me   Me        OMe OMe  N                                           3927                                                                              Q.sub.71                                                                               Me   Me        Me  OMe  CH                                          3928                                                                              Q.sub.81                                                                               Me   Me        OMe OMe  CH                                          3929                                                                              Q.sub.71                                                                               Me   Me        Me  OMe  N                                           3930                                                                              Q.sub.72                                                                               Me   Me        Me  OMe  CH                                          3931                                                                              Q.sub.72                                                                               Me   Me        OMe OMe  CH                                          3932                                                                              Q.sub.72                                                                               Me   Me        Me  OMe  N                                           3933                                                                              Q.sub.73                                                                               Me   Me        Me  OMe  CH                                          3934                                                                              Q.sub.73                                                                               Me   Me        OMe OMe  CH                                          3935                                                                              Q.sub.73                                                                               Me   Me        Me  OMe  N                                           3936                                                                              Q.sub.74                                                                               Me   Me        Me  OMe  CH                                          3937                                                                              Q.sub.74                                                                               Me   Me        OMe OMe  CH                                          3938                                                                              Q.sub.74                                                                               Me   Me        Me  OMe  N                                           3939                                                                              Q.sub.75                                                                               Me   Me        Me  OMe  CH                                          3940                                                                              Q.sub.75                                                                               Me   Me        OMe OMe  CH                                          3941                                                                              Q.sub.75                                                                               Me   Me        Me  OMe  N                                           3942                                                                              Q.sub.76                                                                               Me   Me        Me  OMe  CH                                          3943                                                                              Q.sub.76                                                                               Me   Me        OMe OMe  CH                                          3944                                                                              Q.sub.76                                                                               Me   Me        Me  OMe  N                                           3945                                                                              Me      Q.sub.3                                                                             COOMe     Me  OMe  CH                                          3946                                                                              Me      Q.sub.3                                                                             COOMe     OMe OMe  CH                                          3946                                                                              Me      Q.sub.3                                                                             COOMe     OMe OMe  CH                                          3946                                                                              Me      Q.sub.3                                                                             COOMe     OMe OMe  CH                                          3947                                                                              Me      Q.sub.3                                                                             COOMe     Me  OMe  N                                           3948                                                                              Me      Q.sub.4                                                                             COOMe     Me  OMe  CH                                          3949                                                                              Me      Q.sub.4                                                                             COOMe     OMe OMe  CH                                          3950                                                                              Me      Q.sub.4                                                                             COOMe     Me  OMe  N                                           3951                                                                              Me      Q.sub.6                                                                             COOMe     Me  OMe  CH                                          3952                                                                              Me      Q.sub.6                                                                             COOMe     OMe OMe  CH                                          3953                                                                              Me      Q.sub.6                                                                             COOMe     Me  OMe  N                                           3954                                                                              Me      Q.sub.9                                                                             COOMe     Me  OMe  CH                                          3955                                                                              Me      Q.sub.9                                                                             COOMe     OMe OMe  CH                                          3956                                                                              Me      Q.sub.9                                                                             COOMe     Me  OMe  N                                           3957                                                                              Me      Q.sub.10                                                                            COOMe     Me  OMe  CH                                          3958                                                                              Me      Q.sub.10                                                                            COOMe     OMe OMe  CH                                          3959                                                                              Me      Q.sub.10                                                                            COOMe     Me  OMe  N                                           3960                                                                              Me      Q.sub.11                                                                            COOMe     Me  OMe  CH                                          3961                                                                              Me      Q.sub.11                                                                            COOMe     OMe OMe  CH                                          3962                                                                              Me      Q.sub.11                                                                            COOMe     Me  OMe  N                                           3963                                                                              Me      Q.sub.12                                                                            COOMe     Me  OMe  CH                                          3964                                                                              Me      Q.sub.12                                                                            COOMe     OMe OMe  CH                                          3965                                                                              Me      Q.sub.12                                                                            COOMe     Me  OMe  N                                           3966                                                                              Me      Q.sub.14                                                                            COOMe     Me  OMe  CH                                          3967                                                                              Me      Q.sub.14                                                                            COOMe     OMe OMe  CH                                          3968                                                                              Me      Q.sub.14                                                                            COOMe     Me  OMe  N                                           3969                                                                              Me      Q.sub.15                                                                            COOMe     Me  OMe  CH                                          3970                                                                              Me      Q.sub.15                                                                            COOMe     OMe OMe  CH                                          3971                                                                              Me      Q.sub.15                                                                            COOMe     Me  OMe  N                                           3972                                                                              Me      Q.sub.16                                                                            COOMe     Me  OMe  CH                                          3973                                                                              Me      Q.sub.16                                                                            COOMe     OMe OMe  CH                                          3974                                                                              Me      Q.sub.16                                                                            COOMe     Me  OMe  N                                           3975                                                                              Me      Q.sub.18                                                                            COOMe     Me  OMe  CH                                          3976                                                                              Me      Q.sub.18                                                                            COOMe     OMe OMe  CH                                          3977                                                                              Me      Q.sub.18                                                                            COOMe     Me  OMe  N                                           3978                                                                              Me      Q.sub.19                                                                            COOMe     Me  OMe  CH                                          3979                                                                              Me      Q.sub.19                                                                            COOMe     OMe OMe  CH                                          3980                                                                              Me      Q.sub.19                                                                            COOMe     Me  OMe  N                                           3981                                                                              Me      Q.sub.20                                                                            COOMe     Me  OMe  CH                                          3982                                                                              Me      Q.sub.20                                                                            COOMe     OMe OMe  CH                                          3983                                                                              Me      Q.sub.20                                                                            COOMe     Me  OMe  N                                           3984                                                                              Me      Q.sub.21                                                                            COOMe     Me  OMe  CH                                          3985                                                                              Me      Q.sub.21                                                                            COOMe     OMe OMe  CH                                          3986                                                                              Me      Q.sub.21                                                                            COOMe     Me  OMe  N                                           3987                                                                              Me      Q.sub.22                                                                            COOMe     Me  OMe  CH                                          3988                                                                              Me      Q.sub.22                                                                            COOMe     OMe OMe  CH                                          3989                                                                              Me      Q.sub.22                                                                            COOMe     Me  OMe  N                                           3990                                                                              Me      Q.sub.24                                                                            COOMe     Me  OMe  CH                                          3991                                                                              Me      Q.sub.24                                                                            COOMe     OMe OMe  CH                                          3992                                                                              Me      Q.sub.24                                                                            COOMe     Me  OMe  N                                           3993                                                                              Me      Q.sub.25                                                                            COOMe     Me  OMe  CH                                          3994                                                                              Me      Q.sub.25                                                                            COOMe     OMe OMe  CH                                          3995                                                                              Me      Q.sub.25                                                                            COOMe     Me  OMe  N                                           3996                                                                              Me      Q.sub.28                                                                            COOMe     Me  OMe  CH                                          3997                                                                              Me      Q.sub.28                                                                            COOMe     OMe OMe  CH                                          3998                                                                              Me      Q.sub.28                                                                            COOMe     Me  OMe  N                                           3999                                                                              Me      Q.sub.33                                                                            COOMe     Me  OMe  CH                                          4000                                                                              Me      Q.sub.33                                                                            COOMe     OMe OMe  CH                                          4001                                                                              Me      Q.sub.33                                                                            COOMe     Me  OMe  N                                           4002                                                                              Me      Q.sub.34                                                                            COOMe     Me  OMe  CH                                          4003                                                                              Me      Q.sub.34                                                                            COOMe     OMe OMe  CH                                          4004                                                                              Me      Q.sub.34                                                                            COOMe     Me  OMe  N                                           4005                                                                              Me      Q.sub.35                                                                            COOMe     Me  OMe  CH                                          4006                                                                              Me      Q.sub.35                                                                            COOMe     OMe OMe  CH                                          4007                                                                              Me      Q.sub.35                                                                            COOMe     Me  OMe  N                                           4008                                                                              Me      Q.sub.37                                                                            COOMe     Me  OMe  CH                                          4009                                                                              Me      Q.sub.37                                                                            COOMe     OMe OMe  CH                                          4010                                                                              Me      Q.sub.37                                                                            COOMe     Me  OMe  N                                           4011                                                                              Me      Q.sub.38                                                                            COOMe     Me  OMe  CH                                          4012                                                                              Me      Q.sub.38                                                                            COOMe     OMe OMe  CH                                          4013                                                                              Me      Q.sub.38                                                                            COOMe     Me  OMe  N                                           4014                                                                              Me      Q.sub.39                                                                            COOMe     Me  OMe  CH                                          4015                                                                              Me      Q.sub.39                                                                            COOMe     OMe OMe  CH                                          4016                                                                              Me      Q.sub.39                                                                            COOMe     Me  OMe  N                                           4017                                                                              Me      Q.sub.41                                                                            COOMe     Me  OMe  CH                                          4018                                                                              Me      Q.sub.41                                                                            COOMe     OMe OMe  CH                                          4019                                                                              Me      Q.sub.41                                                                            COOMe     Me  OMe  N                                           4020                                                                              Me      Q.sub.42                                                                            COOMe     Me  OMe  CH                                          4021                                                                              Me      Q.sub.42                                                                            COOMe     OMe OMe  CH                                          4022                                                                              Me      Q.sub.42                                                                            COOMe     Me  OMe  N                                           4023                                                                              Me      Q.sub.43                                                                            COOMe     Me  OMe  CH                                          4024                                                                              Me      Q.sub.43                                                                            COOMe     OMe OMe  CH                                          4025                                                                              Me      Q.sub.43                                                                            COOMe     Me  OMe  N                                           4026                                                                              Me      Q.sub.46                                                                            COOMe     Me  OMe  CH                                          4027                                                                              Me      Q.sub.46                                                                            COOMe     OMe OMe  CH                                          4028                                                                              Me      Q.sub.46                                                                            COOMe     Me  OMe  N                                           4029                                                                              Me      Q.sub.47                                                                            COOMe     Me  OMe  CH                                          4030                                                                              Me      Q.sub.47                                                                            COOMe     OMe OMe  CH                                          4031                                                                              Me      Q.sub.47                                                                            COOMe     Me  OMe  N                                           4032                                                                              Me      Q.sub.48                                                                            COOMe     Me  OMe  CH                                          4033                                                                              Me      Q.sub.48                                                                            COOMe     OMe OMe  CH                                          4034                                                                              Me      Q.sub.48                                                                            COOMe     Me  OMe  N                                           4035                                                                              Me      Q.sub.49                                                                            COOMe     Me  OMe  CH                                          4036                                                                              Me      Q.sub.49                                                                            COOMe     OMe OMe  CH                                          4037                                                                              Me      Q.sub.49                                                                            COOMe     Me  OMe  N                                           4038                                                                              Me      Q.sub.50                                                                            COOMe     Me  OMe  CH                                          4039                                                                              Me      Q.sub.50                                                                            COOMe     OMe OMe  CH                                          4040                                                                              Me      Q.sub.50                                                                            COOMe     Me  OMe  N                                           4041                                                                              Me      Q.sub.51                                                                            COOMe     Me  OMe  CH                                          4042                                                                              Me      Q.sub.51                                                                            COOMe     OMe OMe  CH                                          4043                                                                              Me      Q.sub.51                                                                            COOMe     Me  OMe  N                                           4044                                                                              Me      Q.sub.54                                                                            COOMe     OMe OMe  CH                                          4045                                                                              Me      Q.sub.54                                                                            COOMe     OMe OMe  CH                                          4046                                                                              Me      Q.sub.54                                                                            COOMe     Me  OMe  N                                           4047                                                                              Me      Q.sub.55                                                                            COOMe     Me  OMe  CH                                          4048                                                                              Me      Q.sub.55                                                                            COOMe     OMe OMe  CH                                          4049                                                                              Me      Q.sub.55                                                                            COOMe     Me  OMe  N                                           4050                                                                              Me      Q.sub.56                                                                            COOMe     Me  OMe  CH                                          4051                                                                              Me      Q.sub.56                                                                            COOMe     OMe OMe  CH                                          4052                                                                              Me      Q.sub.56                                                                            COOMe     Me  OMe  N                                           4053                                                                              Me      Q.sub.60                                                                            COOMe     Me  OMe  CH                                          4054                                                                              Me      Q.sub.60                                                                            COOMe     OMe OMe  CH                                          4055                                                                              Me      Q.sub.60                                                                            COOMe     Me  OMe  N                                           4056                                                                              Me      Q.sub.61                                                                            COOMe     Me  OMe  CH                                          4057                                                                              Me      Q.sub.61                                                                            COOMe     OMe OMe  CH                                          4058                                                                              Me      Q.sub.61                                                                            COOMe     Me  OMe  N                                           4059                                                                              Me      Q.sub.62                                                                            COOMe     Me  OMe  CH                                          4060                                                                              Me      Q.sub.62                                                                            COOMe     OMe OMe  CH                                          4061                                                                              Me      Q.sub.62                                                                            COOMe     Me  OMe  N                                           4062                                                                              Me      Q.sub.65                                                                            COOMe     Me  OMe  CH                                          4063                                                                              Me      Q.sub.65                                                                            COOMe     OMe OMe  CH                                          4064                                                                              Me      Q.sub.65                                                                            COOMe     Me  OMe  N                                           4065                                                                              Me      Q.sub.70                                                                            COOMe     Me  OMe  CH                                          4066                                                                              Me      Q.sub.70                                                                            COOMe     OMe OMe  CH                                          4067                                                                              Me      Q.sub.70                                                                            COOMe     Me  OMe  N                                           4068                                                                              Me      Q.sub.7                                                                             Me        OMe OMe  CH                                          4069                                                                              Me      Q.sub.7                                                                             Me        Me  OMe  N                                           4070                                                                              Me      Q.sub.13                                                                            Me        OMe OMe  CH                                          4071                                                                              Me      Q.sub.13                                                                            Me        Me  OMe  N                                           4072                                                                              Me      Q.sub.17                                                                            Me        OMe OMe  CH                                          4073                                                                              Me      Q.sub.17                                                                            Me        Me  OMe  N                                           4074                                                                              Me      Q.sub.23                                                                            Me        OMe OMe  CH                                          4075                                                                              Me      Q.sub.23                                                                            Me        Me  OMe  N                                           4076                                                                              Me      Q.sub.26                                                                            Me        OMe OMe  CH                                          4077                                                                              Me      Q.sub.26                                                                            Me        Me  OMe  N                                           4078                                                                              Me      Q.sub.27                                                                            Me        OMe OMe  CH                                          4079                                                                              Me      Q.sub.27                                                                            Me        Me  OMe  N                                           4080                                                                              Me      Q.sub.29                                                                            Me        OMe OMe  CH                                          4081                                                                              Me      Q.sub.29                                                                            Me        Me  OMe  N                                           4082                                                                              Me      Q.sub.30                                                                            Me        OMe OMe  CH                                          4083                                                                              Me      Q.sub.30                                                                            Me        Me  OMe  N                                           4084                                                                              Me      Q.sub.31                                                                            Me        OMe OMe  CH                                          4085                                                                              Me      Q.sub.31                                                                            Me        Me  OMe  N                                           4086                                                                              Me      Q.sub.36                                                                            Me        OMe OMe  CH                                          4087                                                                              Me      Q.sub.36                                                                            Me        Me  OMe  N                                           4088                                                                              Me      Q.sub.40                                                                            Me        OMe OMe  CH                                          4089                                                                              Me      Q.sub.40                                                                            Me        Me  OMe  N                                           4090                                                                              Me      Q.sub.44                                                                            Me        OMe OMe  CH                                          4091                                                                              Me      Q.sub.44                                                                            Me        Me  OMe  N                                           4092                                                                              Me      Q.sub.52                                                                            Me        OMe OMe  CH                                          4093                                                                              Me      Q.sub.52                                                                            Me        Me  OMe  N                                           4094                                                                              Me      Q.sub.53                                                                            Me        OMe OMe  CH                                          4095                                                                              Me      Q.sub.53                                                                            Me        Me  OMe  N                                           4096                                                                              Me      Q.sub.57                                                                            Me        OMe OMe  CH                                          4097                                                                              Me      Q.sub.57                                                                            Me        Me  OMe  N                                           4098                                                                              Me      Q.sub.58                                                                            Me        OMe OMe  CH                                          4099                                                                              Me      Q.sub.58                                                                            Me        Me  OMe  N                                           4100                                                                              Me      Q.sub.63                                                                            Me        OMe OMe  CH                                          4101                                                                              Me      Q.sub.63                                                                            Me        Me  OMe  N                                           4102                                                                              Me      Q.sub.64                                                                            Me        OMe OMe  CH                                          4103                                                                              Me      Q.sub.64                                                                            Me        Me  OMe  N                                           4104                                                                              Me      Q.sub.66                                                                            Me        OMe OMe  CH                                          4105                                                                              Me      Q.sub.66                                                                            Me        Me  OMe  N                                           4106                                                                              Me      Q.sub.67                                                                            Me        OMe OMe  CH                                          4107                                                                              Me      Q.sub.67                                                                            Me        Me  OMe  N                                           4108                                                                              Me      Q.sub.68                                                                            Me        OMe OMe  CH                                          4109                                                                              Me      Q.sub.68                                                                            Me        Me  OMe  N                                           4110                                                                              Me      Q.sub.69                                                                            Me        OMe OMe  CH                                          4111                                                                              Me      Q.sub.69                                                                            Me        Me  OMe  N                                           4112                                                                              Me      Q.sub.71                                                                            Me        OMe OMe  CH                                          4113                                                                              Me      Q.sub.71                                                                            Me        Me  OMe  N                                           4114                                                                              Me      Q.sub.72                                                                            Me        OMe OMe  CH                                          4115                                                                              Me      Q.sub.72                                                                            Me        Me  OMe  N                                           4116                                                                              Me      Q.sub.73                                                                            Me        OMe OMe  CH                                          4117                                                                              Me      Q.sub.73                                                                            Me        Me  OMe  N                                           4118                                                                              Me      Q.sub.74                                                                            Me        OMe OMe  CH                                          4119                                                                              Me      Q.sub.74                                                                            Me        Me  OMe  N                                           4120                                                                              Me      Q.sub.75                                                                            Me        OMe OMe  CH                                          4121                                                                              Me      Q.sub.75                                                                            Me        Me  OMe  N                                           4122                                                                              Me      Q.sub.76                                                                            Me        OMe OMe  CH                                          4123                                                                              Me      Q.sub.76                                                                            Me        Me  OMe  N                                           5611                                                                              Q.sub.77                                                                               Me   COOMe     Me  OMe  CH                                          5612                                                                              Q.sub.77                                                                               Me   COOMe     OMe OMe  CH                                          5613                                                                              Q.sub.77                                                                               Me   COOMe     Me  OMe  N                                           5614                                                                              Me      Me   Q.sub.77  OMe OMe  CH                                          5615                                                                              Me      Me   Q.sub.77  Me  OMe  N                                           5616                                                                              Q.sub.78                                                                               Me   Cl        Me  Me   CH                                          5617                                                                              Q.sub.78                                                                               Me   Cl        Me  OMe  CH                                          5618                                                                              Q.sub.78                                                                               Me   Cl        OMe OMe  CH                                          5619                                                                              Q.sub.78                                                                               Me   Cl        Me  OMe  N                                           5620                                                                              Q.sub.78                                                                               Me   Cl        OMe OMe  N                                           5621                                                                              Q.sub.78                                                                               Me   OMe       Me  OMe  CH                                          5622                                                                              Q.sub.78                                                                               Me   OMe       OMe OMe  CH                                          5623                                                                              Q.sub.78                                                                               Me   OMe       Me  OMe  N                                           5624                                                                              Q.sub.78                                                                               CF.sub.3                                                                            Me        Me  OMe  CH                                          5625                                                                              Q.sub.78                                                                               CF.sub.3                                                                            Me        OMe OMe  CH                                          5626                                                                              Q.sub.78                                                                               CF.sub.3                                                                            Me        Me  OMe  N                                           5627                                                                              Q.sub.78                                                                               Me   COOMe     Me  Me   CH                                          5628                                                                              Q.sub.78                                                                               Me   COOMe     Me  OMe  CH                                          5629                                                                              Q.sub.78                                                                               Me   COOMe     OMe OMe  CH                                          5630                                                                              Q.sub.78                                                                               Me   COOMe     Me  OMe  N                                           5631                                                                              Q.sub.78                                                                               Me   COOMe     OMe OMe  N                                           5632                                                                              Q.sub.78                                                                               Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          5633                                                                              Q.sub.78                                                                               Me   COOMe     Me                                                                                  ##STR27##                                                                          CH                                          5634                                                                              Q.sub.78                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          5635                                                                              Q.sub.78                                                                               Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          5636                                                                              Q.sub.78                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  N                                           5637                                                                              H       Q.sub.78                                                                            Me        Me  OMe  CH                                          5638                                                                              H       Q.sub.78                                                                            Me        OMe OMe  CH                                          5639                                                                              H       Q.sub.78                                                                            Me        Me  OMe  N                                           5640                                                                              Me      Q.sub.78                                                                            Me        Me  OMe  CH                                          5641                                                                              Me      Q.sub.78                                                                            Me        OMe OMe  CH                                          5642                                                                              Me      Q.sub.78                                                                            Me        Me  OMe  N                                           5643                                                                              Me      Q.sub.78                                                                            Cl        Me  OMe  CH                                          5644                                                                              Me      Q.sub.78                                                                            Cl        OMe OMe  CH                                          5645                                                                              Me      Q.sub.78                                                                            Cl        Me  OMe  N                                           5646                                                                              Me      Q.sub.78                                                                            COOMe     Me  OMe  CH                                          5647                                                                              Me      Q.sub.78                                                                            COOMe     OMe OMe  CH                                          5648                                                                              Me      Q.sub.78                                                                            COOMe     Me  OMe  N                                           5649                                                                              Me      Q.sub.78                                                                            Ph        Me  OMe  CH                                          5650                                                                              Me      Q.sub.78                                                                            Ph        OMe OMe  CH                                          5651                                                                              Me      Q.sub.78                                                                            Ph        Me  OMe  N                                           5652                                                                              Me      Me   Q.sub.78  Me  OMe  CH                                          5653                                                                              Me      Me   Q.sub.78  OMe OMe  CH                                          5654                                                                              Me      Me   Q.sub.78  Me  OMe  N                                           5655                                                                              Q.sub.79                                                                               Me   Cl        Me  Me   CH                                          5656                                                                              Q.sub.79                                                                               Me   Cl        Me  OMe  CH                                          5657                                                                              Q.sub.79                                                                               Me   Cl        OMe OMe  CH                                          5658                                                                              Q.sub.79                                                                               Me   Cl        Me  OMe  N                                           5659                                                                              Q.sub.79                                                                               Me   Cl        OMe OMe  N                                           5660                                                                              Q.sub.79                                                                               Me   OMe       Me  OMe  CH                                          5661                                                                              Q.sub.79                                                                               Me   OMe       OMe OMe  CH                                          5662                                                                              Q.sub.79                                                                               Me   OMe       Me  OMe  N                                           5663                                                                              Q.sub.79                                                                               CF.sub.3                                                                            Me        Me  OMe  CH                                          5664                                                                              Q.sub.79                                                                               CF.sub.3                                                                            Me        OMe OMe  CH                                          5665                                                                              Q.sub.79                                                                               CF.sub.3                                                                            Me        Me  OMe  N                                           5666                                                                              Q.sub.79                                                                               Me   COOMe     Me  Me   CH                                          5667                                                                              Q.sub.79                                                                               Me   COOMe     Me  OMe  CH                                          5668                                                                              Q.sub.79                                                                               Me   COOMe     OMe OMe  CH                                          5669                                                                              Q.sub.79                                                                               Me   COOMe     Me  OMe  N                                           5670                                                                              Q.sub.79                                                                               Me   COOMe     OMe OMe  N                                           5671                                                                              Q.sub.79                                                                               Me   COOMe     Me  OCHF.sub.2                                                                          CH                                          5672                                                                              Q.sub.79                                                                               Me   COOMe     Me                                                                                  ##STR28##                                                                          CH                                          5673                                                                              Q.sub.79                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  CH                                          5674                                                                              Q.sub.79                                                                               Me   SO.sub.2 Me                                                                              OMe OMe  CH                                          5675                                                                              Q.sub.79                                                                               Me   SO.sub.2 Me                                                                              Me  OMe  N                                           5676                                                                              H       Q.sub.79                                                                            Me        Me  OMe  CH                                          5677                                                                              H       Q.sub.79                                                                            Me        OMe OMe  CH                                          5678                                                                              H       Q.sub.79                                                                            Me        Me  OMe  N                                           5679                                                                              Me      Q.sub.79                                                                            Me        Me  OMe  CH                                          5680                                                                              Me      Q.sub.79                                                                            Me        OMe OMe  CH                                          5681                                                                              Me      Q.sub.79                                                                            Me        Me  OMe  N                                           5682                                                                              Me      Q.sub.79                                                                            Cl        Me  OMe  CH                                          5683                                                                              Me      Q.sub.79                                                                            Cl        OMe OMe  CH                                          5684                                                                              Me      Q.sub.79                                                                            Cl        Me  OMe  N                                           5685                                                                              Me      Q.sub.79                                                                            COOMe     Me  OMe  CH                                          5686                                                                              Me      Q.sub.79                                                                            COOMe     OMe OMe  CH                                          5687                                                                              Me      Q.sub.79                                                                            COOMe     Me  OMe  N                                           5688                                                                              Me      Q.sub.79                                                                            Ph        Me  OMe  CH                                          5689                                                                              Me      Q.sub.79                                                                            Ph        OMe OMe  CH                                          5690                                                                              Me      Q.sub.79                                                                            Ph        Me  OMe  N                                           5691                                                                              Me      Me   Q.sub.79  Me  OMe  CH                                          5692                                                                              Me      Me   Q.sub.79  OMe OMe  CH                                          5693                                                                              Me      Me   Q.sub.79  Me  OMe  N                                           5694                                                                              Q.sub.80                                                                               Me   COOMe     Me  Me   CH                                          5695                                                                              Q.sub.80                                                                               Me   COOMe     Me  OMe  CH                                          5696                                                                              Q.sub.80                                                                               Me   COOMe     OMe OMe  CH                                          5697                                                                              Q.sub.80                                                                               Me   COOMe     Me  OMe  N                                           5698                                                                              Q.sub.80                                                                               Me   COOMe     OMe OMe  N                                           5699                                                                              Me      Q.sub.80                                                                            Me        Me  OMe  CH                                          5700                                                                              Me      Q.sub.80                                                                            Me        OMe OMe  CH                                          5701                                                                              Me      Q.sub.80                                                                            Me        Me  OMe  N                                           5702                                                                              Me      Me   Q.sub.80  Me  OMe  CH                                          5703                                                                              Me      Me   Q.sub.80  OMe OMe  CH                                          5704                                                                              Me      Me   Q.sub.80  Me  OMe  N                                           5705                                                                              Q.sub.81                                                                               Me   COOMe     Me  OMe  CH                                          5706                                                                              Q.sub.81                                                                               Me   COOMe     OMe OMe  CH                                          5707                                                                              Q.sub.81                                                                               Me   COOMe     Me  OMe  N                                           5708                                                                              Me      Me   Q.sub.81  OMe OMe  CH                                          5709                                                                              Me      Me   Q.sub.81  Me  OMe  N                                           5710                                                                              Q.sub.82                                                                               Me   COOMe     Me  OMe  CH                                          5711                                                                              Q.sub.82                                                                               Me   COOMe     OMe OMe  CH                                          5712                                                                              Q.sub.82                                                                               Me   COOMe     Me  OMe  N                                           5713                                                                              Me      Me   Q.sub.83  OMe OMe  CH                                          5714                                                                              Me      Me   Q.sub.83  Me  OMe  N                                           5715                                                                              Q.sub.83                                                                               Me   COOMe     Me  OMe  CH                                          5716                                                                              Q.sub.83                                                                               Me   COOMe     OME OME  CH                                          5717                                                                              Q.sub.83                                                                               Me   COOMe     Me  OMe  N                                           5718                                                                              Me      Me   Q.sub.83  OMe OMe  CH                                          5719                                                                              Me      Me   Q.sub.83  Me  OMe  N                                           __________________________________________________________________________

In the above, Q₁ to Q₈₃ are as defined above.

                                      TABLE 3                                      __________________________________________________________________________      ##STR29##                                                                     No.        A          B           D   X        Y       Z                       __________________________________________________________________________     4124       Q.sub.1    H           H   Me       Me      CH                      4125       Q.sub.1    H           H   Me       OMe     CH                      4126       Q.sub.1    H           H   OMe      OMe     CH                      4127       Q.sub.1    H           H   Me       OMe     N                       4128       Q.sub.1    H           H   OMe      OMe     N                       4129       Q.sub.1    H           H   Me       OCHF.sub.2                                                                             CH                      4130       Q.sub.1    H           H   Cl       OMe     CH                      4131       Q.sub.1    H           H   Me       Me      N                       4132       Q.sub.1    Me          H   Me       Me      CH                      4133       Q.sub.1    Me          H   Me       OMe     CH                      4134       Q.sub.1    Me          H   OMe      OMe     CH                      4135       Q.sub.1    Me          H   Me       OMe     N                       4136       Q.sub.1    Me          H   OMe      OMe     N                       4137       Q.sub.1    Me          H   Me       OCHF.sub.2                                                                             CH                      4138       Q.sub.1    Me          H   Cl       OMe     CH                      4139       Q.sub.1    Me          H   Me       Me      N                       4140       Q.sub.1    Et          H   Me       Me      CH                      4141       Q.sub.1    Et          H   Me       OMe     CH                      4142       Q.sub.1    Et          H   OMe      OMe     CH                      4143       Q.sub.1    Et          H   Me       OMe     N                       4144       Q.sub.1    Et          H   OMe      OMe     N                       4145       Q.sub.1    Cl          H   Me       Me      CH                      4146       Q.sub.1    Cl          H   Me       OMe     CH                      4147       Q.sub.1    Cl          H   OMe      OMe     CH                      4148       Q.sub.1    Cl          H   Me       OMe     N                       4149       Q.sub.1    Cl          H   OMe      OMe     N                       4150       Q.sub.1    Br          H   Me       Me      CH                      4151       Q.sub.1    Br          H   Me       OMe     CH                      4152       Q.sub.1    Br          H   OMe      OMe     CH                      4153       Q.sub.1    Br          H   Me       OMe     N                       4154       Q.sub.1    Br          H   OMe      OMe     N                       4155       Q.sub.1    Br          H   Me       OCHF.sub.2                                                                             CH                      4156       Q.sub.1    Br          H   Cl       OMe     CH                      4157       Q.sub.1    Br          H   Me       Me      N                       4158       Q.sub.1    NO.sub.2    H   Me       Me      CH                      4159       Q.sub.1    NO.sub.2    H   Me       OMe     CH                      4160       Q.sub.1    NO.sub.2    H   OMe      OMe     CH                      4161       Q.sub.1    NO.sub.2    H   Me       OMe     N                       4162       Q.sub. 1   NO.sub.2    H   OMe      OMe     N                       4163       Q.sub.1    COOMe       H   Me       Me      CH                      4164       Q.sub.1    COOMe       H   Me       OMe     CH                      4165       Q.sub.1    COOMe       H   OMe      OMe     CH                      4166       Q.sub.1    COOMe       H   Me       OMe     N                       4167       Q.sub.1    COOMe       H   OMe      OMe     N                       4168       Q.sub.1    COOEt       H   Me       Me      CH                      4169       Q.sub.1    COOEt       H   Me       OMe     CH                      4170       Q.sub.1    COOEt       H   OMe      OMe     CH                      4171       Q.sub.1    COOEt       H   Me       OMe     N                       4172       Q.sub.1    COOEt       H   OMe      OMe     N                       4173       Q.sub.1    SO.sub.2 NMe.sub.2                                                                         H   Me       Me      CH                      4174       Q.sub.1    SO.sub.2 NMe.sub.2                                                                         H   Me       OMe     CH                      4175       Q.sub.1    SO.sub.2 NMe.sub.2                                                                         H   OMe      OMe     CH                      4176       Q.sub.1    SO.sub.2 NMe.sub.2                                                                         H   Me       OMe     N                       4177       Q.sub.1    SO.sub.2 NMe.sub.2                                                                         H   OMe      OMe     N                       4178       Q.sub.1    Me          Me  Me       OMe     CH                      4179       Q.sub.1    Me          Me  OMe      OMe     CH                      4180       Q.sub.1    Me          Me  Me       OMe     N                       4181       Q.sub.1    Cl          Me  Me       OMe     CH                      4182       Q.sub.1    Cl          Me  OMe      OMe     CH                      4183       Q.sub.1    Cl          Me  Me       OMe     N                       4184       Q.sub.1    Br          Me  Me       OMe     CH                      4185       Q.sub. 1   Br          Me  OMe      OMe     CH                      4186       Q.sub.1    Br          Me  Me       OMe     N                       4187       Q.sub.1    COOMe       Me  Me       OMe     CH                      4188       Q.sub.1    COOMe       Me  OMe      OMe     CH                      4189       Q.sub.1    COOMe       Me  Me       OMe     N                       4190       Me         Q.sub.1     H   Me       Me      CH                      4191       Me         Q.sub.1     H   Me       OMe     CH                      4192       Me         Q.sub.1     H   OMe      OMe     CH                      4193       Me         Q.sub.1     H   Me       OMe     N                       4194       Me         Q.sub.1     H   OMe      OMe     N                       4195       Et         Q.sub.1     H   Me       OMe     CH                      4196       Et         Q.sub.1     H   OMe      OMe     CH                      4197       Et         Q.sub.1     H   Me       OMe     N                       4198       CH.sub.2 CHCH.sub.2                                                                       Q.sub.1     H   Me       OMe     CH                      4199       CH.sub.2 CHCH.sub.2                                                                       Q.sub.1     H   OMe      OMe     CH                      4200       CH.sub.2 CHCH.sub.2                                                                       Q.sub.1     H   Me       OMe     N                       4201       CH.sub.2 CCH                                                                              Q.sub.1     H   Me       OMe     CH                      4202       CH.sub.2 CCH                                                                              Q.sub.1     H   OMe      OMe     CH                      4203       CH.sub.2 CCH                                                                              Q.sub.1     H   Me       OMe     N                       4204       CH.sub. 2 CN                                                                              Q.sub.1     H   Me       OMe     CH                      4205       CH.sub.2 CN                                                                               Q.sub.1     H   OMe      OMe     CH                      4206       CH.sub.2 CN                                                                               Q.sub.1     H   Me       OMe     N                       4207       CH.sub.2 COOMe                                                                            Q.sub.1     H   Me       OMe     CH                      4208       CH.sub.2 COOMe                                                                            Q.sub.1     H   OMe      OMe     CH                      4209       CH.sub.2 COOMe                                                                            Q.sub.1     H   Me       OMe     N                       4210       COMe       Q.sub.1     H   Me       OMe     CH                      4211       COMe       Q.sub.1     H   OMe      OMe     CH                      4212       COMe       Q.sub.1     H   Me       OMe     N                       4213       SO.sub.2 NMe.sub.2                                                                        Q.sub.1     H   Me       OMe     CH                      4214       SO.sub.2 NMe.sub.2                                                                        Q.sub.1     H   OMe      OMe     CH                      4215       SO.sub.2 NMe.sub.2                                                                        Q.sub.1     H   Me       OMe     N                       4216       SO.sub.2 Me                                                                               Q.sub.1     H   Me       OMe     CH                      4217       SO.sub.2 Me                                                                               Q.sub.1     H   OMe      OMe     CH                      4218       SO.sub.2 Me                                                                               Q.sub.1     H   Me       OMe     N                       4219       Me         Q.sub.1     Me  Me       Me      CH                      4220       Me         Q.sub.1     Me  Me       OMe     CH                      4221       Me         Q.sub.1     Me  OMe      OMe     CH                      4222       Me         Q.sub.1     Me  Me       OMe     N                       4223       Me         Q.sub.1     Me  OMe      OMe     N                       4224       Me         H           Q.sub.1                                                                            Me       Me      CH                      4225       Me         H           Q.sub.1                                                                            Me       OMe     CH                      4226       Me         H           Q.sub.1                                                                            OMe      OMe     CH                      4227       Me         H           Q.sub.1                                                                            Me       OMe     N                       4228       Me         H           Q.sub.1                                                                            OMe      OMe     N                       4229       Me         Me          Q.sub.1                                                                            Me       OMe     CH                      4230       Me         Me          Q.sub.1                                                                            OMe      OMe     CH                      4231       Me         Me          Q.sub.1                                                                            Me       OMe     N                       4232       Me         Cl          Q.sub.1                                                                            Me       OMe     CH                      4233       Me         Cl          Q.sub.1                                                                            OMe      OMe     CH                      4234       Me         Cl          Q.sub.1                                                                            Me       OMe     N                       4235       Me         Br          Q.sub.1                                                                            Me       OMe     CH                      4236       Me         Br          Q.sub.1                                                                            OMe      OMe     CH                      4237       Me         Br          Q.sub.1                                                                            Me       OMe     N                       4238       Me         NO.sub.2    Q.sub.1                                                                            Me       OMe     CH                      4239       Me         NO.sub.2    Q.sub.1                                                                            OMe      OMe     CH                      4240       Me         NO.sub.2    Q.sub.1                                                                            Me       OMe     N                       4241       Et         H           Q.sub.1                                                                            Me       OMe     CH                      4242       Et         H           Q.sub.1                                                                            OMe      OMe     CH                      4243       Et         H           Q.sub.1                                                                            Me       OMe     N                       4244       Q.sub.2    H           H   Me       OMe     CH                      4245       Q.sub.2    H           H   OMe      OMe     CH                      4246       Q.sub.2    H           H   Me       OMe     N                       4247       Q.sub.2    Me          H   Me       OMe     CH                      4248       Q.sub.2    Me          H   OMe      OMe     CH                      4249       Q.sub.2    Me          H   Me       OMe     N                       4250       Q.sub.2    Cl          H   Me       OMe     CH                      4251       Q.sub.2    Cl          H   OMe      OMe     CH                      4252       Q.sub.2    Cl          H   Me       OMe     N                       4253       Q.sub.2    Br          H   Me       OMe     CH                      4254       Q.sub.2    Br          H   OMe      OMe     CH                      4255       Q.sub.2    Br          H   Me       OMe     N                       4256       Q.sub.2    COOMe       H   Me       OMe     CH                      4257       Q.sub.2    COOMe       H   OMe      OMe     CH                      4258       Q.sub.2    COOMe       H   Me       OMe     N                       4259       Q.sub.2    COOEt       H   Me       OMe     CH                      4260       Q.sub.2    COOEt       H   OMe      OMe     CH                      4261       Q.sub.2    COOEt       H   Me       OMe     N                       4262       Me         Q.sub.2     H   Me       Me      CH                      4263       Me         Q.sub.2     H   Me       OMe     CH                      4264       Me         Q.sub.2     H   OMe      OMe     CH                      4265       Me         Q.sub.2     H   Me       OMe     N                       4266       Me         Q.sub.2     H   OMe      OMe     N                       4267       COMe       Q.sub.2     H   Me       OMe     CH                      4268       COMe       Q.sub.2     H   OMe      OMe     CH                      4269       COMe       Q.sub.2     H   Me       OMe     N                       4270       Q.sub.3    H           H   Me       OMe     CH                      4271       Q.sub.3    H           H   OMe      OMe     CH                      4272       Q.sub.3    H           H   Me       OMe     N                       4273       Q.sub.3    Cl          H   Me       OMe     CH                      4274       Q.sub.3    Cl          H   OMe      OMe     CH                      4275       Q.sub.3    Cl          H   Me       OMe     N                       4276       Q.sub.3    COOMe       H   Me       OMe     CH                      4277       Q.sub.3    COOMe       H   OMe      OMe     CH                      4278       Q.sub.3    COOMe       H   Me       OMe     N                       4279       Me         Q.sub.3     H   Me       OMe     CH                      4280       Me         Q.sub.3     H   OMe      OMe     CH                      4281       Me         Q.sub.3     H   Me       OMe     N                       4282       Q.sub.4    H           H   Me       OMe     CH                      4283       Q.sub.4    H           H   OMe      OMe     CH                      4284       Q.sub.4    H           H   Me       OMe     N                       4285       Q.sub.4    Cl          H   Me       OMe     CH                      4286       Q.sub.4    Cl          H   OMe      OMe     CH                      4287       Q.sub.4    Cl          H   Me       OMe     N                       4288       Q.sub.4    COOMe       H   Me       OMe     CH                      4289       Q.sub.4    COOMe       H   OMe      OMe     CH                      4290       Q.sub.4    COOMe       H   Me       OMe     N                       4291       Me         Q.sub.4     H   Me       OMe     CH                      4292       Me         Q.sub.4     H   OMe      OMe     CH                      4293       Me         Q.sub.4     H   Me       OMe     N                       4294       Q.sub.5    H           H   Me       OMe     CH                      4295       Q.sub.5    H           H   OMe      OMe     CH                      4296       Q.sub.5    H           H   Me       OMe     N                       4297       Q.sub.5    Me          H   Me       OMe     CH                      4298       Q.sub.5    Me          H   OMe      OMe     CH                      4299       Q.sub.5    Me          H   Me       OMe     N                       4300       Q.sub.5    Cl          H   Me       OMe     CH                      4301       Q.sub.5    Cl          H   OMe      OMe     CH                      4302       Q.sub.5    Cl          H   Me       OMe     N                       4303       Q.sub.5    Br          H   Me       OMe     CH                      4304       Q.sub.5    Br          H   OMe      OMe     CH                      4305       Q.sub.5    Br          H   Me       OMe     N                       4306       Q.sub.5    COOMe       H   Me       OMe     CH                      4307       Q.sub.5    COOMe       H   OMe      OMe     CH                      4308       Q.sub.5    COOMe       H   Me       OMe     N                       4309       Q.sub.5    COOEt       H   Me       OMe     CH                      4310       Q.sub.5    COOEt       H   OMe      OMe     CH                      4311       Q.sub.5    COOEt       H   Me       OMe     N                       4312       Me         Q.sub.5     H   Me       Me      CH                      4313       Me         Q.sub.5     H   Me       OMe     CH                      4314       Me         Q.sub.5     H   OMe      OMe     CH                      4315       Me         Q.sub.5     H   Me       OMe     N                       4316       Me         Q.sub.5     H   OMe      OMe     N                       4317       COMe       Q.sub.5     H   Me       OMe     CH                      4318       COMe       Q.sub.5     H   OMe      OMe     CH                      4319       COMe       Q.sub.5     H   Me       OMe     N                       4320       Q.sub.6    H           H   Me       OMe     CH                      4321       Q.sub.6    H           H   OMe      OMe     CH                      4322       Q.sub.6    H           H   Me       OMe     N                       4323       Q.sub.6    Cl          H   Me       OMe     CH                      4324       Q.sub.6    Cl          H   OMe      OMe     CH                      4325       Q.sub.6    Cl          H   Me       OMe     N                       4326       Q.sub.6    COOMe       H   Me       OMe     CH                      4327       Q.sub.6    COOMe       H   OMe      OMe     CH                      4328       Q.sub.6    COOMe       H   Me       OMe     N                       4329       Me         Q.sub.6     H   Me       OMe     CH                      4330       Me         Q.sub.6     H   OMe      OMe     CH                      4331       Me         Q.sub.6     H   Me       OMe     N                       4332       Q.sub.7    Cl          H   Me       OMe     CH                      4333       Q.sub.7    Cl          H   OMe      OMe     CH                      4334       Q.sub.7    Cl          H   Me       OMe     N                       4335       Q.sub.7    COOMe       H   Me       OMe     CH                      4336       Q.sub.7    COOMe       H   OMe      OMe     CH                      4337       Q.sub.7    COOMe       H   Me       OMe     N                       4338       Me         Q.sub.7     H   Me       OMe     CH                      4339       Me         Q.sub.7     H   OMe      OMe     CH                      4340       Me         Q.sub.7     H   Me       OMe     N                       4341       Q.sub.8    H           H   Me       OMe     CH                      4342       Q.sub.8    H           H   OMe      OMe     CH                      4343       Q.sub.8    H           H   Me       OMe     N                       4344       Q.sub.8    Me          H   Me       OMe     CH                      4345       Q.sub.8    Me          H   OMe      OMe     CH                      4346       Q.sub.8    Me          H   Me       OMe     N                       4347       Q.sub.8    Cl          H   Me       OMe     CH                      4348       Q.sub.8    Cl          H   OMe      OMe     CH                      4349       Q.sub.8    Cl          H   Me       OMe     N                       4350       Q.sub.8    Br          H   Me       OMe     CH                      4351       Q.sub.8    Br          H   OMe      OMe     CH                      4352       Q.sub.8    Br          H   Me       OMe     N                       4353       Q.sub.8    COOMe       H   Me       OMe     CH                      4354       Q.sub.8    COOMe       H   OMe      OMe     CH                      4355       Q.sub.8    COOMe       H   Me       OMe     N                       4356       Q.sub.8    COOEt       H   Me       OMe     CH                      4357       Q.sub.8    COOEt       H   OMe      OMe     CH                      4358       Q.sub.8    COOEt       H   Me       OMe     N                       4359       Me         Q.sub.8     H   Me       Me      CH                      4360       Me         Q.sub.8     H   Me       OMe     CH                      4361       Me         Q.sub.8     H   OMe      OMe     CH                      4362       Me         Q.sub.8     H   Me       OMe     N                       4363       Me         Q.sub.8     H   OMe      OMe     N                       4364       COMe       Q.sub.8     H   Me       OMe     CH                      4365       COMe       Q.sub.8     H   OMe      OMe     CH                      4366       COMe       Q.sub.8     H   Me       OMe     N                       4367       Q.sub.9    H           H   Me       OMe     CH                      4368       Q.sub.9    H           H   OMe      OMe     CH                      4369       Q.sub.9    H           H   Me       OMe     N                       4370       Q.sub.9    Cl          H   Me       OMe     CH                      4371       Q.sub.9    Cl          H   OMe      OMe     CH                      4372       Q.sub.9    Cl          H   Me       OMe     N                       4373       Q.sub.9    COOMe       H   Me       OMe     CH                      4374       Q.sub.9    COOMe       H   OMe      OMe     CH                      4375       Q.sub.9    COOMe       H   Me       OMe     N                       4376       Me         Q.sub.9     H   Me       OMe     CH                      4377       Me         Q.sub.9     H   OMe      OMe     CH                      4378       Me         Q.sub.9     H   Me       OMe     N                       4379       Q.sub.10   H           H   Me       OMe     CH                      4380       Q.sub.10   H           H   OMe      OMe     CH                      4381       Q.sub.10   H           H   Me       OMe     N                       4382       Q.sub.10   Cl          H   Me       OMe     CH                      4383       Q.sub.10   Cl          H   OMe      OMe     CH                      4384       Q.sub.10   Cl          H   Me       OMe     N                       4385       Q.sub.10   COOMe       H   Me       OMe     CH                      4386       Q.sub.10   COOMe       H   OMe      OMe     CH                      4387       Q.sub.10   COOMe       H   Me       OMe     N                       4388       Me         Q.sub.10    H   Me       OMe     CH                      4389       Me         Q.sub.10    H   OMe      OMe     CH                      4390       Me         Q.sub.10    H   Me       OMe     N                       4391       Q.sub.11   H           H   Me       OMe     CH                      4392       Q.sub.11   H           H   OMe      OMe     CH                      4393       Q.sub.11   H           H   Me       OMe     N                       4394       Q.sub.11   Cl          H   Me       OMe     CH                      4395       Q.sub.11   Cl          H   OMe      OMe     CH                      4396       Q.sub.11   Cl          H   Me       OMe     N                       4397       Q.sub.11   COOMe       H   Me       OMe     CH                      4398       Q.sub.11   COOMe       H   OMe      OMe     CH                      4399       Q.sub.11   COOMe       H   Me       OMe     N                       4400       Me         Q.sub.11    H   Me       OMe     CH                      4401       Me         Q.sub.11    H   OMe      OMe     CH                      4402       Me         Q.sub.11    H   Me       OMe     N                       4403       Q.sub.12   H           H   Me       OMe     CH                      4404       Q.sub.12   H           H   OMe      OMe     CH                      4405       Q.sub.12   H           H   Me       OMe     N                       4406       Q.sub.12   Cl          H   Me       OMe     CH                      4407       Q.sub.12   Cl          H   OMe      OMe     CH                      4408       Q.sub.12   Cl          H   Me       OMe     N                       4409       Q.sub.12   COOMe       H   Me       OMe     CH                      4410       Q.sub.12   COOMe       H   OMe      OMe     CH                      4411       Q.sub.12   COOMe       H   Me       OMe     N                       4412       Me         Q.sub.12    H   Me       OMe     CH                      4413       Me         Q.sub.12    H   OMe      OMe     CH                      4414       Me         Q.sub.12    H   Me       OMe     N                       4415       Q.sub.13   Cl          H   Me       OMe     CH                      4416       Q.sub.13   Cl          H   OMe      OMe     CH                      4417       Q.sub.13   Cl          H   Me       OMe     N                       4418       Q.sub.13   COOMe       H   Me       OMe     CH                      4419       Q.sub.13   COOMe       H   OMe      OMe     CH                      4420       Q.sub.13   COOMe       H   Me       OMe     N                       4421       Me         Q.sub.13    H   Me       OMe     CH                      4422       Me         Q.sub.13    H   OMe      OMe     CH                      4423       Me         Q.sub.13    H   Me       OMe     N                       4424       Q.sub.14   H           H   Me       OMe     CH                      4425       Q.sub.14   H           H   OMe      OMe     CH                      4426       Q.sub.14   H           H   Me       OMe     N                       4427       Q.sub.14   Cl          H   Me       OMe     CH                      4428       Q.sub.14   Cl          H   OMe      OMe     CH                      4429       Q.sub.14   Cl          H   Me       OMe     N                       4430       Q.sub.14   COOMe       H   Me       OMe     CH                      4431       Q.sub.14   COOMe       H   OMe      OMe     CH                      4432       Q.sub.14   COOMe       H   Me       OMe     N                       4433       Me         Q.sub.14    H   Me       OMe     CH                      4434       Me         Q.sub.14    H   OMe      OMe     CH                      4435       Me         Q.sub.14    H   Me       OMe     N                       4436       Q.sub.15   H           H   Me       OMe     CH                      4437       Q.sub.15   H           H   OMe      OMe     CH                      4438       Q.sub.15   H           H   Me       OMe     N                       4439       Q.sub.15   Cl          H   Me       OMe     CH                      4440       Q.sub.15   Cl          H   OMe      OMe     CH                      4441       Q.sub.15   Cl          H   Me       OMe     N                       4442       Q.sub.15   COOMe       H   Me       OMe     CH                      4443       Q.sub.15   COOMe       H   OMe      OMe     CH                      4444       Q.sub.15   COOMe       H   Me       OMe     N                       4445       Me         Q.sub.15    H   Me       OMe     CH                      4446       Me         Q.sub.15    H   OMe      OMe     CH                      4447       Me         Q.sub.15    H   Me       OMe     N                       4448       Q.sub.16   H           H   Me       OMe     CH                      4449       Q.sub.16   H           H   OMe      OMe     CH                      4450       Q.sub.16   H           H   Me       OMe     N                       4451       Q.sub.16   Cl          H   Me       OMe     CH                      4452       Q.sub.16   Cl          H   OMe      OMe     CH                      4453       Q.sub.16   Cl          H   Me       OMe     N                       4454       Q.sub.16   COOMe       H   Me       OMe     CH                      4455       Q.sub.16   COOMe       H   OMe      OMe     CH                      4456       Q.sub.16   COOMe       H   Me       OMe     N                       4457       Me         Q.sub.16    H   Me       OMe     CH                      4458       Me         Q.sub.16    H   OMe      OMe     CH                      4459       Me         Q.sub.16    H   Me       OMe     N                       4460       Q.sub.17   Cl          H   Me       OMe     CH                      4461       Q.sub.17   Cl          H   OMe      OMe     CH                      4462       Q.sub.17   Cl          H   Me       OMe     N                       4463       Q.sub.17   COOMe       H   Me       OMe     CH                      4464       Q.sub.17   COOMe       H   OMe      OMe     CH                      4465       Q.sub.17   COOMe       H   Me       OMe     N                       4466       Me         Q.sub.17    H   Me       OMe     CH                      4467       Me         Q.sub.17    H   OMe      OMe     CH                      4468       Me         Q.sub.17    H   Me       OMe     N                       4469       Q.sub.18   H           H   Me       OMe     CH                      4470       Q.sub.18   H           H   OMe      OMe     CH                      4471       Q.sub.18   H           H   Me       OMe     N                       4472       Q.sub.18   Cl          H   Me       OMe     CH                      4473       Q.sub.18   Cl          H   OMe      OMe     CH                      4474       Q.sub.18   Cl          H   Me       OMe     N                       4475       Q.sub.18   COOMe       H   Me       OMe     CH                      4476       Q.sub.18   COOMe       H   OMe      OMe     CH                      4477       Q.sub.18   COOMe       H   Me       OMe     N                       4478       Me         Q.sub.18    H   Me       OMe     CH                      4479       Me         Q.sub.18    H   OMe      OMe     CH                      4480       Me         Q.sub.18    H   Me       OMe     N                       4481       Q.sub.19   H           H   Me       OMe     CH                      4482       Q.sub.19   H           H   OMe      OMe     CH                      4483       Q.sub.19   H           H   Me       OMe     N                       4484       Q.sub.19   Cl          H   Me       OMe     CH                      4485       Q.sub.19   Cl          H   OMe      OMe     CH                      4486       Q.sub.19   Cl          H   Me       OMe     N                       4487       Q.sub.19   COOMe       H   Me       OMe     CH                      4488       Q.sub.19   COOMe       H   OMe      OMe     CH                      4489       Q.sub.19   COOMe       H   Me       OMe     N                       4490       Me         Q.sub.19    H   Me       OMe     CH                      4491       Me         Q.sub.19    H   OMe      OMe     CH                      4492       Me         Q.sub.19    H   Me       OMe     N                       4493       Q.sub.20   H           H   Me       OMe     CH                      4494       Q.sub.20   H           H   OMe      OMe     CH                      4495       Q.sub.20   H           H   Me       OMe     N                       4496       Q.sub.20   Cl          H   Me       OMe     CH                      4497       Q.sub.20   Cl          H   OMe      OMe     CH                      4498       Q.sub.20   Cl          H   Me       OMe     N                       4499       Q.sub.20   COOMe       H   Me       OMe     CH                      4500       Q.sub.20   COOMe       H   OMe      OMe     CH                      4501       Q.sub.20   COOMe       H   Me       OMe     N                       4502       Me         Q.sub.20    H   Me       OMe     CH                      4503       Me         Q.sub.20    H   OMe      OMe     CH                      4504       Me         Q.sub.20    H   Me       OMe     N                       4505       Q.sub.21   H           H   Me       OMe     CH                      4506       Q.sub.21   H           H   OMe      OMe     CH                      4507       Q.sub.21   H           H   Me       OMe     N                       4508       Q.sub.21   Cl          H   Me       OMe     CH                      4509       Q.sub.21   Cl          H   OMe      OMe     CH                      4510       Q.sub.21   Cl          H   Me       OMe     N                       4511       Q.sub.21   COOMe       H   Me       OMe     CH                      4512       Q.sub.21   COOMe       H   OMe      OMe     CH                      4513       Q.sub.21   COOMe       H   Me       OMe     N                       4514       Me         Q.sub.21    H   Me       OMe     CH                      4515       Me         Q.sub.21    H   OMe      OMe     CH                      4516       Me         Q.sub.21    H   Me       OMe     N                       4517       Q.sub.22   H           H   Me       OMe     CH                      4518       Q.sub.22   H           H   OMe      OMe     CH                      4519       Q.sub.22   H           H   Me       OMe     N                       4520       Q.sub.22   Cl          H   Me       OMe     CH                      4521       Q.sub.22   Cl          H   OMe      OMe     CH                      4522       Q.sub.22   Cl          H   Me       OMe     N                       4523       Q.sub.22   COOMe       H   Me       OMe     CH                      4524       Q.sub.22   COOMe       H   OMe      OMe     CH                      4525       Q.sub.22   COOMe       H   Me       OMe     N                       4526       Me         Q.sub.22    H   Me       OMe     CH                      4527       Me         Q.sub.22    H   OMe      OMe     CH                      4528       Me         Q.sub.22    H   Me       OMe     N                       4529       Q.sub.23   Cl          H   Me       OMe     CH                      4530       Q.sub.23   Cl          H   OMe      OMe     CH                      4531       Q.sub.23   Cl          H   Me       OMe     N                       4532       Q.sub.23   COOMe       H   Me       OMe     CH                      4533       Q.sub.23   COOMe       H   OMe      OMe     CH                      4534       Q.sub.23   COOMe       H   Me       OMe     N                       4535       Me         Q.sub.23    H   Me       OMe     CH                      4536       Me         Q.sub.23    H   OMe      OMe     CH                      4537       Me         Q.sub.23    H   Me       OMe     N                       4532       Q.sub.24   H           H   Me       OMe     CH                      4533       Q.sub.24   H           H   OMe      OMe     CH                      4534       Q.sub.24   H           H   Me       OMe     N                       4535       Q.sub.24   Cl          H   Me       OMe     CH                      4536       Q.sub.24   Cl          H   OMe      OMe     CH                      4537       Q.sub.24   Cl          H   Me       OMe     N                       4538       Q.sub.24   COOMe       H   Me       OMe     CH                      4539       Q.sub.24   COOMe       H   OMe      OMe     CH                      4540       Q.sub.24   COOMe       H   Me       OMe     N                       4541       Me         Q.sub.24    H   Me       OMe     CH                      4542       Me         Q.sub.24    H   OMe      OMe     CH                      4543       Me         Q.sub.24    H   Me       OMe     N                       4544       Q.sub.25   H           H   Me       OMe     CH                      4545       Q.sub.25   H           H   OMe      OMe     CH                      4546       Q.sub.25   H           H   Me       OMe     N                       4547       Q.sub.25   Cl          H   Me       OMe     CH                      4548       Q.sub.25   Cl          H   OMe      OMe     CH                      4549       Q.sub.25   Cl          H   Me       OMe     N                       4550       Q.sub.25   COOMe       H   Me       OMe     CH                      4551       Q.sub.25   COOMe       H   OMe      OMe     CH                      4552       Q.sub.25   COOMe       H   Me       OMe     N                       4553       Me         Q.sub.25    H   Me       OMe     CH                      4554       Me         Q.sub.25    H   OMe      OMe     CH                      4555       Me         Q.sub.25    H   Me       OMe     N                       4556       Q.sub.26   Cl          H   Me       OMe     CH                      4557       Q.sub.26   Cl          H   OMe      OMe     CH                      4558       Q.sub.26   Cl          H   Me       OMe     N                       4559       Q.sub.26   COOMe       H   Me       OMe     CH                      4560       Q.sub.26   COOMe       H   OMe      OMe     CH                      4561       Q.sub.26   COOMe       H   Me       OMe     N                       4562       Me         Q.sub.26    H   Me       OMe     CH                      4563       Me         Q.sub.26    H   OMe      OMe     CH                      4564       Me         Q.sub.26    H   Me       OMe     N                       4565       Q.sub.27   Cl          H   Me       OMe     CH                      4566       Q.sub.27   Cl          H   OMe      OMe     CH                      4567       Q.sub.27   Cl          H   Me       OMe     N                       4568       Q.sub.27   COOMe       H   Me       OMe     CH                      4569       Q.sub.27   COOMe       H   OMe      OMe     CH                      4570       Q.sub.27   COOMe       H   Me       OMe     N                       4571       Me         Q.sub.27    H   Me       OMe     CH                      4572       Me         Q.sub.27    H   OMe      OMe     CH                      4573       Me         Q.sub.27    H   Me       OMe     N                       4574       Q.sub.28   H           H   Me       OMe     CH                      4575       Q.sub.28   H           H   OMe      OMe     CH                      4576       Q.sub.28   H           H   Me       OMe     N                       4577       Q.sub.28   Cl          H   Me       OMe     CH                      4578       Q.sub.28   Cl          H   OMe      OMe     CH                      4579       Q.sub.28   Cl          H   Me       OMe     N                       4580       Q.sub.28   COOMe       H   Me       OMe     CH                      4581       Q.sub.28   COOMe       H   OMe      OMe     CH                      4582       Q.sub.28   COOMe       H   Me       OMe     N                       4583       Me         Q.sub.28    H   Me       OMe     CH                      4584       Me         Q.sub.28    H   OMe      OMe     CH                      4585       Me         Q.sub.28    H   Me       OMe     N                       4586       Q.sub.29   Cl          H   Me       OMe     CH                      4587       Q.sub.29   Cl          H   OMe      OMe     CH                      4588       Q.sub.29   Cl          H   Me       OMe     N                       4589       Q.sub.29   COOMe       H   Me       OMe     CH                      4590       Q.sub.29   COOMe       H   OMe      OMe     CH                      4591       Q.sub.29   COOMe       H   Me       OMe     N                       4592       Me         Q.sub.29    H   Me       OMe     CH                      4593       Me         Q.sub.29    H   OMe      OMe     CH                      4594       Me         Q.sub.29    H   Me       OMe     N                       4595       Q.sub.30   Cl          H   Me       OMe     CH                      4596       Q.sub.30   Cl          H   OMe      OMe     CH                      4597       Q.sub.30   Cl          H   Me       OMe     N                       4598       Q.sub.30   COOMe       H   Me       OMe     CH                      4599       Q.sub.30   COOMe       H   OMe      OMe     CH                      4600       Q.sub.30   COOMe       H   Me       OMe     N                       4601       Me         Q.sub.30    H   Me       OMe     CH                      4602       Me         Q.sub.30    H   OMe      OMe     CH                      4603       Me         Q.sub.30    H   Me       OMe     N                       4604       Q.sub.31   Cl          H   Me       OMe     CH                      4605       Q.sub.31   Cl          H   OMe      OMe     CH                      4606       Q.sub.31   Cl          H   Me       OMe     N                       4607       Q.sub.31   COOMe       H   Me       OMe     CH                      4608       Q.sub.31   COOMe       H   OMe      OMe     CH                      4609       Q.sub.31   COOMe       H   Me       OMe     N                       4610       Me         Q.sub.31    H   Me       OMe     CH                      4611       Me         Q.sub.31    H   OMe      OMe     CH                      4612       Me         Q.sub.31    H   Me       OMe     N                       4613       Q.sub.32   H           H   Me       OMe     CH                      4614       Q.sub.32   H           H   OMe      OMe     CH                      4615       Q.sub.32   H           H   Me       OMe     N                       4616       Q.sub.32   Me          H   Me       OMe     CH                      4617       Q.sub.32   Me          H   OMe      OMe     CH                      4618       Q.sub.32   Me          H   Me       OMe     N                       4619       Q.sub.32   Cl          H   Me       OMe     CH                      4620       Q.sub.32   Cl          H   OMe      OMe     CH                      4621       Q.sub.32   Cl          H   Me       OMe     N                       4622       Q.sub.32   Br          H   Me       OMe     CH                      4623       Q.sub.32   Br          H   OMe      OMe     CH                      4624       Q.sub.32   Br          H   Me       OMe     N                       4625       Q.sub.32   COOMe       H   Me       OMe     CH                      4626       Q.sub.32   COOMe       H   OMe      OMe     CH                      4627       Q.sub.32   COOMe       H   Me       OMe     N                       4628       Q.sub.32   COOEt       H   Me       OMe     CH                      4629       Q.sub.32   COOEt       H   OMe      OMe     CH                      4630       Q.sub.32   COOEt       H   Me       OMe     N                       4631       Me         Q.sub.32    H   Me       Me      CH                      4632       Me         Q.sub.32    H   Me       OMe     CH                      4633       Me         Q.sub.32    H   OMe      OMe     CH                      4634       Me         Q.sub.32    H   Me       OMe     N                       4635       Me         Q.sub.32    H   OMe      OMe     N                       4636       COMe       Q.sub.32    H   Me       OMe     CH                      4637       COMe       Q.sub.32    H   OMe      OMe     CH                      4638       COMe       Q.sub.32    H   Me       OMe     N                       4639       Q.sub.33   H           H   Me       OMe     CH                      4640       Q.sub.33   H           H   OMe      OMe     CH                      4641       Q.sub.33   H           H   Me       OMe     N                       4642       Q.sub.33   Cl          H   Me       OMe     CH                      4643       Q.sub.33   Cl          H   OMe      OMe     CH                      4644       Q.sub.33   Cl          H   Me       OMe     N                       4645       Q.sub.33   COOMe       H   Me       OMe     CH                      4646       Q.sub.33   COOMe       H   OMe      OMe     CH                      4647       Q.sub.33   COOMe       H   Me       OMe     N                       4648       Me         Q.sub.33    H   Me       OMe     CH                      4649       Me         Q.sub.33    H   OMe      OMe     CH                      4650       Me         Q.sub.33    H   Me       OMe     N                       4651       Q.sub.34   H           H   Me       OMe     CH                      4652       Q.sub.34   H           H   OMe      OMe     CH                      4653       Q.sub.34   H           H   Me       OMe     N                       4654       Q.sub.34   Cl          H   Me       OMe     CH                      4655       Q.sub.34   Cl          H   OMe      OMe     CH                      4656       Q.sub.34   Cl          H   Me       OMe     N                       4657       Q.sub.34   COOMe       H   Me       OMe     CH                      4658       Q.sub.34   COOMe       H   OMe      OMe     CH                      4659       Q.sub.34   COOMe       H   Me       OMe     N                       4660       Me         Q.sub.34    H   Me       OMe     CH                      4661       Me         Q.sub.34    H   OMe      OMe     CH                      4662       Me         Q.sub.34    H   Me       OMe     N                       4663       Q.sub.35   H           H   Me       OMe     CH                      4664       Q.sub.35   H           H   OMe      OMe     CH                      4665       Q.sub.35   H           H   Me       OMe     N                       4666       Q.sub.35   Cl          H   Me       OMe     CH                      4667       Q.sub.35   Cl          H   OMe      OMe     CH                      4668       Q.sub.35   Cl          H   Me       OMe     N                       4669       Q.sub.35   COOMe       H   Me       OMe     CH                      4670       Q.sub.35   COOMe       H   OMe      OMe     CH                      4671       Q.sub.35   COOMe       H   Me       OMe     N                       4672       Me         Q.sub.35    H   Me       OMe     CH                      4673       Me         Q.sub.35    H   OMe      OMe     CH                      4674       Me         Q.sub.35    H   Me       OMe     N                       4675       Q.sub.36   Cl          H   Me       OMe     CH                      4676       Q.sub.36   Cl          H   OMe      OMe     CH                      4677       Q.sub.36   Cl          H   Me       OMe     N                       4678       Q.sub.36   COOMe       H   Me       OMe     CH                      4679       Q.sub.36   COOMe       H   OMe      OMe     CH                      4680       Q.sub.36   COOMe       H   Me       OMe     N                       4681       Me         Q.sub.36    H   Me       OMe     CH                      4682       Me         Q.sub.36    H   OMe      OMe     CH                      4683       Me         Q.sub.36    H   Me       OMe     N                       4684       Q.sub.37   H           H   Me       OMe     CH                      4685       Q.sub.37   H           H   OMe      OMe     CH                      4686       Q.sub.37   H           H   Me       OMe     N                       4687       Q.sub.37   Cl          H   Me       OMe     CH                      4688       Q.sub.37   Cl          H   OMe      OMe     CH                      4689       Q.sub.37   Cl          H   Me       OMe     N                       4690       Q.sub.37   COOMe       H   Me       OMe     CH                      4691       Q.sub.37   COOMe       H   OMe      OMe     CH                      4692       Q.sub.37   COOMe       H   Me       OMe     N                       4693       Me         Q.sub.37    H   Me       OMe     CH                      4694       Me         Q.sub.37    H   OMe      OMe     CH                      4695       Me         Q.sub.37    H   Me       OMe     N                       4696       Q.sub.38   H           H   Me       OMe     CH                      4697       Q.sub.38   H           H   OMe      OMe     CH                      4698       Q.sub.38   H           H   Me       OMe     N                       4699       Q.sub.38   Cl          H   Me       OMe     CH                      4700       Q.sub.38   Cl          H   OMe      OMe     CH                      4701       Q.sub.38   Cl          H   Me       OMe     N                       4702       Q.sub.38   COOMe       H   Me       OMe     CH                      4703       Q.sub.38   COOMe       H   OMe      OMe     CH                      4704       Q.sub.38   COOMe       H   Me       OMe     N                       4705       Me         Q.sub.38    H   Me       OMe     CH                      4706       Me         Q.sub.38    H   OMe      OMe     CH                      4707       Me         Q.sub.38    H   Me       OMe     N                       4708       Q.sub.39   H           H   Me       OMe     CH                      4709       Q.sub.39   H           OMe OMe      CH                              4710       Q.sub.39   H           H   Me       OMe     N                       4711       Q.sub.39   Cl          H   Me       OMe     CH                      4712       Q.sub.39   Cl          H   OMe      OMe     CH                      4713       Q.sub.39   Cl          H   Me       OMe     N                       4714       Q.sub.39   COOMe       H   Me       OMe     CH                      4715       Q.sub.39   COOMe       H   OMe      OMe     CH                      4716       Q.sub.39   COOMe       H   Me       OMe     N                       4717       Me         Q.sub.39    H   Me       OMe     CH                      4718       Me         Q.sub.39    H   OMe      OMe     CH                      4719       Me         Q.sub.39    H   Me       OMe     N                       4720       Q.sub.40   Cl          H   Me       OMe     CH                      4721       Q.sub.40   Cl          H   OMe      OMe     CH                      4722       Q.sub.40   Cl          H   Me       OMe     N                       4723       Q.sub.40   COOMe       H   Me       OMe     CH                      4724       Q.sub.40   COOMe       H   OMe      OMe     CH                      4725       Q.sub.40   COOMe       H   Me       OMe     N                       4726       Me         Q.sub.40    H   Me       OMe     CH                      4727       Me         Q.sub.40    H   OMe      OMe     CH                      4728       Me         Q.sub.40    H   Me       OMe     N                       4729       Q.sub.41   H           H   Me       OMe     CH                      4730       Q.sub.41   H           H   OMe      OMe     CH                      4731       Q.sub.41   H           H   Me       OMe     N                       4732       Q.sub.41   Cl          H   Me       OMe     CH                      4733       Q.sub.41   Cl          H   OMe      OMe     CH                      4734       Q.sub.41   Cl          H   Me       OMe     N                       4735       Q.sub.41   COOMe       H   Me       OMe     CH                      4736       Q.sub.41   COOMe       H   OMe      OMe     CH                      4737       Q.sub.41   COOMe       H   Me       OMe     N                       4738       Me         Q.sub.41    H   Me       OMe     CH                      4739       Me         Q.sub.41    H   OMe      OMe     CH                      4740       Me         Q.sub.41    H   Me       OMe     N                       4741       Q.sub.42   H           H   Me       OMe     CH                      4742       Q.sub.42   H           H   OMe      OMe     CH                      4743       Q.sub.42   H           H   Me       OMe     N                       4744       Q.sub.42   Cl          H   OMe      OMe     CH                      4745       Q.sub.42   Cl          H   OMe      OMe     CH                      4746       Q.sub.42   Cl          H   Me       OMe     N                       4747       Q.sub.42   COOMe       H   Me       OMe     CH                      4748       Q.sub.42   COOMe       H   OMe      OMe     CH                      4749       Q.sub.42   COOMe       H   Me       OMe     N                       4750       Me         Q.sub.42    H   Me       OMe     CH                      4751       Me         Q.sub.42    H   OMe      OMe     CH                      4752       Me         Q.sub.42    H   Me       OMe     N                       4753       Q.sub.43   H           H   Me       OMe     CH                      4754       Q.sub.43   H           H   OMe      OMe     CH                      4755       Q.sub.43   H           H   Me       OMe     N                       4756       Q.sub.43   Cl          H   Me       OMe     CH                      4757       Q.sub.43   Cl          H   OMe      OMe     CH                      4758       Q.sub.43   Cl          H   Me       OMe     N                       4759       Q.sub.43   COOMe       H   Me       OMe     CH                      4760       Q.sub.43   COOMe       H   OMe      OMe     CH                      4761       Q.sub.43   COOMe       H   Me       OMe     N                       4762       Me         Q.sub.43    H   Me       OMe     CH                      4763       Me         Q.sub.43    H   OMe      OMe     CH                      4764       Me         Q.sub.43    H   Me       OMe     N                       4765       Q.sub.44   Cl          H   Me       OMe     CH                      4766       Q.sub.44   Cl          H   OMe      OMe     CH                      4767       Q.sub.44   Cl          H   Me       OMe     N                       4768       Q.sub.44   COOMe       H   Me       OMe     CH                      4769       Q.sub. 44  COOMe       H   OMe      OMe     CH                      4770       Q.sub.44   COOMe       H   Me       OMe     N                       4771       Me         Q.sub.44    H   Me       OMe     CH                      4772       Me         Q.sub.44    H   OMe      OMe     CH                      4773       Me         Q.sub.44    H   Me       OMe     N                       4774       Q.sub.45   H           H   Me       OMe     CH                      4775       Q.sub.45   H           H   OMe      OMe     CH                      4776       Q.sub.45   H           H   Me       OMe     N                       4777       Q.sub.45   Me          H   Me       OMe     CH                      4778       Q.sub.45   Me          H   OMe      OMe     CH                      4779       Q.sub.45   Me          H   Me       OMe     N                       4780       Q.sub.45   Cl          H   Me       OMe     CH                      4781       Q.sub.45   Cl          H   OMe      OMe     CH                      4782       Q.sub.45   Cl          H   Me       OMe     N                       4783       Q.sub.45   Br          H   Me       OMe     CH                      4784       Q.sub.45   Br          H   OMe      OMe     CH                      4785       Q.sub.45   Br          H   Me       OMe     N                       4786       Q.sub.45   COOMe       H   Me       OMe     CH                      4787       Q.sub.45   COOMe       H   OMe      OMe     CH                      4788       Q.sub.45   COOMe       H   Me       OMe     N                       4789       Q.sub.45   COOEt       H   Me       OMe     CH                      4790       Q.sub.45   COOEt       H   OMe      OMe     CH                      4791       Q.sub.45   COOEt       H   Me       OMe     N                       4792       Me         Q.sub.45    H   Me       Me      CH                      4793       Me         Q.sub.45    H   Me       OMe     CH                      4794       Me         Q.sub.45    H   OMe      OMe     CH                      4795       Me         Q.sub.45    H   Me       OMe     N                       4796       Me         Q.sub.45    H   OMe      OMe     N                       4797       COOMe      Q.sub.45    H   Me       OMe     CH                      4798       COOMe      Q.sub.45    H   OMe      OMe     CH                      4799       COOMe      Q.sub.45    H   Me       OMe     N                       4800       Q.sub.46   H           H   Me       OMe     CH                      4801       Q.sub.46   H           H   OMe      OMe     CH                      4802       Q.sub.46   H           H   Me       OMe     N                       4803       Q.sub.46   Cl          H   Me       OMe     CH                      4804       Q.sub.46   Cl          H   OMe      OMe     CH                      4805       Q.sub.46   Cl          H   Me       OMe     N                       4806       Q.sub.46   COOMe       H   Me       OMe     CH                      4807       Q.sub.46   COOMe       H   OMe      OMe     CH                      4808       Q.sub.46   COOMe       H   Me       OMe     N                       4809       Me         Q.sub.46    H   Me       OMe     CH                      4810       Me         Q.sub.46    H   Me       OMe     CH                      4811       Me         Q.sub.46    H   Me       OMe     N                       4812       Q.sub.47   H           H   Me       OMe     CH                      4813       Q.sub.47   H           H   OMe      OMe     CH                      4814       Q.sub.47   H           H   Me       OMe     N                       4815       Q.sub.47   Cl          H   Me       OMe     CH                      4816       Q.sub.47   Cl          H   OMe      OMe     CH                      4817       Q.sub.47   Cl          H   Me       OMe     N                       4818       Q.sub.47   COOMe       H   Me       OMe     CH                      4819       Q.sub. 47  COOMe       H   OMe      OMe     CH                      4820       Q.sub.47   COOMe       H   Me       OMe     N                       4821       Me         Q.sub.47    H   Me       OMe     CH                      4822       Me         Q.sub.47    H   OMe      OMe     CH                      4823       Me         Q.sub.47    H   Me       OMe     N                       4824       Q.sub.48   H           Me  OMe      CH                              4825       Q.sub.48   H           OMe OMe      CH                              4826       Q.sub.48   H           Me  OMe      N                               4827       Q.sub.48   Cl          Me  OMe      CH                              4828       Q.sub.48   Cl          OMe OMe      CH                              4829       Q.sub.48   H           Me  OMe      N                               4830       Q.sub.48   COOMe       Me  OMe      CH                              4831       Q.sub.48   COOMe       OMe OMe      CH                              4832       Q.sub.48   COOMe       Me  OMe      N                               4833       Me         Q.sub.48    H   Me       OMe     CH                      4834       Me         Q.sub.48    H   OMe      OMe     CH                      4835       Me         Q.sub.48    H   Me       OMe     N                       4836       Q.sub.49   H           H   Me       OMe     CH                      4837       Q.sub.49   H           H   OMe      OMe     CH                      4838       Q.sub.49   H           H   Me       OMe     N                       4839       Q.sub.49   Cl          H   Me       OMe     CH                      4840       Q.sub.49   Cl          H   OMe      OMe     CH                      4841       Q.sub.49   Cl          H   Me       OMe     N                       4842       Q.sub.49   COOMe       H   Me       OMe     CH                      4843       Q.sub.49   COOMe       H   OMe      OMe     CH                      4844       Q.sub.49   COOMe       H   Me       OMe     N                       4845       Me         Q.sub. 49   H   Me       OMe     CH                      4846       Me         Q.sub.49    H   OMe      OMe     CH                      4847       Me         Q.sub.49    H   Me       OMe     N                       4848       Q.sub.50   H           H   Me       OMe     CH                      4849       Q.sub.50   H           H   OMe      OMe     CH                      4850       Q.sub.50   H           H   Me       OMe     N                       4851       Q.sub.50   Cl          H   Me       OMe     CH                      4852       Q.sub.50   Cl          H   OMe      OMe     CH                      4853       Q.sub.50   Cl          H   Me       OMe     N                       4854       Q.sub.50   COOMe       H   Me       OMe     CH                      4855       Q.sub.50   COOMe       H   OMe      OMe     CH                      4856       Q.sub.50   COOMe       H   Me       OMe     N                       4857       Me         Q.sub.50    H   Me       OMe     CH                      4858       Me         Q.sub.50    H   OMe      OMe     CH                      4859       Me         Q.sub.50    H   Me       OMe     N                       4860       Q.sub.51   H           H   Me       OMe     CH                      4861       Q.sub.51   H           H   OMe      OMe     CH                      4862       Q.sub.51   H           H   Me       OMe     N                       4863       Q.sub.51   Cl          H   Me       OMe     CH                      4864       Q.sub.51   Cl          H   OMe      OMe     CH                      4865       Q.sub.51   Cl          H   Me       OMe     N                       4866       Q.sub.51   COOMe       H   Me       OMe     CH                      4867       Q.sub.51   COOMe       H   OMe      OMe     CH                      4868       Q.sub.51   COOMe       H   Me       OMe     N                       4869       Me         Q.sub.51    H   Me       OMe     CH                      4870       Me         Q.sub. 51   H   OMe      OMe     CH                      4871       Me         Q.sub.51    H   Me       OMe     N                       4872       Q.sub.52   Cl          H   Me       OMe     CH                      4873       Q.sub.52   Cl          H   OMe      OMe     CH                      4874       Q.sub.52   Cl          H   Me       OMe     N                       4875       Q.sub.52   COOMe       H   Me       OMe     CH                      4876       Q.sub.52   COOMe       H   OMe      OMe     CH                      4877       Q.sub.52   COOMe       H   Me       OMe     N                       4878       Me         Q.sub.52    H   Me       OMe     CH                      4879       Me         Q.sub.52    H   OMe      OMe     CH                      4880       Me         Q.sub.52    H   Me       OMe     N                       4881       Q.sub.53   Cl          H   Me       OMe     CH                      4882       Q.sub.53   Cl          H   OMe      OMe     CH                      4883       Q.sub.53   Cl          H   Me       OMe     N                       4884       Q.sub.53   COOMe       H   Me       OMe     CH                      4885       Q.sub.53   COOMe       H   OMe      OMe     CH                      4886       Q.sub.53   COOMe       H   Me       OMe     N                       4887       Me         Q.sub.53    H   Me       OMe     CH                      4888       Me         Q.sub.53    H   OMe      OMe     CH                      4889       Me         Q.sub.53    H   Me       OMe     N                       4890       Q.sub.54   H           H   Me       OMe     CH                      4891       Q.sub.54   H           H   OMe      OMe     CH                      4892       Q.sub.54   H           H   Me       OMe     N                       4893       Q.sub.54   Cl          H   Me       OMe     CH                      4894       Q.sub.54   Cl          H   OMe      OMe     CH                      4895       Q.sub.54   Cl          H   Me       OMe     N                       4896       Q.sub.54   COOMe       H   Me       OMe     CH                      4897       Q.sub.54   COOMe       H   OMe      OMe     CH                      4898       Q.sub.54   COOMe       H   Me       OMe     N                       4899       Me         Q.sub.54    H   Me       OMe     CH                      4900       Me         Q.sub.54    H   OMe      OMe     CH                      4901       Me         Q.sub.54    H   Me       OMe     N                       4902       Q.sub.55   H           H   Me       OMe     CH                      4903       Q.sub.55   H           H   OMe      OMe     CH                      4904       Q.sub.55   H           H   Me       OMe     N                       4905       Q.sub.55   Cl          H   Me       OMe     CH                      4906       Q.sub.55   Cl          H   OMe      OMe     CH                      4907       Q.sub.55   Cl          H   Me       OMe     N                       4908       Q.sub.55   COOMe       H   Me       OMe     CH                      4909       Q.sub.55   COOMe       H   OMe      OMe     CH                      4910       Q.sub.55   COOMe       H   Me       OMe     N                       4911       Me         Q.sub.55    H   Me       OMe     CH                      4912       Me         Q.sub.55    H   OMe      OMe     CH                      4913       Me         Q.sub.55    H   Me       OMe     N                       4914       Q.sub.56   H           H   Me       OMe     CH                      4915       Q.sub.56   H           H   OMe      OMe     CH                      4916       Q.sub.56   H           H   Me       OMe     N                       4917       Q.sub.56   Cl          H   Me       OMe     CH                      4918       Q.sub.56   Cl          H   OMe      OMe     CH                      4919       Q.sub.56   Cl          H   Me       OMe     N                       4920       Q.sub.56   COOMe       H   Me       OMe     CH                      4921       Q.sub.56   COOMe       H   OMe      OMe     CH                      4922       Q.sub.56   COOMe       H   Me       OMe     N                       4923       Me         Q.sub.56    H   Me       OMe     CH                      4924       Me         Q.sub.56    H   OMe      OMe     CH                      4925       Me         Q.sub.56    H   Me       OMe     N                       4926       Q.sub.57   Cl          H   Me       OMe     CH                      4927       Q.sub.57   Cl          H   OMe      OMe     CH                      4928       Q.sub.57   Cl          H   Me       OMe     N                       4929       Q.sub.57   COOMe       H   Me       OMe     CH                      4930       Q.sub.57   COOMe       H   OMe      OMe     CH                      4931       Q.sub.57   COOMe       H   Me       OMe     N                       4932       Me         Q.sub.57    H   Me       OMe     CH                      4933       Me         Q.sub.57    H   OMe      OMe     CH                      4934       Me         Q.sub.57    H   Me       OMe     N                       4935       Q.sub.58   Cl          H   Me       OMe     CH                      4936       Q.sub.58   Cl          H   OMe      OMe     CH                      4937       Q.sub.58   Cl          H   Me       OMe     N                       4938       Q.sub.58   COOMe       H   Me       OMe     CH                      4939       Q.sub.58   COOMe       H   OMe      OMe     CH                      4940       Q.sub.58   COOMe       H   Me       OMe     N                       4941       Me         Q.sub.58    H   Me       OMe     CH                      4942       Me         Q.sub.58    H   OMe      OMe     CH                      4943       Me         Q.sub.58    H   Me       OMe     N                       4944       Q.sub.59   H           H   Me       OMe     CH                      4945       Q.sub.59   H           H   OMe      OMe     CH                      4946       Q.sub.59   H           H   Me       OMe     N                       4947       Q.sub.59   Me          H   Me       OMe     CH                      4948       Q.sub.59   Me          H   OMe      OMe     CH                      4949       Q.sub.59   Me          H   Me       OMe     N                       4950       Q.sub.59   Cl          H   Me       OMe     CH                      4951       Q.sub.59   Cl          H   OMe      OMe     CH                      4952       Q.sub.59   Cl          H   Me       OMe     N                       4953       Q.sub.59   Br          H   Me       OMe     CH                      4954       Q.sub.59   Br          H   OMe      OMe     CH                      4955       Q.sub.59   Br          H   Me       OMe     N                       4956       Q.sub.59   COOMe       H   Me       OMe     CH                      4957       Q.sub.59   COOMe       H   Me       OMe     N                       4958       Q.sub.59   COOMe       H   Me       OMe     N                       4959       Q.sub.59   COOEt       H   Me       OMe     CH                      4960       Q.sub.59   COOEt       H   OMe      OMe     CH                      4961       Q.sub.59   COOEt       H   Me       OMe     N                       4962       Me         Q.sub.59    H   Me       Me      CH                      4963       Me         Q.sub.59    H   Me       OMe     CH                      4964       Me         Q.sub.59    H   OMe      OMe     CH                      4965       Me         Q.sub.59    H   Me       OMe     N                       4966       Me         Q.sub.59    H   Me       OMe     N                       4967       COMe       Q.sub.59    H   Me       OMe     CH                      4968       COMe       Q.sub.59    H   OMe      OMe     CH                      4969       COMe       Q.sub.59    H   Me       OMe     N                       4970       Q.sub.60   H           H   Me       OMe     CH                      4971       Q.sub.60   H           H   OMe      OMe     CH                      4972       Q.sub.60   H           H   Me       OMe     N                       4973       Q.sub.60   Cl          H   Me       OMe     CH                      4974       Q.sub.60   Cl          H   OMe      OMe     CH                      4975       Q.sub.60   Cl          H   Me       OMe     N                       4976       Q.sub.60   COOMe       H   Me       OMe     CH                      4977       Q.sub.60   COOMe       H   OMe      OMe     CH                      4978       Q.sub.60   COOMe       H   Me       OMe     N                       4979       Me         Q.sub.60    H   Me       OMe     CH                      4980       Me         Q.sub.60    H   OMe      OMe     CH                      4981       Me         Q.sub.60    H   Me       OMe     N                       4970       Q.sub.61   H           H   Me       OMe     CH                      4971       Q.sub.61   H           H   OMe      OMe     CH                      4972       Q.sub.61   H           H   Me       OMe     N                       4973       Q.sub.61   Cl          H   Me       OMe     CH                      4974       Q.sub.61   Cl          H   OMe      OMe     CH                      4975       Q.sub.61   Cl          H   Me       OMe     N                       4976       Q.sub.61   COOMe       H   Me       OMe     CH                      4977       Q.sub.61   COOMe       H   OMe      OMe     CH                      4978       Q.sub.61   COOMe       H   Me       OMe     N                       4979       Me         Q.sub.61    H   Me       OMe     CH                      4980       Me         Q.sub.61    H   OMe      OMe     CH                      4981       Me         Q.sub.61    H   Me       OMe     N                       4982       Q.sub.62   H           H   Me       OMe     CH                      4983       Q.sub.62   H           H   OMe      OMe     CH                      4984       Q.sub.62   H           H   Me       OMe     N                       4985       Q.sub.62   Cl          H   Me       OMe     CH                      4986       Q.sub.62   Cl          H   OMe      OMe     CH                      4987       Q.sub.62   Cl          H   Me       OMe     N                       4988       Q.sub.62   COOMe       H   Me       OMe     CH                      4989       Q.sub.62   COOMe       H   OMe      OMe     CH                      4990       Q.sub.62   COOMe       H   Me       OMe     N                       4991       Me         Q.sub.62    H   Me       OMe     CH                      4992       Me         Q.sub.62    H   OMe      OMe     CH                      4993       Me         Q.sub.62    H   Me       OMe     N                       4994       Q.sub.63   Cl          H   Me       OMe     CH                      4995       Q.sub.63   Cl          H   OMe      OMe     CH                      4996       Q.sub.63   Cl          H   Me       OMe     N                       4997       Q.sub.63   COOMe       H   Me       OMe     CH                      4998       Q.sub.63   COOMe       H   OMe      OMe     CH                      4999       Q.sub.63   COOMe       H   Me       OMe     N                       5000       Me         Q.sub.63    H   Me       OMe     CH                      5001       Me         Q.sub.63    H   OMe      OMe     CH                      5002       Me         Q.sub.63    H   Me       OMe     N                       5003       Q.sub.64   Cl          H   Me       OMe     CH                      5004       Q.sub.64   Cl          H   OMe      OMe     CH                      5005       Q.sub.64   Cl          H   Me       OMe     N                       5006       Q.sub.64   COOMe       H   Me       OMe     CH                      5007       Q.sub.64   COOMe       H   OMe      OMe     CH                      5008       Q.sub.64   COOMe       H   Me       OMe     N                       5009       Me         Q.sub.64    H   Me       OMe     CH                      5010       Me         Q.sub.64    H   OMe      OMe     CH                      5011       Me         Q.sub.64    H   Me       OMe     N                       5012       Q.sub.65   H           H   Me       OMe     CH                      5013       Q.sub.65   H           H   OMe      OMe     CH                      5014       Q.sub.65   H           H   Me       OMe     N                       5015       Q.sub.65   Cl          H   Me       OMe     CH                      5016       Q.sub.65   Cl          H   OMe      OMe     CH                      5017       Q.sub.65   Cl          H   Me       OMe     N                       5018       Q.sub.65   COOMe       H   Me       OMe     CH                      5019       Q.sub.65   COOMe       H   OMe      OMe     CH                      5020       Q.sub.65   COOMe       H   Me       OMe     N                       5021       Me         Q.sub.65    H   Me       OMe     CH                      5022       Me         Q.sub.65    H   OMe      OMe     CH                      5023       Me         Q.sub.65    H   Me       OMe     N                       5024       Q.sub.66   Cl          H   Me       OMe     CH                      5025       Q.sub.66   Cl          H   OMe      OMe     CH                      5026       Q.sub.66   Cl          H   Me       OMe     N                       5027       Q.sub.66   COOMe       H   Me       OMe     CH                      5028       Q.sub.66   COOMe       H   OMe      OMe     CH                      5029       Q.sub.66   COOMe       H   Me       OMe     N                       5030       Me         Q.sub.66    H   Me       OMe     CH                      5031       Me         Q.sub.66    H   OMe      OMe     CH                      5032       Me         Q.sub.66    H   Me       OMe     N                       5033       Q.sub. 67  Cl          H   Me       OMe     CH                      5034       Q.sub.67   Cl          H   OMe      OMe     CH                      5035       Q.sub.67   Cl          H   Me       OMe     N                       5036       Q.sub.67   COOMe       H   Me       OMe     CH                      5037       Q.sub.67   COOMe       H   OMe      OMe     CH                      5038       Q.sub.67   COOMe       H   Me       OMe     N                       5039       Me         Q.sub.67    H   Me       OMe     CH                      5040       Me         Q.sub.67    H   OMe      OMe     CH                      5041       Me         Q.sub.67    H   Me       OMe     N                       5042       Q.sub.68   Cl          H   Me       OMe     CH                      5043       Q.sub.68   Cl          H   OMe      OMe     CH                      5044       Q.sub.68   Cl          H   Me       OMe     N                       5045       Q.sub.68   COOMe       H   Me       OMe     CH                      5046       Q.sub.68   COOMe       H   OMe      OMe     CH                      5047       Q.sub.68   COOMe       H   Me       OMe     N                       5048       Me         Q.sub.68    H   Me       OMe     CH                      5049       Me         Q.sub.68    H   OMe      OMe     CH                      5050       Me         Q.sub.68    H   Me       OMe     N                       5051       Q.sub.69   Cl          H   Me       OMe     CH                      5052       Q.sub.69   Cl          h   OEM      OMe     CH                      5053       Q.sub.69   CL          H   Me       OMe     N                       5054       Q.sub.69   COOMe       H   OMe      OMe     CH                      5055       Q.sub.69   COOMe       H   OMe      OMe     CH                      5056       Q.sub.69   COOMe       H   Me       OMe     N                       5057       Me         Q.sub.69    H   Me       OMe     CH                      5058       Me         Q.sub. 69   H   OMe      OMe     CH                      5059       Me         Q.sub.69    H   Me       OMe     N                       5060       Q.sub.70   H           H   Me       OMe     CH                      5061       Q.sub.70   H           H   OMe      OMe     CH                      5062       Q.sub.70   H           H   Me       OMe     N                       5063       Q.sub.70   Cl          H   Me       OMe     CH                      5064       Q.sub.70   Cl          H   OMe      OMe     CH                      5065       Q.sub.70   Cl          H   Me       OMe     N                       5066       Q.sub.70   COOMe       H   Me       OMe     CH                      5067       Q.sub.70   COOMe       H   OMe      OMe     CH                      5068       Q.sub.70   COOMe       H   Me       OMe     N                       5069       Me         Q.sub.70    H   Me       OMe     CH                      5070       Me         Q.sub.70    H   OMe      OMe     CH                      5071       Me         Q.sub.70    H   Me       OMe     N                       5072       Q.sub.71   Cl          H   Me       OMe     CH                      5073       Q.sub.71   Cl          H   OMe      OMe     CH                      5074       Q.sub.71   Cl          H   Me       OMe     N                       5075       Q.sub.71   COOMe       H   Me       OMe     CH                      5076       Q.sub.71   COOMe       H   OMe      OMe     CH                      5077       Q.sub.71   COOMe       H   Me       OMe     N                       5078       Me         Q.sub.71    H   Me       OMe     CH                      5079       Me         Q.sub.71    H   OMe      OMe     CH                      5080       Me         Q.sub.71    H   Me       OMe     N                       5081       Q.sub.72   Cl          H   Me       OMe     CH                      5082       Q.sub.72   Cl          H   OMe      OMe     CH                      5083       Q.sub.72   Cl          H   Me       OMe     N                       5084       Q.sub.72   COOMe       H   Me       OMe     CH                      5085       Q.sub.72   COOMe       H   OMe      OMe     CH                      5086       Q.sub.72   COOMe       H   Me       OMe     N                       5087       Me         Q.sub.72    H   Me       OMe     CH                      5088       Me         Q.sub.72    H   OMe      OMe     CH                      5089       Me         Q.sub.72    H   Me       OMe     N                       5090       Q.sub.73   Cl          H   Me       OMe     CH                      5091       Q.sub.73   Cl          H   OMe      OMe     CH                      5092       Q.sub.73   Cl          H   Me       OMe     N                       5093       Q.sub.73   COOMe       H   Me       OMe     CH                      5094       Q.sub.73   COOMe       H   OMe      OMe     CH                      5095       Q.sub.73   COOMe       H   Me       OMe     N                       5096       Me         Q.sub.73    H   Me       OMe     CH                      5097       Me         Q.sub.73    H   OMe      OMe     CH                      5098       Me         Q.sub.73    H   Me       OMe     N                       5099       Q.sub.74   Cl          H   Me       OMe     CH                      5100       Q.sub.74   Cl          H   OMe      OMe     CH                      5101       Q.sub.74   Cl          H   Me       OMe     N                       5102       Q.sub.74   COOMe       H   Me       OMe     CH                      5103       Q.sub.74   COOMe       H   OMe      OMe     CH                      5104       Q.sub.74   COOMe       H   Me       OMe     N                       5105       Me         Q.sub.74    H   Me       OMe     CH                      5106       Me         Q.sub.74    H   OMe      OMe     CH                      5107       Me         Q.sub.74    H   Me       OMe     N                       5108       Q.sub.75   Cl          H   Me       OMe     CH                      5109       Q.sub.75   Cl          H   OMe      OMe     CH                      5110       Q.sub.75   Cl          H   Me       OMe     N                       5111       Q.sub.75   CL          H   Me       OMe     N                       5112       Q.sub.75   COOMe       H   OMe      OMe     CH                      5113       Q.sub.75   COOMe       H   Me       OMe     N                       5114       Me         Q.sub.75    H   Me       OMe     CH                      5115       Me         Q.sub.75    H   OMe      OMe     CH                      5116       Me         Q.sub.75    H   Me       OMe     N                       5117       76         Cl          H   Me       OMe     CH                      5118       Q.sub.76   Cl          H   OMe OMe  CH                              5119       Q.sub.76   Cl          H   Me       OMe     N                       5120       Q.sub.76   COOMe       H   Me       OMe     CH                      5121       Q.sub.76   COOMe       H   OMe      OMe     CH                      5122       Q.sub.76   COOMe       H   Me       OMe     N                       5123       Me         Q.sub.76    H   Me       OMe     CH                      5124       Me         Q.sub.76    H   OMe      OMe     CH                      5125       Me         Q.sub.76    H   Me       OMe     N                       5720       Q.sub.77   Cl          H   Me       OMe     CH                      5721       Q.sub.77   Cl          H   OMe      OMe     CH                      5722       Q.sub.77   Cl          H   Me       OMe     N                       5723       Q.sub.77   COOMe       H   Me       OMe     CH                      5724       Q.sub.77   COOMe       H   OMe      OMe     CH                      5725       Q.sub.77   COOMe       H   Me       OMe     N                       5726       Me         Q.sub.77    H   Me       OMe     CH                      5727       Me         Q.sub.77    H   OMe      OMe     CH                      5728       Me         Q.sub.77    H   Me       OMe     N                       5729       Q.sub.78   H           H   Me       OMe     CH                      5730       Q.sub.78   H           H   OMe      OMe     CH                      5731       Q.sub.78   H           H   Me       OMe     N                       5732       Q.sub.78   Me          H   Me       OMe     CH                      5733       Q.sub.78   Me          H   OMe      OMe     CH                      5734       Q.sub.78   Me          H   Me       OMe     N                       5735       Q.sub.78   Cl          H   Me       OMe     CH                      5736       Q.sub.78   Cl          H   OMe      OMe     CH                      5737       Q.sub.78   Cl          H   Me       OMe     N                       5738       Q.sub.78   Br          H   Me       OMe     CH                      5739       Q.sub.78   Br          H   OMe      OMe     CH                      5740       Q.sub.78   Br          H   Me       OMe     N                       5741       Q.sub.78   COOMe       H   Me       OMe     CH                      5742       Q.sub.78   COOMe       H   OMe      OMe     CH                      5743       Q.sub.78   COOMe       H   Me       OMe     N                       5744       Q.sub.78   COOEt       H   Me       OMe     CH                      5745       Q.sub.78   COOEt       H   OMe      OMe     CH                      5746       Q.sub.78   COOEt       H   Me       OMe     N                       5747       Me         Q.sub.78    H   Me       Me      CH                      5748       Me         Q.sub.78    H   Me       OMe     CH                      5749       Me         Q.sub.78    H   OMe      OMe     CH                      5750       Me         Q.sub.78    H   Me       OMe     N                       5751       Me         Q.sub.78    H   OMe      OMe     N                       5752       COOMe      Q.sub.78    H   Me       OMe     CH                      5753       COOMe      Q.sub.78    H   OMe      OMe     CH                      5754       COOMe      Q.sub.78    H   Me       OMe     N                       5755       Q.sub.79   H           H   Me       OMe     CH                      5756       Q.sub.79   H           H   OMe      OMe     CH                      5757       Q.sub.79   H           H   Me       OMe     N                       5758       Q.sub.79   Me          H   Me       OMe     CH                      5759       Q.sub.79   Me          H   OMe      OMe     CH                      5760       Q.sub.79   Me          H   Me       OMe     N                       5761       Q.sub.79   Cl          H   Me       OMe     CH                      5762       Q.sub.79   Cl          H   OMe      OMe     CH                      5763       Q.sub.79   Cl          H   Me       OMe     N                       5764       Q.sub.79   Br          H   Me       OMe     CH                      5765       Q.sub.79   Br          H   OMe      OMe     CH                      5766       Q.sub.79   Br          H   Me       OMe     N                       5767       Q.sub.79   COOMe       H   Me       OMe     CH                      5768       Q.sub.79   COOMe       H   OMe      OMe     CH                      5769       Q.sub.79   COOMe       H   Me       OMe     N                       5770       Q.sub.79   COOEt       H   Me       OMe     CH                      5771       Q.sub.79   COOEt       H   OMe      OMe     CH                      5772       Q.sub.79   COOEt       H   Me       OMe     N                       5773       Me         Q.sub.79    H   Me       Me      CH                      5774       Me         Q.sub.79    H   Me       OMe     CH                      5775       Me         Q.sub.79    H   OMe      OMe     CH                      5776       Me         Q.sub.79    H   Me       OMe     N                       5777       Me         Q.sub.79    H   OMe      OMe     N                       5778       COOMe      Q.sub.79    H   Me       OMe     CH                      5779       COOMe      Q.sub.79    H   OMe      OMe     CH                      5780       COOMe      Q.sub.79    H   Me       OMe     N                       5781       Q.sub.80   H           H   Me       OMe     CH                      5782       Q.sub.80   H           H   OMe      OMe     CH                      5783       Q.sub.80   H           H   Me       OMe     N                       5784       Q.sub.80   Cl          H   Me       OMe     CH                      5785       Q.sub.80   Cl          H   OMe      OMe     CH                      5786       Q.sub.80   Cl          H   Me       OMe     N                       5787       Q.sub.80   COOMe       H   Me       OMe     CH                      5788       Q.sub.80   COOMe       H   OMe      OMe     CH                      5789       Q.sub.80   COOMe       H   Me       OMe     N                       5790       Me         Q.sub.80    H   Me       OMe     CH                      5791       Me         Q.sub.80    H   OMe      OMe     CH                      5792       Me         Q.sub.80    H   Me       OMe     N                       5793       Q.sub.81   Cl          H   Me       OMe     CH                      5794       Q.sub.81   Cl          H   OMe      OMe     CH                      5795       Q.sub.81   Cl          H   Me       OMe     N                       5796       Q.sub.81   COOMe       H   Me       OMe     CH                      5797       Q.sub.81   COOMe       H   OMe      OMe     CH                      5798       Q.sub.81   COOMe       H   Me       OMe     N                       5799       Me         Q.sub.81    H   Me       OMe     CH                      5800       Me         Q.sub.81    H   OMe      OMe     CH                      5801       Me         Q.sub.81    H   Me       OMe     N                       5802       Q.sub.82   Cl          H   Me       OMe     CH                      5803       Q.sub.82   Cl          H   OMe      OMe     CH                      5804       Q.sub.82   Cl          H   Me       OMe     N                       5805       Q.sub.82   COOMe       H   OMe      OMe     CH                      5806       Q.sub.82   COOMe       H   OMe      OMe     CH                      5807       Q.sub.82   COOMe       H   Me       OMe     N                       5808       Me         Q.sub.82    H   Me       OMe     CH                      5809       Me         Q.sub.82    H   OMe      OMe     CH                      5810       Me         Q.sub.82    H   Me       OMe     N                       5811       Q.sub.83   Cl          H   Me       OMe     CH                      5812       Q.sub.83   Cl          H   OMe      OMe     CH                      5813       Q.sub.83   Cl          H   Me       OMe     N                       5814       Q.sub.83   COOMe       H   Me       OMe     CH                      5815       Q.sub.83   COOMe       H   OMe      OMe     CH                      5816       Q.sub.83   COOMe       H   Me       OMe     N                       5817       Me         Q.sub.83    H   Me       OMe     CH                      5818       Me         Q.sub.83    H   OMe      OMe     CH                      5819       Me         Q.sub.83    H   Me       OMe     N                       6551       Q.sub.16   COOEt       H   OMe      OMe     CH                      4677       Q.sub.36   Cl          H   Me       OMe     N                       4678       Q.sub.36   COOMe       H   Me       OMe     CH                      4679       Q.sub.36   COOMe       H   OMe      OMe     CH                      4680       Q.sub.36   COOMe       H   Me       OMe     N                       4681       Me         Q.sub.36    H   Me       OMe     CH                      4682       Me         Q.sub.36    H   OMe      OMe     CH                      4683       Me         Q.sub.36    H   Me       OMe     N                       4684       Q.sub.37   H           H   Me       OMe     CH                      4685       Q.sub.37   H           H   OMe      OMe     CH                      4686       Q.sub.37   H           H   Me       OMe     N                       4687       Q.sub.37   Cl          H   Me       OMe     CH                      4688       Q.sub.37   Cl          H   OMe      OMe     CH                      4689       Q.sub.37   Cl          H   Me       OMe     N                       4690       Q.sub.37   COOMe       H   Me       OMe     CH                      4691       Q.sub.37   COOMe       H   OMe      OMe     CH                      4692       Q.sub.37   COOMe       H   Me       OMe     N                       4693       Me         Q.sub.37    H   Me       OMe     CH                      4694       Me         Q.sub.37    H   OMe      OMe     CH                      4695       Me         Q.sub.37    H   Me       OMe     N                       4696       Q.sub.38   H           H   Me       OMe     CH                      4697       Q.sub.38   H           H   OMe      OMe     CH                      4698       Q.sub.38   H           H   Me       OMe     N                       4699       Q.sub.38   Cl          H   Me       OMe     CH                      4700       Q.sub.38   Cl          H   OMe      OMe     CH                      4701       Q.sub.38   Cl          H   Me       OMe     N                       4702       Q.sub.38   COOMe       H   Me       OMe     CH                      4703       Q.sub.38   COOMe       H   OMe      OMe     CH                      4704       Q.sub.38   COOMe       H   Me       OMe     N                       4705       Me         Q.sub.38    H   Me       OMe     CH                      4706       Me         Q.sub.38    H   OMe      OMe     CH                      4707       Me         Q.sub.38    H   Me       OMe     N                       4708       Q.sub.39   H           H   Me       OMe     CH                      4709       Q.sub.39   H           OMe OMe      CH                              4710       Q.sub.39   H           H   Me       OMe     N                       4711       Q.sub.39   Cl          H   Me       OMe     CH                      4712       Q.sub.39   Cl          H   OMe      OMe     CH                      4713       Q.sub.39   Cl          H   Me       OMe     N                       4714       Q.sub.39   COOMe       H   Me       OMe     CH                      4715       Q.sub.39   COOMe       H   OMe      OMe     CH                      4716       Q.sub.39   COOMe       H   Me       OMe     N                       4717       Me         Q.sub.39    H   Me       OMe     CH                      4718       Me         Q.sub.39    H   OMe      OMe     CH                      4719       Me         Q.sub.39    H   Me       OMe     N                       4720       Q.sub.40   Cl          H   Me       OMe     CH                      4721       Q.sub.40   Cl          H   OMe      OMe     CH                      4722       Q.sub.40   Cl          H   Me       OMe     N                       4723       Q.sub.40   COOMe       H   Me       OMe     CH                      4724       Q.sub.40   COOMe       H   OMe      OMe     CH                      4725       Q.sub.40   COOMe       H   Me       OMe     N                       4726       Me         Q.sub.40    H   Me       OMe     CH                      4727       Me         Q.sub.40    H   OMe      OMe     CH                      4728       Me         Q.sub.40    H   Me       OMe     N                       4729       Q.sub.41   H           H   Me       OMe     CH                      4730       Q.sub.41   H           H   OMe      OMe     CH                      4731       Q.sub.41   H           H   Me       OMe     N                       4732       Q.sub.41   Cl          H   Me       OMe     CH                      4733       Q.sub.41   Cl          H   OMe      OMe     CH                      4734       Q.sub.41   Cl          H   Me       OMe     N                       4735       Q.sub.41   COOMe       H   Me       OMe     CH                      4736       Q.sub.41   COOMe       H   OMe      OMe     CH                      4737       Q.sub.41   COOMe       H   Me       OMe     N                       4738       Me         Q.sub.41    H   Me       OMe     CH                      4739       Me         Q.sub.41    H   OMe      OMe     CH                      4740       Me         Q.sub.41    H   Me       OMe     N                       4741       Q.sub.42   H           H   Me       OMe     CH                      4742       Q.sub.42   H           H   OMe      OMe     CH                      4743       Q.sub.42   H           H   Me       OMe     N                       4744       Q.sub.42   Cl          H   OMe      OMe     CH                      4745       Q.sub.42   Cl          H   OMe      OMe     CH                      4746       Q.sub.42   Cl          H   Me       OMe     N                       4747       Q.sub.42   COOMe       H   Me       OMe     CH                      4748       Q.sub.42   COOMe       H   OMe      OMe     CH                      4749       Q.sub.42   COOMe       H   Me       OMe     N                       4750       Me         Q.sub.42    H   Me       OMe     CH                      4751       Me         Q.sub.42    H   OMe      OMe     CH                      4752       Me         Q.sub.42    H   Me       OMe     N                       4753       Q.sub.43   H           H   Me       OMe     CH                      4754       Q.sub.43   H           H   OMe      OMe     CH                      4755       Q.sub.43   H           H   Me       OMe     N                       4756       Q.sub.43   Cl          H   Me       OMe     CH                      4757       Q.sub.43   Cl          H   OMe      OMe     CH                      4758       Q.sub.43   Cl          H   Me       OMe     N                       4759       Q.sub.43   COOMe       H   Me       OMe     CH                      4760       Q.sub.43   COOMe       H   OMe      OMe     CH                      4761       Q.sub.43   COOMe       H   Me       OMe     N                       4762       Me         Q.sub.43    H   Me       OMe     CH                      4763       Me         Q.sub.43    H   OMe      OMe     CH                      4764       Me         Q.sub.43    H   Me       OMe     N                       4765       Q.sub.44   Cl          H   Me       OMe     CH                      4766       Q.sub.44   Cl          H   OMe      OMe     CH                      4767       Q.sub.44   Cl          H   Me       OMe     N                       4768       Q.sub.44   COOMe       H   Me       OMe     CH                      4769       Q.sub.44   COOMe       H   OMe      OMe     CH                      4770       Q.sub.44   COOMe       H   Me       OMe     N                       4771       Me         Q.sub.44    H   Me       OMe     CH                      4772       Me         Q.sub.44    H   OMe      OMe     CH                      4773       Me         Q.sub.44    H   Me       OMe     N                       4774       Q.sub.45   H           H   Me       OMe     CH                      4775       Q.sub.45   H           H   OMe      OMe     CH                      4776       Q.sub.45   H           H   Me       OMe     N                       4777       Q.sub.45   Me          H   Me       OMe     CH                      4778       Q.sub.45   Me          H   OMe      OMe     CH                      4779       Q.sub.45   Me          H   Me       OMe     N                       4780       Q.sub.45   Cl          H   Me       OMe     CH                      4781       Q.sub.45   Cl          H   OMe      OMe     CH                      4782       Q.sub.45   Cl          H   Me       OMe     N                       4783       Q.sub.45   Br          H   Me       OMe     CH                      4784       Q.sub.45   Br          H   OMe      OMe     CH                      4785       Q.sub.45   Br          H   Me       OMe     N                       4786       Q.sub.45   COOMe       H   Me       OMe     CH                      4787       Q.sub.45   COOMe       H   OMe      OMe     CH                      4788       Q.sub.45   COOMe       H   Me       OMe     N                       4789       Q.sub.45   COOEt       H   Me       OMe     CH                      4790       Q.sub.45   COOEt       H   OMe      OMe     CH                      4791       Q.sub.45   COOEt       H   Me       OMe     N                       4792       Me         Q.sub.45    H   Me       Me      CH                      4793       Me         Q.sub.45    H   Me       OMe     CH                      4794       Me         Q.sub.45    H   OMe      OMe     CH                      4795       Me         Q.sub.45    H   Me       OMe     N                       4796       Me         Q.sub.45    H   OMe      OMe     N                       4797       COOMe      Q.sub.45    H   Me       OMe     CH                      4798       COOMe      Q.sub.45    H   OMe      OMe     CH                      4799       COOMe      Q.sub.45    H   Me       OMe     N                       4800       Q.sub.46   H           H   Me       OMe     CH                      4801       Q.sub.46   H           H   OMe      OMe     CH                      4802       Q.sub.46   H           H   Me       OMe     N                       4803       Q.sub.46   Cl          H   Me       OMe     CH                      4804       Q.sub.46   Cl          H   OMe      OMe     CH                      4805       Q.sub.46   Cl          H   Me       OMe     N                       4806       Q.sub.46   COOMe       H   Me       OMe     CH                      4807       Q.sub.46   COOMe       H   OMe      OMe     CH                      4808       Q.sub.46   COOMe       H   Me       OMe     N                       4809       Me         Q.sub.46    H   Me       OMe     CH                      4810       Me         Q.sub.46    H   Me       OMe     CH                      4811       Me         Q.sub.46    H   Me       OMe     N                       4812       Q.sub.47   H           H   Me       OMe     CH                      4813       Q.sub.47   H           H   OMe      OMe     CH                      4814       Q.sub.47   H           H   Me       OMe     N                       4815       Q.sub.47   Cl          H   Me       OMe     CH                      4816       Q.sub.47   Cl          H   OMe      OMe     CH                      4817       Q.sub.47   Cl          H   Me       OMe     N                       4818       Q.sub.47   COOMe       H   Me       OMe     CH                      4819       Q.sub.47   COOMe       H   OMe      OMe     CH                      4820       Q.sub.47   COOMe       H   Me       OMe     N                       4821       Me         Q.sub.47    H   Me       OMe     CH                      4822       Me         Q.sub.47    H   OMe      OMe     CH                      4823       Me         Q.sub.47    H   Me       OMe     N                       4824       Q.sub.48   H           Me  OMe      CH                              4825       Q.sub.48   H           OMe OMe      CH                              4826       Q.sub.48   H           Me  OMe      N                               4827       Q.sub.48   Cl          Me  OMe      CH                              4828       Q.sub.48   Cl          OMe OMe      CH                              4829       Q.sub.48   H           Me  OMe      N                               4830       Q.sub.48   COOMe       Me  OMe      CH                              4831       Q.sub.48   COOMe       OMe OMe      CH                              4832       Q.sub.48   COOMe       Me  OMe      N                               4833       Me         Q.sub.48    H   Me       OMe     CH                      4834       Me         Q.sub.48    H   OMe      OMe     CH                      4835       Me         Q.sub.48    H   Me       OMe     N                       4836       Q.sub.49   H           H   Me       OMe     CH                      4837       Q.sub.49   H           H   OMe      OMe     CH                      4838       Q.sub.49   H           H   Me       OMe     N                       4839       Q.sub.49   Cl          H   Me       OMe     CH                      4840       Q.sub.49   Cl          H   OMe      OMe     CH                      4841       Q.sub.49   Cl          H   Me       OMe     N                       4842       Q.sub.49   COOMe       H   Me       OMe     CH                      4843       Q.sub.49   COOMe       H   OMe      OMe     CH                      4844       Q.sub.49   COOMe       H   Me       OMe     N                       4845       Me         Q.sub.49    H   Me       OMe     CH                      4846       Me         Q.sub.49    H   OMe      OMe     CH                      4847       Me         Q.sub.49    H   Me       OMe     N                       4848       Q.sub.50   H           H   Me       OMe     CH                      4849       Q.sub.50   H           H   OMe      OMe     CH                      4850       Q.sub.50   H           H   Me       OMe     N                       4851       Q.sub.50   Cl          H   Me       OMe     CH                      4852       Q.sub.50   Cl          H   OMe      OMe     CH                      4853       Q.sub.50   Cl          H   Me       OMe     N                       4854       Q.sub.50   COOMe       H   Me       OMe     CH                      4855       Q.sub.50   COOMe       H   OMe      OMe     CH                      4856       Q.sub.50   COOMe       H   Me       OMe     N                       4857       Me         Q.sub.50    H   Me       OMe     CH                      4858       Me         Q.sub.50    H   OMe      OMe     CH                      4859       Me         Q.sub.50    H   Me       OMe     N                       4860       Q.sub.51   H           H   Me       OMe     CH                      4861       Q.sub.51   H           H   OMe      OMe     CH                      4862       Q.sub.51   H           H   Me       OMe     N                       4863       Q.sub.51   Cl          H   Me       OMe     CH                      4864       Q.sub.51   Cl          H   OMe      OMe     CH                      4865       Q.sub.51   Cl          H   Me       OMe     N                       4866       Q.sub.51   COOMe       H   Me       OMe     CH                      4867       Q.sub.51   COOMe       H   OMe      OMe     CH                      4868       Q.sub.51   COOMe       H   Me       OMe     N                       4869       Me         Q.sub.51    H   Me       OMe     CH                      4870       Me         Q.sub.51    H   OMe      OMe     CH                      4871       Me         Q.sub.51    H   Me       OMe     N                       4872       Q.sub.52   Cl          H   Me       OMe     CH                      4873       Q.sub.52   Cl          H   OMe      OMe     CH                      4874       Q.sub.52   Cl          H   Me       OMe     N                       4875       Q.sub.52   COOMe       H   Me       OMe     CH                      4876       Q.sub.52   COOMe       H   OMe      OMe     CH                      4877       Q.sub.52   COOMe       H   Me       OMe     N                       4878       Me         Q.sub.52    H   Me       OMe     CH                      4879       Me         Q.sub.52    H   OMe      OMe     CH                      4880       Me         Q.sub.52    H   Me       OMe     N                       4881       Q.sub.53   Cl          H   Me       OMe     CH                      4882       Q.sub.53   Cl          H   OMe      OMe     CH                      4883       Q.sub.53   Cl          H   Me       OMe     N                       4884       Q.sub.53   COOMe       H   Me       OMe     CH                      4885       Q.sub.53   COOMe       H   OMe      OMe     CH                      4886       Q.sub.53   COOMe       H   Me       OMe     N                       4887       Me         Q.sub.53    H   Me       OMe     CH                      4888       Me         Q.sub.53    H   OMe      OMe     CH                      4889       Me         Q.sub.53    H   Me       OMe     N                       4890       Q.sub.54   H           H   Me       OMe     CH                      4891       Q.sub.54   H           H   OMe      OMe     CH                      4892       Q.sub.54   H           H   Me       OMe     N                       4893       Q.sub.54   Cl          H   Me       OMe     CH                      4894       Q.sub.54   Cl          H   OMe      OMe     CH                      4895       Q.sub.54   Cl          H   Me       OMe     N                       4896       Q.sub.54   COOMe       H   Me       OMe     CH                      4897       Q.sub.54   COOMe       H   OMe      OMe     CH                      4898       Q.sub.54   COOMe       H   Me       OMe     N                       4899       Me         Q.sub.54    H   Me       OMe     CH                      4900       Me         Q.sub.54    H   OMe      OMe     CH                      4901       Me         Q.sub.54    H   Me       OMe     N                       4902       Q.sub.55   H           H   Me       OMe     CH                      4903       Q.sub.55   H           H   OMe      OMe     CH                      4904       Q.sub.55   H           H   Me       OMe     N                       4905       Q.sub.55   Cl          H   Me       OMe     CH                      4906       Q.sub.55   Cl          H   OMe      OMe     CH                      4907       Q.sub.55   Cl          H   Me       OMe     N                       4908       Q.sub.55   COOMe       H   Me       OMe     CH                      4909       Q.sub.55   COOMe       H   OMe      OMe     CH                      4910       Q.sub.55   COOMe       H   Me       OMe     N                       4911       Me         Q.sub.55    H   Me       OMe     CH                      4912       Me         Q.sub.55    H   OMe      OMe     CH                      4913       Me         Q.sub.55    H   Me       OMe     N                       4914       Q.sub.56   H           H   Me       OMe     CH                      4915       Q.sub.56   H           H   OMe      OMe     CH                      4916       Q.sub.56   H           H   Me       OMe     N                       4917       Q.sub.56   Cl          H   Me       OMe     CH                      4918       Q.sub.56   Cl          H   OMe      OMe     CH                      4919       Q.sub.56   Cl          H   Me       OMe     N                       4920       Q.sub.56   COOMe       H   Me       OMe     CH                      4921       Q.sub.56   COOMe       H   OMe      OMe     CH                      4922       Q.sub.56   COOMe       H   Me       OMe     N                       4923       Me         Q.sub.56    H   Me       OMe     CH                      4924       Me         Q.sub.56    H   OMe      OMe     CH                      4925       Me         Q.sub.56    H   Me       OMe     N                       4926       Q.sub.57   Cl          H   Me       OMe     CH                      4927       Q.sub.57   Cl          H   OMe      OMe     CH                      4928       Q.sub.57   Cl          H   Me       OMe     N                       4929       Q.sub.57   COOMe       H   Me       OMe     CH                      4930       Q.sub.57   COOMe       H   OMe      OMe     CH                      4931       Q.sub.57   COOMe       H   Me       OMe     N                       4932       Me         Q.sub.57    H   Me       OMe     CH                      4933       Me         Q.sub.57    H   OMe      OMe     CH                      4934       Me         Q.sub.57    H   Me       OMe     N                       4935       Q.sub.58   Cl          H   Me       OMe     CH                      4936       Q.sub.58   Cl          H   OMe      OMe     CH                      4937       Q.sub.58   Cl          H   Me       OMe     N                       4938       Q.sub.58   COOMe       H   Me       OMe     CH                      4939       Q.sub.58   COOMe       H   OMe      OMe     CH                      4940       Q.sub.58   COOMe       H   Me       OMe     N                       4941       Me         Q.sub.58    H   Me       OMe     CH                      4942       Me         Q.sub.58    H   OMe      OMe     CH                      4943       Me         Q.sub.58    H   Me       OMe     N                       4944       Q.sub.59   H           H   Me       OMe     CH                      4945       Q.sub.59   H           H   OMe      OMe     CH                      4946       Q.sub.59   H           H   Me       OMe     N                       4947       Q.sub.59   Me          H   Me       OMe     CH                      4948       Q.sub.59   Me          H   OMe      OMe     CH                      4949       Q.sub.59   Me          H   Me       OMe     N                       4950       Q.sub.59   Cl          H   Me       OMe     CH                      4951       Q.sub.59   Cl          H   OMe      OMe     CH                      4952       Q.sub.59   Cl          H   Me       OMe     N                       4953       Q.sub.59   Br          H   Me       OMe     CH                      4954       Q.sub.59   Br          H   OMe      OMe     CH                      4955       Q.sub.59   Br          H   Me       OMe     N                       4956       Q.sub.59   COOMe       H   Me       OMe     CH                      4957       Q.sub.59   COOMe       H   Me       OMe     N                       4958       Q.sub.59   COOMe       H   Me       OMe     N                       4959       Q.sub.59   COOEt       H   Me       OMe     CH                      4960       Q.sub.59   COOEt       H   OMe      OMe     CH                      4961       Q.sub.59   COOEt       H   Me       OMe     N                       4962       Me         Q.sub.59    H   Me       Me      CH                      4963       Me         Q.sub.59    H   Me       OMe     CH                      4964       Me         Q.sub.59    H   OMe      OMe     CH                      4965       Me         Q.sub.59    H   Me       OMe     N                       4966       Me         Q.sub.59    H   Me       OMe     N                       4967       COMe       Q.sub.59    H   Me       OMe     CH                      4968       COMe       Q.sub.59    H   OMe      OMe     CH                      4969       COMe       Q.sub.59    H   Me       OMe     N                       4970       Q.sub.60   H           H   Me       OMe     CH                      4971       Q.sub.60   H           H   OMe      OMe     CH                      4972       Q.sub.60   H           H   Me       OMe     N                       4973       Q.sub.60   Cl          H   Me       OMe     CH                      4974       Q.sub.60   Cl          H   OMe      OMe     CH                      4975       Q.sub.60   Cl          H   Me       OMe     N                       4976       Q.sub.60   COOMe       H   Me       OMe     CH                      4977       Q.sub.60   COOMe       H   OMe      OMe     CH                      4978       Q.sub.60   COOMe       H   Me       OMe     N                       4979       Me         Q.sub.60    H   Me       OMe     CH                      4980       Me         Q.sub.60    H   OMe      OMe     CH                      4981       Me         Q.sub.60    H   Me       OMe     N                       4970       Q.sub.61   H           H   Me       OMe     CH                      4971       Q.sub.61   H           H   OMe      OMe     CH                      4972       Q.sub.61   H           H   Me       OMe     N                       4973       Q.sub.61   Cl          H   Me       OMe     CH                      4974       Q.sub.61   Cl          H   OMe      OMe     CH                      4975       Q.sub.61   Cl          H   Me       OMe     N                       4976       Q.sub.61   COOMe       H   Me       OMe     CH                      4977       Q.sub.61   COOMe       H   OMe      OMe     CH                      4978       Q.sub.61   COOMe       H   Me       OMe     N                       4979       Me         Q.sub.61    H   Me       OMe     CH                      4980       Me         Q.sub.61    H   OMe      OMe     CH                      4981       Me         Q.sub.61    H   Me       OMe     N                       4982       Q.sub.62   H           H   Me       OMe     CH                      4983       Q.sub.62   H           H   OMe      OMe     CH                      4984       Q.sub.62   H           H   Me       OMe     N                       4985       Q.sub.62   Cl          H   Me       OMe     CH                      4986       Q.sub.62   Cl          H   OMe      OMe     CH                      4987       Q.sub.62   Cl          H   Me       OMe     N                       4988       Q.sub.62   COOMe       H   Me       OMe     CH                      4989       Q.sub.62   COOMe       H   OMe      OMe     CH                      4990       Q.sub.62   COOMe       H   Me       OMe     N                       4991       Me         Q.sub.62    H   Me       OMe     CH                      4992       Me         Q.sub.62    H   OMe      OMe     CH                      4993       Me         Q.sub.62    H   Me       OMe     N                       4994       Q.sub.63   Cl          H   Me       OMe     CH                      4995       Q.sub.63   Cl          H   OMe      OMe     CH                      4996       Q.sub.63   Cl          H   Me       OMe     N                       4997       Q.sub.63   COOMe       H   Me       OMe     CH                      4998       Q.sub.63   COOMe       H   OMe      OMe     CH                      4999       Q.sub.63   COOMe       H   Me       OMe     N                       5000       Me         Q.sub.63    H   Me       OMe     CH                      5001       Me         Q.sub.63    H   OMe      OMe     CH                      5002       Me         Q.sub.63    H   Me       OMe     N                       5003       Q.sub.64   Cl          H   Me       OMe     CH                      5004       Q.sub.64   Cl          H   OMe      OMe     CH                      5005       Q.sub.64   Cl          H   Me       OMe     N                       5006       Q.sub.64   COOMe       H   Me       OMe     CH                      5007       Q.sub.64   COOMe       H   OMe      OMe     CH                      5008       Q.sub.64   COOMe       H   Me       OMe     N                       5009       Me         Q.sub.64    H   Me       OMe     CH                      5010       Me         Q.sub.64    H   OMe      OMe     CH                      5011       Me         Q.sub.64    H   Me       OMe     N                       5012       Q.sub.65   H           H   Me       OMe     CH                      5013       Q.sub.65   H           H   OMe      OMe     CH                      5014       Q.sub.65   H           H   Me       OMe     N                       5015       Q.sub.65   Cl          H   Me       OMe     CH                      5016       Q.sub.65   Cl          H   OMe      OMe     CH                      5017       Q.sub.65   Cl          H   Me       OMe     N                       5018       Q.sub.65   COOMe       H   Me       OMe     CH                      5019       Q.sub.65   COOMe       H   OMe      OMe     CH                      5020       Q.sub.65   COOMe       H   Me       OMe     N                       5021       Me         Q.sub.65    H   Me       OMe     CH                      5022       Me         Q.sub.65    H   OMe      OMe     CH                      5023       Me         Q.sub.65    H   Me       OMe     N                       5024       Q.sub.66   Cl          H   Me       OMe     CH                      5025       Q.sub.66   Cl          H   OMe      OMe     CH                      5026       Q.sub.66   Cl          H   Me       OMe     N                       5027       Q.sub.66   COOMe       H   Me       OMe     CH                      5028       Q.sub.66   COOMe       H   OMe      OMe     CH                      5029       Q.sub.66   COOMe       H   Me       OMe     N                       5030       Me         Q.sub.66    H   Me       OMe     CH                      5031       Me         Q.sub.66    H   OMe      OMe     CH                      5032       Me         Q.sub.66    H   Me       OMe     N                       5033       Q.sub.67   Cl          H   Me       OMe     CH                      5034       Q.sub.67   Cl          H   OMe      OMe     CH                      5035       Q.sub.67   Cl          H   Me       OMe     N                       5036       Q.sub.67   COOMe       H   Me       OMe     CH                      5037       Q.sub.67   COOMe       H   OMe      OMe     CH                      5038       Q.sub.67   COOMe       H   Me       OMe     N                       5039       Me         Q.sub.67    H   Me       OMe     CH                      5040       Me         Q.sub.67    H   OMe      OMe     CH                      5041       Me         Q.sub.67    H   Me       OMe     N                       5042       Q.sub.68   Cl          H   Me       OMe     CH                      5043       Q.sub.68   Cl          H   OMe      OMe     CH                      5044       Q.sub.68   Cl          H   Me       OMe     N                       5045       Q.sub.68   COOMe       H   Me       OMe     CH                      5046       Q.sub.68   COOMe       H   OMe      OMe     CH                      5047       Q.sub.68   COOMe       H   Me       OMe     N                       5048       Me         Q.sub.68    H   Me       OMe     CH                      5049       Me         Q.sub.68    H   OMe      OMe     CH                      5050       Me         Q.sub.68    H   Me       OMe     N                       5051       Q.sub.69   Cl          H   Me       OMe     CH                      5052       Q.sub.69   Cl          h   OEM      OMe     CH                      5053       Q.sub.69   CL          H   Me       OMe     N                       5054       Q.sub.69   COOMe       H   OMe      OMe     CH                      5055       Q.sub.69   COOMe       H   OMe      OMe     CH                      5056       Q.sub.69   COOMe       H   Me       OMe     N                       5057       Me         Q.sub.69    H   Me       OMe     CH                      5058       Me         Q.sub.69    H   OMe      OMe     CH                      5059       Me         Q.sub.69    H   Me       OMe     N                       5060       Q.sub.70   H           H   Me       OMe     CH                      5061       Q.sub.70   H           H   OMe      OMe     CH                      5062       Q.sub.70   H           H   Me       OMe     N                       5063       Q.sub.70   Cl          H   Me       OMe     CH                      5064       Q.sub.70   Cl          H   OMe      OMe     CH                      5065       Q.sub.70   Cl          H   Me       OMe     N                       5066       Q.sub.70   COOMe       H   Me       OMe     CH                      5067       Q.sub.70   COOMe       H   OMe      OMe     CH                      5068       Q.sub.70   COOMe       H   Me       OMe     N                       5069       Me         Q.sub.70    H   Me       OMe     CH                      5070       Me         Q.sub.70    H   OMe      OMe     CH                      5071       Me         Q.sub.70    H   Me       OMe     N                       5072       Q.sub.71   Cl          H   Me       OMe     CH                      5073       Q.sub.71   Cl          H   OMe      OMe     CH                      5074       Q.sub.71   Cl          H   Me       OMe     N                       5075       Q.sub.71   COOMe       H   Me       OMe     CH                      5076       Q.sub.71   COOMe       H   OMe      OMe     CH                      5077       Q.sub.71   COOMe       H   Me       OMe     N                       5078       Me         Q.sub.71    H   Me       OMe     CH                      5079       Me         Q.sub.71    H   OMe      OMe     CH                      5080       Me         Q.sub.71    H   Me       OMe     N                       5081       Q.sub.72   Cl          H   Me       OMe     CH                      5082       Q.sub.72   Cl          H   OMe      OMe     CH                      5083       Q.sub.72   Cl          H   Me       OMe     N                       5084       Q.sub.72   COOMe       H   Me       OMe     CH                      5085       Q.sub.72   COOMe       H   OMe      OMe     CH                      5086       Q.sub.72   COOMe       H   Me       OMe     N                       5087       Me         Q.sub.72    H   Me       OMe     CH                      5088       Me         Q.sub.72    H   OMe      OMe     CH                      5089       Me         Q.sub.72    H   Me       OMe     N                       5090       Q.sub.73   Cl          H   Me       OMe     CH                      5091       Q.sub.73   Cl          H   OMe      OMe     CH                      5092       Q.sub.73   Cl          H   Me       OMe     N                       5093       Q.sub.73   COOMe       H   Me       OMe     CH                      5094       Q.sub.73   COOMe       H   OMe      OMe     CH                      5095       Q.sub.73   COOMe       H   Me       OMe     N                       5096       Me         Q.sub.73    H   Me       OMe     CH                      5097       Me         Q.sub.73    H   OMe      OMe     CH                      5098       Me         Q.sub.73    H   Me       OMe     N                       5099       Q.sub.74   Cl          H   Me       OMe     CH                      5100       Q.sub.74   Cl          H   OMe      OMe     CH                      5101       Q.sub.74   Cl          H   Me       OMe     N                       5102       Q.sub.74   COOMe       H   Me       OMe     CH                      5103       Q.sub.74   COOMe       H   OMe      OMe     CH                      5104       Q.sub.74   COOMe       H   Me       OMe     N                       5105       Me         Q.sub.74    H   Me       OMe     CH                      5106       Me         Q.sub.74    H   OMe      OMe     CH                      5107       Me         Q.sub.74    H   Me       OMe     N                       5108       Q.sub.75   Cl          H   Me       OMe     CH                      5109       Q.sub.75   Cl          H   OMe      OMe     CH                      5110       Q.sub.75   Cl          H   Me       OMe     N                       5111       Q.sub.75   CL          H   Me       OMe     N                       5112       Q.sub.75   COOMe       H   OMe      OMe     CH                      5113       Q.sub.75   COOMe       H   Me       OMe     N                       5114       Me         Q.sub.75    H   Me       OMe     CH                      5115       Me         Q.sub.75    H   OMe      OMe     CH                      5116       Me         Q.sub.75    H   Me       OMe     N                       5117       76         Cl          H   Me       OMe     CH                      5118       Q.sub.76   Cl          H   OMe OMe  CH                              5119       Q.sub.76   Cl          H   Me       OMe     N                       5120       Q.sub.76   COOMe       H   Me       OMe     CH                      5121       Q.sub.76   COOMe       H   OMe      OMe     CH                      5122       Q.sub.76   COOMe       H   Me       OMe     N                       5123       Me         Q.sub.76    H   Me       OMe     CH                      5124       Me         Q.sub.76    H   OMe      OMe     CH                      5125       Me         Q.sub.76    H   Me       OMe     N                       5720       Q.sub.77   Cl          H   Me       OMe     CH                      5721       Q.sub.77   Cl          H   OMe      OMe     CH                      5722       Q.sub.77   Cl          H   Me       OMe     N                       5723       Q.sub.77   COOMe       H   Me       OMe     CH                      5724       Q.sub.77   COOMe       H   OMe      OMe     CH                      5725       Q.sub.77   COOMe       H   Me       OMe     N                       5726       Me         Q.sub.77    H   Me       OMe     CH                      5727       Me         Q.sub.77    H   OMe      OMe     CH                      5728       Me         Q.sub.77    H   Me       OMe     N                       5729       Q.sub.78   H           H   Me       OMe     CH                      5730       Q.sub.78   H           H   OMe      OMe     CH                      5731       Q.sub.78   H           H   Me       OMe     N                       5732       Q.sub.78   Me          H   Me       OMe     CH                      5733       Q.sub.78   Me          H   OMe      OMe     CH                      5734       Q.sub.78   Me          H   Me       OMe     N                       5735       Q.sub.78   Cl          H   Me       OMe     CH                      5736       Q.sub.78   Cl          H   OMe      OMe     CH                      5737       Q.sub.78   Cl          H   Me       OMe     N                       5738       Q.sub.78   Br          H   Me       OMe     CH                      5739       Q.sub.78   Br          H   OMe      OMe     CH                      5740       Q.sub.78   Br          H   Me       OMe     N                       5741       Q.sub.78   COOMe       H   Me       OMe     CH                      5742       Q.sub.78   COOMe       H   OMe      OMe     CH                      5743       Q.sub.78   COOMe       H   Me       OMe     N                       5744       Q.sub.78   COOEt       H   Me       OMe     CH                      5745       Q.sub.78   COOEt       H   OMe      OMe     CH                      5746       Q.sub.78   COOEt       H   Me       OMe     N                       5747       Me         Q.sub.78    H   Me       Me      CH                      5748       Me         Q.sub.78    H   Me       OMe     CH                      5749       Me         Q.sub.78    H   OMe      OMe     CH                      5750       Me         Q.sub.78    H   Me       OMe     N                       5751       Me         Q.sub.78    H   OMe      OMe     N                       5752       COOMe      Q.sub.78    H   Me       OMe     CH                      5753       COOMe      Q.sub.78    H   OMe      OMe     CH                      5754       COOMe      Q.sub.78    H   Me       OMe     N                       5755       Q.sub.79   H           H   Me       OMe     CH                      5756       Q.sub.79   H           H   OMe      OMe     CH                      5757       Q.sub.79   H           H   Me       OMe     N                       5758       Q.sub.79   Me          H   Me       OMe     CH                      5759       Q.sub.79   Me          H   OMe      OMe     CH                      5760       Q.sub.79   Me          H   Me       OMe     N                       5761       Q.sub.79   Cl          H   Me       OMe     CH                      5762       Q.sub.79   Cl          H   OMe      OMe     CH                      5763       Q.sub.79   Cl          H   Me       OMe     N                       5764       Q.sub.79   Br          H   Me       OMe     CH                      5765       Q.sub.79   Br          H   OMe      OMe     CH                      5766       Q.sub.79   Br          H   Me       OMe     N                       5767       Q.sub.79   COOMe       H   Me       OMe     CH                      5768       Q.sub.79   COOMe       H   OMe      OMe     CH                      5769       Q.sub.79   COOMe       H   Me       OMe     N                       5770       Q.sub.79   COOEt       H   Me       OMe     CH                      5771       Q.sub.79   COOEt       H   OMe      OMe     CH                      5772       Q.sub.79   COOEt       H   Me       OMe     N                       5773       Me         Q.sub.79    H   Me       Me      CH                      5774       Me         Q.sub.79    H   Me       OMe     CH                      5775       Me         Q.sub.79    H   OMe      OMe     CH                      5776       Me         Q.sub.79    H   Me       OMe     N                       5777       Me         Q.sub.79    H   OMe      OMe     N                       5778       COOMe      Q.sub.79    H   Me       OMe     CH                      5779       COOMe      Q.sub.79    H   OMe      OMe     CH                      5780       COOMe      Q.sub.79    H   Me       OMe     N                       5781       Q.sub.80   H           H   Me       OMe     CH                      5782       Q.sub.80   H           H   OMe      OMe     CH                      5783       Q.sub.80   H           H   Me       OMe     N                       5784       Q.sub.80   Cl          H   Me       OMe     CH                      5785       Q.sub.80   Cl          H   OMe      OMe     CH                      5786       Q.sub.80   Cl          H   Me       OMe     N                       5787       Q.sub.80   COOMe       H   Me       OMe     CH                      5788       Q.sub.80   COOMe       H   OMe      OMe     CH                      5789       Q.sub.80   COOMe       H   Me       OMe     N                       5790       Me         Q.sub.80    H   Me       OMe     CH                      5791       Me         Q.sub.80    H   OMe      OMe     CH                      5792       Me         Q.sub.80    H   Me       OMe     N                       5793       Q.sub.81   Cl          H   Me       OMe     CH                      5794       Q.sub.81   Cl          H   OMe      OMe     CH                      5795       Q.sub.81   Cl          H   Me       OMe     N                       5796       Q.sub.81   COOMe       H   Me       OMe     CH                      5797       Q.sub.81   COOMe       H   OMe      OMe     CH                      5798       Q.sub.81   COOMe       H   Me       OMe     N                       5799       Me         Q.sub.81    H   Me       OMe     CH                      5800       Me         Q.sub.81    H   OMe      OMe     CH                      5801       Me         Q.sub.81    H   Me       OMe     N                       5802       Q.sub.82   Cl          H   Me       OMe     CH                      5803       Q.sub.82   Cl          H   OMe      OMe     CH                      5804       Q.sub.82   Cl          H   Me       OMe     N                       5805       Q.sub.82   COOMe       H   OMe      OMe     CH                      5806       Q.sub.82   COOMe       H   OMe      OMe     CH                      5807       Q.sub.82   COOMe       H   Me       OMe     N                       5808       Me         Q.sub.82    H   Me       OMe     CH                      5809       Me         Q.sub.82    H   OMe      OMe     CH                      5810       Me         Q.sub.82    H   Me       OMe     N                       5811       Q.sub.83   Cl          H   Me       OMe     CH                      5812       Q.sub.83   Cl          H   OMe      OMe     CH                      5813       Q.sub.83   Cl          H   Me       OMe     N                       5814       Q.sub.83   COOMe       H   Me       OMe     CH                      5815       Q.sub.83   COOMe       H   OMe      OMe     CH                      5816       Q.sub.83   COOMe       H   Me       OMe     N                       5817       Me         Q.sub.83    H   Me       OMe     CH                      5818       Me         Q.sub.83    H   OMe      OMe     CH                      5819       Me         Q.sub.83    H   Me       OMe     N                       6551       Q.sub.16   COOEt       H   OMe      OMe     CH                      __________________________________________________________________________

In the above, Q₁ to Q₈₃ are as defined above.

                                      TABLE 4                                      __________________________________________________________________________      ##STR30##                                                                     No. A   B  D     E       W X  Y   Z                                            __________________________________________________________________________     5126                                                                               Q.sub.1                                                                            H  COOMe H       S Me OMe CH                                           5127                                                                               Q.sub.1                                                                            H  COOMe H       S OMe                                                                               OMe CH                                           5128                                                                               Q.sub.1                                                                            H  COOEt H       S Me OMe CH                                           5129                                                                               Q.sub.1                                                                            H  COOEt H       S OMe                                                                               OMe CH                                           5130                                                                               Q.sub.1                                                                            H  COOEt H       S Me OMe N                                            5131                                                                               Q.sub.1                                                                            H  COOMe Me      O Me OMe CH                                           5132                                                                               Q.sub.1                                                                            H  COOMe Me      O OMe                                                                               OMe CH                                           5133                                                                               Q.sub.1                                                                            H  COOEt Me      O Me OMe CH                                           5134                                                                               Q.sub.1                                                                            H  COOEt Me      O OMe                                                                               OMe CH                                           5135                                                                               Q.sub.1                                                                            H  COOEt Me      O Me OMe N                                            5136                                                                               Q.sub.1                                                                            H  COOMe OMe     O Me OMe CH                                           5137                                                                               Q.sub.1                                                                            H  COOMe OMe     O OMe                                                                               OMe CH                                           5138                                                                               Q.sub.1                                                                            H  COOEt OMe     O Me OMe CH                                           5139                                                                               Q.sub.1                                                                            H  COOEt OMe     O OMe                                                                               OMe CH                                           5140                                                                               Q.sub.1                                                                            H  COOEt OMe     O Me OMe N                                            5141                                                                               Q.sub.1                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5142                                                                               Q.sub.1                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5143                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5144                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5145                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O Me OMe N                                            5146                                                                               Q.sub.1                                                                            H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5147                                                                               Q.sub.1                                                                            H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5148                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CCH                                                                           O Me OMe CH                                           5149                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5150                                                                               Q.sub.1                                                                            H  COOEt CH.sub.2 CCH                                                                           O Me OMe N                                            5151                                                                               Q.sub.2                                                                            H  COOMe H       S Me OMe CH                                           5152                                                                               Q.sub.2                                                                            H  COOMe H       S OMe                                                                               OMe CH                                           5153                                                                               Q.sub.2                                                                            H  COOEt H       S Me OMe CH                                           5154                                                                               Q.sub.2                                                                            H  COOEt H       S OMe                                                                               OMe CH                                           5155                                                                               Q.sub.2                                                                            H  COOMe Me      O Me OMe CH                                           5156                                                                               Q.sub.2                                                                            H  COOMe Me      O OMe                                                                               OMe CH                                           5157                                                                               Q.sub.2                                                                            H  COOEt Me      O OMe                                                                               OMe CH                                           5158                                                                               Q.sub.2                                                                            H  COOMe OMe     O Me OMe CH                                           5159                                                                               Q.sub.2                                                                            H  COOMe OMe     O OMe                                                                               OMe CH                                           5160                                                                               Q.sub.2                                                                            H  COOEt OMe     O OMe                                                                               OMe CH                                           5161                                                                               Q.sub.2                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5162                                                                               Q.sub.2                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5163                                                                               Q.sub.2                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5164                                                                               Q.sub.2                                                                            H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5165                                                                               Q.sub.2                                                                            H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5166                                                                               Q.sub.2                                                                            H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5167                                                                               Q.sub.8                                                                            H  COOMe H       S Me OMe CH                                           5168                                                                               Q.sub.8                                                                            H  COOMe H       S OMe                                                                               OMe CH                                           5169                                                                               Q.sub.8                                                                            H  COOEt H       S Me OMe CH                                           5170                                                                               Q.sub.8                                                                            H  COOEt H       S OMe                                                                               OMe CH                                           5171                                                                               Q.sub.8                                                                            H  COOMe Me      O Me OMe CH                                           5172                                                                               Q.sub.8                                                                            H  COOMe Me      O OMe                                                                               OMe CH                                           5173                                                                               Q.sub.8                                                                            H  COOEt Me      O OMe                                                                               OMe CH                                           5174                                                                               Q.sub.8                                                                            H  COOMe OMe     O Me OMe CH                                           5175                                                                               Q.sub.8                                                                            H  COOMe OMe     O OMe                                                                               OMe CH                                           5176                                                                               Q.sub.8                                                                            H  COOEt OMe     O OMe                                                                               OMe CH                                           5177                                                                               Q.sub.8                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5178                                                                               Q.sub.8                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5179                                                                               Q.sub.8                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5180                                                                               Q.sub.8                                                                            H  COOMe CH.sub.2 C CH                                                                          O Me OMe CH                                           5181                                                                               Q.sub.8                                                                            H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5182                                                                               Q.sub.8                                                                            H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5183                                                                               Q.sub.32                                                                           H  COOMe H       S Me OMe CH                                           5184                                                                               Q.sub.32                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5185                                                                               Q.sub.32                                                                           H  COOEt H       S Me OMe CH                                           5186                                                                               Q.sub.32                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5187                                                                               Q.sub.32                                                                           H  COOMe Me      O Me OMe CH                                           5188                                                                               Q.sub.32                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5189                                                                               Q.sub.32                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5190                                                                               Q.sub.32                                                                           H  COOMe OMe     O Me OMe CH                                           5191                                                                               Q.sub.32                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5192                                                                               Q.sub.32                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5193                                                                               Q.sub.32                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5194                                                                               Q.sub.32                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5195                                                                               Q.sub.32                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5196                                                                               Q.sub.32                                                                           H  COOMe CH.sub. 2 CCH                                                                          O Me OMe CH                                           5197                                                                               Q.sub.32                                                                           H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5198                                                                               Q.sub.32                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5199                                                                               Q.sub.45                                                                           H  COOMe H       S Me OMe CH                                           5200                                                                               Q.sub.45                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5201                                                                               Q.sub.45                                                                           H  COOEt H       S Me OMe CH                                           5202                                                                               Q.sub.45                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5203                                                                               Q.sub.45                                                                           H  COOMe Me      O Me OMe CH                                           5204                                                                               Q.sub.45                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5205                                                                               Q.sub.45                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5206                                                                               Q.sub.45                                                                           H  COOMe OMe     O Me OMe CH                                           5207                                                                               Q.sub.45                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5208                                                                               Q.sub.45                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5209                                                                               Q.sub.45                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5210                                                                               Q.sub.45                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5211                                                                               Q.sub.45                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5212                                                                               Q.sub.45                                                                           H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5213                                                                               Q.sub.45                                                                           H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5214                                                                               Q.sub.45                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5215                                                                               Q.sub.59                                                                           H  COOMe H       S Me OMe CH                                           5216                                                                               Q.sub.59                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5217                                                                               Q.sub.59                                                                           H  COOEt H       S Me OMe CH                                           5218                                                                               Q.sub.59                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5219                                                                               Q.sub.59                                                                           H  COOMe Me      O Me OMe CH                                           5220                                                                               Q.sub.59                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5221                                                                               Q.sub.59                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5222                                                                               Q.sub.59                                                                           H  COOMe OMe     O Me OMe CH                                           5223                                                                               Q.sub.59                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5224                                                                               Q.sub.59                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5225                                                                               Q.sub.59                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5226                                                                               Q.sub.59                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5227                                                                               Q.sub.59                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5228                                                                               Q.sub.59                                                                           H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5229                                                                               Q.sub.59                                                                           H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5230                                                                               Q.sub.59                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5231                                                                               Me  H  Q.sub.1                                                                              H       S Me OMe CH                                           5232                                                                               Me  H  Q.sub.1                                                                              H       S OMe                                                                               OMe CH                                           5233                                                                               Me  H  Q.sub.1                                                                              H       S Me OMe CH                                           5234                                                                               Me  H  Q.sub.1                                                                              H       S OMe                                                                               OMe CH                                           5235                                                                               Me  H  Q.sub.1                                                                              H       S Me OMe N                                            5236                                                                               Me  H  Q.sub.1                                                                              Me      O Me OMe CH                                           5237                                                                               Me  H  Q.sub.1                                                                              Me      O OMe                                                                               OMe CH                                           5238                                                                               Me  H  Q.sub.1                                                                              Me      O Me OMe CH                                           5239                                                                               Me  H  Q.sub.1                                                                              Me      O OMe                                                                               OMe CH                                           5240                                                                               Me  H  Q.sub.1                                                                              Me      O Me OMe N                                            5241                                                                               Me  H  Q.sub.1                                                                              OMe     O Me OMe CH                                           5242                                                                               Me  H  Q.sub.1                                                                              OMe     O OMe                                                                               OMe CH                                           5243                                                                               Me  H  Q.sub. 1                                                                             OMe     O Me OMe CH                                           5244                                                                               Me  H  Q.sub.1                                                                              OMe     O OMe                                                                               OMe CH                                           5245                                                                               Me  H  Q.sub.1                                                                              OMe     O Me OMe N                                            5246                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5247                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5248                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5249                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5250                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CHCH.sub.2                                                                    O Me OMe N                                            5251                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CCH                                                                           O Me OMe CH                                           5252                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5253                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CCH                                                                           O Me OMe CH                                           5254                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5255                                                                               Me  H  Q.sub.1                                                                              CH.sub.2 C CH                                                                          O Me OMe N                                            5820                                                                               Q.sub.5                                                                            H  COOMe H       S Me OMe CH                                           5821                                                                               Q.sub.5                                                                            H  COOMe H       S OMe                                                                               OMe CH                                           5822                                                                               Q.sub.5                                                                            H  COOEt H       S Me OMe CH                                           5823                                                                               Q.sub.5                                                                            H  COOEt H       S OMe                                                                               OMe CH                                           5824                                                                               Q.sub.5                                                                            H  COOMe Me      O Me OMe CH                                           5825                                                                               Q.sub.5                                                                            H  COOMe Me      O OMe                                                                               OMe CH                                           5826                                                                               Q.sub.5                                                                            H  COOEt Me      O OMe                                                                               OMe CH                                           5827                                                                               Q.sub.5                                                                            H  COOMe OMe     O Me OMe CH                                           5828                                                                               Q.sub.5                                                                            H  COOMe OMe     O OMe                                                                               OMe CH                                           5829                                                                               Q.sub.5                                                                            H  COOEt OMe     O OMe                                                                               OMe CH                                           5830                                                                               Q.sub.5                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5831                                                                               Q.sub.5                                                                            H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5832                                                                               Q.sub.5                                                                            H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5833                                                                               Q.sub.5                                                                            H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5834                                                                               Q.sub.5                                                                            H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5835                                                                               Q.sub.5                                                                            H  COOEt CH.sub.2 C CH                                                                          O OMe                                                                               OMe CH                                           5836                                                                               Q.sub.10                                                                           H  COOMe H       S Me OMe CH                                           5837                                                                               Q.sub.10                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5838                                                                               Q.sub.10                                                                           H  COOEt H       S Me OMe CH                                           5839                                                                               Q.sub.10                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5840                                                                               Q.sub.10                                                                           H  COOMe Me      O Me OMe CH                                           5841                                                                               Q.sub.10                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5842                                                                               Q.sub.10                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5843                                                                               Q.sub.10                                                                           H  COOMe OMe     O Me OMe CH                                           5844                                                                               Q.sub.10                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5845                                                                               Q.sub.10                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5846                                                                               Q.sub.10                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5847                                                                               Q.sub.10                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5848                                                                               Q.sub.10                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5849                                                                               Q.sub.10                                                                           H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5850                                                                               Q.sub.10                                                                           H  COOMe CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5851                                                                               Q.sub.10                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5852                                                                               Q.sub.78                                                                           H  COOMe H       S Me OMe CH                                           5853                                                                               Q.sub.78                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5854                                                                               Q.sub.78                                                                           H  COOEt H       S Me OMe CH                                           5855                                                                               Q.sub.78                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5856                                                                               Q.sub.78                                                                           H  COOMe Me      O Me OMe CH                                           5857                                                                               Q.sub.78                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5858                                                                               Q.sub.78                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5859                                                                               Q.sub.78                                                                           H  COOMe OMe     O Me OMe CH                                           5860                                                                               Q.sub.78                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5861                                                                               Q.sub.78                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5862                                                                               Q.sub.78                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5863                                                                               Q.sub.78                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5864                                                                               Q.sub.78                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5865                                                                               Q.sub.78                                                                           H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5866                                                                               Q.sub.78                                                                           H  COOMe CH.sub.2 C CH                                                                          O OMe                                                                               OMe CH                                           5867                                                                               Q.sub.78                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           5868                                                                               Q.sub.79                                                                           H  COOMe H       S Me OMe CH                                           5869                                                                               Q.sub.79                                                                           H  COOMe H       S OMe                                                                               OMe CH                                           5870                                                                               Q.sub.79                                                                           H  COOEt H       S Me OMe CH                                           5871                                                                               Q.sub.79                                                                           H  COOEt H       S OMe                                                                               OMe CH                                           5872                                                                               Q.sub.79                                                                           H  COOMe Me      O Me OMe CH                                           5873                                                                               Q.sub.79                                                                           H  COOMe Me      O OMe                                                                               OMe CH                                           5874                                                                               Q.sub.79                                                                           H  COOEt Me      O OMe                                                                               OMe CH                                           5875                                                                               Q.sub.79                                                                           H  COOMe OMe     O Me OMe CH                                           5876                                                                               Q.sub.79                                                                           H  COOMe OMe     O OMe                                                                               OMe CH                                           5877                                                                               Q.sub.79                                                                           H  COOEt OMe     O OMe                                                                               OMe CH                                           5878                                                                               Q.sub.79                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O Me OMe CH                                           5879                                                                               Q.sub.79                                                                           H  COOMe CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5880                                                                               Q.sub.79                                                                           H  COOEt CH.sub.2 CHCH.sub.2                                                                    O OMe                                                                               OMe CH                                           5881                                                                               Q.sub.79                                                                           H  COOMe CH.sub.2 CCH                                                                           O Me OMe CH                                           5882                                                                               Q.sub.79                                                                           H  COOMe CH.sub. 2 CCH                                                                          O OMe                                                                               OMe CH                                           5883                                                                               Q.sub.79                                                                           H  COOEt CH.sub.2 CCH                                                                           O OMe                                                                               OMe CH                                           __________________________________________________________________________

In the above, Q₁ to Q₇₉ are as defined above.

                  TABLE 5                                                          ______________________________________                                          ##STR31##                                                                     No.     A      B       D      X.sup.1                                                                               Y.sup.1                                                                             Z                                    ______________________________________                                         5256    Q.sub.1                                                                               H       COOMe  Me     Me   CH                                   5257    Q.sub.1                                                                               H       COOMe  Me     OMe  CH                                   5258    Q.sub.1                                                                               H       COOEt  Me     Me   CH                                   5259    Q.sub.1                                                                               H       COOEt  Me     OMe  CH                                   5260    Q.sub.1                                                                               H       COOEt  Me     Me   N                                    5261    Q.sub.2                                                                               H       COOMe  Me     Me   CH                                   5262    Q.sub.2                                                                               H       COOMe  Me     OMe  CH                                   5263    Q.sub.8                                                                               H       COOMe  Me     Me   CH                                   5264    Q.sub.8                                                                               H       COOMe  Me     OMe  CH                                   5265    Q.sub.32                                                                              H       COOMe  Me     Me   CH                                   5266    Q.sub.32                                                                              H       COOMe  Me     OMe  CH                                   5267    Q.sub.45                                                                              H       COOMe  Me     Me   CH                                   5268    Q.sub.45                                                                              H       COOMe  Me     OMe  CH                                   5269    Q.sub.59                                                                              H       COOMe  Me     Me   CH                                   5270    Q.sub.59                                                                              H       COOMe  Me     OMe  CH                                   5271    Me     H       Q.sub.1                                                                               Me     Me   CH                                   5272    Me     H       Q.sub.1                                                                               Me     OMe  CH                                   5273    Me     H       Q.sub.1                                                                               Me     Me   N                                    5884    Q.sub.5                                                                               H       COOMe  Me     Me   CH                                   5885    Q.sub.5                                                                               H       COOMe  Me     OMe  CH                                   5886    Q.sub.10                                                                              H       COOMe  Me     Me   CH                                   5887    Q.sub.10                                                                              H       COOMe  Me     OMe  CH                                   5888    Q.sub.78                                                                              H       COOMe  Me     Me   CH                                   5889    Q.sub.78                                                                              H       COOMe  Me     OMe  CH                                   5890    Q.sub.79                                                                              H       COOMe  Me     Me   CH                                   5891    Q.sub.79                                                                              H       COOMe  Me     OMe  CH                                   ______________________________________                                    

In the above, Q₁ to Q₇₉ are as defined above.

                  TABLE 6                                                          ______________________________________                                          ##STR32##                                                                     No.    A        B      D        X.sup.1                                                                             Y.sup.1                                                                               Z                                  ______________________________________                                         5274   Q.sub.1  Me     Me       Me   Me     CH                                 5275   Q.sub.1  Me     Me       Me   OMe    CH                                 5276   Q.sub.1  Me     COOMe    Me   Me     CH                                 5277   Q.sub.1  Me     COOMe    Me   OMe    CH                                 5278   Q.sub.1  Me     COOMe    Me   Me     N                                  5279   Q.sub.2  Me     COOMe    Me   Me     CH                                 5280   Q.sub.2  Me     COOMe    Me   OMe    CH                                 5281   Q.sub.8  Me     COOMe    Me   Me     CH                                 5282   Q.sub.8  Me     COOMe    Me   OMe    CH                                 5283   Q.sub.32 Me     COOMe    Me   Me     CH                                 5284   Q.sub.32 Me     COOMe    Me   OMe    CH                                 5285   Q.sub.45 Me     COOMe    Me   Me     CH                                 5286   Q.sub.45 Me     COOMe    Me   OMe    CH                                 5287   Q.sub.59 Me     COOMe    Me   Me     CH                                 5288   Q.sub.59 Me     COOMe    Me   OMe    CH                                 ______________________________________                                    

In the above, Q₁ to Q₅₉ are as defined above.

                  TABLE 7                                                          ______________________________________                                          ##STR33##                                                                     No.     A      B          D   X.sup.1                                                                               Y.sup.1                                                                             Z                                    ______________________________________                                         5289    Q.sub.1                                                                               Cl         H   Me     Me   CH                                   5290    Q.sub.1                                                                               Cl         H   Me     OMe  CH                                   5291    Q.sub.1                                                                               COOMe      H   Me     Me   CH                                   5292    Q.sub.1                                                                               COOMe      H   Me     OMe  CH                                   5293    Me     Q.sub.1    H   Me     Me   CH                                   5294    Me     Q.sub.1    H   Me     OMe  CH                                   5295    Q.sub.2                                                                               Cl         H   Me     Me   CH                                   5296    Q.sub.2                                                                               Cl         H   Me     OMe  CH                                   5297    Q.sub.8                                                                               Cl         H   Me     Me   CH                                   5298    Q.sub.8                                                                               Cl         H   Me     OMe  CH                                   5299    Q.sub.45                                                                              Cl         H   Me     Me   CH                                   5300    Q.sub.45                                                                              Cl         H   Me     OMe  CH                                   ______________________________________                                    

In the above, Q₁ to Q₄₅ are as defined above.

                  TABLE 8                                                          ______________________________________                                          ##STR34##                                                                     No.    A         B     D          X.sup.2                                                                             Y.sup.2                                 ______________________________________                                         5301   Q.sub.1   H     COOMe      Me   Me                                      5302   Q.sub.1   H     COOMe      OMe  Me                                      5303   Q.sub.1   H     COOMe      SMe  Me                                      5304   Q.sub.1   H     COOEt      Me   Me                                      5305   Q.sub.1   H     COOEt      OMe  Me                                      5306   Q.sub.1   H     COOEt      SMe  Me                                      5307   Q.sub.2   H     COOMe      Me   Me                                      5308   Q.sub.2   H     COOMe      OMe  Me                                      5309   Q.sub.8   H     COOMe      Me   Me                                      5310   Q.sub.8   H     COOMe      OMe  Me                                      5311   Q.sub.32  H     COOMe      Me   Me                                      5312   Q.sub.32  H     COOMe      OMe  Me                                      5313   Q.sub.45  H     COOMe      Me   Me                                      5314   Q.sub.45  H     COOMe      OMe  Me                                      5315   Q.sub.59  H     COOMe      Me   Me                                      5316   Q.sub.59  H     COOMe      OMe  Me                                      5317   Me        H     Q.sub.1    Me   Me                                      5318   Me        H     Q.sub.1    OMe  Me                                      5319   Me        H     Q.sub.1    SMe  Me                                      5892   Q.sub.5   H     COOMe      Me   Me                                      5893   Q.sub.5   H     COOMe      OMe  Me                                      5894   Q.sub.10  H     COOMe      Me   Me                                      5895   Q.sub.10  H     COOMe      OMe  Me                                      5896   Q.sub.78  H     COOMe      Me   Me                                      5897   Q.sub.78  H     COOMe      OMe  Me                                      5898   Q.sub.79  H     COOMe      Me   Me                                      5899   Q.sub.79  H     COOMe      OMe  Me                                      ______________________________________                                    

In the above, Q₁ to Q₇₉ are as defined above.

                  TABLE 9                                                          ______________________________________                                          ##STR35##                                                                     No.    A         B      D         X.sup.2                                                                             Y.sup.2                                 ______________________________________                                         5320   Q.sub.1   Me     Me        Me   Me                                      5321   Q.sub.1   Me     Me        OMe  Me                                      5322   Q.sub.1   Me     COOMe     Me   Me                                      5323   Q.sub.1   Me     COOMe     OMe  Me                                      5324   Q.sub.1   Me     COOMe     SMe  Me                                      5325   Q.sub.2   Me     COOMe     Me   Me                                      5326   Q.sub.2   Me     COOMe     OMe  Me                                      5327   Q.sub.8   Me     COOMe     Me   Me                                      5328   Q.sub.8   Me     COOMe     OMe  Me                                      5329   Q.sub.32  Me     COOMe     Me   Me                                      5330   Q.sub.32  Me     COOMe     OMe  Me                                      5331   Q.sub.45  Me     COOMe     Me   Me                                      5332   Q.sub.45  Me     COOMe     OMe  Me                                      5333   Q.sub.59  Me     COOMe     Me   Me                                      5334   Q.sub.59  Me     COOMe     OMe  Me                                      ______________________________________                                    

In the above, Q₁ to Q₅₉ are as defined above.

                  TABLE 10                                                         ______________________________________                                          ##STR36##                                                                     No.    A         B        D      X.sup.2                                                                             Y.sup.2                                  ______________________________________                                         5335   Q.sub.1   Cl       H      Me   Me                                       5336   Q.sub.1   Cl       H      OMe  Me                                       5337   Q.sub.1   COOMe    H      Me   Me                                       5338   Q.sub.1   COOMe    H      OMe  Me                                       5339   Me        Q.sub.1  H      Me   Me                                       5340   Me        Q.sub.1  H      OMe  Me                                       5341   Q.sub.2   Cl       H      Me   Me                                       5342   Q.sub.2   Cl       H      OMe  Me                                       5343   Q.sub.8   Cl       H      Me   Me                                       5344   Q.sub.8   Cl       H      OMe  Me                                       5345   Q.sub.45  Cl       H      Me   Me                                       5346   Q.sub.45  Cl       H      OMe  Me                                       ______________________________________                                    

In the above, Q₁ to Q₄₅ are as defined above.

                                      TABLE 11                                     __________________________________________________________________________      ##STR37##                                                                     No. A      B    D          X   Y     Z                                         __________________________________________________________________________     5900                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Me  Me    CH                                        5901                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Me  OMe   CH                                        5902                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      OMe OMe   CH                                        5903                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Me  Me    N                                         5904                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Me  OMe   N                                         5905                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      OMe OMe   N                                         5906                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Me  OCHF.sub.2                                                                           CH                                        5907                                                                               CH.sub.2 Q.sub.1                                                                      H    COOMe      Cl  OMe   CH                                        5908                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      Me  Me    CH                                        5909                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      Me  OMe   CH                                        5910                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      OMe OMe   CH                                        5911                                                                               CH.sub. 2 Q.sub.1                                                                     H    COOEt      Me  Me    N                                         5912                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      Me  OMe   N                                         5913                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      OMe OMe   N                                         5914                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      Me  OCHF.sub.2                                                                           CH                                        5915                                                                               CH.sub.2 Q.sub.1                                                                      H    COOEt      Cl  OMe   CH                                        5916                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPrn     Me  OMe   CH                                        5917                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPrn     OMe OMe   CH                                        5918                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPrn     Me  OMe   N                                         5919                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPri     Me  OMe   CH                                        5920                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPri     OMe OMe   CH                                        5921                                                                               CH.sub.2 Q.sub.1                                                                      H    COOPri     Me  OMe   N                                         5922                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CH.sub.2 Cl                                                                   Me  OMe   CH                                        5923                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CH.sub.2 Cl                                                                   OMe OMe   CH                                        5924                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CH.sub.2 Cl                                                                   Me  OMe   N                                         5925                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CHCH.sub.2                                                                    Me  OMe   CH                                        5926                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CHCH.sub.2                                                                    OMe OMe   CH                                        5927                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CHCH.sub.2                                                                    Me  OMe   N                                         5928                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CCH                                                                           Me  OMe   CH                                        5929                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CCH                                                                           OMe OMe   CH                                        5930                                                                               CH.sub.2 Q.sub.1                                                                      H    COOCH.sub.2 CCH                                                                           Me  OMe   N                                         5931                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOMe      Me  Me    CH                                        5932                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOMe      Me  OMe   CH                                        5933                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOMe      OMe OMe   CH                                        5934                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOMe      Me  OMe   N                                         5935                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOMe      OMe OMe   N                                         5936                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOEt      Me  Me    CH                                        5937                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOEt      Me  OMe   CH                                        5938                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOEt      OMe OMe   CH                                        5939                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOEt      Me  OMe   N                                         5940                                                                               CH.sub.2 Q.sub.1                                                                      Me   COOEt      OMe OMe   N                                         5941                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOMe      Me  OMe   CH                                        5942                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOMe      OMe OMe   CH                                        5943                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOMe      Me  OMe   N                                         5944                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOEt      Me  OMe   CH                                        5945                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOEt      OMe OMe   CH                                        5946                                                                               CH.sub.2 Q.sub.1                                                                      Cl   COOEt      Me  OMe   N                                         5947                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOMe      Me  OMe   CH                                        5948                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOMe      OMe OMe   CH                                        5949                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOMe      Me  OMe   N                                         5950                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOEt      Me  OMe   CH                                        5951                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOEt      OMe OMe   CH                                        5952                                                                               CH.sub.2 Q.sub.1                                                                      OMe  COOEt      Me  OMe   N                                         5953                                                                               CH.sub.2 Q.sub.1                                                                      H    Cl         Me  OMe   CH                                        5954                                                                               CH.sub.2 Q.sub.1                                                                      H    Cl         OMe OMe   CH                                        5955                                                                               CH.sub.2 Q.sub.1                                                                      H    Cl         Me  OMe   N                                         5956                                                                               CH.sub.2 Q.sub.1                                                                      H    NO.sub.2   Me  OMe   CH                                        5957                                                                               CH.sub.2 Q.sub.1                                                                      H    NO.sub.2   OMe OMe   CH                                        5958                                                                               CH.sub.2 Q.sub.1                                                                      H    NO.sub.2   Me  OMe   N                                         5959                                                                               CH.sub.2 Q.sub.1                                                                      H    SO.sub.2 NMe.sub.2                                                                        Me  OMe   CH                                        5960                                                                               CH.sub.2 Q.sub.1                                                                      H    SO.sub.2 NMe.sub.2                                                                        OMe OMe   CH                                        5961                                                                               CH.sub.2 Q.sub.1                                                                      H    SO.sub.2 NMe.sub.2                                                                        Me  OMe   N                                         5962                                                                               CH.sub.2 Q.sub.1                                                                      H    CN         Me  OMe   CH                                        5963                                                                               CH.sub.2 Q.sub.1                                                                      H    CN         OMe OMe   CH                                        5964                                                                               CH.sub.2 Q.sub.1                                                                      H    CN         Me  OMe   N                                         5965                                                                               CH.sub.2 Q.sub.1                                                                      Me   CN         Me  OMe   CH                                        5966                                                                               CH.sub.2 Q.sub.1                                                                      Me   CN         OMe OMe   CH                                        5967                                                                               CH.sub.2 Q.sub.1                                                                      Me   CN         Me  OMe   N                                         5968                                                                               CH.sub.2 Q.sub.1                                                                      H    Me         Me  OMe   CH                                        5969                                                                               CH.sub.2 Q.sub.1                                                                      H    Me         OMe OMe   CH                                        5970                                                                               CH.sub.2 Q.sub.1                                                                      H    Me         Me  OMe   N                                         5971                                                                               CH.sub.2 Q.sub.1                                                                      H    Et         Me  OMe   CH                                        5972                                                                               CH.sub.2 Q.sub.1                                                                      H    Et         OMe OMe   CH                                        5973                                                                               CH.sub.2 Q.sub.1                                                                      H    Et         Me  OMe   N                                         5974                                                                               CH.sub.2 Q.sub.1                                                                      H    H          Me  OMe   CH                                        5975                                                                               CH.sub.2 Q.sub.1                                                                      H    H          OMe OMe   CH                                        5976                                                                               CH.sub.2 Q.sub.1                                                                      H    H          Me  OMe   N                                         5977                                                                               CH.sub.2 Q.sub.1                                                                      H    COPh       Me  OMe   CH                                        5978                                                                               CH.sub.2 Q.sub.1                                                                      H    COPh       OMe OMe   CH                                        5979                                                                               CH.sub.2 Q.sub.1                                                                      H    COPh       Me  OMe   N                                         5980                                                                               Me     CH.sub.2 Q.sub.1                                                                    COOMe      Me  OMe   CH                                        5981                                                                               Me     CH.sub.2 Q.sub.1                                                                    COOMe      OMe OMe   CH                                        5982                                                                               Me     CH.sub.2 Q.sub.1                                                                    COOMe      Me  OMe   N                                         5983                                                                               H      H    CH.sub.2 Q.sub.1                                                                          Me  OMe   CH                                        5984                                                                               H      H    CH.sub.2 Q.sub.1                                                                          OMe OMe   CH                                        5985                                                                               H      H    CH.sub.2 Q.sub.1                                                                          Me  OMe   N                                         5986                                                                               Me     H    CH.sub.2 Q.sub.1                                                                          Me  Me    CH                                        5987                                                                               Me     H    CH.sub.2 Q.sub.1                                                                          Me  OMe   CH                                        5988                                                                               Me     H    CH.sub.2 Q.sub.1                                                                          OMe OMe   CH                                        5989                                                                               Me     H    CH.sub.2 Q.sub.1                                                                          Me  OMe   N                                         5990                                                                               Me     H    CH.sub.2 Q.sub.1                                                                          OMe OMe   N                                         5991                                                                               Me     Me   CH.sub.2 Q.sub.1                                                                          Me  OMe   CH                                        5992                                                                               Me     Me   CH.sub.2 Q.sub.1                                                                          OMe OMe   CH                                        5993                                                                               Me     Me   CH.sub.2 Q.sub.1                                                                          Me  OMe   N                                         5994                                                                               CHMeQ.sub.1                                                                           H    COOMe      Me  OMe   CH                                        5995                                                                               CHMeQ.sub.1                                                                           H    COOMe      OMe OMe   CH                                        5996                                                                               CHMeQ.sub.1                                                                           H    COOEt      Me  OMe   CH                                        5997                                                                               CHMeQ.sub.1                                                                           H    COOEt      OMe OMe   CH                                        5998                                                                               CHMeQ.sub.1                                                                           Me   COOMe      Me  OMe   CH                                        5999                                                                               CHMeQ.sub.1                                                                           Me   COOMe      OMe OMe   CH                                        6000                                                                               CHMeQ.sub.1                                                                           Me   COOEt      Me  OMe   CH                                        6001                                                                               CHMeQ.sub.1                                                                           Me   COOEt      OMe OMe   CH                                        6002                                                                               CHMeQ.sub.1                                                                           H    H          Me  OMe   CH                                        6003                                                                               CHMeQ.sub.1                                                                           H    H          OMe OMe   CH                                        6004                                                                               Me     H    CHMeQ.sub.1                                                                               Me  OMe   CH                                        6005                                                                               Me     H    CHMeQ.sub.1                                                                               OMe OMe   CH                                        6006                                                                               CH.sub.2 Q.sub.24                                                                     H    COOMe      Me  Me    CH                                        6007                                                                               CH.sub.2 Q.sub.24                                                                     H    COOMe      Me  OMe   CH                                        6008                                                                               CH.sub.2 Q.sub.24                                                                     H    COOMe      OMe OMe   CH                                        6009                                                                               CH.sub.2 Q.sub.24                                                                     H    COOMe      Me  OMe   N                                         6010                                                                               CH.sub.2 Q.sub.24                                                                     H    COOMe      OMe OMe   N                                         6011                                                                               CH.sub.2 Q.sub.24                                                                     H    COOEt      Me  Me    CH                                        6012                                                                               CH.sub.2 Q.sub.24                                                                     H    COOEt      Me  OMe   CH                                        6013                                                                               CH.sub.2 Q.sub.24                                                                     H    COOEt      OMe OMe   CH                                        6014                                                                               CH.sub.2 Q.sub.24                                                                     H    COOEt      Me  OMe   N                                         6015                                                                               CH.sub.2 Q.sub.24                                                                     H    COOEt      OMe OMe   N                                         6016                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOMe      Me  OMe   CH                                        6017                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOMe      OMe OMe   CH                                        6018                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOMe      Me  OMe   N                                         6019                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOEt      Me  OMe   CH                                        6020                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOEt      OMe OMe   CH                                        6021                                                                               CH.sub.2 Q.sub.24                                                                     Me   COOEt      Me  OMe   N                                         6022                                                                               CH.sub.2 Q.sub.24                                                                     H    CN         Me  OMe   CH                                        6023                                                                               CH.sub.2 Q.sub.24                                                                     H    CN         OMe OMe   CH                                        6024                                                                               CH.sub.2 Q.sub.24                                                                     H    CN         Me  OMe   N                                         6025                                                                               CH.sub.2 Q.sub.24                                                                     H    H          Me  OMe   CH                                        6026                                                                               CH.sub.2 Q.sub.24                                                                     H    H          OMe OMe   CH                                        6027                                                                               CH.sub.2 Q.sub.24                                                                     H    H          Me  OMe   N                                         6028                                                                               Me     H    CH.sub.2 Q.sub.24                                                                         Me  Me    CH                                        6029                                                                               Me     H    CH.sub.2 Q.sub.24                                                                         Me  OMe   CH                                        6030                                                                               Me     H    CH.sub.2 Q.sub.24                                                                         OMe OMe   CH                                        6031                                                                               Me     H    CH.sub.2 Q.sub.24                                                                         Me  OMe   N                                         6032                                                                               Me     H    CH.sub.2 Q.sub.24                                                                         OMe OMe   N                                         6033                                                                               CH.sub.2 Q.sub.28                                                                     H    COOMe      Me  Me    CH                                        6034                                                                               CH.sub.2 Q.sub.28                                                                     H    COOMe      Me  OMe   CH                                        6035                                                                               CH.sub.2 Q.sub.28                                                                     H    COOMe      OMe OMe   CH                                        6036                                                                               CH.sub.2 Q.sub.28                                                                     H    COOMe      Me  OMe   N                                         6037                                                                               CH.sub.2 Q.sub.28                                                                     H    COOMe      OMe OMe   N                                         6038                                                                               CH.sub.2 Q.sub.28                                                                     H    COOEt      Me  Me    CH                                        6039                                                                               CH.sub.2 Q.sub.28                                                                     H    COOEt      Me  OMe   CH                                        6040                                                                               CH.sub.2 Q.sub.28                                                                     H    COOEt      OMe OMe   CH                                        6041                                                                               CH.sub.2 Q.sub.28                                                                     H    COOEt      Me  OMe   N                                         6042                                                                               CH.sub.2 Q.sub.28                                                                     H    COOEt      OMe OMe   N                                         6043                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOMe      Me  OMe   CH                                        6044                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOMe      OMe OMe   CH                                        6045                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOMe      Me  OMe   N                                         6046                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOEt      Me  OMe   CH                                        6047                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOEt      OMe OMe   CH                                        6048                                                                               CH.sub.2 Q.sub.28                                                                     Me   COOEt      Me  OMe   N                                         6049                                                                               CH.sub.2 Q.sub.28                                                                     H    CN         Me  OMe   CH                                        6050                                                                               CH.sub.2 Q.sub.28                                                                     H    CN         OMe OMe   CH                                        6051                                                                               CH.sub.2 Q.sub.28                                                                     H    CN         Me  OMe   N                                         6052                                                                               CH.sub.2 Q.sub.28                                                                     H    H          Me  OMe   CH                                        6053                                                                               CH.sub.2 Q.sub.28                                                                     H    H          OMe OMe   CH                                        6054                                                                               CH.sub.2 Q.sub.28                                                                     H    H          Me  OMe   N                                         6055                                                                               Me     H    CH.sub.2 Q.sub.28                                                                         Me  Me    CH                                        6056                                                                               Me     H    CH.sub.2 Q.sub.28                                                                         Me  OMe   CH                                        6057                                                                               Me     H    CH.sub.2 Q.sub.28                                                                         OMe OMe   CH                                        6058                                                                               Me     H    CH.sub.2 Q.sub.28                                                                         Me  OMe   N                                         6059                                                                               Me     H    CH.sub.2 Q.sub.28                                                                         OMe OMe   N                                         6060                                                                               CH.sub.2 Q.sub.32                                                                     H    COOMe      Me  Me    CH                                        6061                                                                               CH.sub.2 Q.sub.32                                                                     H    COOMe      Me  OMe   CH                                        6062                                                                               CH.sub.2 Q.sub.32                                                                     H    COOMe      OMe OMe   CH                                        6063                                                                               CH.sub.2 Q.sub.32                                                                     H    COOMe      Me  OMe   N                                         6064                                                                               CH.sub.2 Q.sub.32                                                                     H    COOMe      OMe OMe   N                                         6065                                                                               CH.sub.2 Q.sub.32                                                                     H    COOEt      Me  Me    CH                                        6066                                                                               CH.sub.2 Q.sub.32                                                                     H    COOEt      Me  OMe   CH                                        6067                                                                               CH.sub.2 Q.sub.32                                                                     H    COOEt      OMe OMe   CH                                        6068                                                                               CH.sub.2 Q.sub.32                                                                     H    COOEt      Me  OMe   N                                         6069                                                                               CH.sub.2 Q.sub.32                                                                     H    COOEt      OMe OMe   N                                         6070                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOMe      Me  OMe   CH                                        6071                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOMe      OMe OMe   CH                                        6072                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOMe      Me  OMe   N                                         6073                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOEt      Me  OMe   CH                                        6074                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOEt      OMe OMe   CH                                        6075                                                                               CH.sub.2 Q.sub.32                                                                     Me   COOEt      Me  OMe   N                                         6076                                                                               CH.sub.2 Q.sub.32                                                                     H    CN         Me  OMe   CH                                        6077                                                                               CH.sub.2 Q.sub.32                                                                     H    CN         OMe OMe   CH                                        6078                                                                               CH.sub.2 Q.sub.32                                                                     H    CN         Me  OMe   N                                         6079                                                                               CH.sub.2 Q.sub.32                                                                     H    H          Me  OMe   CH                                        6080                                                                               CH.sub.2 Q.sub.32                                                                     H    H          OMe OMe   CH                                        6081                                                                               CH.sub.2 Q.sub.32                                                                     H    H          Me  OMe   N                                         6082                                                                               Me     H    CH.sub.2 Q.sub.32                                                                         Me  Me    CH                                        6083                                                                               Me     H    CH.sub.2 Q.sub.32                                                                         Me  OMe   CH                                        6084                                                                               Me     H    CH.sub.2 Q.sub.32                                                                         OMe OMe   CH                                        6085                                                                               Me     H    CH.sub.2 Q.sub.32                                                                         Me  OMe   N                                         6086                                                                               Me     H    CH.sub.2 Q.sub.32                                                                         OMe OMe   N                                         6087                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOMe      Me  Me    CH                                        6088                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOMe      Me  OMe   CH                                        6089                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOMe      OMe OMe   CH                                        6090                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOMe      Me  OMe   N                                         6091                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOMe      OMe OMe   N                                         6092                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOEt      Me  Me    CH                                        6093                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOEt      Me  OMe   CH                                        6094                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOEt      OMe OMe   CH                                        6095                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOEt      Me  OMe   N                                         6096                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    COOEt      OMe OMe   N                                         6097                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOMe      Me  OMe   CH                                        6098                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOMe      OMe OMe   CH                                        6099                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOMe      Me  OMe   N                                         6100                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOEt      Me  OMe   CH                                        6101                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOEt      OMe OMe   CH                                        6102                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me   COOEt      Me  OMe   N                                         6103                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    CN         Me  OMe   CH                                        6104                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    CN         OMe OMe   CH                                        6105                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    CN         Me  OMe   N                                         6106                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    H          Me  OMe   CH                                        6107                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    H          OMe OMe   CH                                        6108                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             H    H          Me  OMe   N                                         6109                                                                               Me     H    CH.sub.2 CH.sub.2 Q.sub.1                                                                 Me  Me    CH                                        6110                                                                               Me     H    CH.sub.2 CH.sub.2 Q.sub.1                                                                 Me  OMe   CH                                        6111                                                                               Me     H    CH.sub.2 CH.sub.2 Q.sub.1                                                                 OMe OMe   CH                                        6112                                                                               Me     H    CH.sub.2 CH.sub.2 Q.sub.1                                                                 Me  OMe   N                                         6113                                                                               Me     H    CH.sub.2 CH.sub.2 Q.sub.1                                                                 OMe OMe   N                                         __________________________________________________________________________

In the above, Q₁ to Q₃₂ are as defined above.

                                      TABLE 12                                     __________________________________________________________________________      ##STR38##                                                                     No. A      B      D      X  Y     Z                                            __________________________________________________________________________     6114                                                                               CH.sub.2 Q.sub.1                                                                      Me     Cl     Me Me    CH                                           6115                                                                               CH.sub.2 Q.sub.1                                                                      Me     Cl     Me OMe   CH                                           6116                                                                               CH.sub.2 Q.sub.1                                                                      Me     Cl     OMe                                                                               OMe   CH                                           6117                                                                               CH.sub.2 Q.sub.1                                                                      Me     Cl     Me OMe   N                                            6118                                                                               CH.sub.2 Q.sub.1                                                                      Me     Cl     OMe                                                                               OMe   N                                            6119                                                                               CH.sub.2 Q.sub.1                                                                      Me     OMe    Me OMe   CH                                           6120                                                                               CH.sub.2 Q.sub.1                                                                      Me     OMe    OMe                                                                               OMe   CH                                           6121                                                                               CH.sub.2 Q.sub.1                                                                      Me     OMe    Me OMe   N                                            6122                                                                               CH.sub.2 Q.sub.1                                                                      CF.sub.3                                                                              Me     Me OMe   CH                                           6123                                                                               CH.sub.2 Q.sub.1                                                                      CF.sub.3                                                                              Me     OMe                                                                               OMe   CH                                           6124                                                                               CH.sub.2 Q.sub.1                                                                      CF.sub.3                                                                              Me     Me OMe   N                                            6125                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  Me Me    CH                                           6126                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  Me OMe   CH                                           6127                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  OMe                                                                               OMe   CH                                           6128                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  Me OMe   N                                            6129                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  OMe                                                                               OMe   N                                            6130                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  Me OCHF.sub.2                                                                           CH                                           6131                                                                               CH.sub.2 Q.sub.1                                                                      Me     COOMe  Me                                                                                 ##STR39##                                                                           CH                                           6132                                                                               CH.sub.2 Q.sub.1                                                                      Me     SO.sub.2 Me                                                                           Me OMe   CH                                           6133                                                                               CH.sub.2 Q.sub.1                                                                      Me     SO.sub.2 Me                                                                           OMe                                                                               OMe   CH                                           6134                                                                               CH.sub.2 Q.sub.1                                                                      Me     SO.sub.2 Me                                                                           Me OMe   N                                            6135                                                                               H      CH.sub.2 Q.sub.1                                                                      Me     Me OMe   CH                                           6136                                                                               H      CH.sub.2 Q.sub.1                                                                      Me     OMe                                                                               OMe   CH                                           6137                                                                               H      CH.sub.2 Q.sub.1                                                                      Me     Me OMe   N                                            6138                                                                               Me     CH.sub.2 Q.sub.1                                                                      Me     Me OMe   CH                                           6139                                                                               Me     CH.sub.2 Q.sub.1                                                                      Me     OMe                                                                               OMe   CH                                           6140                                                                               Me     CH.sub.2 Q.sub.1                                                                      Me     Me OMe   N                                            6141                                                                               Me     CH.sub.2 Q.sub.1                                                                      Cl     Me OMe   CH                                           6142                                                                               Me     CH.sub.2 Q.sub.1                                                                      Cl     OMe                                                                               OMe   CH                                           6143                                                                               Me     CH.sub.2 Q.sub.1                                                                      Cl     Me OMe   N                                            6144                                                                               Me     CH.sub.2 Q.sub.1                                                                      COOMe  Me OMe   CH                                           6145                                                                               Me     CH.sub.2 Q.sub.1                                                                      COOMe  OMe                                                                               OMe   CH                                           6146                                                                               Me     CH.sub.2 Q.sub.1                                                                      COOMe  Me OMe   N                                            6147                                                                               Me     CH.sub.2 Q.sub.1                                                                      Ph     Me OMe   CH                                           6148                                                                               Me     CH.sub.2 Q.sub.1                                                                      Ph     OMe                                                                               OMe   CH                                           6149                                                                               Me     CH.sub.2 Q.sub.1                                                                      Ph     Me OMe   N                                            6150                                                                               Me     Me     CH.sub.2 Q.sub.1                                                                      Me OMe   CH                                           6151                                                                               Me     Me     CH.sub.2 Q.sub.1                                                                      OMe                                                                               OMe   CH                                           6152                                                                               Me     Me     CH.sub.2 Q.sub.1                                                                      Me OMe   N                                            6153                                                                               CHMeQ.sub.1                                                                           Me     COOMe  Me OMe   CH                                           6154                                                                               CHMeQ.sub.1                                                                           Me     COOMe  OMe                                                                               OMe   CH                                           6155                                                                               CHMeQ.sub.1                                                                           Me     COOMe  Me OMe   N                                            6156                                                                               Me     Me     CHMeQ.sub.1                                                                           OMe                                                                               OMe   CH                                           6157                                                                               Me     Me     CHMeQ.sub.1                                                                           Me OMe   N                                            6158                                                                               CH.sub.2 Q.sub.24                                                                     Me     COOMe  Me Me    CH                                           6159                                                                               CH.sub.2 Q.sub.24                                                                     Me     COOMe  Me OMe   CH                                           6160                                                                               CH.sub.2 Q.sub.24                                                                     Me     COOMe  OMe                                                                               OMe   CH                                           6161                                                                               CH.sub.2 Q.sub.24                                                                     Me     COOMe  Me OMe   N                                            6162                                                                               CH.sub.2 Q.sub.24                                                                     Me     COOMe  OMe                                                                               OMe   N                                            6163                                                                               Me     CH.sub.2 Q.sub.24                                                                     Me     Me OMe   CH                                           6164                                                                               Me     CH.sub.2 Q.sub.24                                                                     Me     OMe                                                                               OMe   CH                                           6165                                                                               Me     CH.sub.2 Q.sub.24                                                                     Me     Me OMe   N                                            6166                                                                               Me     Me     CH.sub.2 Q.sub.24                                                                     Me OMe   CH                                           6167                                                                               Me     Me     CH.sub.2 Q.sub.24                                                                     OMe                                                                               OMe   CH                                           6168                                                                               Me     Me     CH.sub.2 Q.sub.24                                                                     Me OMe   N                                            6169                                                                               CH.sub.2 Q.sub.28                                                                     Me     COOMe  Me Me    CH                                           6170                                                                               CH.sub.2 Q.sub.28                                                                     Me     COOMe  Me OMe   CH                                           6171                                                                               CH.sub.2 Q.sub.28                                                                     Me     COOMe  OMe                                                                               OMe   CH                                           6172                                                                               CH.sub.2 Q.sub.28                                                                     Me     COOMe  Me OMe   N                                            6173                                                                               CH.sub.2 Q.sub.28                                                                     Me     COOMe  OMe                                                                               OMe   N                                            6174                                                                               Me     CH.sub.2 Q.sub.28                                                                     Me     Me OMe   CH                                           6175                                                                               Me     CH.sub.2 Q.sub.28                                                                     Me     OMe                                                                               OMe   CH                                           6176                                                                               Me     CH.sub.2 Q.sub.28                                                                     Me     Me OMe   N                                            6177                                                                               Me     Me     CH.sub.2 Q.sub.28                                                                     Me OMe   CH                                           6178                                                                               Me     Me     CH.sub.2 Q.sub.28                                                                     OMe                                                                               OMe   CH                                           6179                                                                               Me     Me     CH.sub.2 Q.sub.28                                                                     Me OMe   N                                            6180                                                                               CH.sub.2 Q.sub.32                                                                     Me     COOMe  Me Me    CH                                           6181                                                                               CH.sub.2 Q.sub.32                                                                     Me     COOMe  Me OMe   CH                                           6182                                                                               CH.sub.2 Q.sub.32                                                                     Me     COOMe  OMe                                                                               OMe   CH                                           6183                                                                               CH.sub.2 Q.sub.32                                                                     Me     COOMe  Me OMe   N                                            6184                                                                               CH.sub.2 Q.sub.32                                                                     Me     COOMe  OMe                                                                               OMe   N                                            6185                                                                               Me     CH.sub.2 Q.sub.32                                                                     Me     Me OMe   CH                                           6186                                                                               Me     CH.sub.2 Q.sub.32                                                                     Me     OMe                                                                               OMe   CH                                           6187                                                                               Me     CH.sub.2 Q.sub.32                                                                     Me     Me OMe   N                                            6188                                                                               Me     Me     CH.sub.2 Q.sub.32                                                                     Me OMe   CH                                           6189                                                                               Me     Me     CH.sub.2 Q.sub.32                                                                     OMe                                                                               OMe   CH                                           6190                                                                               Me     Me     CH.sub.2 Q.sub.32                                                                     Me OMe   N                                            6191                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     COOMe  Me Me    CH                                           6192                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     COOMe  Me OMe   CH                                           6193                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     COOMe  OMe                                                                               OMe   CH                                           6194                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     COOMe  Me OMe   N                                            6195                                                                               CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     COOMe  OMe                                                                               OMe   N                                            6196                                                                               Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     Me OMe   CH                                           6197                                                                               Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     OMe                                                                               OMe   CH                                           6198                                                                               Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             Me     Me OMe   N                                            6199                                                                               Me     Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             Me OMe   CH                                           6200                                                                               Me     Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             OMe                                                                               OMe   CH                                           6201                                                                               Me     Me     CH.sub.2 CH.sub.2 Q.sub.1                                                             Me OMe   N                                            __________________________________________________________________________

In the above, Q₁ to Q₃₂ are as defined above.

                  TABLE 13                                                         ______________________________________                                          ##STR40##                                                                     No.   A          B          D    X     Y    Z                                  ______________________________________                                         6202  CH.sub.2 Q.sub.1                                                                          H          H    Me    OMe  CH                                 6203  CH.sub.2 Q.sub.1                                                                          H          H    OMe   OMe  CH                                 6204  CH.sub.2 Q.sub.1                                                                          H          H    Me    OMe  N                                  6205  CH.sub.2 Q.sub.1                                                                          Me         H    Me    OMe  CH                                 6206  CH.sub.2 Q.sub.1                                                                          Me         H    OMe   OMe  CH                                 6207  CH.sub.2 Q.sub.1                                                                          Me         H    Me    OMe  N                                  6208  CH.sub.2 Q.sub.1                                                                          Cl         H    Me    OMe  CH                                 6209  CH.sub.2 Q.sub.1                                                                          Cl         H    OMe   OMe  CH                                 6210  CH.sub.2 Q.sub.1                                                                          Cl         H    Me    OMe  N                                  6211  CH.sub.2 Q.sub.1                                                                          Br         H    Me    OMe  CH                                 6212  CH.sub.2 Q.sub.1                                                                          Br         H    OMe   OMe  CH                                 6213  CH.sub.2 Q.sub.1                                                                          Br         H    Me    OMe  N                                  6214  CH.sub.2 Q.sub.1                                                                          COOMe      H    Me    OMe  CH                                 6215  CH.sub.2 Q.sub.1                                                                          COOMe      H    OMe   OMe  CH                                 6216  CH.sub.2 Q.sub.1                                                                          COOMe      H    Me    OMe  N                                  6217  CH.sub.2 Q.sub.1                                                                          COOEt      H    Me    OMe  CH                                 6218  CH.sub.2 Q.sub.1                                                                          COOEt      H    OMe   OMe  CH                                 6219  CH.sub.2 Q.sub.1                                                                          COOEt      H    Me    OMe  N                                  6220  Me         CH.sub.2 Q.sub.1                                                                          H    Me    Me   CH                                 6221  Me         CH.sub.2 Q.sub.1                                                                          H    Me    OMe  CH                                 6222  Me         CH.sub.2 Q.sub.1                                                                          H    OMe   OMe  CH                                 6223  Me         CH.sub.2 Q.sub.1                                                                          H    Me    OMe  N                                  6224  Me         CH.sub.2 Q.sub.1                                                                          H    OMe   OMe  N                                  6225  COMe       CH.sub.2 Q.sub.1                                                                          H    Me    OMe  CH                                 6226  COMe       CH.sub.2 Q.sub.1                                                                          H    OMe   OMe  CH                                 6227  COMe       CH.sub.2 Q.sub.1                                                                          H    Me    OMe  N                                  6228  CHMeQ.sub.1                                                                               Cl         H    Me    OMe  CH                                 6229  CHMeQ.sub.1                                                                               Cl         H    OMe   OMe  CH                                 6230  CHMeQ.sub.1                                                                               Cl         H    Me    OMe  N                                  6231  CHMeQ.sub.1                                                                               COOMe      H    Me    OMe  CH                                 6232  CHMeQ.sub.1                                                                               COOMe      H    OMe   OMe  CH                                 6233  CHMeQ.sub.1                                                                               COOMe      H    Me    OMe  N                                  6234  Me         CHMeQ.sub.1                                                                               H    Me    OMe  CH                                 6235  Me         CHMeQ.sub.1                                                                               H    OMe   OMe  CH                                 6236  Me         CHMeQ.sub.1                                                                               H    Me    OMe  N                                  6237  CH.sub.2 Q.sub.24                                                                         H          H    Me    OMe  CH                                 6238  CH.sub.2 Q.sub.24                                                                         H          H    OMe   OMe  CH                                 6239  CH.sub.2 Q.sub.24                                                                         H          H    Me    OMe  N                                  6240  CH.sub.2 Q.sub.24                                                                         Cl         H    Me    OMe  CH                                 6241  CH.sub.2 Q.sub.24                                                                         Cl         H    OMe   OMe  CH                                 6242  CH.sub.2 Q.sub.24                                                                         Cl         H    Me    OMe  N                                  6243  CH.sub.2 Q.sub.24                                                                         COOMe      H    Me    OMe  CH                                 6244  CH.sub.2 Q.sub.24                                                                         COOMe      H    OMe   OMe  CH                                 6245  CH.sub.2 Q.sub.24                                                                         COOMe      H    Me    OMe  N                                  6246  Me         CH.sub.2 Q.sub.24                                                                         H    Me    OMe  CH                                 6247  Me         CH.sub.2 Q.sub.24                                                                         H    OMe   OMe  CH                                 6248  Me         CH.sub.2 Q.sub.24                                                                         H    Me    OMe  N                                  6249  CH.sub.2 Q.sub.28                                                                         H          H    Me    OMe  CH                                 6250  CH.sub.2 Q.sub.28                                                                         H          H    OMe   OMe  CH                                 6251  CH.sub.2 Q.sub.28                                                                         H          H    Me    OMe  N                                  6252  CH.sub.2 Q.sub.28                                                                         Cl         H    Me    OMe  CH                                 6253  CH.sub.2 Q.sub.28                                                                         Cl         H    OMe   OMe  CH                                 6254  CH.sub.2 Q.sub.28                                                                         Cl         H    Me    OMe  N                                  6255  CH.sub.2 Q.sub.28                                                                         COOMe      H    Me    OMe  CH                                 6256  CH.sub.2 Q.sub.28                                                                         COOMe      H    OMe   OMe  CH                                 6257  CH.sub.2 Q.sub.28                                                                         COOMe      H    Me    OMe  N                                  6258  Me         CH.sub.2 Q.sub.28                                                                         H    Me    OMe  CH                                 6259  Me         CH.sub.2 Q.sub.28                                                                         H    OMe   OMe  CH                                 6260  Me         CH.sub.2 Q.sub.28                                                                         H    Me    OMe  N                                  6261  CH.sub.2 Q.sub.32                                                                         H          H    Me    OMe  CH                                 6262  CH.sub.2 Q.sub.32                                                                         H          H    OMe   OMe  CH                                 6263  CH.sub.2 Q.sub.32                                                                         H          H    Me    OMe  N                                  6264  CH.sub.2 Q.sub.32                                                                         Cl         H    Me    OMe  CH                                 6265  CH.sub.2 Q.sub.32                                                                         Cl         H    OMe   OMe  CH                                 6266  CH.sub.2 Q.sub.32                                                                         Cl         H    Me    OMe  N                                  6267  CH.sub.2 Q.sub.32                                                                         COOMe      H    Me    OMe  CH                                 6268  CH.sub.2 Q.sub.32                                                                         COOMe      H    OMe   OMe  CH                                 6269  CH.sub.2 Q.sub.32                                                                         COOMe      H    Me    OMe  N                                  6270  Me         CH.sub.2 Q.sub.32                                                                         H    Me    OMe  CH                                 6271  Me         CH.sub.2 Q.sub.32                                                                         H    OMe   OMe  CH                                 6272  Me         CH.sub.2 Q.sub.32                                                                         H    Me    OMe  N                                  6273  CH.sub.2 CH.sub.2 Q.sub.1                                                                 H          H    Me    OMe  CH                                 6274  CH.sub.2 CH.sub.2 Q.sub.1                                                                 H          H    OMe   OMe  CH                                 6275  CH.sub.2 CH.sub.2 Q.sub.1                                                                 H          H    Me    OMe  N                                  6276  CH.sub.2 CH.sub.2 Q.sub.1                                                                 Cl         H    Me    OMe  CH                                 6277  CH.sub.2 CH.sub.2 Q.sub.1                                                                 Cl         H    OMe   OMe  CH                                 6278  CH.sub.2 CH.sub.2 Q.sub.1                                                                 Cl         H    Me    OMe  N                                  6279  CH.sub.2 CH.sub.2 Q.sub.1                                                                 COOMe      H    Me    OMe  CH                                 6280  CH.sub.2 CH.sub.2 Q.sub.1                                                                 COOMe      H    OMe   OMe  CH                                 6281  CH.sub.2 CH.sub.2 Q.sub.1                                                                 COOMe      H    Me    OMe  N                                  6282  Me         CH.sub.2 CH.sub.2 Q.sub.1                                                                 H    Me    OMe  CH                                 6283  Me         CH.sub.2 CH.sub.2 Q.sub.1                                                                 H    OMe   OMe  CH                                 6284  Me         CH.sub.2 CH.sub.2 Q.sub.1                                                                 H    Me    OMe  N                                  ______________________________________                                    

In the above, Q₁ to Q₃₂ are as defined above.

                                      TABLE 14                                     __________________________________________________________________________      ##STR41##                                                                     No. A   B   D          R.sup.16                                                                           X   Y     Z                                         __________________________________________________________________________     6285                                                                               Q.sub.1                                                                            H   COOMe      H   Me  OMe   CH                                        6286                                                                               Q.sub.1                                                                            H   COOMe      H   OMe OMe   CH                                        6287                                                                               Q.sub.1                                                                            H   COOEt      H   Me  OMe   CH                                        6288                                                                               Q.sub.1                                                                            H   COOEt      H   OMe OMe   CH                                        6289                                                                               Q.sub.1                                                                            Me  COOMe      H   Me  OMe   CH                                        6290                                                                               Q.sub.1                                                                            Me  COOMe      H   OMe OMe   CH                                        6291                                                                               Q.sub.1                                                                            Me  COOEt      H   Me  OMe   CH                                        6292                                                                               Q.sub.1                                                                            Me  COOEt      H   OMe OMe   CH                                        6293                                                                               Q.sub.1                                                                            H   H          H   Me  OMe   CH                                        6294                                                                               Q.sub.1                                                                            H   H          H   OMe OMe   CH                                        6295                                                                               Me  H   Q.sub.1    H   Me  OMe   CH                                        6296                                                                               Me  H   Q.sub.1    H   OMe OMe   CH                                        6297                                                                               Q.sub.1                                                                            H   COOMe      Me  Me  Me    CH                                        6298                                                                               Q.sub.1                                                                            H   COOMe      Me  Me  OMe   CH                                        6299                                                                               Q.sub.1                                                                            H   COOMe      Me  OMe OMe   CH                                        6300                                                                               Q.sub.1                                                                            H   COOMe      Me  Me  OMe   N                                         6301                                                                               Q.sub.1                                                                            H   COOMe      Me  OMe OMe   N                                         6302                                                                               Q.sub.1                                                                            H   COOEt      Me  Me  Me    CH                                        6303                                                                               Q.sub.1                                                                            H   COOEt      Me  Me  OMe   CH                                        6304                                                                               Q.sub.1                                                                            H   COOEt      Me  OMe OMe   CH                                        6305                                                                               Q.sub.1                                                                            H   COOEt      Me  Me  OMe   N                                         6306                                                                               Q.sub.1                                                                            H   COOEt      Me  OMe OMe   N                                         6307                                                                               Q.sub.1                                                                            Me  COOMe      Me  Me  OMe   CH                                        6308                                                                               Q.sub.1                                                                            Me  COOMe      Me  OMe OMe   CH                                        6309                                                                               Q.sub.1                                                                            Me  COOMe      Me  Me  OMe   N                                         6310                                                                               Q.sub.1                                                                            Me  COOEt      Me  Me  OMe   CH                                        6311                                                                               Q.sub.1                                                                            Me  COOEt      Me  OMe OMe   CH                                        6312                                                                               Q.sub.1                                                                            Me  COOEt      Me  Me  OMe   N                                         6313                                                                               Q.sub.1                                                                            H   CN         Me  Me  OMe   CH                                        6314                                                                               Q.sub.1                                                                            H   CN         Me  OMe OMe   CH                                        6315                                                                               Q.sub.1                                                                            H   CN         Me  Me  OMe   N                                         6316                                                                               Q.sub.1                                                                            H   H          Me  Me  OMe   CH                                        6317                                                                               Q.sub.1                                                                            H   H          Me  OMe OMe   CH                                        6318                                                                               Q.sub.1                                                                            H   H          Me  Me  OMe   N                                         6319                                                                               Me  H   Q.sub.1    Me  Me  Me    CH                                        6320                                                                               Me  H   Q.sub.1    Me  Me  OMe   CH                                        6321                                                                               Me  H   Q.sub.1    Me  OMe OMe   CH                                        6322                                                                               Me  H   Q.sub.1    Me  Me  OMe   N                                         6323                                                                               Me  H   Q.sub.1    Me  OMe OMe   N                                         6324                                                                               Q.sub.1                                                                            H   COOMe      Et  Me  OMe   CH                                        6325                                                                               Q.sub.1                                                                            H   COOMe      Et  OMe OMe   CH                                        6326                                                                               Q.sub.1                                                                            H   COOEt      Et  Me  OMe   CH                                        6327                                                                               Q.sub.1                                                                            H   COOEt      Et  OMe OMe   CH                                        6328                                                                               Q.sub.1                                                                            Me  COOMe      Et  Me  OMe   CH                                        6329                                                                               Q.sub.1                                                                            Me  COOMe      Et  OMe OMe   CH                                        6330                                                                               Q.sub.1                                                                            Me  COOEt      Et  Me  OMe   CH                                        6331                                                                               Q.sub.1                                                                            Me  COOEt      Et  OMe OMe   CH                                        6332                                                                               Q.sub.1                                                                            H   H          Et  Me  OMe   CH                                        6333                                                                               Q.sub.1                                                                            H   H          Et  OMe OMe   CH                                        6334                                                                               Me  H   Q.sub.1    Et  Me  OMe   CH                                        6335                                                                               Me  H   Q.sub.1    Et  OMe OMe   CH                                        6336                                                                               Q.sub.1                                                                            H   COOMe      OMe Me  Me    CH                                        6337                                                                               Q.sub.1                                                                            H   COOMe      OMe Me  OMe   CH                                        6338                                                                               Q.sub.1                                                                            H   COOMe      OMe OMe OMe   CH                                        6339                                                                               Q.sub.1                                                                            H   COOMe      OMe Me  Me    N                                         6340                                                                               Q.sub.1                                                                            H   COOMe      OMe Me  OMe   N                                         6341                                                                               Q.sub.1                                                                            H   COOMe      OMe OMe OMe   N                                         6342                                                                               Q.sub.1                                                                            H   COOMe      OMe Me  OCHF.sub.2                                                                           CH                                        6343                                                                               Q.sub.1                                                                            H   COOMe      OMe Cl  OMe   CH                                        6344                                                                               Q.sub.1                                                                            H   COOEt      OMe Me  Me    CH                                        6345                                                                               Q.sub.1                                                                            H   COOEt      OMe Me  OMe   CH                                        6346                                                                               Q.sub.1                                                                            H   COOEt      OMe OMe OMe   CH                                        6347                                                                               Q.sub.1                                                                            H   COOEt      OMe Me  Me    N                                         6348                                                                               Q.sub.1                                                                            H   COOEt      OMe Me  OMe   N                                         6349                                                                               Q.sub.1                                                                            H   COOEt      OMe OMe OMe   N                                         6350                                                                               Q.sub.1                                                                            H   COOEt      OMe Me  OCHF.sub.2                                                                           CH                                        6351                                                                               Q.sub.1                                                                            H   COOEt      OMe Cl  OMe   CH                                        6352                                                                               Q.sub.1                                                                            H   COOPrn     OMe Me  OMe   CH                                        6353                                                                               Q.sub.1                                                                            H   COOPrn     OMe OMe OMe   CH                                        6354                                                                               Q.sub.1                                                                            H   COOPrn     OMe Me  OMe   N                                         6355                                                                               Q.sub.1                                                                            H   COOPri     OMe Me  OMe   CH                                        6356                                                                               Q.sub.1                                                                            H   COOPri     OMe OMe OMe   CH                                        6357                                                                               Q.sub.1                                                                            H   COOPri     OMe Me  OMe   N                                         6358                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CH.sub.2 Cl                                                                   OMe Me  OMe   CH                                        6359                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CH.sub.2 Cl                                                                   OMe OMe OMe   CH                                        6360                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CH.sub.2 Cl                                                                   OMe Me  OMe   N                                         6361                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CHCH.sub.2                                                                    OMe Me  OMe   CH                                        6362                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CHCH.sub.2                                                                    OMe OMe OMe   CH                                        6363                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CHCH.sub.2                                                                    OMe Me  OMe   N                                         6364                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CCH                                                                           OMe Me  OMe   CH                                        6365                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CCH                                                                           OMe OMe OMe   CH                                        6366                                                                               Q.sub.1                                                                            H   COOCH.sub.2 CCH                                                                           OMe Me  OMe   N                                         6367                                                                               Q.sub.1                                                                            Me  COOMe      OMe Me  Me    CH                                        6368                                                                               Q.sub.1                                                                            Me  COOMe      OMe Me  OMe   CH                                        6359                                                                               Q.sub.1                                                                            Me  COOMe      OMe OMe OMe   CH                                        6370                                                                               Q.sub.1                                                                            Me  COOMe      OMe Me  OMe   N                                         6371                                                                               Q.sub.1                                                                            Me  COOMe      OMe OMe OMe   N                                         6372                                                                               Q.sub.1                                                                            Me  COOEt      OMe Me  Me    CH                                        6373                                                                               Q.sub.1                                                                            Me  COOEt      OMe Me  OMe   CH                                        6374                                                                               Q.sub.1                                                                            Me  COOEt      OMe OMe OMe   CH                                        6375                                                                               Q.sub.1                                                                            Me  COOEt      OMe Me  OMe   N                                         6376                                                                               Q.sub.1                                                                            Me  COOEt      OMe OMe OMe   N                                         6377                                                                               Q.sub.1                                                                            Cl  COOMe      OMe Me  OMe   CH                                        6378                                                                               Q.sub.1                                                                            Cl  COOMe      OMe OMe OMe   CH                                        6379                                                                               Q.sub.1                                                                            Cl  COOMe      OMe Me  OMe   N                                         6380                                                                               Q.sub.1                                                                            Cl  COOEt      OMe Me  OMe   CH                                        6381                                                                               Q.sub.1                                                                            Cl  COOEt      OMe OMe OMe   CH                                        6382                                                                               Q.sub.1                                                                            Cl  COOEt      OMe Me  OMe   N                                         6383                                                                               Q.sub.1                                                                            OMe COOMe      OMe Me  OMe   CH                                        6384                                                                               Q.sub.1                                                                            OMe COOMe      OMe OMe OMe   CH                                        6385                                                                               Q.sub.1                                                                            OMe COOMe      OMe Me  OMe   N                                         6386                                                                               Q.sub.1                                                                            OMe COOEt      OMe Me  OMe   CH                                        6387                                                                               Q.sub.1                                                                            OMe COOEt      OMe OMe OMe   CH                                        6388                                                                               Q.sub.1                                                                            OMe COOEt      OMe Me  OMe   N                                         6389                                                                               Q.sub.1                                                                            H   Cl         OMe Me  OMe   CH                                        6390                                                                               Q.sub.1                                                                            H   Cl         OMe OMe OMe   CH                                        6391                                                                               Q.sub.1                                                                            H   Cl         OMe Me  OMe   N                                         6392                                                                               Q.sub.1                                                                            H   NO.sub.2   OMe Me  OMe   CH                                        6393                                                                               Q.sub.1                                                                            H   NO.sub.2   OMe OMe OMe   CH                                        6394                                                                               Q.sub.1                                                                            H   NO.sub.2   OMe Me  OMe   N                                         6395                                                                               Q.sub.1                                                                            H   SO.sub.2 NMe.sub.2                                                                        OMe Me  OMe   CH                                        6396                                                                               Q.sub.1                                                                            H   SO.sub.2 NMe.sub.2                                                                        OMe OMe OMe   CH                                        6397                                                                               Q.sub.1                                                                            H   SO.sub.2 NMe.sub.2                                                                        OMe Me  OMe   N                                         6398                                                                               Q.sub.1                                                                            H   CN         OMe Me  OMe   CH                                        6399                                                                               Q.sub. 1                                                                           H   CN         OMe OMe OMe   CH                                        6400                                                                               Q.sub.1                                                                            H   CN         OMe Me  OMe   N                                         6401                                                                               Q.sub.1                                                                            Me  CN         OMe Me  OMe   CH                                        6402                                                                               Q.sub.1                                                                            Me  CN         OMe OMe OMe   CH                                        6403                                                                               Q.sub.1                                                                            Me  CN         OMe Me  OMe   N                                         6404                                                                               Q.sub.1                                                                            H   Me         OMe Me  OMe   CH                                        6405                                                                               Q.sub.1                                                                            H   Me         OMe OMe OMe   CH                                        6406                                                                               Q.sub.1                                                                            H   Me         OMe Me  OMe   N                                         6407                                                                               Q.sub.1                                                                            H   Et         OMe Me  OMe   CH                                        6408                                                                               Q.sub.1                                                                            H   Et         OMe OMe OMe   CH                                        6409                                                                               Q.sub.1                                                                            H   Et         OMe Me  OMe   N                                         6410                                                                               Q.sub.1                                                                            H   H          OMe Me  OMe   CH                                        6411                                                                               Q.sub.1                                                                            H   H          OMe OMe OMe   CH                                        6412                                                                               Q.sub.1                                                                            H   H          OMe Me  OMe   N                                         6413                                                                               Q.sub.1                                                                            H   COPh       OMe Me  OMe   CH                                        6414                                                                               Q.sub.1                                                                            H   COPh       OMe OMe OMe   CH                                        6415                                                                               Q.sub.1                                                                            H   COPh       OMe Me  OMe   N                                         6416                                                                               Me  Q.sub.1                                                                            COOMe      OMe Me  OMe   CH                                        6417                                                                               Me  Q.sub.1                                                                            COOMe      OMe OMe OMe   CH                                        6418                                                                               Me  Q.sub.1                                                                            COOMe      OMe Me  OMe   N                                         6419                                                                               H   H   Q.sub.1    OMe Me  OMe   CH                                        6420                                                                               H   H   Q.sub.1    OMe OMe OMe   CH                                        6421                                                                               H   H   Q.sub. 1   OMe Me  OMe   N                                         6422                                                                               Me  H   Q.sub.1    OMe Me  Me    CH                                        6423                                                                               Me  H   Q.sub.1    OMe Me  OMe   CH                                        6424                                                                               Me  H   Q.sub.1    OMe OMe OMe   CH                                        6425                                                                               Me  H   Q.sub.1    OMe Me  OMe   N                                         6426                                                                               Me  H   Q.sub.1    OMe OMe OMe   N                                         6427                                                                               Me  Me  Q.sub.1    OMe Me  OMe   CH                                        6428                                                                               Me  Me  Q.sub.1    OMe OMe OMe   CH                                        6429                                                                               Me  Me  Q.sub.1    OMe Me  OMe   N                                         6430                                                                               Q.sub.1                                                                            H   COOMe      OEt Me  OMe   CH                                        6431                                                                               Q.sub.1                                                                            H   COOMe      OEt OMe OMe   CH                                        6432                                                                               Q.sub.1                                                                            H   COOEt      OEt Me  OMe   CH                                        6433                                                                               Q.sub.1                                                                            H   COOEt      OEt OMe OMe   CH                                        6434                                                                               Q.sub.1                                                                            Me  COOMe      OEt Me  OMe   CH                                        6435                                                                               Q.sub.1                                                                            Me  COOMe      OEt OMe OMe   CH                                        6436                                                                               Q.sub.1                                                                            Me  COOEt      OEt Me  OMe   CH                                        6437                                                                               Q.sub.1                                                                            Me  COOEt      OEt OMe OMe   CH                                        6438                                                                               Q.sub.1                                                                            H   H          OEt Me  OMe   CH                                        6439                                                                               Q.sub.1                                                                            H   H          OEt OMe OMe   CH                                        6440                                                                               Me  H   Q.sub.1    OEt Me  OMe   CH                                        6441                                                                               Me  H   Q.sub.1    OEt OMe OMe   CH                                        6442                                                                               Q.sub.2                                                                            H   COOMe      OMe Me  Me    CH                                        6443                                                                               Q.sub.2                                                                            H   COOMe      OMe Me  OMe   CH                                        6444                                                                               Q.sub.2                                                                            H   COOMe      OMe OMe OMe   CH                                        6445                                                                               Q.sub.2                                                                            H   COOMe      OMe Me  OMe   N                                         6446                                                                               Q.sub.2                                                                            H   COOMe      OMe OMe OMe   N                                         6447                                                                               Q.sub.2                                                                            H   COOEt      OMe Me  Me    CH                                        6448                                                                               Q.sub.2                                                                            H   COOEt      OMe Me  OMe   CH                                        6449                                                                               Q.sub.2                                                                            H   COOEt      OMe OMe OMe   CH                                        6450                                                                               Q.sub.2                                                                            H   COOEt      OMe Me  OMe   N                                         6451                                                                               Q.sub.2                                                                            H   COOEt      OMe OMe OMe   N                                         6452                                                                               Q.sub.2                                                                            Me  COOMe      OMe Me  OMe   CH                                        6453                                                                               Q.sub.2                                                                            Me  COOMe      OMe OMe OMe   CH                                        6454                                                                               Q.sub.2                                                                            Me  COOMe      OMe Me  OMe   N                                         6455                                                                               Q.sub.2                                                                            Me  COOEt      OMe Me  OMe   CH                                        6456                                                                               Q.sub.2                                                                            Me  COOEt      OMe OMe OMe   CH                                        6457                                                                               Q.sub.2                                                                            Me  COOEt      OMe Me  OMe   N                                         6458                                                                               Q.sub.2                                                                            H   CN         OMe Me  OMe   CH                                        6459                                                                               Q.sub.2                                                                            H   CN         OMe OMe OMe   CH                                        6460                                                                               Q.sub.2                                                                            H   CN         OMe Me  OMe   N                                         6461                                                                               Q.sub.2                                                                            H   H          OMe Me  OMe   CH                                        6462                                                                               Q.sub.2                                                                            H   H          OMe OMe OMe   CH                                        6463                                                                               Q.sub.2                                                                            H   H          OMe Me  OMe   N                                         6464                                                                               Me  H   Q.sub.2    OMe Me  Me    CH                                        6465                                                                               Me  H   Q.sub.2    OMe Me  OMe   CH                                        6466                                                                               Me  H   Q.sub.2    OMe OMe OMe   CH                                        6467                                                                               Me  H   Q.sub.2    OMe Me  OMe   N                                         6468                                                                               Me  H   Q.sub.2    OMe OMe OMe   N                                         6469                                                                               Q.sub.5                                                                            H   COOMe      OMe Me  Me    CH                                        6470                                                                               Q.sub.5                                                                            H   COOMe      OMe Me  OMe   CH                                        6471                                                                               Q.sub.5                                                                            H   COOMe      OMe OMe OMe   CH                                        6472                                                                               Q.sub.5                                                                            H   COOMe      OMe Me  OMe   N                                         6473                                                                               Q.sub.5                                                                            H   COOMe      OMe OMe OMe   N                                         6474                                                                               Q.sub.5                                                                            H   COOEt      OMe Me  Me    CH                                        6475                                                                               Q.sub.5                                                                            H   COOEt      OMe Me  OMe   CH                                        6476                                                                               Q.sub.5                                                                            H   COOEt      OMe OMe OMe   CH                                        6477                                                                               Q.sub.5                                                                            H   COOEt      OMe Me  OMe   N                                         6478                                                                               Q.sub.5                                                                            H   COOEt      OMe OMe OMe   N                                         6479                                                                               Q.sub.5                                                                            Me  COOMe      OMe Me  OMe   CH                                        6480                                                                               Q.sub.5                                                                            Me  COOMe      OMe OMe OMe   CH                                        6481                                                                               Q.sub.5                                                                            Me  COOMe      OMe Me  OMe   N                                         6482                                                                               Q.sub.5                                                                            Me  COOEt      OMe Me  OMe   CH                                        6483                                                                               Q.sub.5                                                                            Me  COOEt      OMe OMe OMe   CH                                        6484                                                                               Q.sub.5                                                                            Me  COOEt      OMe Me  OMe   N                                         6485                                                                               Q.sub.5                                                                            H   CN         OMe Me  OMe   CH                                        6486                                                                               Q.sub.5                                                                            H   CN         OMe OMe OMe   CH                                        6487                                                                               Q.sub.5                                                                            H   CN         OMe Me  OMe   N                                         6488                                                                               Q.sub.5                                                                            H   H          OMe Me  OMe   CH                                        6489                                                                               Q.sub.5                                                                            H   H          OMe OMe OMe   CH                                        6490                                                                               Q.sub.5                                                                            H   H          OMe Me  OMe   N                                         6491                                                                               Me  H   Q.sub.5    OMe Me  Me    CH                                        6492                                                                               Me  H   Q.sub.5    OMe Me  OMe   CH                                        6493                                                                               Me  H   Q.sub.5    OMe OMe OMe   CH                                        6494                                                                               Me  H   Q.sub.5    OMe Me  OMe   N                                         6495                                                                               Me  H   Q.sub.5    OMe OMe OMe   N                                         6496                                                                               Q.sub.10                                                                           H   COOMe      OMe Me  Me    CH                                        6497                                                                               Q.sub.10                                                                           H   COOMe      OMe Me  OMe   CH                                        6498                                                                               Q.sub.10                                                                           H   COOMe      OMe OMe OMe   CH                                        6499                                                                               Q.sub.10                                                                           H   COOMe      OMe Me  OMe   N                                         6500                                                                               Q.sub.10                                                                           H   COOMe      OMe OMe OMe   N                                         6501                                                                               Q.sub.10                                                                           H   COOEt      OMe Me  Me    CH                                        6502                                                                               Q.sub.10                                                                           H   COOEt      OMe Me  OMe   CH                                        6503                                                                               Q.sub.10                                                                           H   COOEt      OMe OMe OMe   CH                                        6504                                                                               Q.sub.10                                                                           H   COOEt      OMe Me  OMe   N                                         6505                                                                               Q.sub.10                                                                           H   COOEt      OMe OMe OMe   N                                         6506                                                                               Q.sub.10                                                                           Me  COOMe      OMe Me  OMe   CH                                        6507                                                                               Q.sub.10                                                                           Me  COOMe      OMe OMe OMe   CH                                        6508                                                                               Q.sub.10                                                                           Me  COOMe      OMe Me  OMe   N                                         6509                                                                               Q.sub.10                                                                           Me  COOEt      OMe Me  OMe   CH                                        6510                                                                               Q.sub.10                                                                           Me  COOEt      OMe OMe OMe   CH                                        6511                                                                               Q.sub.10                                                                           Me  COOEt      OMe Me  OMe   N                                         6512                                                                               Q.sub.10                                                                           H   CN         OMe Me  OMe   CH                                        6513                                                                               Q.sub.10                                                                           H   CN         OMe OMe OMe   CH                                        6514                                                                               Q.sub.10                                                                           H   CN         OMe Me  OMe   N                                         6515                                                                               Q.sub.10                                                                           H   H          OMe Me  OMe   CH                                        6516                                                                               Q.sub.10                                                                           H   H          OMe OMe OMe   CH                                        6517                                                                               Q.sub.10                                                                           H   H          OMe Me  OMe   N                                         6518                                                                               Me  H   Q.sub.10   OMe Me  Me    CH                                        6519                                                                               Me  H   Q.sub.10   OMe Me  OMe   CH                                        6520                                                                               Me  H   Q.sub.10   OMe OMe OMe   CH                                        6521                                                                               Me  H   Q.sub.10   OMe Me  OMe   N                                         6522                                                                               Me  H   Q.sub.10   OMe OMe OMe   N                                         6523                                                                               Q.sub.32                                                                           H   COOMe      OMe Me  Me    CH                                        6524                                                                               Q.sub.32                                                                           H   COOMe      OMe Me  OMe   CH                                        6525                                                                               Q.sub.32                                                                           H   COOMe      OMe OMe OMe   CH                                        6526                                                                               Q.sub.32                                                                           H   COOMe      OMe Me  OMe   N                                         6527                                                                               Q.sub.32                                                                           H   COOMe      OMe OMe OMe   N                                         6528                                                                               Q.sub.32                                                                           H   COOEt      OMe Me  Me    CH                                        6529                                                                               Q.sub.32                                                                           H   COOEt      OMe Me  OMe   CH                                        6530                                                                               Q.sub.32                                                                           H   COOEt      OMe OMe OMe   CH                                        6531                                                                               Q.sub.32                                                                           H   COOEt      OMe Me  OMe   N                                         6532                                                                               Q.sub.32                                                                           H   COOEt      OMe OMe OMe   N                                         6533                                                                               Q.sub.32                                                                           Me  COOMe      OMe Me  OMe   CH                                        6534                                                                               Q.sub.32                                                                           Me  COOMe      OMe OMe OMe   CH                                        6535                                                                               Q.sub.32                                                                           Me  COOMe      OMe Me  OMe   N                                         6536                                                                               Q.sub.32                                                                           Me  COOEt      OMe Me  OMe   CH                                        6537                                                                               Q.sub.32                                                                           Me  COOEt      OMe OMe OMe   CH                                        6538                                                                               Q.sub.32                                                                           Me  COOEt      OMe Me  OMe   N                                         6539                                                                               Q.sub.32                                                                           H   CN         OMe Me  OMe   CH                                        6540                                                                               Q.sub.32                                                                           H   CN         OMe OMe OMe   CH                                        6541                                                                               Q.sub.32                                                                           H   CN         OMe Me  OMe   N                                         6542                                                                               Q.sub.32                                                                           H   H          OMe Me  OMe   CH                                        6543                                                                               Q.sub.32                                                                           H   H          OMe OMe OMe   CH                                        6544                                                                               Q.sub.32                                                                           H   H          OMe Me  OMe   N                                         6545                                                                               Me  H   Q.sub.32   OMe Me  Me    CH                                        6546                                                                               Me  H   Q.sub.32   OMe Me  OMe   CH                                        6547                                                                               Me  H   Q.sub.32   OMe OMe OMe   CH                                        6548                                                                               Me  H   Q.sub.32   OMe Me  Me    N                                         6549                                                                               Me  H   Q.sub.32   OMe Me  OMe   N                                         6550                                                                               Me  H   Q.sub.32   OMe OMe OMe   N                                         __________________________________________________________________________

In the above, Q₁ to Q₃₂ are as defined above.

                  TABLE 15                                                         ______________________________________                                         Comp. No.     m.p. (°C.)                                                ______________________________________                                         1             159˜160                                                    2               166˜166.5                                                3             182˜183                                                    31            166˜167                                                    47            154˜157                                                    48            143˜145                                                    49            140˜142                                                    50            137˜140                                                    51            133˜136                                                    52            141˜145                                                    53            147˜152                                                    54            146˜149                                                    55            175˜179                                                    62            136˜139                                                    75            106˜108                                                    76            138˜141                                                    77            144˜147                                                    90            123˜130                                                    137           102˜104                                                    138           124˜126                                                    139           150˜152                                                    140           93˜96                                                      408           172˜174                                                    481           182˜185                                                    490           152˜156                                                    491           167˜170                                                    492           165˜168                                                    497           174˜177                                                    917           123˜124                                                    918           178˜179                                                    919           194˜195                                                    1369          162˜165                                                    2127          110˜115                                                    3621          168˜170                                                    3622          180˜182                                                    3623          196˜199                                                    3624          174˜175                                                    3625          176˜178                                                    4151          173˜176                                                    4152          216˜218                                                    5258          139˜142                                                    5305          102˜105                                                    132           129˜132                                                    134           129˜132                                                    100           127˜129                                                    105           149˜152                                                    581           135˜140                                                    583           167˜171                                                    638           90˜95                                                      640           181˜184                                                    771           152˜155                                                    772           169˜173                                                    773           151˜154                                                    862           161˜163                                                    863           176˜178                                                    864           191˜193                                                    885           170˜171                                                    886           140˜141                                                    887           174˜175                                                    892           154˜157                                                    1359          159˜161                                                    1361          180˜ 181                                                   895           128˜131                                                    896           131˜134                                                    969           178.5˜179.5                                                2323          138˜140                                                    1453          155˜157                                                    1455          165˜167                                                    2548          205˜207                                                    2549          167˜171                                                    2550          169˜172                                                    2551          163˜165                                                    2552          183˜185                                                    2553          204˜207                                                    5347          113˜116                                                    288           197˜199                                                    630           163˜166                                                    632           173˜175                                                    663            98˜100                                                    666           108˜111                                                    668           100˜103                                                    5349          162˜166                                                    5370          143˜146                                                    5462          100˜103                                                    5463          114˜117                                                    5464          145˜147                                                    5554          119˜121                                                    5555          165˜168                                                    5602          134˜137                                                    6218          95˜96                                                      605           125-128                                                          661           110-113                                                          1071          160-161                                                          1073          152-153                                                          5454          156-159                                                          5456          192-194                                                          6211          115-118                                                          2763          136-139                                                          6551          202-204                                                          110           159-161                                                          121           131-132                                                          126           135-137                                                          1485          158-161                                                          1487          177-180                                                          662           113-114                                                          ______________________________________                                    

In application of the compounds of this invention as herbicides, they can be applied by mixing with suitable carriers such as solid carriers, including for example clay, talc, bentonite, diatomaceous earth and others or liquid carriers, including for example water, alcohols (methanol, ethanol and the like), aromatic hydrocarbons (benzene, toluene, xylene and the like), chlorinated hydrocarbons, ethers, ketones, esters (ethyl acetate, etc.), acid amides (dimethylformamide, etc.) and others. They can be provided for practical use with addition of any desired additive selected from an emulsifier, a dispersing agent, a suspending agent, a wetting agent, a spreader and a stablizer and in any desired form such as a soluble concentrate, an emulsifiable concentrate, a wettable powder, a dust, a granule, a suspension concentrate, etc.

In the following, there are shown examples of formulations of herbicides containing the compounds of this invention as active ingredients, but they are not limitative of this invention. In the exemplary formulations shown below, "parts" mean "parts by weight".

    ______________________________________                                         Exemplary Formulation 1: Wettable powder                                       ______________________________________                                         Compound No. 3 of this invention                                                                          50 parts                                            Ziegleit A                 46 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                2 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name, produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

All of the above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 2: Wettable powder                                       ______________________________________                                         Compound No. 49 of this invention                                                                         45 parts                                            Ziegleit A                 51 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                2 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 4 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 3: Emulsifiable concentrate                              ______________________________________                                         Compound No. 49 of this invention                                                                         2 parts                                             Xylene                     78 parts                                            Dimethylformamide          15 parts                                            Solpol 2680                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

    ______________________________________                                         Exemplary Formulation 4: Suspension concentrate                                ______________________________________                                         Compound No. 1369 of this invention                                                                       25     parts                                        Agrisol S-710              10     parts                                        (nonionic surfactant;trade name; produced by                                   Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           20     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      44.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 5: Granule                                               ______________________________________                                         Compound No. 3 of this invention                                                                       0.1    part                                            Bentonite               55     parts                                           Talc                    44.9   parts                                           ______________________________________                                    

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

    ______________________________________                                         Exemplary Formulation 6: Granule                                               ______________________________________                                         Compound No. 408 of this invention                                                                      0.5    part                                           Bentonite                55.0   parts                                          Talc                     44.5   parts                                          ______________________________________                                    

All of the above components are mixed and pulverized homogenerously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

    ______________________________________                                         Exemplary Formulation 7: Wettable powder                                       ______________________________________                                         Compound No. 1 of this invention                                                                          10 parts                                            Ziegleit PFP               83 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 8: Wettable powder                                       ______________________________________                                         Compound No. 132 of this invention                                                                        20 parts                                            Ziegleit PFP               73 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 9: Wettable powder                                       ______________________________________                                         Compound No. 638 of this invention                                                                        30 parts                                            Ziegleit PFP               63 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 10: Wettable powder                                      ______________________________________                                         Compound No. 771 of this invention                                                                        40 parts                                            Ziegleit PFP               53 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 11: Wettable powder                                      ______________________________________                                         Compound No. 885 of this invention                                                                        50 parts                                            Ziegleit PFP               43 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 12: Wettable powder                                      ______________________________________                                         Compound No. 887 of this invention                                                                        50 parts                                            Ziegleit PFP               43 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 13: Wettable powder                                      ______________________________________                                         Compound No. 896 of this invention                                                                        60 parts                                            Ziegleit PFP               33 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 14: Wettable powder                                      ______________________________________                                         Compound No. 1359 of this invention                                                                       70 parts                                            Ziegleit PFP               23 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 15: Wettable powder                                      ______________________________________                                         Compound No. 1455 of this invention                                                                       80 parts                                            Ziegleit PFP               13 parts                                            (kaolin type clay; trade name; produced by                                     Ziegleit Kogyo Co., Ltd.)                                                      Solpol 5039                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     Carplex (anticaking agent) 2 parts                                             (white carbon; trade name; produced by Shionogi                                Seiyaku Co., Ltd.)                                                             ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare a wettable powder.

    ______________________________________                                         Exemplary Formulation 16: Emulsifiable concentrate                             ______________________________________                                         Compound No. 863 of this invention                                                                        1     part                                          Xylene                     79    parts                                         Dimethylformamide          15    parts                                         Solpol 2680                5     parts                                         (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

    ______________________________________                                         Exemplary Formulation 17: Emulsifiable concentrate                             ______________________________________                                         Compound No. 886 of this invention                                                                        1.5 parts                                           Xylene                     78.5 parts                                          Dimethylformamide          15 parts                                            Solpol 2680                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

    ______________________________________                                         Exemplary Formulation 18: Emulsifiable concentrate                             ______________________________________                                         Compound No. 5347 of this invention                                                                       2 parts                                             Xylene                     78 parts                                            Dimethylformamide          15 parts                                            Solpol 2680                5 parts                                             (mixture of nonionic surfactant and anionic                                    surfactant; trade name; produced by Toho Kagaku                                Co., Ltd.)                                                                     ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.

    ______________________________________                                         Exemplary Formulation 19: Suspension concentrate                               ______________________________________                                         Compound No. 583 of this invention                                                                        10     parts                                        Agrisol B-710              10     parts                                        (nonionic surfactant; trade name; produced by                                  Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           20     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      59.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 20: Suspension concentrate                               ______________________________________                                         Compound No. 640 of this invention                                                                        20     parts                                        Agrisol B-710              10     parts                                        (nonionic surfactant; trade name; produced by                                  Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           20     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      49.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 21: Suspension concentrate                               ______________________________________                                         Compound No. 1361 of this invention                                                                       30     parts                                        Agrisol B-710              10     parts                                        (nonionic surfactant; trade name; produced by                                  Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           20     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      39.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 22: Suspension concentrate                               ______________________________________                                         Compound No. 1453 of this invention                                                                       40     parts                                        Agrisol B-710              10     parts                                        (nonionic surfactant; trade name; produced by                                  Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           20     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      29.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 23: Suspension concentrate                               ______________________________________                                         Compound No. 2323 of this invention                                                                       60     parts                                        Agrisol B-710              10     parts                                        (nonionic surfactant; trade name; produced by                                  Kao-Atlas Co., Ltd.)                                                           Runox 1000 C               0.5    part                                         (anionic surfactant; trade name; produced by Toho                              Kagaku Co., Ltd.)                                                              1% Rodopol water           10     parts                                        (thickener; trade name; produced by Rohne                                      Poulainc)                                                                      Water                      19.5   parts                                        ______________________________________                                    

The above components are mixed homogeneously to provide a suspnsion concentrate preparation.

    ______________________________________                                         Exemplary Formulation 24: Granule                                              ______________________________________                                         Compound No. 885 of this invention                                                                      0.05   part                                           Bentonite                55.0   parts                                          Talc                     44.95  parts                                          ______________________________________                                    

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

    ______________________________________                                         Exemplary Formulation 25: Granule                                              ______________________________________                                         Compound No. 886 of this invention                                                                      0.2    part                                           Bentonite                55.0   parts                                          Talc                     44.8   parts                                          ______________________________________                                    

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

    ______________________________________                                         Exemplary Formulation 26: Granule                                              ______________________________________                                         Compound No. 887 of this invention                                                                      1.0    part                                           Bentonite                55.0   parts                                          Talc                     44.0   parts                                          ______________________________________                                    

All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.

If desired, the compound of this invention may be applied as a mixture with other kinds of herbicides, various insecticides, sterilizers or adjuvants during preparation or spraying In particular, when applied in beet fields, useful ones include phenmedipham, desmedipham, lenacil, pyrazone., ethofumesate and so on.

As the other kinds of herbicides mentioned above, there may be included those as described in Farm Chemicals Handbook, 70th Edition (1984).

The compounds of this invention can also be applied, in addition to the agricultural and horticultural fields such as farm fields, paddy fields, fruit gardens and the like, to athletic grounds, vacant lands, belts along railroads and others. The amounts of the herbicide to be applied, which may differ depending on the scenes to be applied, the time of application, the application method, the kinds of the objective grasses and the crops harvested, may generally range suitably from about 0.25 to about 10 kg per hectare. When applied to beets in particular, it may range suitably from 0.25 to 500 g/ha, preferably from 0.5 to 250 g/ha.

The following test examples are set forth for illustration of the utility of the compounds of this invention as herbicides.

TEST EXAMPLE 1 Herbicidal Effect Test by Soil Treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa atrovirens), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium) and (L) sugar beet (Beta vulgaris) were sown mixedly. After covering soil to about 1.5 cm over the seeds, herbicides were sprayed evenly on the soil surface to predetermined proportions of the active ingredient. In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria shown below. The results are shown in Table 16.

Some of the compounds of this invention show the selectivity on certain crops.

    ______________________________________                                         Judgement criteria:                                                            ______________________________________                                         5. . . Growth control rates of more than 90% (almost                           completely withered)                                                           4. . . Growth control rates of 70 to 90%                                       3. . . Growth control rates of 40 to 70%                                       2. . . Growth control rates of 20 to 40%                                       1. . . Growth control rates of 5 to 20%                                        0. . . Growth control rates of less than 5%                                    (substantially no effect)                                                      ______________________________________                                    

The above growth control rates are determined by measuring the top fresh weights of the treated plants and those of the non-treated plants, and calculated from the following formula: ##EQU1##

TEST EXAMPLE 2 Herbicidal effect test by stem-leaf treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa atrovirens), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium) and (L) sugar beet (Beta vulgaris) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.

In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface of the stem-leaf portions of various weeds by means of a small sprayer.

Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria as shown in Test example 1. The results are shown in Table 17.

TEST EXAMPLE 3 Agricultural chemical damage test on sugar beet

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (L) sugar beet (Beta vulgaris), (M) cocklebar (Xanthium strumarium), (N) wild mustard (Sinapis arvensis), (E) black nightshade (Solanum nigrum L.) and (O) cleavers (Galium aparine)) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.

On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on sugar beet were examined. The results are shown in Table 18.

TEST EXAMPLE 4 Agricultural chemical damage test on wheat

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (I) wheat (Triticum vulgare) and (P) wild oat (Avena fatua) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the third and the fourth leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.

On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on wheat were examined. The results are shown in Table 19.

                                      TABLE 16                                     __________________________________________________________________________          Amount                                                                         of                                                                             active                                                                         ingre-                                                                         dient                                                                     Comp.                                                                               applied                                                                   No.  kg/ha                                                                               (A)                                                                               (B)                                                                               (C)                                                                               (D)                                                                               (E)                                                                               (F)                                                                               (G)                                                                               (H)                                                                               (I)                                                                              (J)                                                                              (K)                                                                               (L)                                   __________________________________________________________________________     No. 3                                                                               0.02 5  5  5  5  5  5  5  5  0 5 5  --                                         0.04 5  5  5  5  5  5  5  5  1 5 5  --                                    No. 31                                                                              0.16 5  5  4  5  5  5  5  5  0 5 5  --                                    No. 49                                                                              0.02 5  2  1  5  5  5  5  5  5 5 5  0                                          0.04 5  3  3  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  1                                     No. 53                                                                              0.16 1  0  1  4  2  5  5  1  0 0 0  --                                         0.32 2  1  2  5  3  5  5  2  1 1 1  --                                    No. 139                                                                             0.02 5  2  2  5  5  5  5  5  5 5 5  0                                          0.04 5  4  3  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  1                                     No. 408                                                                             0.16 2  4  1  5  3  5  5  5  0 3 3  --                                    No. 490                                                                             0.08 4  4  4  4  5  5  5  3  3 1 1  --                                         0.16 5  4  4  4  5  5  5  4  4 1 1  --                                    No.491                                                                              0.02 0  3  3  4  4  4  5  4  3 3 3  --                                         0.04 4  4  5  4  5  5  5  5  5 5 3  --                                         0.08 5  5  5  5  5  5  5  5  5 5 4  --                                    No. 492                                                                             0.02 5  4  2  5  5  5  5  5  5 5 5  --                                         0.04 5  5  3  5  5  5  5  5  5 5 5  --                                    No. 497                                                                             0.08 4  4  2  4  5  4  5  3  3 2 1  --                                         0.16 5  4  3  4  5  5  5  4  5 3 3  --                                    No. 1369                                                                            0.02 5  4  4  5  5  5  5  5  5 5 3  --                                         0.04 5  5  5  5  5  5  5  5  5 5 5  --                                    No. 3624                                                                            0.16 5  2  5  4  2  4  5  5  5 1 0  --                                    No. 4151                                                                            0.04 2  0  3  2  0  0  5  2  0 0 0  --                                         0.08 3  3  4  3  0  0  5  3  0 0 0  --                                         0.16 4  4  5  5  0  0  5  4  0 0 0  --                                    No. 5258                                                                            0.32 0  1  4  2  1  4  3  0  0 0 0  --                                    No. 132                                                                             0.32 5  3  3  4  4  5  4  5  2 5 0  --                                    No. 583                                                                             0.16 5  5  2  5  5  5  5  5  5 5 5  --                                         0.32 5  5  3  5  5  5  5  5  5 5 5  --                                    No. 638                                                                             0.04 5  4  5  5  5  5  5  5  5 5 5  --                                         0.08 5  5  5  5  5  5  5  5  5 5 5  --                                    No. 640                                                                             0.04 5  5  3  5  5  5  5  5  3 4 3  0                                          0.08 5  5  4  5  5  5  5  5  5 5 5  1                                     No. 771                                                                             0.04 3  3  3  5  5  5  5  3  3 3 3  --                                         0.08 4  4  4  5  5  5  5  4  4 4 4  --                                    No. 772                                                                             0.04 5  5  5  5  5  5  5  5  5 5 5  --                                         0.08 5  5  5  5  5  5  5  5  5 5 5  --                                    No. 773                                                                             0.04 5  4  3  5  5  5  5  5  4 4 3  --                                         0.08 5  5  4  5  5  5  5  5  5 5 4  --                                    No. 862                                                                             0.08 4  3  2  5  5  5  5  5  2 4 2  --                                         0.16 5  4  3  5  5  5  5  5  3 5 3  --                                    No. 864                                                                             0.04 4  4  1  5  5  5  5  3  1 3 0  --                                         0.08 5  5  2  5  5  5  5  4  3 4 1  --                                    No. 885                                                                             0.08 5  4  3  5  5  5  5  5  0 5 1  --                                         0.16 5  5  5  5  5  5  5  5  0 5 3  --                                    No. 887                                                                             0.08 5  5  2  5  5  5  5  5  0 5 5  0                                          0.16 5  5  3  5  5  5  5  5  0 5 5  0                                     No. 896                                                                             0.04 5  3  3  5  5  5  5  5  5 4 3  0                                          0.08 5  4  4  5  5  5  5  5  5 5 4  0                                     No. 2323                                                                            0.04 5  3  5  5  5  5  5  5  0 1 0  0                                          0.08 5  4  5  5  5  5  5  5  0 2 0  0                                     No. 1455                                                                            0.16 5  4  5  5  5  5  5  5  3 5 5  --                                         0.32 5  4  5  5  5  5  5  5  4 5 5  --                                    No. 100                                                                             0.02 5  2  1  5  5  5  5  5  5 5 5  0                                          0.04 5  3  3  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  0                                     No. 105                                                                             0.02 5  2  1  5  5  5  5  5  5 5 5  0                                          0.04 5  3  3  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  0                                     No. 630                                                                             0.02 0  3  2  5  5  5  5  5  0 5 4  --                                         0.04 0  5  4  5  5  5  5  5  0 5 4  --                                         0.08 2  5  5  5  5  5  5  5  0 5 5  --                                    No. 632                                                                             0.02 0  4  3  5  5  5  5  5  0 5 5  0                                          0.04 0  5  4  5  5  5  5  5  0 5 5  0                                          0.08 2  5  5  5  5  5  5  5  0 5 5  0                                     No. 668                                                                             0.02 5  4  4  5  5  5  5  5  4 5 5  0                                          0.04 5  5  5  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  1                                     No. 892                                                                             0.02 5  4  3  5  5  5  5  5  3 5 5  0                                          0.04 5  5  4  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  0                                     No. 2549                                                                            0.63 5  5  5  5  5  5  5  5  5 5 0  --                                    No. 2550                                                                            0.63 5  5  5  5  5  5  5  5  5 5 0  --                                    No. 2551                                                                            0.63 5  5  5  5  5  5  5  5  5 5 0  --                                    No. 2552                                                                            0.63 5  5  5  5  5  5  5  5  5 5 0  --                                    No. 5370                                                                            0.02 5  4  2  5  5  5  5  5  4 5 5  0                                          0.04 5  5  4  5  5  5  5  5  5 5 5  0                                          0.08 5  5  5  5  5  5  5  5  5 5 5  0                                     __________________________________________________________________________

                                      TABLE 17                                     __________________________________________________________________________          Amount                                                                         of                                                                             active                                                                         ingre-                                                                         dient                                                                     Comp.                                                                               applied                                                                   No.  kg/ha                                                                               (A)                                                                               (B)                                                                               (C)                                                                               (D)                                                                               (E)                                                                               (F)                                                                               (G)                                                                               (H)                                                                               (I)                                                                              (J)                                                                              (K)                                                                               (L)                                   __________________________________________________________________________          0.01 5  5  4  5  5  5  5  5  1 5 5  5                                     No. 1                                                                               0.02 5  5  5  5  5  5  5  5  1 5 5  5                                          0.04 5  5  5  5  5  5  5  5  2 5 5  5                                     No. 2                                                                               0.04 2  5  2  5  5  5  5  5  0 5 5  5                                          0.08 4  5  3  5  5  5  5  5  0 5 5  5                                          0.01 5  5  1  5  5  5  5  5  0 5 5  0                                     No. 3                                                                               0.02 5  5  1  5  5  5  5  5  0 5 5  0                                          0.04 5  5  3  5  5  5  5  5  0 5 5  1                                          0.04 1  5  1  5  5  5  5  5  0 5 5  5                                     No. 31                                                                              0.08 2  5  1  5  5  5  5  5  0 5 5  5                                          0.01 5  3  2  4  5  5  5  5  0 5 5  0                                     No. 48                                                                              0.02 5  4  2  5  5  5  5  5  1 5 5  0                                          0.04 5  5  3  5  5  5  5  5  2 5 5  0                                          0.01 5  5  2  5  5  5  5  5  5 5 5  0                                     No. 49                                                                              0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                     No. 51                                                                              0.32 5  5  3  5  5  5  5  5  5 5 5  5                                          0.04 4  3  0  4  5  5  3  4  2 3 3  4                                     No. 52                                                                              0.08 5  3  0  4  5  5  4  5  2 3 4  5                                          0.16 5  3  0  5  5  5  5  5  2 4 4  5                                     No. 53                                                                              0.16 3  3  2  5  5  5  5  4  0 0 3  3                                          0.16 1  3  0  5  5  5  5  2  1 3 3  5                                     No. 55                                                                              0.32 2  4  1  5  5  5  5  3  2 4 4  5                                          0.01 5  3  2  5  5  5  5  5  5 5 5  0                                     No. 138                                                                             0.02 5  4  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                          0.01 5  5  2  5  5  5  5  5  5 5 5  0                                     No. 139                                                                             0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  1                                     No. 140                                                                             0.32 5  5  3  5  5  5  5  5  5 5 5  5                                          0.04 0  4  0  5  5  5  5  5  0 5 5  5                                     No. 408                                                                             0.08 2  5  0  5  5  5  5  5  0 5 5  5                                          0.16 3  5  0  5  5  5  5  5  0 5 5  5                                          0.04 4  0  0  2  5  5  5  3  0 5 5  5                                     No. 481                                                                             0.08 5  0  0  3  5  5  5  4  0 5 5  5                                          0.16 5  0  0  4  5  5  5  5  0 5 5  5                                          0.08 3  5  2  5  5  5  4  4  1 2 2  4                                     No. 490                                                                             0.16 4  5  3  5  5  5  5  5  2 3 3  5                                          0.01 4  4  3  3  5  5  5  4  4 5 5  5                                     No. 491                                                                             0.02 5  4  3  4  5  5  5  5  5 5 5  5                                          0.04 5  5  3  5  5  5  5  5  5 5 5  5                                          0.04 5  5  3  5  5  5  5  5  5 5 5  5                                     No. 492                                                                             0.08 5  5  3  5  5  5  5  5  5 5 5  5                                          0.08 3  4  2  4  5  5  5  3  2 3 5  5                                     No. 497                                                                             0.16 4  5  2  5  5  5  5  5  3 5 5  5                                          0.04 5  5  5  5  5  5  5  5  5 5 5  0                                     No. 1369                                                                            0.08 5  5  5  5  5  5  5  5  5 5 5  1                                          0.08 2  3  2  2  5  5  4  5  1 4 3  0                                     No. 2127                                                                            0.16 3  4  4  5  5  5  5  5  3 5 4  1                                          0.08 5  5  5  3  5  5  5  5  5 2 0  5                                     No. 3624                                                                            0.16 5  5  5  4  5  5  5  5  5 3 0  5                                     No. 3625                                                                            0.16 4  5  5  3  4  5  4  2  3 2 2  5                                          0.04 3  5  4  5  3  0  5  5  0 4 0  5                                     No. 4151                                                                            0.08 4  5  5  5  4  1  5  5  2 5 0  5                                          0.16 5  5  5  5  5  2  5  5  3 5 1  5                                          0.04 0  4  2  4  2  2  5  5  0 3 0  5                                     No. 4152                                                                            0.08 2  5  4  5  3  5  5  5  0 4 1  5                                          0.16 4  5  5  5  4  5  5  5  0 5 1  5                                     No. 5258                                                                            0.32 2  4  2  4  5  5  4  1  1 3 4  3                                          0.02 5  5  3  5  5  5  5  5  0 5 3  5                                     No. 132                                                                             0.04 5  5  3  5  5  5  5  5  1 5 4  5                                          0.04 5  5  2  5  5  5  5  5  5 5 5  2                                     No. 583                                                                             0.08 5  5  3  5  5  5  5  5  5 5 5  4                                          0.04 5  5  3  5  5  5  5  5  1 5 5  5                                     No. 638                                                                             0.08 5  5  4  5  5  5  5  5  2 5 5  5                                          0.02 5  5  2  5  5  5  5  5  2 5 5  1                                     No. 640                                                                             0.04 5  5  2  5  5  5  5  5  4 5 5  1                                          0.08 5  5  3  5  5  5  5  5  5 5 5  2                                          0.04 5  5  2  3  5  4  5  3  3 5 4  5                                     No. 771                                                                             0.08 5  5  3  4  5  5  5  4  4 5 5  5                                          0.04 4  5  2  4  5  5  5  5  4 5 4  5                                     No. 772                                                                             0.08 5  5  4  5  5  5  5  5  5 5 5  5                                          0.04 3  5  2  4  5  5  5  4  4 5 5  5                                     No. 773                                                                             0.08 5  5  3  5  5  5  5  5  5 5 5  5                                          0.04 5  5  2  4  5  5  5  4  4 5 4  5                                     No. 862                                                                             0.08 5  5  3  5  5  5  5  5  4 5 5  5                                     No. 863                                                                             0.32 5  5  2  4  5  5  4  5  2 5 5  3                                          0.04 4  5  2  4  5  5  5  4  2 4 3  3                                     No. 864                                                                             0.08 5  5  3  4  5  5  5  4  3 5 5  4                                          0.01 0  5  1  5  5  5  5  3  0 5 5  5                                     No. 885                                                                             0.02 1  5  2  5  5  5  5  5  0 5 5  5                                          0.04 2  5  3  5  5  5  5  5  0 5 5  5                                          0.16 0  5  1  5  5  4  4  4  0 4 3  1                                     No. 886                                                                             0.32 0  5  1  5  5  5  5  5  0 4 5  1                                          0.01 0  5  1  5  5  5  5  5  0 5 5  0                                     No. 887                                                                             0.02 2  5  1  5  5  5  5  5  0 5 5  1                                          0.04 3  5  2  5  5  5  5  5  0 5 5  1                                     No. 1359                                                                            0.63 5  2  1  4  5  5  5  4  0 4 4  4                                          0.04 5  5  3  4  5  5  5  5  0 5 5  0                                     No. 1361                                                                            0.08 5  5  4  5  5  5  5  5  0 5 5  1                                          0.02 4  4  2  5  5  5  5  5  0 5 4  0                                     No. 896                                                                             0.04 5  5  3  5  5  5  5  5  1 5 5  1                                          0.08 5  5  4  5  5  5  5  5  2 5 5  2                                          0.04 5  5  2  5  5  5  5  5  0 4 3  4                                     No. 2323                                                                            0.08 5  5  3  5  5  5  5  5  0 5 4  5                                          0.16 5  5  0  5  5  5  5  5  0 5 5  5                                     No. 1453                                                                            0.32 5  5  1  5  5  5  5  5  0 5 5  5                                          0.04 5  5  3  5  5  5  5  5  5 5 5  5                                     No. 1455                                                                            0.08 5  5  4  5  5  5  5  5  5 5 5  5                                          0.01 5  5  2  5  5  5  5  5  5 5 5  0                                     No. 100                                                                             0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                          0.01 5  5  2  5  5  5  5  5  5 5 5  0                                     No. 105                                                                             0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                     No. 581                                                                             0.16 5  3  4  5  5  5  5  5  5 5 5  5                                          0.01 0  4  2  5  5  5  5  5  0 5 5  5                                     No. 630                                                                             0.02 0  4  2  5  5  5  5  5  0 5 5  5                                          0.04 0  5  3  5  5  5  5  5  0 5 5  5                                          0.01 0  4  2  5  5  5  5  5  0 5 5  0                                     No. 632                                                                             0.02 0  5  3  5  5  5  5  5  0 5 5  0                                          0.04 0  5  3  5  5  5  5  5  0 5 5  0                                          0.01 5  5  3  5  5  5  5  5  5 5 5  0                                     No. 668                                                                             0.02 5  5  4  5  5  5  5  5  5 5 5  1                                          0.04 5  5  5  5  5  5  5  5  5 5 5  2                                          0.01 5  5  2  5  5  5  5  5  5 5 5  0                                     No. 892                                                                             0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                     No. 2549                                                                            0.32 5  5  4  5  5  5  5  5  5 5 1  5                                     No. 2550                                                                            0.63 5  5  4  5  5  4  5  5  5 5 0  5                                     No. 2551                                                                            0.32 5  5  4  5  5  5  5  5  5 5 1  5                                     No. 2552                                                                            0.63 5  4  5  5  4  5  5  5  5 5 0  5                                          0.01 5  4  2  5  5  5  5  5  4 5 5  0                                     No. 5370                                                                            0.02 5  5  3  5  5  5  5  5  5 5 5  0                                          0.04 5  5  3  5  5  5  5  5  5 5 5  0                                     __________________________________________________________________________

                  TABLE 18                                                         ______________________________________                                                Amount                                                                         of                                                                             active                                                                         ingre-                                                                         dient                                                                   Comp.  applied                                                                 No.    kg/ha    (M)      (E)  (N)    (O)  (L)                                  ______________________________________                                                0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 3  0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 48 0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    0                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 49 0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 138                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    0                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 139                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 1369                                                                              0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.04     5        5    5      5    0                                    No. 2127                                                                              0.08     5        5    5      5    0                                           0.16     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 100                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    0                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 105                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    0                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 134                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    1                                           0.08     5        5    5      5    2                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 630                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 640                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 668                                                                               0.02     5        5    5      5    1                                           0.04     5        5    5      5    2                                           0.08     5        5    5      5    3                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 887                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 892                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 896                                                                               0.02     5        5    5      5    0                                           0.04     5        5    5      5    1                                           0.08     5        5    5      5    2                                           0.01     5        5    5      5    0                                    No. 1361                                                                              0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 1455                                                                              0.02     5        5    5      5    0                                           0.04     5        5    5      5    1                                           0.08     5        5    5      5    2                                           0.01     5        5    5      5    0                                    No. 5349                                                                              0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                           0.005    5        5    5      5    0                                           0.01     5        5    5      5    0                                    No. 5370                                                                              0.02     5        5    5      5    0                                           0.04     5        5    5      5    0                                           0.08     5        5    5      5    1                                    ______________________________________                                    

                  TABLE 19                                                         ______________________________________                                                   Amount                                                                         of                                                                             active                                                                         ingre-                                                                         dient                                                                Comp.     applied                                                              No.       kg/ha          (I)   (P)                                             ______________________________________                                                   0.01           0     4                                               1         0.02           0     5                                                         0.04           0     5                                                         0.01           0     4                                               132       0.02           0     5                                                         0.04           0     5                                               ______________________________________                                     

We claim:
 1. A process for growing wheat and selectively preventing or controlling the growth of wild oats in the same site in which the wheat is being cultivated which comprises applying to said site an amount of an active compound sufficient to control the growth of wild oats without adversely affecting the growth of the wheat, said active compound being N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide or N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide.
 2. The process of claim 1, wherein said compound is N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide.
 3. The process of claim 1, wherein said compound is N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide.
 4. The process of claim 1, wherein said active compound is applied to said site when the wheat is in a leaf stage.
 5. The process of claim 2, wherein said active compound is applied to said site when the wheat is in a leaf stage.
 6. The process of claim 3, wherein said active compound is applied to said site when the wheat is in a leaf stage. 